The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Anne D Donaldson - One of the best experts on this subject based on the ideXlab platform.
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is pcna unloading the Central Function of the elg1 atad5 replication factor c like complex
Cell Cycle, 2013Co-Authors: T. Kubota, Kyungjae Myung, Anne D DonaldsonAbstract:Maintaining genome stability is crucial for all cells. The budding yeast Elg1 protein, the major subunit of a replication factor C-like complex, is important for genome stability, since cells lacking Elg1 exhibit increased recombination and chromosomal rearrangements. This genome maintenance Function of Elg1 seems to be conserved in higher eukaryotes, since removal of the human Elg1 homolog, encoded by the ATAD5 gene, also causes genome instability leading to tumorigenesis. The fundamental molecular Function of the Elg1/ATAD5-replication factor C-like complex (RLC) was, until recently, elusive, although Elg1/ATAD5-RLC was known to interact with the replication sliding clamp PCNA. Two papers have now reported that following DNA replication, the Elg1/ATAD5-RLC is required to remove PCNA from chromatin in yeast and human cells. In this Review, we summarize the evidence that Elg1/ATAD5-RLC acts as a PCNA unloader and discuss the still enigmatic relationship between the Function of Elg1/ATAD5-RLC in PCNA unloading and the role of Elg1/ATAD5 in maintaining genomic stability.
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Is PCNA unloading the Central Function of the Elg1/ATAD5 replication factor C-like complex?
Cell Cycle, 2013Co-Authors: T. Kubota, Kyungjae Myung, Anne D DonaldsonAbstract:Maintaining genome stability is crucial for all cells. The budding yeast Elg1 protein, the major subunit of a replication factor C-like complex, is important for genome stability, since cells lacking Elg1 exhibit increased recombination and chromosomal rearrangements. This genome maintenance Function of Elg1 seems to be conserved in higher eukaryotes, since removal of the human Elg1 homolog, encoded by the ATAD5 gene, also causes genome instability leading to tumorigenesis. The fundamental molecular Function of the Elg1/ATAD5-replication factor C-like complex (RLC) was, until recently, elusive, although Elg1/ATAD5-RLC was known to interact with the replication sliding clamp PCNA. Two papers have now reported that following DNA replication, the Elg1/ATAD5-RLC is required to remove PCNA from chromatin in yeast and human cells. In this Review, we summarize the evidence that Elg1/ATAD5-RLC acts as a PCNA unloader and discuss the still enigmatic relationship between the Function of Elg1/ATAD5-RLC in PCNA unloading and the role of Elg1/ATAD5 in maintaining genomic stability.
Zhu Q - One of the best experts on this subject based on the ideXlab platform.
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Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration
Acta pharmaceutica Sinica, 2016Co-Authors: Zhuang Xp, Zhu QAbstract:Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as Central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface. The interaction between S1P and S1PR1 plays a core role in T cell migration, which is important for T cell maturation, homing and activation. The Central Function of S1P/S1PR1 in T cell migration made it a popular drug target in treatment research of immune diseases. This review summarizes the current knowledge of the mechanism of S1P/S1PR1 mediating T cell migration and the research progress of S1P/S1PR1 as drug target.
T. Kubota - One of the best experts on this subject based on the ideXlab platform.
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is pcna unloading the Central Function of the elg1 atad5 replication factor c like complex
Cell Cycle, 2013Co-Authors: T. Kubota, Kyungjae Myung, Anne D DonaldsonAbstract:Maintaining genome stability is crucial for all cells. The budding yeast Elg1 protein, the major subunit of a replication factor C-like complex, is important for genome stability, since cells lacking Elg1 exhibit increased recombination and chromosomal rearrangements. This genome maintenance Function of Elg1 seems to be conserved in higher eukaryotes, since removal of the human Elg1 homolog, encoded by the ATAD5 gene, also causes genome instability leading to tumorigenesis. The fundamental molecular Function of the Elg1/ATAD5-replication factor C-like complex (RLC) was, until recently, elusive, although Elg1/ATAD5-RLC was known to interact with the replication sliding clamp PCNA. Two papers have now reported that following DNA replication, the Elg1/ATAD5-RLC is required to remove PCNA from chromatin in yeast and human cells. In this Review, we summarize the evidence that Elg1/ATAD5-RLC acts as a PCNA unloader and discuss the still enigmatic relationship between the Function of Elg1/ATAD5-RLC in PCNA unloading and the role of Elg1/ATAD5 in maintaining genomic stability.
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Is PCNA unloading the Central Function of the Elg1/ATAD5 replication factor C-like complex?
Cell Cycle, 2013Co-Authors: T. Kubota, Kyungjae Myung, Anne D DonaldsonAbstract:Maintaining genome stability is crucial for all cells. The budding yeast Elg1 protein, the major subunit of a replication factor C-like complex, is important for genome stability, since cells lacking Elg1 exhibit increased recombination and chromosomal rearrangements. This genome maintenance Function of Elg1 seems to be conserved in higher eukaryotes, since removal of the human Elg1 homolog, encoded by the ATAD5 gene, also causes genome instability leading to tumorigenesis. The fundamental molecular Function of the Elg1/ATAD5-replication factor C-like complex (RLC) was, until recently, elusive, although Elg1/ATAD5-RLC was known to interact with the replication sliding clamp PCNA. Two papers have now reported that following DNA replication, the Elg1/ATAD5-RLC is required to remove PCNA from chromatin in yeast and human cells. In this Review, we summarize the evidence that Elg1/ATAD5-RLC acts as a PCNA unloader and discuss the still enigmatic relationship between the Function of Elg1/ATAD5-RLC in PCNA unloading and the role of Elg1/ATAD5 in maintaining genomic stability.
Zhuang Xp - One of the best experts on this subject based on the ideXlab platform.
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Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration
Acta pharmaceutica Sinica, 2016Co-Authors: Zhuang Xp, Zhu QAbstract:Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as Central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface. The interaction between S1P and S1PR1 plays a core role in T cell migration, which is important for T cell maturation, homing and activation. The Central Function of S1P/S1PR1 in T cell migration made it a popular drug target in treatment research of immune diseases. This review summarizes the current knowledge of the mechanism of S1P/S1PR1 mediating T cell migration and the research progress of S1P/S1PR1 as drug target.
Kyungjae Myung - One of the best experts on this subject based on the ideXlab platform.
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is pcna unloading the Central Function of the elg1 atad5 replication factor c like complex
Cell Cycle, 2013Co-Authors: T. Kubota, Kyungjae Myung, Anne D DonaldsonAbstract:Maintaining genome stability is crucial for all cells. The budding yeast Elg1 protein, the major subunit of a replication factor C-like complex, is important for genome stability, since cells lacking Elg1 exhibit increased recombination and chromosomal rearrangements. This genome maintenance Function of Elg1 seems to be conserved in higher eukaryotes, since removal of the human Elg1 homolog, encoded by the ATAD5 gene, also causes genome instability leading to tumorigenesis. The fundamental molecular Function of the Elg1/ATAD5-replication factor C-like complex (RLC) was, until recently, elusive, although Elg1/ATAD5-RLC was known to interact with the replication sliding clamp PCNA. Two papers have now reported that following DNA replication, the Elg1/ATAD5-RLC is required to remove PCNA from chromatin in yeast and human cells. In this Review, we summarize the evidence that Elg1/ATAD5-RLC acts as a PCNA unloader and discuss the still enigmatic relationship between the Function of Elg1/ATAD5-RLC in PCNA unloading and the role of Elg1/ATAD5 in maintaining genomic stability.
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Is PCNA unloading the Central Function of the Elg1/ATAD5 replication factor C-like complex?
Cell Cycle, 2013Co-Authors: T. Kubota, Kyungjae Myung, Anne D DonaldsonAbstract:Maintaining genome stability is crucial for all cells. The budding yeast Elg1 protein, the major subunit of a replication factor C-like complex, is important for genome stability, since cells lacking Elg1 exhibit increased recombination and chromosomal rearrangements. This genome maintenance Function of Elg1 seems to be conserved in higher eukaryotes, since removal of the human Elg1 homolog, encoded by the ATAD5 gene, also causes genome instability leading to tumorigenesis. The fundamental molecular Function of the Elg1/ATAD5-replication factor C-like complex (RLC) was, until recently, elusive, although Elg1/ATAD5-RLC was known to interact with the replication sliding clamp PCNA. Two papers have now reported that following DNA replication, the Elg1/ATAD5-RLC is required to remove PCNA from chromatin in yeast and human cells. In this Review, we summarize the evidence that Elg1/ATAD5-RLC acts as a PCNA unloader and discuss the still enigmatic relationship between the Function of Elg1/ATAD5-RLC in PCNA unloading and the role of Elg1/ATAD5 in maintaining genomic stability.