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Jost B Jonas - One of the best experts on this subject based on the ideXlab platform.

  • prevalence of retinal vein occlusions and estimated Cerebrospinal Fluid Pressure the kailuan eye study
    Eye and Brain, 2021
    Co-Authors: Qian Wang, Wen Bin Wei, Jing Yan Yang, Jost B Jonas, Xuehui Shi, Shuohua Chen, Yanni Yan, Wenjia Zhou, Li Dong, Ya Xing Wang
    Abstract:

    Purpose To investigate the prevalence of retinal vein occlusions (RVOs) and associated factors in a Chinese population. Patients and Methods The cross-sectional community-based Kailuan Eye Study included individuals who participated in the Kailuan Study. RVOs were diagnosed on the fundus photographs. Estimated Cerebrospinal Fluid Pressure (eCSFP) was calculated as "eCSFP=0.44*Body Mass Index+0.16*Diastolic Blood Pressure-0.18*Age". Results The study included 12,499 participants with a mean age of 52.9±13.1 years. The overall prevalence of RVO was 120/12,499 or 0.96%, with branch RVOs observed in 116/12,499 individuals and central RVOs in 4/12,499 individuals. RVOs started at the optic disc in 19 participants (15.8% of all RVOs), and in 101 (84.2%) individuals arterio-venous crossings outside the optic disc. In multivariable analysis, a higher RVO prevalence was associated with older age (P<0.001), higher eCSFP (P<0.001), and higher fasting serum glucose concentration (P<0.001). Differentiating between RVOs at arterio-venous crossings and RVOs at the optic disc revealed that the prevalence of both RVO types was associated with higher eCSFP (P<0.001 and P=0.004, respectively) after adjusting for age and fasting serum glucose concentration. Conclusion In this adult Chinese population recruited on a community basis, the prevalence of any RVO (mean: 0.96) was associated with older age, higher eCSFP and higher fasting serum glucose concentration. Higher eCSFP may play an etiologic role in RVOs.

  • analysis of Cerebrospinal Fluid Pressure estimation using formulae derived from clinical data
    Investigative Ophthalmology & Visual Science, 2016
    Co-Authors: David Fleischman, Ningli Wang, Jost B Jonas, John P Berdahl, Sandra S Stinnett, Michael P Fautsch, Amanda K Bicket, Rand R Allingham
    Abstract:

    Purpose: To evaluate a frequently used regression model and a new, modified regression model to estimate Cerebrospinal Fluid Pressure (CSFP). Methods: Datasets from the Beijing iCOP study from Tongren Hospital, Beijing, China, and the Mayo Clinic, Rochester, Minnesota, were tested in this retrospective, case-control study. An often-used regression model derived from the Beijing iCOP dataset, but without radiographic data, was used to predict CSFP by using demographic and physiologic data. A regression model was created using the Mayo Clinic dataset and tested against a validation group. The Mayo Clinic-derived formula was also tested against the Beijing Eye Study population. Intraclass correlation was used to assess predicted versus actual CSFP. Results: The Beijing-derived regression equation was reported to have an intraclass correlation coefficient (ICC) of 0.71, indicating strong correlation between predicted and actual CSFP in the study population. The Beijing iCOP regression model poorly predicted CSFP in the Mayo Clinic population with an ICC of 0.14. The Mayo Clinic-derived regression model similarly did not predict CSFP in its Mayo Clinic validation group (ICC 0.28 ± 0.04) nor in the Beijing Eye Study population (ICC 0.06). Conclusions: Formulae used to predict CSFP derived from clinical data fared poorly against a large retrospective dataset. This may be related to differences in lumbar puncture technique, in the populations tested, or the timing of collection of physiologic variables in the Mayo Clinic dataset. Caution should be used when interpreting results based on formulaic derivation of CSFP.

  • dynein kinesin and morphological changes in optic nerve axons in a rat model with Cerebrospinal Fluid Pressure reduction the beijing intracranial and intraocular Pressure icop study
    Acta Ophthalmologica, 2016
    Co-Authors: Zheng Zhang, Kegao Liu, Jost B Jonas, Jingxue Zhang, Ningli Wang
    Abstract:

    Purpose To examine the influence of experimentally reduced Cerebrospinal Fluid Pressure (CSFP) as compared to elevated intraocular Pressure (IOP) on axonal morphology and axonal motor proteins in retinal ganglion cells (RGCs). Methods The experimental study included 39 rats which underwent Cerebrospinal Fluid drainage for 6 hr, 30 rats which unilaterally underwent IOP elevation for 6 hr and 30 rats in a control group. Six hours after baseline, the animals were killed and the eyes were histologically and immunohistochemically examined. Results In experimental models in the high-IOP group and the low-CSFP group as compared to the control group, RGC axons became abnormally dilated and accumulated vesicles. Both groups as compared to the control group showed an accumulation of dynein IC (intermediate chain) at the optic nerve head and retina and a reduction in kinesin HC (heavy chain) immunoreactivity in the optic nerve fibre axons. As a corollary, Western blot analysis revealed an elevation of dynein IC protein levels in the optic nerve head and retina and a decrease in kinesin HC protein levels in the optic nerve. Conclusions Experimental models with an acute IOP rise or with an acute CSFP reduction showed similar morphologic changes in the retinal ganglion cell axons and similar immunohistochemical changes in the axonal motor proteins kinesin HC and dynein IC. It supports the hypothesis that an experimental model with an acute reduction in CSFP as well as an experimental model with an acute rise in IOP may share similarities in the process of optic nerve damage.

  • incident retinal vein occlusions and estimated Cerebrospinal Fluid Pressure the beijing eye study
    Acta Ophthalmologica, 2015
    Co-Authors: Qi Sheng You, Xiaobin Xie, Diya Yang, Ningli Wang, Ya Xing Wang, Jost B Jonas
    Abstract:

    Purpose To examine whether the incidence of retinal vein occlusions (RVOs) is associated with estimated Cerebrospinal Fluid Pressure (CSFP). Methods The population-based Beijing Eye Study, which included 4439 subjects (age: 40 + years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). Fundus photographs were examined for the new development of RVOs, differentiated into central RVOs (CRVOs) and branch RVOs (BRVOs). CSFP was calculated as CSFP [mmHg] = 0.44 × Body Mass Index [kg/m2] + 0.16 × Diastolic Blood Pressure [mmHg]−0.18 × Age[Years]. Results Incident BRVOs were detected in 50 eyes and incident CRVOs in 8 eyes. BRVOs were located at arterio-venous crossings in 39 eyes. In multivariate analysis, a higher estimated CSFP was associated with a higher incidence of CRVOs (p = 0.004; standardized coefficient beta: 0.06; regression coefficient B: 5.35; 95% confidence interval (CI):1.73, 8.96) after adjusting for urban region (p < 0.001; beta: −0.52; B: −3.93; 95% CI: −4.29, −3.57), higher educational level (p = 0.001; beta: 0.13; B: 0.44; 95% CI: 0.28, 0.60), higher blood concentrations of triglycerides (p < 0.001; beta: 0.08; B: 0.11; 95% CI: 0.05, 0.16) and higher intraocular Pressure (p < 0.001; beta: 0.16; B:0.21; 95% CI: 0.16, 0.27). As a corollary, a higher incidence of RVOs as a whole, as well as a higher incidence of CRVOs combined with a higher incidence of BRVOs originating at the optic nerve head, both were significantly associated with higher estimated CSFP (p = 0.002; odds ratio (OR): 1.15; 95% CI: 1.05, 1.25; and p = 0.037; OR: 1.17; 95% CI: 1.01, 1.35, respectively) after adjusting for older age. Conclusions A higher estimated CSFP was associated with a higher incidence of RVOs originating at the optic nerve head (i.e. CRVOs, hemi-central RVOs and BRVOs originating at the optic nerve head), and vice versa, a higher incidence of RVOs was associated with a higher estimated CSFP. It suggested an influence of higher estimated CSFP on higher central retinal vein Pressure.

  • axonal transport in the rat optic nerve following short term reduction in Cerebrospinal Fluid Pressure or elevation in intraocular Pressure
    Investigative Ophthalmology & Visual Science, 2015
    Co-Authors: Zheng Zhang, Diya Yang, Jost B Jonas, D Liu, Jacky M K Kwong, Jingxue Zhang, Qian Liu, Jinda Wang, Ningli Wang
    Abstract:

    PURPOSE To examine the influence of short-term reduction in Cerebrospinal Fluid Pressure (CSFP) as compared with short-term elevation in IOP on axonal transport. METHODS The study included 111 adult Sprague-Dawley rats. For 6 hours, IOP was unilaterally elevated to 40 mm Hg (IOP40-group; n = 27), IOP was unilaterally increased to a value of 25 mm Hg below the mean blood Pressure (PP25-group; n = 27), or CSFP was reduced by continuous aspiration of Cerebrospinal Fluid (Low-CSFP-group; n = 27). A sham control group (with a trocar in cisterna magna without Cerebrospinal Fluid release) included 24 rats. The left eyes of the IOP40 study group and PP25 study group served as additional contralateral control group. Orthograde axonal transport was examined by intravitreally injected rhodamine-β-isothiocyanate; retrograde axoplasmic flow was assessed by fluorogold injected into the superior colliculi. RESULTS At 24 hours after baseline, rhodamine-β-isothiocyanate (RITC) staining intensity of the optic nerve was lower (P < 0.05) in the IOP40-group, PP25-group, and Low-CSFP-group than in the control groups. At 6 hours after the fluorogold injection, fluorogold fluorescence was significantly lower in the IOP40-group, the PP25-group, and the Low-CSFP-group than in the control groups. At 5 days after baseline, the fluorogold fluorescence no longer differed significantly between the IOP40-group or the Low-CSFP-group and the control groups. At 1 week after baseline, retinal ganglion cell density was markedly reduced only in the PP25-group. CONCLUSIONS Both short-term lowering of CSFP and short-term rise in IOP were associated with a disturbance of both the orthograde and retrograde axonal transport. The findings support the notion of an association between abnormally low CSFP and optic nerve damage.

Ningli Wang - One of the best experts on this subject based on the ideXlab platform.

  • visual impairment in astronauts after long duration space flight a backward of glaucomatous optic neuropathy beijing intracranial and intraocular Pressure icop study
    2019
    Co-Authors: Diya Yang, Ningli Wang
    Abstract:

    There have been extensive studies on physiologic changes of the astronauts in microgravity environment. However, the effect of this environment on eye remained greatly unknown until recently a report from the National Aeronautics and Space Administration (NASA) documented astronauts presenting visual impairment, anatomical changes in the eye, and elevated Cerebrospinal Fluid Pressure (CSFP) during long-duration space flight [1]. Loss of visual acuity is a significant threat to astronauts’ performance, safety, and health. It is therefore important to understand the pathogenesis of this condition.

  • analysis of Cerebrospinal Fluid Pressure estimation using formulae derived from clinical data
    Investigative Ophthalmology & Visual Science, 2016
    Co-Authors: David Fleischman, Ningli Wang, Jost B Jonas, John P Berdahl, Sandra S Stinnett, Michael P Fautsch, Amanda K Bicket, Rand R Allingham
    Abstract:

    Purpose: To evaluate a frequently used regression model and a new, modified regression model to estimate Cerebrospinal Fluid Pressure (CSFP). Methods: Datasets from the Beijing iCOP study from Tongren Hospital, Beijing, China, and the Mayo Clinic, Rochester, Minnesota, were tested in this retrospective, case-control study. An often-used regression model derived from the Beijing iCOP dataset, but without radiographic data, was used to predict CSFP by using demographic and physiologic data. A regression model was created using the Mayo Clinic dataset and tested against a validation group. The Mayo Clinic-derived formula was also tested against the Beijing Eye Study population. Intraclass correlation was used to assess predicted versus actual CSFP. Results: The Beijing-derived regression equation was reported to have an intraclass correlation coefficient (ICC) of 0.71, indicating strong correlation between predicted and actual CSFP in the study population. The Beijing iCOP regression model poorly predicted CSFP in the Mayo Clinic population with an ICC of 0.14. The Mayo Clinic-derived regression model similarly did not predict CSFP in its Mayo Clinic validation group (ICC 0.28 ± 0.04) nor in the Beijing Eye Study population (ICC 0.06). Conclusions: Formulae used to predict CSFP derived from clinical data fared poorly against a large retrospective dataset. This may be related to differences in lumbar puncture technique, in the populations tested, or the timing of collection of physiologic variables in the Mayo Clinic dataset. Caution should be used when interpreting results based on formulaic derivation of CSFP.

  • dynein kinesin and morphological changes in optic nerve axons in a rat model with Cerebrospinal Fluid Pressure reduction the beijing intracranial and intraocular Pressure icop study
    Acta Ophthalmologica, 2016
    Co-Authors: Zheng Zhang, Kegao Liu, Jost B Jonas, Jingxue Zhang, Ningli Wang
    Abstract:

    Purpose To examine the influence of experimentally reduced Cerebrospinal Fluid Pressure (CSFP) as compared to elevated intraocular Pressure (IOP) on axonal morphology and axonal motor proteins in retinal ganglion cells (RGCs). Methods The experimental study included 39 rats which underwent Cerebrospinal Fluid drainage for 6 hr, 30 rats which unilaterally underwent IOP elevation for 6 hr and 30 rats in a control group. Six hours after baseline, the animals were killed and the eyes were histologically and immunohistochemically examined. Results In experimental models in the high-IOP group and the low-CSFP group as compared to the control group, RGC axons became abnormally dilated and accumulated vesicles. Both groups as compared to the control group showed an accumulation of dynein IC (intermediate chain) at the optic nerve head and retina and a reduction in kinesin HC (heavy chain) immunoreactivity in the optic nerve fibre axons. As a corollary, Western blot analysis revealed an elevation of dynein IC protein levels in the optic nerve head and retina and a decrease in kinesin HC protein levels in the optic nerve. Conclusions Experimental models with an acute IOP rise or with an acute CSFP reduction showed similar morphologic changes in the retinal ganglion cell axons and similar immunohistochemical changes in the axonal motor proteins kinesin HC and dynein IC. It supports the hypothesis that an experimental model with an acute reduction in CSFP as well as an experimental model with an acute rise in IOP may share similarities in the process of optic nerve damage.

  • incident retinal vein occlusions and estimated Cerebrospinal Fluid Pressure the beijing eye study
    Acta Ophthalmologica, 2015
    Co-Authors: Qi Sheng You, Xiaobin Xie, Diya Yang, Ningli Wang, Ya Xing Wang, Jost B Jonas
    Abstract:

    Purpose To examine whether the incidence of retinal vein occlusions (RVOs) is associated with estimated Cerebrospinal Fluid Pressure (CSFP). Methods The population-based Beijing Eye Study, which included 4439 subjects (age: 40 + years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). Fundus photographs were examined for the new development of RVOs, differentiated into central RVOs (CRVOs) and branch RVOs (BRVOs). CSFP was calculated as CSFP [mmHg] = 0.44 × Body Mass Index [kg/m2] + 0.16 × Diastolic Blood Pressure [mmHg]−0.18 × Age[Years]. Results Incident BRVOs were detected in 50 eyes and incident CRVOs in 8 eyes. BRVOs were located at arterio-venous crossings in 39 eyes. In multivariate analysis, a higher estimated CSFP was associated with a higher incidence of CRVOs (p = 0.004; standardized coefficient beta: 0.06; regression coefficient B: 5.35; 95% confidence interval (CI):1.73, 8.96) after adjusting for urban region (p < 0.001; beta: −0.52; B: −3.93; 95% CI: −4.29, −3.57), higher educational level (p = 0.001; beta: 0.13; B: 0.44; 95% CI: 0.28, 0.60), higher blood concentrations of triglycerides (p < 0.001; beta: 0.08; B: 0.11; 95% CI: 0.05, 0.16) and higher intraocular Pressure (p < 0.001; beta: 0.16; B:0.21; 95% CI: 0.16, 0.27). As a corollary, a higher incidence of RVOs as a whole, as well as a higher incidence of CRVOs combined with a higher incidence of BRVOs originating at the optic nerve head, both were significantly associated with higher estimated CSFP (p = 0.002; odds ratio (OR): 1.15; 95% CI: 1.05, 1.25; and p = 0.037; OR: 1.17; 95% CI: 1.01, 1.35, respectively) after adjusting for older age. Conclusions A higher estimated CSFP was associated with a higher incidence of RVOs originating at the optic nerve head (i.e. CRVOs, hemi-central RVOs and BRVOs originating at the optic nerve head), and vice versa, a higher incidence of RVOs was associated with a higher estimated CSFP. It suggested an influence of higher estimated CSFP on higher central retinal vein Pressure.

  • axonal transport in the rat optic nerve following short term reduction in Cerebrospinal Fluid Pressure or elevation in intraocular Pressure
    Investigative Ophthalmology & Visual Science, 2015
    Co-Authors: Zheng Zhang, Diya Yang, Jost B Jonas, D Liu, Jacky M K Kwong, Jingxue Zhang, Qian Liu, Jinda Wang, Ningli Wang
    Abstract:

    PURPOSE To examine the influence of short-term reduction in Cerebrospinal Fluid Pressure (CSFP) as compared with short-term elevation in IOP on axonal transport. METHODS The study included 111 adult Sprague-Dawley rats. For 6 hours, IOP was unilaterally elevated to 40 mm Hg (IOP40-group; n = 27), IOP was unilaterally increased to a value of 25 mm Hg below the mean blood Pressure (PP25-group; n = 27), or CSFP was reduced by continuous aspiration of Cerebrospinal Fluid (Low-CSFP-group; n = 27). A sham control group (with a trocar in cisterna magna without Cerebrospinal Fluid release) included 24 rats. The left eyes of the IOP40 study group and PP25 study group served as additional contralateral control group. Orthograde axonal transport was examined by intravitreally injected rhodamine-β-isothiocyanate; retrograde axoplasmic flow was assessed by fluorogold injected into the superior colliculi. RESULTS At 24 hours after baseline, rhodamine-β-isothiocyanate (RITC) staining intensity of the optic nerve was lower (P < 0.05) in the IOP40-group, PP25-group, and Low-CSFP-group than in the control groups. At 6 hours after the fluorogold injection, fluorogold fluorescence was significantly lower in the IOP40-group, the PP25-group, and the Low-CSFP-group than in the control groups. At 5 days after baseline, the fluorogold fluorescence no longer differed significantly between the IOP40-group or the Low-CSFP-group and the control groups. At 1 week after baseline, retinal ganglion cell density was markedly reduced only in the PP25-group. CONCLUSIONS Both short-term lowering of CSFP and short-term rise in IOP were associated with a disturbance of both the orthograde and retrograde axonal transport. The findings support the notion of an association between abnormally low CSFP and optic nerve damage.

Diya Yang - One of the best experts on this subject based on the ideXlab platform.

  • visual impairment in astronauts after long duration space flight a backward of glaucomatous optic neuropathy beijing intracranial and intraocular Pressure icop study
    2019
    Co-Authors: Diya Yang, Ningli Wang
    Abstract:

    There have been extensive studies on physiologic changes of the astronauts in microgravity environment. However, the effect of this environment on eye remained greatly unknown until recently a report from the National Aeronautics and Space Administration (NASA) documented astronauts presenting visual impairment, anatomical changes in the eye, and elevated Cerebrospinal Fluid Pressure (CSFP) during long-duration space flight [1]. Loss of visual acuity is a significant threat to astronauts’ performance, safety, and health. It is therefore important to understand the pathogenesis of this condition.

  • incident retinal vein occlusions and estimated Cerebrospinal Fluid Pressure the beijing eye study
    Acta Ophthalmologica, 2015
    Co-Authors: Qi Sheng You, Xiaobin Xie, Diya Yang, Ningli Wang, Ya Xing Wang, Jost B Jonas
    Abstract:

    Purpose To examine whether the incidence of retinal vein occlusions (RVOs) is associated with estimated Cerebrospinal Fluid Pressure (CSFP). Methods The population-based Beijing Eye Study, which included 4439 subjects (age: 40 + years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). Fundus photographs were examined for the new development of RVOs, differentiated into central RVOs (CRVOs) and branch RVOs (BRVOs). CSFP was calculated as CSFP [mmHg] = 0.44 × Body Mass Index [kg/m2] + 0.16 × Diastolic Blood Pressure [mmHg]−0.18 × Age[Years]. Results Incident BRVOs were detected in 50 eyes and incident CRVOs in 8 eyes. BRVOs were located at arterio-venous crossings in 39 eyes. In multivariate analysis, a higher estimated CSFP was associated with a higher incidence of CRVOs (p = 0.004; standardized coefficient beta: 0.06; regression coefficient B: 5.35; 95% confidence interval (CI):1.73, 8.96) after adjusting for urban region (p < 0.001; beta: −0.52; B: −3.93; 95% CI: −4.29, −3.57), higher educational level (p = 0.001; beta: 0.13; B: 0.44; 95% CI: 0.28, 0.60), higher blood concentrations of triglycerides (p < 0.001; beta: 0.08; B: 0.11; 95% CI: 0.05, 0.16) and higher intraocular Pressure (p < 0.001; beta: 0.16; B:0.21; 95% CI: 0.16, 0.27). As a corollary, a higher incidence of RVOs as a whole, as well as a higher incidence of CRVOs combined with a higher incidence of BRVOs originating at the optic nerve head, both were significantly associated with higher estimated CSFP (p = 0.002; odds ratio (OR): 1.15; 95% CI: 1.05, 1.25; and p = 0.037; OR: 1.17; 95% CI: 1.01, 1.35, respectively) after adjusting for older age. Conclusions A higher estimated CSFP was associated with a higher incidence of RVOs originating at the optic nerve head (i.e. CRVOs, hemi-central RVOs and BRVOs originating at the optic nerve head), and vice versa, a higher incidence of RVOs was associated with a higher estimated CSFP. It suggested an influence of higher estimated CSFP on higher central retinal vein Pressure.

  • axonal transport in the rat optic nerve following short term reduction in Cerebrospinal Fluid Pressure or elevation in intraocular Pressure
    Investigative Ophthalmology & Visual Science, 2015
    Co-Authors: Zheng Zhang, Diya Yang, Jost B Jonas, D Liu, Jacky M K Kwong, Jingxue Zhang, Qian Liu, Jinda Wang, Ningli Wang
    Abstract:

    PURPOSE To examine the influence of short-term reduction in Cerebrospinal Fluid Pressure (CSFP) as compared with short-term elevation in IOP on axonal transport. METHODS The study included 111 adult Sprague-Dawley rats. For 6 hours, IOP was unilaterally elevated to 40 mm Hg (IOP40-group; n = 27), IOP was unilaterally increased to a value of 25 mm Hg below the mean blood Pressure (PP25-group; n = 27), or CSFP was reduced by continuous aspiration of Cerebrospinal Fluid (Low-CSFP-group; n = 27). A sham control group (with a trocar in cisterna magna without Cerebrospinal Fluid release) included 24 rats. The left eyes of the IOP40 study group and PP25 study group served as additional contralateral control group. Orthograde axonal transport was examined by intravitreally injected rhodamine-β-isothiocyanate; retrograde axoplasmic flow was assessed by fluorogold injected into the superior colliculi. RESULTS At 24 hours after baseline, rhodamine-β-isothiocyanate (RITC) staining intensity of the optic nerve was lower (P < 0.05) in the IOP40-group, PP25-group, and Low-CSFP-group than in the control groups. At 6 hours after the fluorogold injection, fluorogold fluorescence was significantly lower in the IOP40-group, the PP25-group, and the Low-CSFP-group than in the control groups. At 5 days after baseline, the fluorogold fluorescence no longer differed significantly between the IOP40-group or the Low-CSFP-group and the control groups. At 1 week after baseline, retinal ganglion cell density was markedly reduced only in the PP25-group. CONCLUSIONS Both short-term lowering of CSFP and short-term rise in IOP were associated with a disturbance of both the orthograde and retrograde axonal transport. The findings support the notion of an association between abnormally low CSFP and optic nerve damage.

  • facts and myths of Cerebrospinal Fluid Pressure for the physiology of the eye
    Progress in Retinal and Eye Research, 2015
    Co-Authors: Jost B Jonas, Diya Yang, Ningli Wang, Robert Ritch, Songhomitra Pandajonas
    Abstract:

    The orbital Cerebrospinal Fluid Pressure (CSFP) represents the true counter-Pressure against the intraocular Pressure (IOP) across the lamina cribrosa and is, therefore, one of the two determinants of the trans-lamina cribrosa Pressure difference (TLPD). From this anatomic point of view, an elevated TLPD could be due to elevated IOP or abnormally low orbital CSFP. Both experimental and clinical studies have suggested that a low CSFP could be associated with glaucomatous optic neuropathy in normal-Pressure glaucoma. These included monkey studies with an experimental long-term reduction in CSFP, and clinical retrospective and prospective studies on patients with normal-Pressure glaucoma. Since the choroidal blood drains via the vortex veins through the superior ophthalmic vein into the intracranial cavernous sinus, anatomy suggests that the CSFP could influence choroidal thickness. A population-based study revealed that thicker subfoveal choroidal thickness was associated with higher CSFP. Since the central retinal vein passes through the orbital CSF space, anatomy suggests that the retinal venous Pressure should be at least as high as the orbital CSFP. Other experimental, clinical or population-based studies suggested an association between higher CSFP and higher retinal venous Pressure and wider retinal veins. Consequently, a higher estimated CSFP was associated with arterial hypertensive retinopathy (with respect to the dilated retinal vein diameter and higher arterial-to-venous diameter) and with the prevalence, severity and incidence of diabetic retinopathy. Physiologically, CSFP was related with higher IOP. The influence of the CSFP on the episcleral venous Pressure and/or a regulation of both CSFP and IOP by a center in the dorsomedial/perifornical hypothalamus may be responsible for this. In summary, the CSFP may be an overlooked parameter in ocular physiology and pathology. Abnormal changes in the CSFP, in particular in relationship to the IOP, may have pathophysiologic importance.

  • retinal vessel diameter and estimated Cerebrospinal Fluid Pressure in arterial hypertension the beijing eye study
    American Journal of Hypertension, 2014
    Co-Authors: Jost B Jonas, Qi Sheng You, Diya Yang, Ningli Wang, Ya Xing Wang, Shuang Wang, Wen Bin Wei
    Abstract:

    BACKGROUND Hypertensive retinal microvascular abnormalities include an increased retinal vein-to-artery diameter ratio. Because central retinal vein Pressure depends on Cerebrospinal Fluid Pressure (CSFP), we examined whether the retinal vein-to-artery diameter ratio and other retinal hypertensive signs are associated with CSFP. METHODS Participants of the population-based Beijing Eye Study (n = 1,574 subjects) underwent measurement of the temporal inferior and superior retinal artery and vein diameter. CSFP was calculated as 0.44 × body mass index (kg/m(2)) + 0.16 × diastolic blood Pressure (mm Hg) - 0.18 × age (years) - 1.91. RESULTS Larger retinal vein diameters and higher vein-to-artery diameter ratios were significantly associated with higher estimated CSFP (P = 0.001) in multivariable analysis. In contrast, temporal inferior retinal arterial diameter was marginally associated (P = 0.03) with estimated CSFP, and temporal superior artery diameter was not significantly associated (P = 0.10) with estimated CSFP; other microvascular abnormalities, such as arteriovenous crossing signs, were also not significantly associated with estimated CSFP. In a reverse manner, higher estimated CSFP as a dependent variable in the multivariable analysis was associated with wider retinal veins and higher vein-to-artery diameter ratio. In the same model, estimated CSFP was not significantly correlated with retinal artery diameters or other retinal microvascular abnormalities. Correspondingly, arterial hypertension was associated with retinal microvascular abnormalities such as arteriovenous crossing signs (P = 0.003), thinner temporal retinal arteries (P < 0.001), higher CSFP (P < 0.001), and wider retinal veins (P = 0.001) or, as a corollary, with a higher vein-to-artery diameter ratio in multivariable analysis. CONCLUSIONS Wider retinal vein diameters are associated with higher estimated CSFP and vice versa. In arterial hypertension, an increased retinal vein-to-artery diameter ratio depends on elevated CSFP, which is correlated with blood Pressure.

Rand R Allingham - One of the best experts on this subject based on the ideXlab platform.

  • analysis of Cerebrospinal Fluid Pressure estimation using formulae derived from clinical data
    Investigative Ophthalmology & Visual Science, 2016
    Co-Authors: David Fleischman, Ningli Wang, Jost B Jonas, John P Berdahl, Sandra S Stinnett, Michael P Fautsch, Amanda K Bicket, Rand R Allingham
    Abstract:

    Purpose: To evaluate a frequently used regression model and a new, modified regression model to estimate Cerebrospinal Fluid Pressure (CSFP). Methods: Datasets from the Beijing iCOP study from Tongren Hospital, Beijing, China, and the Mayo Clinic, Rochester, Minnesota, were tested in this retrospective, case-control study. An often-used regression model derived from the Beijing iCOP dataset, but without radiographic data, was used to predict CSFP by using demographic and physiologic data. A regression model was created using the Mayo Clinic dataset and tested against a validation group. The Mayo Clinic-derived formula was also tested against the Beijing Eye Study population. Intraclass correlation was used to assess predicted versus actual CSFP. Results: The Beijing-derived regression equation was reported to have an intraclass correlation coefficient (ICC) of 0.71, indicating strong correlation between predicted and actual CSFP in the study population. The Beijing iCOP regression model poorly predicted CSFP in the Mayo Clinic population with an ICC of 0.14. The Mayo Clinic-derived regression model similarly did not predict CSFP in its Mayo Clinic validation group (ICC 0.28 ± 0.04) nor in the Beijing Eye Study population (ICC 0.06). Conclusions: Formulae used to predict CSFP derived from clinical data fared poorly against a large retrospective dataset. This may be related to differences in lumbar puncture technique, in the populations tested, or the timing of collection of physiologic variables in the Mayo Clinic dataset. Caution should be used when interpreting results based on formulaic derivation of CSFP.

  • the role of Cerebrospinal Fluid Pressure in glaucoma and other ophthalmic diseases a review
    Saudi Journal of Ophthalmology, 2013
    Co-Authors: David Fleischman, Rand R Allingham
    Abstract:

    Glaucoma is one of the most common causes of blindness in the world. Well-known risk factors include age, race, a positive family history and elevated intraocular Pressures. A newly proposed risk factor is decreased Cerebrospinal Fluid Pressure (CSFP). This concept is based on the notion that a Pressure differential exists across the lamina cribrosa, which separates the intraocular space from the subarachnoid Fluid space. In this construct, an increased translaminar Pressure difference will occur with a relative increase in elevated intraocular Pressure or a reduction in CSFP. This net change in Pressure is proposed to act on the tissues within the optic nerve head, potentially contributing to glaucomatous optic neuropathy. Similarly, patients with ocular hypertension who have elevated CSFPs, would enjoy a relatively protective effect from glaucomatous damage. This review will focus on the current literature pertaining to the role of CSFP in glaucoma. Additionally, the authors examine the relationship between glaucoma and other known CSFP-related ophthalmic disorders.

  • Cerebrospinal Fluid Pressure decreases with older age
    PLOS ONE, 2012
    Co-Authors: David Fleischman, John P Berdahl, Jana Zaydlarova, Sandra S Stinnett, Michael P Fautsch, Rand R Allingham
    Abstract:

    Purpose Clinical studies implicate low Cerebrospinal Fluid Pressure (CSFP) or a high translaminar Pressure difference in the pathogenesis of primary open angle glaucoma (POAG) and normal tension glaucoma (NTG). This study was performed to examine the effect of age, sex, race and body mass index (BMI) on CSFP. Methods Electronic medical records from all patients who had a lumbar puncture (LP) performed at the Mayo Clinic from 1996–2009 were reviewed. Information including age, sex, race, height and weight, ocular and medical diagnoses, intraocular Pressure (IOP) and LP opening Pressure was obtained. Patients using medications or with medical diagnoses known to affect CSFP, and those who underwent neurosurgical procedures or where more than one LP was performed were excluded from analysis. Results Electronic medical records of 33,922 patients with a history of having an LP during a 13-year period (1996–2009) were extracted. Of these, 12,118 patients met all entry criteria. Relative to mean CSFP at age group 20–49 (mean 11.5±2.8 mmHg), mean CSFP declined steadily after age 50, with percent reduction of 2.5% for the 50–54 age group (mean 11.2±2.7 mmHg, p<0.002) to 26.9% for the 90–95 group (mean 8.4±2.4 mmHg, p<0.001). Females had lower CSFP than males throughout all age groups. BMI was positively and independently associated with CSFP within all age groups. Conclusion There is a sustained and significant reduction of CSFP with age that begins in the 6th decade. CSFP is consistently lower in females. BMI is positively and independently associated with CSFP in all age groups. The age where CSFP begins to decline coincides with the age where the prevalence of POAG increases. These data support the hypothesis that reduced CSFP may be a risk factor for POAG and may provide an explanation for the mechanism that underlies the age-related increase in the prevalence of POAG and NTG.

  • body mass index has a linear relationship with Cerebrospinal Fluid Pressure
    Investigative Ophthalmology & Visual Science, 2012
    Co-Authors: John P Berdahl, David Fleischman, Jana Zaydlarova, Sandra S Stinnett, Rand R Allingham, Michael P Fautsch
    Abstract:

    Purpose. To examine the relationship between body mass index (BMI) and Cerebrospinal Fluid Pressure (CSFP), as low BMI and low CSFP have recently been described as risk factors for primary open-angle glaucoma (POAG).

  • Cerebrospinal Fluid Pressure is decreased in primary open angle glaucoma
    Ophthalmology, 2008
    Co-Authors: John P Berdahl, Rand R Allingham, Douglas H Johnson
    Abstract:

    Purpose To compare Cerebrospinal Fluid (CSF) Pressure in patients with primary open-angle glaucoma (POAG) with that in nonglaucomatous patients. Design Case–control study. Participants Thirty-one thousand, seven hundred and eighty-six subjects underwent lumbar puncture (LP) between 1996 and 2007 at the Mayo Clinic, Rochester, Minnesota. Of these, 28 patients who had POAG and 49 patients who did not have POAG were analyzed. Methods Retrospective review of medical records. Comparison of the 2 groups and factors associated with CSF Pressure were analyzed by univariate and multivariate analyses. Main Outcome Measures Demographics (age and gender), medical history, medication use, indication for LP, intraocular Pressure (IOP), optic disc cup-to-disc ratio, visual field assessment, and CSF Pressure. Results The mean CSF Pressure ± standard deviation was 13.0±4.2 mmHg in nonglaucoma patients and 9.2±2.9 mmHg in POAG patients ( P P P P P Conclusions Cerebrospinal Fluid Pressure is significantly lower in POAG patients compared with that in nonglaucomatous controls. These data support the notion that CSF Pressure may play an important contributory role in the pathogenesis of POAG.

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  • three decade evaluation of Cerebrospinal Fluid Pressure in open angle glaucoma at a tertiary care center
    Journal of Ophthalmology, 2020
    Co-Authors: Catherine G Knier, John P Berdahl, David Fleischman, David O Hodge, Michael P Fautsch
    Abstract:

    Elevated intraocular Pressure (IOP) is the most prevalent risk factor for primary open-angle glaucoma. However, IOP alone does not fully describe a mechanical basis for disease in patients with normal tension glaucoma or primary open-angle glaucoma. The translaminar Pressure difference (TLPD) theory proposes that the Pressure gradient generated by the difference of IOP and Cerebrospinal Fluid Pressure (CSFp) acting at the level of the optic nerve can lead to cupping and glaucoma when IOP is higher than normal and/or CSFp is lower than normal. The study results to date have generally supported the TLPD theory; however, varying methods, populations, and sample sizes make it difficult to compare results. To further assess whether there is an association between low CSFp and open-angle glaucoma, 30 years of clinical data that assess 96,543 lumbar punctures were analyzed. Patients with open-angle glaucoma showed a significantly lower CSFp than randomly selected normal control patients (9.9 ± 3 mm·Hg (n = 86) versus 12.1 ± 3.6 mm·Hg (n = 114), ) following adjustment for age and sex. This retrospective study provides strong evidence for an association between open-angle glaucoma and low CSFp.

  • analysis of Cerebrospinal Fluid Pressure estimation using formulae derived from clinical data
    Investigative Ophthalmology & Visual Science, 2016
    Co-Authors: David Fleischman, Ningli Wang, Jost B Jonas, John P Berdahl, Sandra S Stinnett, Michael P Fautsch, Amanda K Bicket, Rand R Allingham
    Abstract:

    Purpose: To evaluate a frequently used regression model and a new, modified regression model to estimate Cerebrospinal Fluid Pressure (CSFP). Methods: Datasets from the Beijing iCOP study from Tongren Hospital, Beijing, China, and the Mayo Clinic, Rochester, Minnesota, were tested in this retrospective, case-control study. An often-used regression model derived from the Beijing iCOP dataset, but without radiographic data, was used to predict CSFP by using demographic and physiologic data. A regression model was created using the Mayo Clinic dataset and tested against a validation group. The Mayo Clinic-derived formula was also tested against the Beijing Eye Study population. Intraclass correlation was used to assess predicted versus actual CSFP. Results: The Beijing-derived regression equation was reported to have an intraclass correlation coefficient (ICC) of 0.71, indicating strong correlation between predicted and actual CSFP in the study population. The Beijing iCOP regression model poorly predicted CSFP in the Mayo Clinic population with an ICC of 0.14. The Mayo Clinic-derived regression model similarly did not predict CSFP in its Mayo Clinic validation group (ICC 0.28 ± 0.04) nor in the Beijing Eye Study population (ICC 0.06). Conclusions: Formulae used to predict CSFP derived from clinical data fared poorly against a large retrospective dataset. This may be related to differences in lumbar puncture technique, in the populations tested, or the timing of collection of physiologic variables in the Mayo Clinic dataset. Caution should be used when interpreting results based on formulaic derivation of CSFP.

  • Cerebrospinal Fluid Pressure decreases with older age
    PLOS ONE, 2012
    Co-Authors: David Fleischman, John P Berdahl, Jana Zaydlarova, Sandra S Stinnett, Michael P Fautsch, Rand R Allingham
    Abstract:

    Purpose Clinical studies implicate low Cerebrospinal Fluid Pressure (CSFP) or a high translaminar Pressure difference in the pathogenesis of primary open angle glaucoma (POAG) and normal tension glaucoma (NTG). This study was performed to examine the effect of age, sex, race and body mass index (BMI) on CSFP. Methods Electronic medical records from all patients who had a lumbar puncture (LP) performed at the Mayo Clinic from 1996–2009 were reviewed. Information including age, sex, race, height and weight, ocular and medical diagnoses, intraocular Pressure (IOP) and LP opening Pressure was obtained. Patients using medications or with medical diagnoses known to affect CSFP, and those who underwent neurosurgical procedures or where more than one LP was performed were excluded from analysis. Results Electronic medical records of 33,922 patients with a history of having an LP during a 13-year period (1996–2009) were extracted. Of these, 12,118 patients met all entry criteria. Relative to mean CSFP at age group 20–49 (mean 11.5±2.8 mmHg), mean CSFP declined steadily after age 50, with percent reduction of 2.5% for the 50–54 age group (mean 11.2±2.7 mmHg, p<0.002) to 26.9% for the 90–95 group (mean 8.4±2.4 mmHg, p<0.001). Females had lower CSFP than males throughout all age groups. BMI was positively and independently associated with CSFP within all age groups. Conclusion There is a sustained and significant reduction of CSFP with age that begins in the 6th decade. CSFP is consistently lower in females. BMI is positively and independently associated with CSFP in all age groups. The age where CSFP begins to decline coincides with the age where the prevalence of POAG increases. These data support the hypothesis that reduced CSFP may be a risk factor for POAG and may provide an explanation for the mechanism that underlies the age-related increase in the prevalence of POAG and NTG.

  • body mass index has a linear relationship with Cerebrospinal Fluid Pressure
    Investigative Ophthalmology & Visual Science, 2012
    Co-Authors: John P Berdahl, David Fleischman, Jana Zaydlarova, Sandra S Stinnett, Rand R Allingham, Michael P Fautsch
    Abstract:

    Purpose. To examine the relationship between body mass index (BMI) and Cerebrospinal Fluid Pressure (CSFP), as low BMI and low CSFP have recently been described as risk factors for primary open-angle glaucoma (POAG).

  • Cerebrospinal Fluid Pressure is decreased in primary open angle glaucoma
    Ophthalmology, 2008
    Co-Authors: John P Berdahl, Rand R Allingham, Douglas H Johnson
    Abstract:

    Purpose To compare Cerebrospinal Fluid (CSF) Pressure in patients with primary open-angle glaucoma (POAG) with that in nonglaucomatous patients. Design Case–control study. Participants Thirty-one thousand, seven hundred and eighty-six subjects underwent lumbar puncture (LP) between 1996 and 2007 at the Mayo Clinic, Rochester, Minnesota. Of these, 28 patients who had POAG and 49 patients who did not have POAG were analyzed. Methods Retrospective review of medical records. Comparison of the 2 groups and factors associated with CSF Pressure were analyzed by univariate and multivariate analyses. Main Outcome Measures Demographics (age and gender), medical history, medication use, indication for LP, intraocular Pressure (IOP), optic disc cup-to-disc ratio, visual field assessment, and CSF Pressure. Results The mean CSF Pressure ± standard deviation was 13.0±4.2 mmHg in nonglaucoma patients and 9.2±2.9 mmHg in POAG patients ( P P P P P Conclusions Cerebrospinal Fluid Pressure is significantly lower in POAG patients compared with that in nonglaucomatous controls. These data support the notion that CSF Pressure may play an important contributory role in the pathogenesis of POAG.