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Jyh-horng Sheu - One of the best experts on this subject based on the ideXlab platform.

  • Sesquiterpenoids from the Formosan Soft Coral Lemnalia flava
    2020
    Co-Authors: Ho Cheng Huang, Michael Y. Chiang, Zhihong Wen, Chihsin Hsu, Chihhua Chao, Atallah F Ahmed, Yao-haur Kuo, Jyh-horng Sheu
    Abstract:

    Abstract-Three sesquiterpenoids with unprecedented skeletons, paralemnanone (1), isoparalemnanone (2), and paralemnanol (3), were isolated from the Formosan Soft Coral Paralemnalia thyrsoides. Their structures were elucidated by extensive spectroscopic analysis, and the structure of 1 was further confirmed by X-ray crystallographic analysis. The absolute stereochemistries of 1-3 were established by application of the Mosher's method on 2. Ó 2006 Elsevier Ltd. All rights reserved. Soft Corals of the genus Paralemnalia 1 and Lemnalia 2 have been found to be a rich source of sesquiterpenoids (neolemnane and nardosinane carbon skeleton) and norsesquiterpenoids. Our previous study on the secondary metabolites of a Taiwanese Soft Coral Paralemnalia thyrsoides has resulted in the isolation of three terpenoids, paralemnolins A-C. 4 The inhibition of these metabolites toward the pro-inflammatory proteins (iNOS and COX-2) expression was also investigated. The Soft Coral P. thyrsoides (1.8 kg) was collected by hand using scuba at Green Island, Taiwan in July, 2004. The EtOH extract (67.3 g) of the frozen organism was partitioned between EtOAc and H 2 O. The EtOAcsoluble portion (33.0 g) was subjected to column chromatography over silica gel using n-hexane-EtOAc mixtures of increasing polarity. A fraction eluted n-hexane-EtOAc (3:1) was further purified by reverse phase HPLC (Purospher RP-18e, 5 lm, 10 · 250 mm), using acetonitrile-H 2 O (2:1) to afford 3 (2.9 mg). Another fraction eluted with n-hexane-EtOAc (2:1) was chromatographed by reverse phase HPLC using acetonitrile-H 2 O (2:1), and followed by normal phase HPLC (Lichrosorb Si 60, 7 lm, 25 · 250 mm), eluting with n-hexane-EtOAc (5:1), to yield 1 (3.1 mg) and 2 (12.6 mg). Paralemnon

  • New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
    MDPI AG, 2018
    Co-Authors: Chia-chi Peng, Tsong-long Hwang, Changfeng Dai, Chiungyao Huang, Atallah F Ahmed, Jyh-horng Sheu
    Abstract:

    Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan Soft Coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1–7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils

  • lobophylins f h three new cembrene diterpenoids from Soft Coral lobophytum crassum
    Journal of Asian Natural Products Research, 2017
    Co-Authors: Tarik A. Mohamed, Abdelsamed I Elshamy, Jyh-horng Sheu, Taha A Hussien, Juihsin Su, Mohamed-elamir F. Hegazy
    Abstract:

    AbstractThree new cembrenoids, lobophylins F-H (1–3), along with three known ones, lobophylins A-C (4–6), were isolated from the ethyl acetate extract of the Taiwan water Soft Coral Lobophytum crassum. The structures of isolated cembrenoids were elucidated on the basis of extensive spectroscopic methods such as IR, 1D, 2D NMR and HR–ESI–MS.

  • bioactive steroids from the formosan Soft Coral umbellulifera petasites
    Marine Drugs, 2016
    Co-Authors: Chiungyao Huang, Yen-ju Tseng, Tsong-long Hwang, Pingjyun Sung, Changfeng Dai, Chewei Chang, Jessica Lee, Huichun Wang, Jyh-horng Sheu
    Abstract:

    Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine Soft Coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities.

  • tortuosenes a and b new diterpenoid metabolites from the formosan Soft Coral sarcophyton tortuosum
    Organic Letters, 2014
    Co-Authors: Yen-ju Tseng, Tsong-long Hwang, Bowei Chen, Hsing-yin Chen, Jyh-horng Sheu
    Abstract:

    Tortuosenes A and B (1 and 2), possessing new diterpenoid molecular structures, were isolated from the Formosan Soft Coral Sarcophyton tortuosum along with a known cembrane, emblide (3). The structures of 1 and 2 were established by extensive spectroscopic analysis, and the absolute configuration of 1 was determined by TDDFT ECD calculations. Tortuosene A was found to display significant inhibitory effects on the generation of the superoxide anion in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced neutrophils.

Shang-kwei Wang - One of the best experts on this subject based on the ideXlab platform.

  • ubiquitin proteasome modulating dolabellanes and secosteroids from Soft Coral clavularia flava
    Marine Drugs, 2020
    Co-Authors: Cheyen Chiu, Shang-kwei Wang, Xuehua Ling, Chang-yih Duh
    Abstract:

    We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from Soft Coral Clavularia flava, which potentiates proteasome inhibition. Chemical structure elucidation revealed they are dolabellane- and secosteroid-based compounds including a new dolabellane, clavinflol C (1), three known dolabellanes, stolonidiol (2), stolonidiol-17-acetate (3), and clavinflol B (4) as well as two new secosteroids, 3β,11-dihydroxy-24-methyl-9,11-secocholest-5-en-9,23-dione (5) and 3β,11-dihydroxy-24-methylene-9,11-secocholest-5-en-9,23-dione (6). All six compounds show less cytotoxicity than those of known proteasome inhibitors, bortezomib and MG132. In summary, the high-content measurements of control inhibitors, bortezomib and MG132, manifest the highest ratio >2 in high-content measurement. Of the isolated compounds, 2 and 5 showed higher activity, followed by 3 and 6, and then 1 and 4 exhibited moderate inhibition.

  • Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata
    MDPI AG, 2018
    Co-Authors: Fu-yun Hsu, Shang-kwei Wang, Chang-yih Duh
    Abstract:

    A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from Soft Coral Sinularia nanolobata. The structures of the new compounds were elucidated by extensive analysis of spectroscopic data

  • sandensone a a novel sesquiterpenoid from the formosan Soft Coral sinularia sandensis
    ChemInform, 2015
    Co-Authors: Shiyie Cheng, Shang-kwei Wang, Peiwen Chen, Chang-yih Duh
    Abstract:

    Abstract A chromatographic and NMR spectroscopy-based fractionation on the acetone extracts of the Soft Coral Sinularia sandensis led to the isolation of a novel sesquiterpenoid, sandensone A (1). The structure of 1 was elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as HRESIMS spectrometry. The absolute configuration at C-12 of 1 was determined as R using a modified Mosher’s method. The cytotoxicity against A549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus) were evaluated in vitro.

  • polyoxygenated cembrane diterpenoids from the Soft Coral sarcophyton ehrenbergi
    International Journal of Molecular Sciences, 2015
    Co-Authors: Shiyie Cheng, Shang-kwei Wang, Mukeng Hsieh, Chang-yih Duh
    Abstract:

    Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the Soft Coral Sarcophyton ehrenbergi. The structures of 1–5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC50 values of 25.0 μg/mL.

  • Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
    MDPI AG, 2014
    Co-Authors: Yen-ju Tseng, Shang-kwei Wang, Yuan-chien Yang, Chang-yih Duh
    Abstract:

    Four new cembrane-type diterpenes; numerosol A–D (1–4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese Soft Coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 μM

Lin Wenhan - One of the best experts on this subject based on the ideXlab platform.

  • Sarcophyolides B-E, New Cembranoids from the Soft Coral Sarcophyton elegans
    marine drugs, 2013
    Co-Authors: Xi Zhifang, Bie Wei, Chen Wei, Liu Dong, Van Ofwegen Leen, Proksch Peter, Lin Wenhan
    Abstract:

    Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the Soft Coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000328621900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, MedicinalSCI(E)PubMed7ARTICLE93186-31961

  • Cembranoids from the Soft Coral Sinularia rigida with Antifouling Activities
    农业化学与食品化学杂志, 2013
    Co-Authors: Lai Daowan, Deng Zhiwei, Van Ofwegen Leen, Proksch Peter, Geng Zhufeng, Lin Wenhan
    Abstract:

    Chemical examination of the Soft Coral Sinularia rigida resulted in the isolation of 12 new cembranoids, namely, sinulariols T-Z(5) (1-12), together with a known analogue, 13. Their structures were determined on the basis of ID and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analyses in association with MS and IR data. Compounds 7 and 13 showed potent antifouling activity for the inhibition against the barnacle Balanus amphitrite and moderate inhibition against Bugula neritina. The primary structure-activity relationship is discussed.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319250500015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Agriculture, MultidisciplinaryChemistry, AppliedFood Science & TechnologySCI(E)EIPubMed6ARTICLE194585-45926

  • Pavidolides A-E, new cembranoids from the Soft Coral Sinularia pavida
    四面体通讯, 2012
    Co-Authors: Shen Shi, Liu Dong, Van Ofwegen Leen, Proksch Peter, Zhu Huajie, Chen Dawei, Lin Wenhan
    Abstract:

    Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine Soft Coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. (C) 2012 Elsevier Ltd. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309618000010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, OrganicSCI(E)9ARTICLE435759-57625

  • Sinulariols A-S, 19-oxygenated cembranoids from the Chinese Soft Coral Sinularia rigida
    tetrahedron, 2011
    Co-Authors: Lai Daowan, Deng Zhiwei, Van Ofwegen Leen, Proksch Peter, Li Yongxin, Xu Minjuan, Qian Peiyuan, Lin Wenhan
    Abstract:

    Chemical examination of a Chinese Soft Coral Sinularia rigida resulted in the isolation and characterization of 19 new cembrane-type diterpenoids, designated as sinulariols A-S (1-19). Their structures were determined on the basis of extensive spectroscopic (2D NMR, IR, and MS) analysis in association with modified Mosher's method. All compounds featured unusual 19-oxygenated functionalities, which are rarely found from cembranoid family. The biogenetic transformation of the isolated compounds is postulated. Part of the isolated cembranoids showed significant anti-fouling activity. (C) 2011 Elsevier Ltd. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293606200021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, OrganicSCI(E)15ARTICLE336018-60296

  • Lobophytones O-T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
    marine drugs, 2010
    Co-Authors: Yan Pengcheng, Deng Zhiwei, Van Ofwegen Leen, Proksch Peter, Lin Wenhan
    Abstract:

    Chemical examination of a Chinese Soft Coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O-S (1-5) and a new "monomeric" cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000285712200007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Chemistry, MedicinalSCI(E)PubMed15ARTICLE112837-2848

Chang-yih Duh - One of the best experts on this subject based on the ideXlab platform.

  • ubiquitin proteasome modulating dolabellanes and secosteroids from Soft Coral clavularia flava
    Marine Drugs, 2020
    Co-Authors: Cheyen Chiu, Shang-kwei Wang, Xuehua Ling, Chang-yih Duh
    Abstract:

    We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from Soft Coral Clavularia flava, which potentiates proteasome inhibition. Chemical structure elucidation revealed they are dolabellane- and secosteroid-based compounds including a new dolabellane, clavinflol C (1), three known dolabellanes, stolonidiol (2), stolonidiol-17-acetate (3), and clavinflol B (4) as well as two new secosteroids, 3β,11-dihydroxy-24-methyl-9,11-secocholest-5-en-9,23-dione (5) and 3β,11-dihydroxy-24-methylene-9,11-secocholest-5-en-9,23-dione (6). All six compounds show less cytotoxicity than those of known proteasome inhibitors, bortezomib and MG132. In summary, the high-content measurements of control inhibitors, bortezomib and MG132, manifest the highest ratio >2 in high-content measurement. Of the isolated compounds, 2 and 5 showed higher activity, followed by 3 and 6, and then 1 and 4 exhibited moderate inhibition.

  • Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata
    MDPI AG, 2018
    Co-Authors: Fu-yun Hsu, Shang-kwei Wang, Chang-yih Duh
    Abstract:

    A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from Soft Coral Sinularia nanolobata. The structures of the new compounds were elucidated by extensive analysis of spectroscopic data

  • sandensone a a novel sesquiterpenoid from the formosan Soft Coral sinularia sandensis
    ChemInform, 2015
    Co-Authors: Shiyie Cheng, Shang-kwei Wang, Peiwen Chen, Chang-yih Duh
    Abstract:

    Abstract A chromatographic and NMR spectroscopy-based fractionation on the acetone extracts of the Soft Coral Sinularia sandensis led to the isolation of a novel sesquiterpenoid, sandensone A (1). The structure of 1 was elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as HRESIMS spectrometry. The absolute configuration at C-12 of 1 was determined as R using a modified Mosher’s method. The cytotoxicity against A549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus) were evaluated in vitro.

  • polyoxygenated cembrane diterpenoids from the Soft Coral sarcophyton ehrenbergi
    International Journal of Molecular Sciences, 2015
    Co-Authors: Shiyie Cheng, Shang-kwei Wang, Mukeng Hsieh, Chang-yih Duh
    Abstract:

    Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the Soft Coral Sarcophyton ehrenbergi. The structures of 1–5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC50 values of 25.0 μg/mL.

  • Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
    MDPI AG, 2014
    Co-Authors: Yen-ju Tseng, Shang-kwei Wang, Yuan-chien Yang, Chang-yih Duh
    Abstract:

    Four new cembrane-type diterpenes; numerosol A–D (1–4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese Soft Coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 μM

Tsong-long Hwang - One of the best experts on this subject based on the ideXlab platform.

  • New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
    MDPI AG, 2018
    Co-Authors: Chia-chi Peng, Tsong-long Hwang, Changfeng Dai, Chiungyao Huang, Atallah F Ahmed, Jyh-horng Sheu
    Abstract:

    Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan Soft Coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1–7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils

  • bioactive steroids from the formosan Soft Coral umbellulifera petasites
    Marine Drugs, 2016
    Co-Authors: Chiungyao Huang, Yen-ju Tseng, Tsong-long Hwang, Pingjyun Sung, Changfeng Dai, Chewei Chang, Jessica Lee, Huichun Wang, Jyh-horng Sheu
    Abstract:

    Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4–11), were isolated from a Formosan marine Soft Coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1–3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1–11 were also examined to evaluate the anti-inflammatory potential, and 2–4 were shown to exhibit significant activities.

  • tortuosenes a and b new diterpenoid metabolites from the formosan Soft Coral sarcophyton tortuosum
    Organic Letters, 2014
    Co-Authors: Yen-ju Tseng, Tsong-long Hwang, Bowei Chen, Hsing-yin Chen, Jyh-horng Sheu
    Abstract:

    Tortuosenes A and B (1 and 2), possessing new diterpenoid molecular structures, were isolated from the Formosan Soft Coral Sarcophyton tortuosum along with a known cembrane, emblide (3). The structures of 1 and 2 were established by extensive spectroscopic analysis, and the absolute configuration of 1 was determined by TDDFT ECD calculations. Tortuosene A was found to display significant inhibitory effects on the generation of the superoxide anion in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced neutrophils.

  • Tortuosenes A and B, New Diterpenoid Metabolites from the Formosan Soft Coral Sarcophyton tortuosum
    2014
    Co-Authors: Kuan-hua Lin, Yen-ju Tseng, Tsong-long Hwang, Changfeng Dai, Bowei Chen, Hsing-yin Chen, Jyh-horng Sheu
    Abstract:

    Tortuosenes A and B (1 and 2), possessing new diterpenoid molecular structures, were isolated from the Formosan Soft Coral Sarcophyton tortuosum along with a known cembrane, emblide (3). The structures of 1 and 2 were established by extensive spectroscopic analysis, and the absolute configuration of 1 was determined by TDDFT ECD calculations. Tortuosene A was found to display significant inhibitory effects on the generation of the superoxide anion in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced neutrophils

  • flexibilins a c new cembrane type diterpenoids from the formosan Soft Coral sinularia flexibilis
    Marine Drugs, 2013
    Co-Authors: Michael Y. Chiang, Tsong-long Hwang, Yung-husan Chen, Nai-cheng Lin, Wei-hsien Wang, Lee-shing Fang, Yuehhsiung Kuo, Pingjyun Sung
    Abstract:

    Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the Soft Coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.