The Experts below are selected from a list of 78 Experts worldwide ranked by ideXlab platform
Yasumi Ohshima - One of the best experts on this subject based on the ideXlab platform.
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does a dna less Cellular Organism exist on earth
Genes to Cells, 2011Co-Authors: Akira Hiyoshi, Kohji Miyahara, Chiaki Kato, Yasumi OhshimaAbstract:All the self-reproducing Cellular Organisms so far examined have DNA as the genome. However, a DNA-less Organism carrying an RNA genome is suggested by the fact that many RNA viruses exist and the widespread view that an RNA world existed before the present DNA world. Such a possibility is most plausible in the microbial world where biological diversity is enormous and most Organisms have not been identified. We have developed experimental methodology to search DNA-less microOrganisms, which is based on cultivation with drugs that inhibit replication or expression of DNA, detection of DNA in colonies with a fluorescent dye and double staining for DNA and RNA at a Cellular level. These methods have been applied for about 100 microbial samples from various waters including hot springs, soils including deep sea sediments, and Organisms. We found many colonies and cells which apparently looked DNA-less and examined them further. So far, all such colonies that reformed colonies on isolation were identified to be DNA-positive. However, considering the difficulty in cultivation, we think it possible for DNA-less microOrganisms to live around us. We believe that our ideas and results will be of interest and useful to discover one in the future.
Renjie Jiao - One of the best experts on this subject based on the ideXlab platform.
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histone chaperone caf 1 essential roles in multi Cellular Organism development
Cellular and Molecular Life Sciences, 2015Co-Authors: Jiyong Liu, Wumin Deng, Renjie JiaoAbstract:More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-Cellular Organism development.
Joav Merrick - One of the best experts on this subject based on the ideXlab platform.
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human development viii a theory of deep quantum chemistry and cell consciousness quantum chemistry controls genes and biochemistry to give cells and higher Organisms consciousness and complex behavior
The Scientific World Journal, 2006Co-Authors: Soren Ventegodt, Tyge Dahl Hermansen, Trine Flensborgmadsen, Maj Lyck Nielsen, Joav MerrickAbstract:Deep quantum chemistry is a theory of deeply structured quantum fields carrying the biological information of the cell, making it able to remember, intend, represent the inner and outer world for comparison, understand what it “sees”, and make choices on its structure, form, behavior and division. We suggest that deep quantum chemistry gives the cell consciousness and all the qualities and abilities related to consciousness. We use geometric symbolism, which is a pre-mathematical and philosophical approach to problems that cannot yet be handled mathematically. Using Occams razor we have started with the simplest model that works; we presume this to be a many-dimensional, spiral fractal. We suggest that all the electrons of the large biological molecules orbitals make one huge “cell-orbital”, which is structured according to the spiral fractal nature of quantum fields. Consciousness of single cells, multi Cellular structures as e.g. organs, multi-Cellular Organisms and multi-individual colonies (like ants) and human societies can thus be explained by deep quantum chemistry. When biochemical activity is strictly controlled by the quantum-mechanical super-orbital of the cell, this orbital can deliver energetic quanta as biological information, distributed through many fractal levels of the cell to guide form and behavior of an individual single or a multi-Cellular Organism. The top level of information is the consciousness of the cell or Organism, which controls all the biochemical processes. By this speculative work inspired by Penrose and Hameroff we hope to inspire other researchers to formulate more strict and mathematically correct hypothesis on the complex and coherence nature of matter, life and consciousness.
Akira Hiyoshi - One of the best experts on this subject based on the ideXlab platform.
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does a dna less Cellular Organism exist on earth
Genes to Cells, 2011Co-Authors: Akira Hiyoshi, Kohji Miyahara, Chiaki Kato, Yasumi OhshimaAbstract:All the self-reproducing Cellular Organisms so far examined have DNA as the genome. However, a DNA-less Organism carrying an RNA genome is suggested by the fact that many RNA viruses exist and the widespread view that an RNA world existed before the present DNA world. Such a possibility is most plausible in the microbial world where biological diversity is enormous and most Organisms have not been identified. We have developed experimental methodology to search DNA-less microOrganisms, which is based on cultivation with drugs that inhibit replication or expression of DNA, detection of DNA in colonies with a fluorescent dye and double staining for DNA and RNA at a Cellular level. These methods have been applied for about 100 microbial samples from various waters including hot springs, soils including deep sea sediments, and Organisms. We found many colonies and cells which apparently looked DNA-less and examined them further. So far, all such colonies that reformed colonies on isolation were identified to be DNA-positive. However, considering the difficulty in cultivation, we think it possible for DNA-less microOrganisms to live around us. We believe that our ideas and results will be of interest and useful to discover one in the future.
Jiyong Liu - One of the best experts on this subject based on the ideXlab platform.
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histone chaperone caf 1 essential roles in multi Cellular Organism development
Cellular and Molecular Life Sciences, 2015Co-Authors: Jiyong Liu, Wumin Deng, Renjie JiaoAbstract:More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-Cellular Organism development.