The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Nicola J. Robertson - One of the best experts on this subject based on the ideXlab platform.
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brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia ischemia studied by simultaneous phosphorus magnetic resonance and broadband near infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
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Simulating NIRS and MRS measurements during Cerebral Hypoxia-ischaemia in piglets using a computational model.
Advances in experimental medicine and biology, 2014Co-Authors: Tharindi Hapuarachchi, Eb Cady, Alan Bainbridge, S Faulkner, D Price, K. D. Broad, David L. Thomas, Tracy Moroz, Xavier Golay, Nicola J. RobertsonAbstract:We present a group analysis of the changes in Cerebral haemodynamics, and the oxidation state of cytochrome-c-oxidase measured using broadband near-infrared spectroscopy (NIRS) and intracellular pH measured by phosphorous (31P) magnetic resonance spectroscopy (MRS) during and after Cerebral Hypoxia-ischaemia (HI) in 15 piglets. We use a previously published computational model of Cerebral metabolism in the piglet [1] to integrate these measurements and simulate HI. We successfully simulate changes in cellular metabolism including shifts in intracellular pH observed in the piglet brain during HI. In this process, we optimise physiological parameters in the model identified through sensitivity analysis (such as the rate of glucose metabolism and intracellular lactate concentration), to fit simulated and measured data. The model fits the data reasonably and suggests a 20 % drop in glucose consumption, a ~65 % increase in lactate concentration and ~35 % drop in the Cerebral metabolic rate of oxygen (CMRO2) during HI.
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Brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia–ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
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268 Effect of Delayed Whole-Body Cooling to 33°C or 35°C After Transient Cerebral Hypoxia-Ischaemia in the Newborn Piglet
Pediatric Research, 2005Co-Authors: F O'brien, Osuke Iwata, Sachiko Iwata, John S. Thornton, E Devita, Susan C. Charman, Roger J. Ordidge, Eb Cady, Js Wyatt, Nicola J. RobertsonAbstract:268 Effect of Delayed Whole-Body Cooling to 33°C or 35°C After Transient Cerebral Hypoxia-Ischaemia in the Newborn Piglet
Alan Bainbridge - One of the best experts on this subject based on the ideXlab platform.
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brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia ischemia studied by simultaneous phosphorus magnetic resonance and broadband near infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
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Simulating NIRS and MRS measurements during Cerebral Hypoxia-ischaemia in piglets using a computational model.
Advances in experimental medicine and biology, 2014Co-Authors: Tharindi Hapuarachchi, Eb Cady, Alan Bainbridge, S Faulkner, D Price, K. D. Broad, David L. Thomas, Tracy Moroz, Xavier Golay, Nicola J. RobertsonAbstract:We present a group analysis of the changes in Cerebral haemodynamics, and the oxidation state of cytochrome-c-oxidase measured using broadband near-infrared spectroscopy (NIRS) and intracellular pH measured by phosphorous (31P) magnetic resonance spectroscopy (MRS) during and after Cerebral Hypoxia-ischaemia (HI) in 15 piglets. We use a previously published computational model of Cerebral metabolism in the piglet [1] to integrate these measurements and simulate HI. We successfully simulate changes in cellular metabolism including shifts in intracellular pH observed in the piglet brain during HI. In this process, we optimise physiological parameters in the model identified through sensitivity analysis (such as the rate of glucose metabolism and intracellular lactate concentration), to fit simulated and measured data. The model fits the data reasonably and suggests a 20 % drop in glucose consumption, a ~65 % increase in lactate concentration and ~35 % drop in the Cerebral metabolic rate of oxygen (CMRO2) during HI.
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Brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia–ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
Ernest B. Cady - One of the best experts on this subject based on the ideXlab platform.
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brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia ischemia studied by simultaneous phosphorus magnetic resonance and broadband near infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
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Brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia–ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
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Relation of impaired energy metabolism to apoptosis and necrosis following transient Cerebral Hypoxia-ischaemia
Cell death and differentiation, 1998Co-Authors: Huseyin Mehmet, Xue Yue, Juliet Penrice, Ernest B. Cady, John C Wyatt, Catherine Sarraf, Marion V Squier, Anthony D EdwardsAbstract:Relation of impaired energy metabolism to apoptosis and necrosis following transient Cerebral Hypoxia-ischaemia
K. D. Broad - One of the best experts on this subject based on the ideXlab platform.
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brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia ischemia studied by simultaneous phosphorus magnetic resonance and broadband near infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
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Simulating NIRS and MRS measurements during Cerebral Hypoxia-ischaemia in piglets using a computational model.
Advances in experimental medicine and biology, 2014Co-Authors: Tharindi Hapuarachchi, Eb Cady, Alan Bainbridge, S Faulkner, D Price, K. D. Broad, David L. Thomas, Tracy Moroz, Xavier Golay, Nicola J. RobertsonAbstract:We present a group analysis of the changes in Cerebral haemodynamics, and the oxidation state of cytochrome-c-oxidase measured using broadband near-infrared spectroscopy (NIRS) and intracellular pH measured by phosphorous (31P) magnetic resonance spectroscopy (MRS) during and after Cerebral Hypoxia-ischaemia (HI) in 15 piglets. We use a previously published computational model of Cerebral metabolism in the piglet [1] to integrate these measurements and simulate HI. We successfully simulate changes in cellular metabolism including shifts in intracellular pH observed in the piglet brain during HI. In this process, we optimise physiological parameters in the model identified through sensitivity analysis (such as the rate of glucose metabolism and intracellular lactate concentration), to fit simulated and measured data. The model fits the data reasonably and suggests a 20 % drop in glucose consumption, a ~65 % increase in lactate concentration and ~35 % drop in the Cerebral metabolic rate of oxygen (CMRO2) during HI.
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Brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia–ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
David L. Thomas - One of the best experts on this subject based on the ideXlab platform.
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brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia ischemia studied by simultaneous phosphorus magnetic resonance and broadband near infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.
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Simulating NIRS and MRS measurements during Cerebral Hypoxia-ischaemia in piglets using a computational model.
Advances in experimental medicine and biology, 2014Co-Authors: Tharindi Hapuarachchi, Eb Cady, Alan Bainbridge, S Faulkner, D Price, K. D. Broad, David L. Thomas, Tracy Moroz, Xavier Golay, Nicola J. RobertsonAbstract:We present a group analysis of the changes in Cerebral haemodynamics, and the oxidation state of cytochrome-c-oxidase measured using broadband near-infrared spectroscopy (NIRS) and intracellular pH measured by phosphorous (31P) magnetic resonance spectroscopy (MRS) during and after Cerebral Hypoxia-ischaemia (HI) in 15 piglets. We use a previously published computational model of Cerebral metabolism in the piglet [1] to integrate these measurements and simulate HI. We successfully simulate changes in cellular metabolism including shifts in intracellular pH observed in the piglet brain during HI. In this process, we optimise physiological parameters in the model identified through sensitivity analysis (such as the rate of glucose metabolism and intracellular lactate concentration), to fit simulated and measured data. The model fits the data reasonably and suggests a 20 % drop in glucose consumption, a ~65 % increase in lactate concentration and ~35 % drop in the Cerebral metabolic rate of oxygen (CMRO2) during HI.
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Brain mitochondrial oxidative metabolism during and after Cerebral Hypoxia–ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy
NeuroImage, 2014Co-Authors: Alan Bainbridge, Ernest B. Cady, Ilias Tachtsidis, S Faulkner, D Price, Tingting Zhu, E. Baer, K. D. Broad, David L. Thomas, Nicola J. RobertsonAbstract:Background Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of Cerebral mitochondrial cytochrome-c-oxidase (Δ[oxCCO]) and 31P metabolite peak-area ratios during and after transient Cerebral Hypoxia–ischemia (HI) in the newborn piglet.