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Marco Mura - One of the best experts on this subject based on the ideXlab platform.

  • retinal relaxation following membrane peeling effect on vision Central Macular Thickness and vector analysis of motion
    Journal of clinical and translational research, 2020
    Co-Authors: Marc D. De Smet, Karina Julian, Jerick Maurin, Laurent P. Jolissaint, Marco Mura
    Abstract:

    Background Epiretinal membranes (ERM) form as a result of an inward displacement of retinal structures. Removal of an ERM leads to the outward displacement of retinal vessels and visual improvement. Purpose The aim of the study was to evaluate the direction and extent of displacement of retinal/superficial vascular structures after a membrane peeling procedure by means of image comparison and in selected cases, a vector analysis of displacement. Methodology Scanning laser ophthalmoscope images of the retina of eyes undergoing ERM peeling were compared before and 6 months after surgery. Stratification was made between prominent and limited displacement, with assessment of visual acuity (VA), and Central Macular Thickness (CMT). In three cases, using the optic nerve as reference, 50 landmarks were chosen within the posterior pole along large and small vascular structures allowing the construction of a vector map of displacement over 1 year. Results Nine eyes with prominent and six with limited displacement were assessed. Improvement in VA was similar for both groups, while CMT drop was greatest for the worst group. Vector analysis showed that most vascular movement occurs over the first 6 months, covers most of the posterior retina, is centered around distinct nodes, and may lead to several hundred micrometers of displacement. Conclusions Superficial retinal relaxation has no direct implication on visual recovery. It originates in nodes of retinal contraction. Its extent can be significant, covering most of the posterior pole. Relevance for Patients A better understanding of retinal relaxation following the peeling of ERM may help better understand when intervention is required and which part of the membrane is critical to surgical success.

  • Retinal relaxation following membrane peeling: Effect on vision, Central Macular Thickness, and vector analysis of motion
    2019
    Co-Authors: Marc D. De Smet, Karina Julian, Jerick Maurin, Laurent P. Jolissaint, Marco Mura
    Abstract:

    Abstract Purpose: Removal of an epiretinal membrane (ERM) leads to the outward displacement of retinal vessels and visual improvement. The direction and extent of displacement in the form of a vector analysis over the posterior pole can provide a better understanding of the dynamics and duration of this process, while the magnitude might have implications in terms of visual outcome. Methods: Scanning laser ophthalmoscope images of the retina of eyes undergoing ERM peeling were compared before and 6 months after surgery. Stratification was made between prominent and limited displacement, with assessment of visual acuity (VA), and Central Macular Thickness (CMT). In three cases, using the optic nerve as reference, 50 landmarks were chosen within the posterior pole along large and small vascular structures allowing the construction of a vector map of displacement over 1 year. Results: Nine eyes with prominent displacement (up to 400µm) and 6 eyes with limited displacement were assessed. Three lines of improvements in VA were observed in both groups over a 6 month period. Starting vision was lower in the eyes with prominent displacement. The CMT decrease was variable in onset in both groups but when observed was present within the first 3 months. CMT decrease was most significant in eyes with the greatest vascular displacement (initial: mean 445+/- 173µm; 6 months mean 352+/- 95µm) compared to eyes with less displacement (initial 366+/- 82µm; at 6 months 317 +/- 94µm). Vector analysis showed that most vascular movements occurred over the first 6 months, and involved the whole surface of the posterior retina, extending in some cases beyond the arcades. The displacement originated around distinct nodes of contraction.Conclusions: Retinal relaxation can occur over a large surface area. The superficial displacement of structures which served as a basis for the current analysis did not correlate with the change in vision. Vision recovery is likely correlated more closely with wrinkling of outer retinal layers.

  • Retinal relaxation following membrane peeling: Effect on vision, Central Macular Thickness, and vector analysis of motion
    2019
    Co-Authors: Marc D. De Smet, Karina Julian, Jerick Maurin, Laurent P. Jolissaint, Marco Mura
    Abstract:

    Abstract Purpose Removal of an epiretinal membrane (ERM) leads to the outward displacement of retinal vessels and visual improvement. The direction and extent of displacement in the form of a vector analysis over the posterior pole can provide a better understanding of the dynamics and duration of this process, while the magnitude might have implications in terms of visual outcome. Methods Scanning laser ophthalmoscope images of the retina of eyes undergoing ERM peeling were compared before and 6 months after surgery. Stratification was made between prominent and limited displacement, with assessment of visual acuity (VA), and Central Macular Thickness (CMT). In three cases, using the optic nerve as reference, 50 landmarks were chosen within the posterior pole along large and small vascular structures allowing the construction of a vector map of displacement over 1 year. Results Nine eyes with prominent and 6 with limited displacement were assessed. Improvement in VA was similar for both groups, while CMT drop was greatest for the worst group. Vector analysis showed that most vascular movement occurs over the first 6 months, covers most of the posterior retina, is centered around distinct nodes, may lead to several hundred microns of displacement. Conclusions Retinal relaxation has no direct implication on visual recovery. It originates in nodes of retinal contraction. Its extent can be significant

Shuichi Yamamoto - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of visual acuity and Central Macular Thickness after vitrectomy for diffuse diabetic Macular edema with or without preoperative treatments
    Nippon Ganka Gakkai zasshi, 2013
    Co-Authors: Tomohiro Nizawa, Miyuki Arai, Yoko Takatsuna, Toshiyuki Oshitari, Eiju Sato, Shuichi Yamamoto
    Abstract:

    PURPOSE To compare the surgical outcomes during pars plana vitrectomy (PPV) for diffuse diabetic Macular edema (DME) with pretreatment to those without pretreatment. METHODS The medical charts of 43 eyes of 46 patients who underwent PPV for DME were reviewed. The previously treated (Prev. Tx) group included 19 eyes of 20 patients who were pretreated with intravitreal bevacizumab, sub-Tenon injection of triamcinolone acetonide, and/or subthreshold micropulse diode laser photocoagulation before the PPV. The treatment naive (Tx.Naive) group included 24 eyes of 26 patients who underwent PPV alone. The Central Macular Thickness (CMT) and best-corrected visual acuity (BCVA) were measured before treatment and 1, 3, and 6 months after. RESULTS In both groups, BCVA at 3 and 6 months and CMT at 1 month or later were significantly better than preoperative visual acuity. CMT at 1 month or later significantly decreased from the preoperative value (p

  • Visual acuity and Central Macular Thickness comparison between posterior sub-Tenon's capsule triamcinolone injection and vitrectomy for diffuse diabetic Macular oedema
    Acta Ophthalmologica, 2012
    Co-Authors: S Nonomura, Toshiyuki Oshitari, Shuichi Yamamoto
    Abstract:

    Purpose To compare the effect of posterior sub-Tenon's capsule triamcinolone acetonide injection (STTA) with the surgical outcomes of pars plana vitrectomy (PPV) for diffuse diabetic Macular edema (DME). Methods The medical records of 52 patients (52 eyes) with diffuse DME were reviewed. 26 eyes underwent STTA (20mg) and other 26 eyes – vitrectomy combined with cataract surgery. The Central Macular Thickness (CMT) measured by OCT and best-corrected visual acuity (BCVA) were examined before and 1, 3, and 6 months after treatment. Statistical analysis was performed with student t-test, Mann-Whitney U-test and repeated measured ANOVA. Results Preop BCVA was 0.65±0.4 logMAR units in the STTA group and 0.77±0.3 logMAR units in the PPV group. One, 3 and 6 months postop BCVA were 0.59±0.4, 0.53±0.5 and 0.47±0.4 in the STTA group and 0.77±0.3, 0.59±0.4, and 0.59±0.4 in the PPV group. Preop CMT were 608.1±220μm in the STTA group and 534.4±157μm in the PPV group. One, 3 and 6 months postop CMT were 392.1±193μm, 284.4±101.7μm and 331.4±121μm in the STTA group and 386.8±175μm, 354.2±101.7μm and 354.2±156.4μm in the PPV group. The differences in the BCVA and the CMT between two groups were not significant at any periods before and after treatment. Conclusion Although STTA and PPV can significantly improve the BCVA and reduce the CMT in patients with diffuse DME, the differences in the BCVA and the CMT were not significant. Considering the minor invasion, STTA can be the first choice for the treatment of diffuse DME.

  • comparison of visual acuity and Central Macular Thickness after vitrectomy for diffuse diabetic Macular edema with or without preoperative treatments
    Investigative Ophthalmology & Visual Science, 2012
    Co-Authors: Tomohiro Nizawa, Miyuki Arai, Yoko Takatsuna, Toshiyuki Oshitari, Eiju Sato, Shuichi Yamamoto
    Abstract:

    PURPOSE To compare the surgical outcomes during pars plana vitrectomy (PPV) for diffuse diabetic Macular edema (DME) with pretreatment to those without pretreatment. METHODS The medical charts of 43 eyes of 46 patients who underwent PPV for DME were reviewed. The previously treated (Prev. Tx) group included 19 eyes of 20 patients who were pretreated with intravitreal bevacizumab, sub-Tenon injection of triamcinolone acetonide, and/or subthreshold micropulse diode laser photocoagulation before the PPV. The treatment naive (Tx.Naive) group included 24 eyes of 26 patients who underwent PPV alone. The Central Macular Thickness (CMT) and best-corrected visual acuity (BCVA) were measured before treatment and 1, 3, and 6 months after. RESULTS In both groups, BCVA at 3 and 6 months and CMT at 1 month or later were significantly better than preoperative visual acuity. CMT at 1 month or later significantly decreased from the preoperative value (p<0.05). The differences in the BCVA and CMT between the Prev. Tx and Tx.Naive group were not significant. CONCLUSIONS PPV either with or without preoperative treatments can significantly improve the BCVA and reduce the CMT in patients with diffuse DME.

Mayuresh Naik - One of the best experts on this subject based on the ideXlab platform.

  • Effect of Uncomplicated Cataract Surgery on Central Macular Thickness in Diabetic and Non-diabetic Subjects.
    Journal of ophthalmic & vision research, 2019
    Co-Authors: Brahm Prakash Guliani, Isha Agarwal, Mayuresh Naik
    Abstract:

    Purpose: To assess the quantitative changes of macula in diabetic and non-diabetic eyes after uncomplicated cataract surgery. Methods: In this prospective interventional study being performed in a tertiary healthcare hospital, a total of 660 eyes were divided into two groups. Group 1 included 330 eyes from healthy subjects and group 2 included 330 eyes from well-controlled diabetic subjects with no diabetic retinopathy planned for phacoemulsification with foldable IOL implantation by the same surgeon under similar settings. Optical Coherence Tomography (Heidelberg Spectralis SD-OCT) was used to assess preoperative and postoperative Central Macular Thickness (CMT) at weeks 1 and 6. Results: The mean CMT in group 1 preoperatively, at postoperative week 1, and at post-operative week 6 was 257.03 ± 20.904, 262.82 ± 17.010, and 265.15 ± 20.078 μm, respectively. The corresponding values in group 2 were 255.36 ± 17.852, 259.15 ± 16.644, and 266.09 ± 18.844 μm, respectively. There was no significant difference in the mean CMT values between the two groups on any of the three occasions when the CMT was measured (P = 0.374 and P = 0.313 at weeks 1 and 6, respectively). Conclusion: There was no statistically significant difference in CMT between normal subjects and diabetic subjects without diabetic retinopathy preoperatively and in early postoperative period after uncomplicated phacoemulsification surgery.

Marc D. De Smet - One of the best experts on this subject based on the ideXlab platform.

  • retinal relaxation following membrane peeling effect on vision Central Macular Thickness and vector analysis of motion
    Journal of clinical and translational research, 2020
    Co-Authors: Marc D. De Smet, Karina Julian, Jerick Maurin, Laurent P. Jolissaint, Marco Mura
    Abstract:

    Background Epiretinal membranes (ERM) form as a result of an inward displacement of retinal structures. Removal of an ERM leads to the outward displacement of retinal vessels and visual improvement. Purpose The aim of the study was to evaluate the direction and extent of displacement of retinal/superficial vascular structures after a membrane peeling procedure by means of image comparison and in selected cases, a vector analysis of displacement. Methodology Scanning laser ophthalmoscope images of the retina of eyes undergoing ERM peeling were compared before and 6 months after surgery. Stratification was made between prominent and limited displacement, with assessment of visual acuity (VA), and Central Macular Thickness (CMT). In three cases, using the optic nerve as reference, 50 landmarks were chosen within the posterior pole along large and small vascular structures allowing the construction of a vector map of displacement over 1 year. Results Nine eyes with prominent and six with limited displacement were assessed. Improvement in VA was similar for both groups, while CMT drop was greatest for the worst group. Vector analysis showed that most vascular movement occurs over the first 6 months, covers most of the posterior retina, is centered around distinct nodes, and may lead to several hundred micrometers of displacement. Conclusions Superficial retinal relaxation has no direct implication on visual recovery. It originates in nodes of retinal contraction. Its extent can be significant, covering most of the posterior pole. Relevance for Patients A better understanding of retinal relaxation following the peeling of ERM may help better understand when intervention is required and which part of the membrane is critical to surgical success.

  • Retinal relaxation following membrane peeling: Effect on vision, Central Macular Thickness, and vector analysis of motion
    2019
    Co-Authors: Marc D. De Smet, Karina Julian, Jerick Maurin, Laurent P. Jolissaint, Marco Mura
    Abstract:

    Abstract Purpose: Removal of an epiretinal membrane (ERM) leads to the outward displacement of retinal vessels and visual improvement. The direction and extent of displacement in the form of a vector analysis over the posterior pole can provide a better understanding of the dynamics and duration of this process, while the magnitude might have implications in terms of visual outcome. Methods: Scanning laser ophthalmoscope images of the retina of eyes undergoing ERM peeling were compared before and 6 months after surgery. Stratification was made between prominent and limited displacement, with assessment of visual acuity (VA), and Central Macular Thickness (CMT). In three cases, using the optic nerve as reference, 50 landmarks were chosen within the posterior pole along large and small vascular structures allowing the construction of a vector map of displacement over 1 year. Results: Nine eyes with prominent displacement (up to 400µm) and 6 eyes with limited displacement were assessed. Three lines of improvements in VA were observed in both groups over a 6 month period. Starting vision was lower in the eyes with prominent displacement. The CMT decrease was variable in onset in both groups but when observed was present within the first 3 months. CMT decrease was most significant in eyes with the greatest vascular displacement (initial: mean 445+/- 173µm; 6 months mean 352+/- 95µm) compared to eyes with less displacement (initial 366+/- 82µm; at 6 months 317 +/- 94µm). Vector analysis showed that most vascular movements occurred over the first 6 months, and involved the whole surface of the posterior retina, extending in some cases beyond the arcades. The displacement originated around distinct nodes of contraction.Conclusions: Retinal relaxation can occur over a large surface area. The superficial displacement of structures which served as a basis for the current analysis did not correlate with the change in vision. Vision recovery is likely correlated more closely with wrinkling of outer retinal layers.

  • Retinal relaxation following membrane peeling: Effect on vision, Central Macular Thickness, and vector analysis of motion
    2019
    Co-Authors: Marc D. De Smet, Karina Julian, Jerick Maurin, Laurent P. Jolissaint, Marco Mura
    Abstract:

    Abstract Purpose Removal of an epiretinal membrane (ERM) leads to the outward displacement of retinal vessels and visual improvement. The direction and extent of displacement in the form of a vector analysis over the posterior pole can provide a better understanding of the dynamics and duration of this process, while the magnitude might have implications in terms of visual outcome. Methods Scanning laser ophthalmoscope images of the retina of eyes undergoing ERM peeling were compared before and 6 months after surgery. Stratification was made between prominent and limited displacement, with assessment of visual acuity (VA), and Central Macular Thickness (CMT). In three cases, using the optic nerve as reference, 50 landmarks were chosen within the posterior pole along large and small vascular structures allowing the construction of a vector map of displacement over 1 year. Results Nine eyes with prominent and 6 with limited displacement were assessed. Improvement in VA was similar for both groups, while CMT drop was greatest for the worst group. Vector analysis showed that most vascular movement occurs over the first 6 months, covers most of the posterior retina, is centered around distinct nodes, may lead to several hundred microns of displacement. Conclusions Retinal relaxation has no direct implication on visual recovery. It originates in nodes of retinal contraction. Its extent can be significant

Yekta Sendul - One of the best experts on this subject based on the ideXlab platform.

  • Cental Macular Thickness in Patients with Type 2 Diabetes Mellitus without Clinical Retinopathy
    Journal of ophthalmology, 2013
    Co-Authors: Mehmet Demir, Burcu Dirim, Zeynep Acar, Murat Yılmaz, Yekta Sendul
    Abstract:

    Objective. To compare Central Macular Thickness (CMT) of diabetic patients with type 2 diabetes without clinical retinopathy and healthy subjects. Materials and Methods. Optical coherence tomography (OCT) measurements were performed in 124 eyes of 62 subjects with diabetes mellitus without clinical retinopathy (study group: 39 females, 23 males; mean age: 55.06 ± 9.77 years) and in 120 eyes of 60 healthy subjects (control group: 35 females, 25 males; mean age: 55.78 ± 10.34 years). Blood biochemistry parameters were analyzed in all cases. The data for Central Macular Thickness (at 1 mm), the levels of fasting plasma glucose, and glycosylated hemoglobin (HbA1c) were compared in both groups. Results. The mean Central Macular Thickness was 232.12 ± 24.41 µm in the study group and 227.19 ± 29.94 µm in the control group. The mean HbA1c level was 8.92 ± 2.58% in the study group and 5.07 ± 0.70% in the control group (). No statistically significant relationship was found between CMT, HbA1c, and fasting plasma glucose level in either group (). Conclusions. Central Macular Thickness was not significantly thicker in patients with type 2 diabetes without clinical retinopathy than in healthy subjects.