The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform
Yulin Li - One of the best experts on this subject based on the ideXlab platform.
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STUDIES ON MACROCYCLIC DITERPENOIDS (XV) ‐ TOTAL SYNTHESIS OF (R)‐(‐)‐CEMRENE‐A
Bulletin des Sociétés Chimiques Belges, 2010Co-Authors: Yulin LiAbstract:The total synthesis of (R)-(-)-Cembrene-A was described in ∼29% overall yield from E-geranyl acetone and (R)-(+)-limonene through ten steps by using the modified Wittig reaction and titanium-induced intramolecular carbonyl coupling as key steps.
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Total Synthesis of (±)-IsoCembrene: A Tactic for Both Diene Construction and Macrocycle Formation
Synthetic Communications, 2003Co-Authors: Fengzhi Zhang, Lizeng Peng, Tao Zhang, Yulin LiAbstract:Abstract The total synthesis of (±)-isoCembrene 1, a naturally occurring Cembrene diterpenoid, has been achieved via a unified, convergent and highly efficient strategy by imploying an intramolecular Stille sp2–sp2 macrocyclization as the key step and it presents an ideal opportunity to extend the effectiveness of the tactic for both 1,3-diene construction and macrocycle formation.
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A Facile Total Synthesis of (±)-Cembrene by Titanium-Induced Keto Ester Cyclization
Synthesis, 1994Co-Authors: Weidong Li, Ying Li, Yulin LiAbstract:A direct approach of titanium-induced intramolecular keto ester cyclization was applied to the total synthesis of macrocyclic diterpenoids, by which (±)-Cembrene was synthesized from geranyl-acetone by a short and efficient route
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facile and practical total syntheses of mukulol and Cembrene by low valent titanium induced keto ester cyclization
Chemistry Letters, 1994Co-Authors: Weidong Li, Ying Li, Yulin LiAbstract:A direct approach of low-valent titanium-induced intramolecular keto ester cyclization was first applied to the total syntheses of macrocyclic diterpenoids, by which (±)-mukulol and (±)-Cembrene were synthesized from geranylacetone by a short and efficient route.
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Facile and Practical Total Syntheses of (±)-Mukulol and (±)-Cembrene by Low-valent Titanium-induced Keto Ester Cyclization
Chemistry Letters, 1994Co-Authors: Weidong Li, Ying Li, Yulin LiAbstract:A direct approach of low-valent titanium-induced intramolecular keto ester cyclization was first applied to the total syntheses of macrocyclic diterpenoids, by which (±)-mukulol and (±)-Cembrene were synthesized from geranylacetone by a short and efficient route.
Mohamedelamir F Hegazy - One of the best experts on this subject based on the ideXlab platform.
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Sarcoehrenbergilides D–F: cytotoxic Cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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sarcoehrenbergilides d f cytotoxic Cembrene diterpenoids from the soft coral sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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Cembrene diterpenoids with ether linkages from sarcophyton ehrenbergi an anti proliferation and molecular docking assessment
Marine Drugs, 2017Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W PareAbstract:Three new Cembrene diterpenoids, sarcoehrenbergilid A–C (1–3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and characterized from a solvent extract of the Red Sea soft coral Sarcophyton ehrenbergi. Chemical structures were elucidated by NMR and MS analyses with absolute stereochemistry determined by X-ray analysis. Since these isolated Cembrene diterpenes contained 10 or more carbons in a large flexible ring, conformer stabilities were examined based on density functional theory calculations. Anti-proliferative activities for 1–8 were evaluated against three human tumor cell lines of different origins including the: lung (A549), colon (Caco-2), and liver (HepG2). Sardisterol (8) was the most potent of the metabolites isolated with an IC50 of 27.3 µM against the A549 cell line. Since an elevated human-cancer occurrence is associated with an aberrant receptor function for the epidermal growth factor receptor (EGFR), molecular docking studies were used to examine preferential metabolite interactions/binding and probe the mode-of-action for metabolite-anti tumor activity.
Paul W Pare - One of the best experts on this subject based on the ideXlab platform.
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Sarcoehrenbergilides D–F: cytotoxic Cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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sarcoehrenbergilides d f cytotoxic Cembrene diterpenoids from the soft coral sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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Cembrene diterpenoids with ether linkages from sarcophyton ehrenbergi an anti proliferation and molecular docking assessment
Marine Drugs, 2017Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W PareAbstract:Three new Cembrene diterpenoids, sarcoehrenbergilid A–C (1–3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and characterized from a solvent extract of the Red Sea soft coral Sarcophyton ehrenbergi. Chemical structures were elucidated by NMR and MS analyses with absolute stereochemistry determined by X-ray analysis. Since these isolated Cembrene diterpenes contained 10 or more carbons in a large flexible ring, conformer stabilities were examined based on density functional theory calculations. Anti-proliferative activities for 1–8 were evaluated against three human tumor cell lines of different origins including the: lung (A549), colon (Caco-2), and liver (HepG2). Sardisterol (8) was the most potent of the metabolites isolated with an IC50 of 27.3 µM against the A549 cell line. Since an elevated human-cancer occurrence is associated with an aberrant receptor function for the epidermal growth factor receptor (EGFR), molecular docking studies were used to examine preferential metabolite interactions/binding and probe the mode-of-action for metabolite-anti tumor activity.
Thomas Efferth - One of the best experts on this subject based on the ideXlab platform.
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sarcoehrenbergilides d f cytotoxic Cembrene diterpenoids from the soft coral sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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Sarcoehrenbergilides D–F: cytotoxic Cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
Shinji Ohta - One of the best experts on this subject based on the ideXlab platform.
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Sarcoehrenbergilides D–F: cytotoxic Cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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sarcoehrenbergilides d f cytotoxic Cembrene diterpenoids from the soft coral sarcophyton ehrenbergi
RSC Advances, 2019Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W Pare, Akemi Umeyama, Thomas EfferthAbstract:A solvent extract of the soft coral Sarcophyton ehrenbergi afforded Cembrene diterpenoids, sarcoehrenbergilid D–F (1–3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1–3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).
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Cembrene diterpenoids with ether linkages from sarcophyton ehrenbergi an anti proliferation and molecular docking assessment
Marine Drugs, 2017Co-Authors: Mohamedelamir F Hegazy, Abdelsamed I Elshamy, Tarik A Mohamed, Ahmed R Hamed, Mahmoud A A Ibrahim, Shinji Ohta, Paul W PareAbstract:Three new Cembrene diterpenoids, sarcoehrenbergilid A–C (1–3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and characterized from a solvent extract of the Red Sea soft coral Sarcophyton ehrenbergi. Chemical structures were elucidated by NMR and MS analyses with absolute stereochemistry determined by X-ray analysis. Since these isolated Cembrene diterpenes contained 10 or more carbons in a large flexible ring, conformer stabilities were examined based on density functional theory calculations. Anti-proliferative activities for 1–8 were evaluated against three human tumor cell lines of different origins including the: lung (A549), colon (Caco-2), and liver (HepG2). Sardisterol (8) was the most potent of the metabolites isolated with an IC50 of 27.3 µM against the A549 cell line. Since an elevated human-cancer occurrence is associated with an aberrant receptor function for the epidermal growth factor receptor (EGFR), molecular docking studies were used to examine preferential metabolite interactions/binding and probe the mode-of-action for metabolite-anti tumor activity.