The Experts below are selected from a list of 390 Experts worldwide ranked by ideXlab platform
Jean Louis Vincent - One of the best experts on this subject based on the ideXlab platform.
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hyponatremia in neurological patients Cerebral Salt Wasting versus inappropriate antidiuretic hormone secretion
Intensive Care Medicine, 2008Co-Authors: Serge Brimioulle, Carlos Orellanajimenez, Adel Aminian, Jean Louis VincentAbstract:Objective To assess whether hyponatremia in acute neurological patients is associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or with the Cerebral Salt-Wasting syndrome (CSWS).
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hyponatremia in neurological patients Cerebral Salt Wasting versus inappropriate antidiuretic hormone secretion
Intensive Care Medicine, 2008Co-Authors: Serge Brimioulle, Carlos Orellanajimenez, Adel Aminian, Jean Louis VincentAbstract:To assess whether hyponatremia in acute neurological patients is associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or with the Cerebral Salt-Wasting syndrome (CSWS). Clinical, controlled, prospective study. Department of intensive care of a tertiary care academic hospital. Forty acute neurological patients with hyponatremia suggesting SIADH or CSWS (20) or with normonatremia (20). None. Measurement of clinical and biological variables. Measurement of blood, plasma, and red blood cell volumes to discriminate SIADH and CSWS. Renal, adrenal and thyroid functions were normal in all patients. Average blood, plasma, and red blood cell volumes were 54, 37 and 17 ml/kg in control patients and 54, 37 and 18 ml/kg in hyponatremic patients, respectively. The adequate blood volumes in hyponatremic patients confirm the diagnosis of SIADH and do not support the concept of CSWS.
Stéphane Ranque - One of the best experts on this subject based on the ideXlab platform.
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Severe Toxoplasma gondii I/III recombinant-genotype encephalitis in a human immunodeficiency virus patient.
Journal of Clinical Microbiology, 2007Co-Authors: Séverine Genot, Jacqueline Franck, Jean-marie Forel, Stanislas Rebaudet, Daniel Ajzenberg, André Maues De Paula, Marie-laure Dardé, Andreas Stein, Stéphane RanqueAbstract:The reactivation of an uncommon type I/III recombinant-genotype Toxoplasma gondii strain resulted in unusually severe encephalitis and chorioretinitis associated with a Cerebral Salt Wasting syndrome in an African human immunodeficiency virus patient. This observation suggests an influence of the parasite genotype on disease expression in immunocompromised patients.
Serge Brimioulle - One of the best experts on this subject based on the ideXlab platform.
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hyponatremia in neurological patients Cerebral Salt Wasting versus inappropriate antidiuretic hormone secretion
Intensive Care Medicine, 2008Co-Authors: Serge Brimioulle, Carlos Orellanajimenez, Adel Aminian, Jean Louis VincentAbstract:Objective To assess whether hyponatremia in acute neurological patients is associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or with the Cerebral Salt-Wasting syndrome (CSWS).
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hyponatremia in neurological patients Cerebral Salt Wasting versus inappropriate antidiuretic hormone secretion
Intensive Care Medicine, 2008Co-Authors: Serge Brimioulle, Carlos Orellanajimenez, Adel Aminian, Jean Louis VincentAbstract:To assess whether hyponatremia in acute neurological patients is associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or with the Cerebral Salt-Wasting syndrome (CSWS). Clinical, controlled, prospective study. Department of intensive care of a tertiary care academic hospital. Forty acute neurological patients with hyponatremia suggesting SIADH or CSWS (20) or with normonatremia (20). None. Measurement of clinical and biological variables. Measurement of blood, plasma, and red blood cell volumes to discriminate SIADH and CSWS. Renal, adrenal and thyroid functions were normal in all patients. Average blood, plasma, and red blood cell volumes were 54, 37 and 17 ml/kg in control patients and 54, 37 and 18 ml/kg in hyponatremic patients, respectively. The adequate blood volumes in hyponatremic patients confirm the diagnosis of SIADH and do not support the concept of CSWS.
Paul A Nyquist - One of the best experts on this subject based on the ideXlab platform.
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haptoglobin 2 2 genotype is associated with Cerebral Salt Wasting syndrome in aneurysmal subarachnoid hemorrhage
Neurosurgery, 2016Co-Authors: Santosh B Murthy, Justin M Caplan, Wendy C Ziai, Andrew P Levy, Rafael J Tamargo, Gustavo Pradilla, Yogesh Moradiya, Eric B Schneider, Hadar Shalom, Paul A NyquistAbstract:BACKGROUND Haptoglobin (Hp) genotype has been shown to be a predictor of clinical outcomes in subarachnoid hemorrhage. Cerebral Salt Wasting (CSW) has been suggested to precede the development of symptomatic vasospasm. OBJECTIVE To determine if Hp genotype was associated with CSW and subsequent vasospasm after aneurysmal subarachnoid hemorrhage. METHODS Hp genotypic determination was done for patients admitted with a diagnosis of subarachnoid hemorrhage. Outcome measures included CSW, delayed Cerebral infarction, and Glasgow Outcome Score of 4 to 5 at 30 days. Criteria for CSW included hyponatremia 4 L in 12 hours with urine sodium >40 mEq/L. RESULTS A total of 133 patients were included in the study. The 3 Hp subgroups did not differ in terms of baseline characteristics. CSW occurred in 1 patient (3.4%) with Hp 1-1, 8 (14.0%) patients with Hp 2-1, and 15 (31.9%) patients with Hp 2-2 (P = .004). In the multivariate regression model, Hp 2-2 was associated with CSW (odds ratio [OR]: 4.94; CI: 1.78-17.43; P = .01), but Hp 2-1 was not (OR: 2.92; CI: 0.56-4.95; P = .15) compared with Hp 1-1. There were no associations between Hp genotypes and functional outcome or delayed Cerebral infarction. CSW was associated with delayed Cerebral infarction (OR: 7.46; 95% CI: 2.54-21.9; P < .001). CONCLUSION Hp 2-2 genotype was an independent predictor of CSW after subarachnoid hemorrhage. Because CSW is strongly associated with delayed Cerebral infarction, the use of Hp genotype testing requires more investigation, and larger prospective confirmation is warranted. Additionally, a more objective definition of CSW needs to be delineated.
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abstract 42 haptoglobin 2 2 phenotype is associated with Cerebral Salt Wasting syndrome in aneurysmal subarachnoid hemorrhage
Stroke, 2015Co-Authors: Santosh B Murthy, Justin M Caplan, Shalom Hadar, Wendy C Ziai, Andrew P Levy, Rafael J Tamargo, Paul A NyquistAbstract:INTRODUCTION: The Haptoglobin (Hp) phenotype has been shown to be a predictor of clinical outcomes in cerebrovascular disorders. We sought to determine if the Hp phenotype was predictive of Cerebral Salt Wasting (CSW) following aneurysmal subarachnoid hemorrhage (SAH). METHODS: Patients admitted with a diagnosis of SAH were divided into three groups based on their genetically determined Hp phenotype: 1-1, 2-1, and 2-2. Outcome measures included CSW, delayed Cerebral infarction (DCI) and favorable outcome -Glasgow Outcome score (GOS) of 4-5 at 30 days. CSW was diagnosed by a clinician, and met the following criteria: hyponatremia 4 liters in 12 hours with urine sodium > 40 mEq/L. Pearson’s Chi Square and Wilcoxon-Mann-Whitney tests were used for categorical and continuous variables respectively. Logistic regression was used to assess association between Hp phenotype and SAH outcomes. RESULTS: A total of 133 patients were included in the study. The distribution of Hp phenotype was- Hp 1-1: 29 (21.8%), Hp 2-1: 57 (42.9%), Hp 2-2: 47 (35.3%). The three Hp subgroups did not differ in terms of demographic variables, comorbidities or SAH characteristics. CSW occurred in 1 patient (3.4%) with Hp 1-1, 8 (14.0%) with Hp 2-1 and 15 (31.9%) with Hp 2-2 (p=0.004). In the multivariate analysis adjusted for age, sex, race, Hunt-Hess score and hydrocephalus, Hp 2-2 was associated with CSW (OR: 4.94 CI: 1.78-17.43, p=0.013) but Hp 2-1 was not (OR: 2.92, CI: 0.56-4.95, p=0.150). There were no associations between Hp phenotypes and favorable outcomes or DCI. CSW correlated strongly with development of DCI (OR: 7.16, OR: 2.48-20.62, p<0.001). CONCLUSIONS: Hp 2-2 phenotype was an independent predictor of Cerebral Salt Wasting following SAH. There were no associations between Hp phenotype and DCI or good functional outcome.
Séverine Genot - One of the best experts on this subject based on the ideXlab platform.
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Severe Toxoplasma gondii I/III recombinant-genotype encephalitis in a human immunodeficiency virus patient.
Journal of Clinical Microbiology, 2007Co-Authors: Séverine Genot, Jacqueline Franck, Jean-marie Forel, Stanislas Rebaudet, Daniel Ajzenberg, André Maues De Paula, Marie-laure Dardé, Andreas Stein, Stéphane RanqueAbstract:The reactivation of an uncommon type I/III recombinant-genotype Toxoplasma gondii strain resulted in unusually severe encephalitis and chorioretinitis associated with a Cerebral Salt Wasting syndrome in an African human immunodeficiency virus patient. This observation suggests an influence of the parasite genotype on disease expression in immunocompromised patients.