The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Yoshinori Fujimoto - One of the best experts on this subject based on the ideXlab platform.
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a 3 vinyl Cephem Derivative a useful intermediate in the synthesis of cepham antibiotics from aspergillus awamori associated with banana fruit
Natural Product Communications, 2015Co-Authors: H M S K H Bandara, N S Kumar, Lalith Jayasinghe, Hironori Masubuti, Yoshinori FujimotoAbstract:Aspergillus awamori was isolated from a diseased banana fruit, Musa acuminata cv. Ambul. The fungus was fermented in potato dextrose broth and on potato dextrose agar media and the fungal media were extracted with EtOAc. Chromatographic separation of the EtOAc extracts furnished 4-methoxybenzyl 7-phenylacetamido-3-vinyl-3-Cephem-4-carboxylate (1), along with three naphtho-γ-pyrones, flavasperone (2), foncesinone A (3) and aurasperone A (4), and three alkaloids, aspernigrin A (5), pestalamide C (6) and nigragillin (7). Compound 1, a known key intermediate in the chemical synthesis of cepham antibiotics, was isolated from a natural source for the first time. Compound 1 is the first 3-vinyl Cephem Derivative of microbial origin.
H M S K H Bandara - One of the best experts on this subject based on the ideXlab platform.
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a 3 vinyl Cephem Derivative a useful intermediate in the synthesis of cepham antibiotics from aspergillus awamori associated with banana fruit
Natural Product Communications, 2015Co-Authors: H M S K H Bandara, N S Kumar, Lalith Jayasinghe, Hironori Masubuti, Yoshinori FujimotoAbstract:Aspergillus awamori was isolated from a diseased banana fruit, Musa acuminata cv. Ambul. The fungus was fermented in potato dextrose broth and on potato dextrose agar media and the fungal media were extracted with EtOAc. Chromatographic separation of the EtOAc extracts furnished 4-methoxybenzyl 7-phenylacetamido-3-vinyl-3-Cephem-4-carboxylate (1), along with three naphtho-γ-pyrones, flavasperone (2), foncesinone A (3) and aurasperone A (4), and three alkaloids, aspernigrin A (5), pestalamide C (6) and nigragillin (7). Compound 1, a known key intermediate in the chemical synthesis of cepham antibiotics, was isolated from a natural source for the first time. Compound 1 is the first 3-vinyl Cephem Derivative of microbial origin.
Hisashi Takasugi - One of the best experts on this subject based on the ideXlab platform.
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studies on anti helicobacter pylori agents part 3 a novel efficacious Cephem Derivative fr193879
Bioorganic & Medicinal Chemistry Letters, 2004Co-Authors: Yoshiki Yoshida, Keiji Matsuda, Hiroshi Sasaki, Yoshimi Matsumoto, Satoru Matsumoto, Shuichi Tawara, Hisashi TakasugiAbstract:The synthesis, therapeutic efficacy against H. pylori, and preliminary safety of the novel Cephem Derivative, FR193879 (8a) are described. Compound 8a having a (4-carbamoylmethylthiazol-2-yl)thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have good safety showing a nontoxic dose of >100 mg/kg in dogs in a 4-week repeat dose toxicity study and extremely potent therapeutic efficacy against H. pylori, showing 30 times superior activity compared to AMPC, and did not display cross-resistance with CAM or MNZ.
N S Kumar - One of the best experts on this subject based on the ideXlab platform.
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a 3 vinyl Cephem Derivative a useful intermediate in the synthesis of cepham antibiotics from aspergillus awamori associated with banana fruit
Natural Product Communications, 2015Co-Authors: H M S K H Bandara, N S Kumar, Lalith Jayasinghe, Hironori Masubuti, Yoshinori FujimotoAbstract:Aspergillus awamori was isolated from a diseased banana fruit, Musa acuminata cv. Ambul. The fungus was fermented in potato dextrose broth and on potato dextrose agar media and the fungal media were extracted with EtOAc. Chromatographic separation of the EtOAc extracts furnished 4-methoxybenzyl 7-phenylacetamido-3-vinyl-3-Cephem-4-carboxylate (1), along with three naphtho-γ-pyrones, flavasperone (2), foncesinone A (3) and aurasperone A (4), and three alkaloids, aspernigrin A (5), pestalamide C (6) and nigragillin (7). Compound 1, a known key intermediate in the chemical synthesis of cepham antibiotics, was isolated from a natural source for the first time. Compound 1 is the first 3-vinyl Cephem Derivative of microbial origin.
Lalith Jayasinghe - One of the best experts on this subject based on the ideXlab platform.
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a 3 vinyl Cephem Derivative a useful intermediate in the synthesis of cepham antibiotics from aspergillus awamori associated with banana fruit
Natural Product Communications, 2015Co-Authors: H M S K H Bandara, N S Kumar, Lalith Jayasinghe, Hironori Masubuti, Yoshinori FujimotoAbstract:Aspergillus awamori was isolated from a diseased banana fruit, Musa acuminata cv. Ambul. The fungus was fermented in potato dextrose broth and on potato dextrose agar media and the fungal media were extracted with EtOAc. Chromatographic separation of the EtOAc extracts furnished 4-methoxybenzyl 7-phenylacetamido-3-vinyl-3-Cephem-4-carboxylate (1), along with three naphtho-γ-pyrones, flavasperone (2), foncesinone A (3) and aurasperone A (4), and three alkaloids, aspernigrin A (5), pestalamide C (6) and nigragillin (7). Compound 1, a known key intermediate in the chemical synthesis of cepham antibiotics, was isolated from a natural source for the first time. Compound 1 is the first 3-vinyl Cephem Derivative of microbial origin.