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R Uhler - One of the best experts on this subject based on the ideXlab platform.

  • Relevance of human papillomavirus screening in management of Cervical Intraepithelial Neoplasia.
    American journal of obstetrics and gynecology, 1997
    Co-Authors: R H Kaufman, E Adam, J Icenogle, H Lawson, N Lee, K O Reeves, J Irwin, T Simon, M Press, R Uhler
    Abstract:

    To evaluate the utility of human papillomavirus detection in identifying women with abnormal Papanicolaou smears who can be safely followed up with cytologic study only, we conducted a study to determine the sensitivity, specificity, and negative and positive predictive values of a Food and Drug Administration-approved human papillomavirus test kit for detection of Cervical Intraepithelial Neoplasia in colposcopically directed biopsy specimens. We enrolled women with abnormal Papanicolaou smears referred to a colposcopy clinic serving indigent patients. All 1128 women had a referral Papanicolaou smear, a clinic Papanicolaou smear, and a sample for human papillomavirus deoxyribonucleic acid test; 1075 underwent colposcopically directed biopsies and endoCervical curettage. We used the HPV Profile kit for human papillomavirus testing. Of 486 women with low-grade squamous Intraepithelial lesions on Papanicolaou smear, 35.4% had high-risk human papillomavirus deoxyribonucleic acid detected, and of 592 with high-grade lesions, 44.4% had high-risk human papillomavirus detected. Among 527 women with biopsy specimens showing Cervical Intraepithelial Neoplasia and in 267 with Cervical Intraepithelial Neoplasia grades 2 or 3, 38.7% and 56.2% had high-risk human papillomavirus deoxyribonucleic acid detected. However, the sensitivity of human papillomavirus deoxyribonucleic acid detection to identify biopsy-confirmed Cervical Intraepithelial Neoplasia grades 2 or 3 was 55.7%, and the positive predictive value of the test was only 34.9%. Human papillomavirus appears to be causally associated with Cervical cancer but human papillomavirus screening does not appear to be of value to identify women with abnormal Papanicolaou smears who can be safely followed up with cytologic study alone.

  • Relevance of human papillomavirus screening in management of Cervical Intraepithelial Neoplasia
    American Journal of Obstetrics and Gynecology, 1997
    Co-Authors: R H Kaufman, E Adam, J Icenogle, K O Reeves, T Simon, M Press, Herschel W. Lawson, Nancy C. Lee, John C. Irwin, R Uhler
    Abstract:

    Abstract OBJECTIVE: To evaluate the utility of human papillomavirus detection in identifying women with abnormal Papanicolaou smears who can be safely followed up with cytologic study only, we conducted a study to determine the sensitivity, specificity, and negative and positive predictive values of a Food and Drug Administration–approved human papillomavirus test kit for detection of Cervical Intraepithelial Neoplasia in colposcopically directed biopsy specimens. STUDY DESIGN: We enrolled women with abnormal Papanicolaou smears referred to a colposcopy clinic serving indigent patients. All 1128 women had a referral Papanicolaou smear, a clinic Papanicolaou smear, and a sample for human papillomavirus deoxyribonucleic acid test; 1075 underwent colposcopically directed biopsies and endoCervical curettage. We used the HPV Profile kit for human papillomavirus testing. RESULTS: Of 486 women with low-grade squamous Intraepithelial lesions on Papanicolaou smear, 35.4% had high-risk human papillomavirus deoxyribonucleic acid detected, and of 592 with high-grade lesions, 44.4% had high-risk human papillomavirus detected. Among 527 women with biopsy specimens showing Cervical Intraepithelial Neoplasia and in 267 with Cervical Intraepithelial Neoplasia grades 2 or 3, 38.7% and 56.2% had high-risk human papillomavirus deoxyribonucleic acid detected. However, the sensitivity of human papillomavirus deoxyribonucleic acid detection to identify biopsy-confirmed Cervical Intraepithelial Neoplasia grades 2 or 3 was 55.7%, and the positive predictive value of the test was only 34.9%. CONCLUSION: Human papillomavirus appears to be causally associated with Cervical cancer but human papillomavirus screening does not appear to be of value to identify women with abnormal Papanicolaou smears who can be safely followed up with cytologic study alone. (Am J Obstet Gynecol 1997;176:87-92.)

Anna-maija Tapper - One of the best experts on this subject based on the ideXlab platform.

  • Risk of preterm birth in women with Cervical Intraepithelial Neoplasia grade one: a population-based cohort study.
    Acta obstetricia et gynecologica Scandinavica, 2017
    Co-Authors: Annu Heinonen, Mika Gissler, Jorma Paavonen, Anna-maija Tapper, Maija Jakobsson
    Abstract:

    Introduction In this population-based register study our objective was to explore the association of Cervical Intraepithelial Neoplasia, grade 1 and loop electrosurcigal excision procedure with preterm birth. Material and methods Our population consisted of 4759 women diagnosed with Cervical Intraepithelial Neoplasia, grade 1 during 1997–2009 and their 3021 subsequent deliveries analyzed by loop electrosurcigal excision procedure and parity. Hospital Discharge Register was used to identify women diagnosed for Cervical Intraepithelial Neoplasia, grade 1 and these data were linked with the Medical Birth Register data. We calculated odds ratios with 95% confidence intervals. Results Cervical Intraepithelial Neoplasia, grade 1 patients with loop electrosurcigal excision procedure had 54 (6.7%) subsequent preterm births and the corresponding figure among Cervical Intraepithelial Neoplasia, grade 1 patients without loop electrosurcigal excision procedure was 116 (5.2%). This results in odds ratios 1.31 (95% confidence interval 0.94–1.83). We assessed the risk before and after diagnosis of Cervical Intraepithelial Neoplasia, grade 1 both for patients with loop electrosurcigal excision procedure (odds ratios 1.47, 95% confidence interval 1.05–2.06) and without loop electrosurcigal excision procedure (odds ratios 0.90, 95% confidence interval 0.71–1.13). An increased risk for preterm birth after diagnosis of Cervical Intraepithelial Neoplasia, grade 1 and loop electrosurcigal excision procedure was observed. We also compared both groups to the background population in the Medical Birth Register. For Cervical Intraepithelial Neoplasia, grade 1 patients without loop electrosurcigal excision procedure the risk for preterm birth was not increased (odds ratios 0.95, 95% confidence interval 0.76–1.21) whereas for Cervical Intraepithelial Neoplasia, grade 1 patients treated with loop electrosurcigal excision procedure the risk for preterm birth was increased (odds ratios 1.45, 95% confidence interval 1.02–1.92). Conclusions Loop electrosurcigal excision procedure itself increases the risk for preterm birth. Cervical Intraepithelial Neoplasia, grade 1 as such does not increase the risk for preterm birth.

  • preterm delivery after surgical treatment for Cervical Intraepithelial Neoplasia
    Obstetrics & Gynecology, 2007
    Co-Authors: Maija Jakobsson, Mika Gissler, Jorma Paavonen, Susanna Sainio, Anna-maija Tapper
    Abstract:

    OBJECTIVE:To study whether a treatment of Cervical Intraepithelial Neoplasia (CIN) is associated with an adverse outcome in the subsequent pregnancies.METHODS:This study is a register-based retrospective cohort study from Finland. National data of 25,827 women having a surgical treatment of the cerv

Maija Jakobsson - One of the best experts on this subject based on the ideXlab platform.

  • Risk of preterm birth in women with Cervical Intraepithelial Neoplasia grade one: a population-based cohort study.
    Acta obstetricia et gynecologica Scandinavica, 2017
    Co-Authors: Annu Heinonen, Mika Gissler, Jorma Paavonen, Anna-maija Tapper, Maija Jakobsson
    Abstract:

    Introduction In this population-based register study our objective was to explore the association of Cervical Intraepithelial Neoplasia, grade 1 and loop electrosurcigal excision procedure with preterm birth. Material and methods Our population consisted of 4759 women diagnosed with Cervical Intraepithelial Neoplasia, grade 1 during 1997–2009 and their 3021 subsequent deliveries analyzed by loop electrosurcigal excision procedure and parity. Hospital Discharge Register was used to identify women diagnosed for Cervical Intraepithelial Neoplasia, grade 1 and these data were linked with the Medical Birth Register data. We calculated odds ratios with 95% confidence intervals. Results Cervical Intraepithelial Neoplasia, grade 1 patients with loop electrosurcigal excision procedure had 54 (6.7%) subsequent preterm births and the corresponding figure among Cervical Intraepithelial Neoplasia, grade 1 patients without loop electrosurcigal excision procedure was 116 (5.2%). This results in odds ratios 1.31 (95% confidence interval 0.94–1.83). We assessed the risk before and after diagnosis of Cervical Intraepithelial Neoplasia, grade 1 both for patients with loop electrosurcigal excision procedure (odds ratios 1.47, 95% confidence interval 1.05–2.06) and without loop electrosurcigal excision procedure (odds ratios 0.90, 95% confidence interval 0.71–1.13). An increased risk for preterm birth after diagnosis of Cervical Intraepithelial Neoplasia, grade 1 and loop electrosurcigal excision procedure was observed. We also compared both groups to the background population in the Medical Birth Register. For Cervical Intraepithelial Neoplasia, grade 1 patients without loop electrosurcigal excision procedure the risk for preterm birth was not increased (odds ratios 0.95, 95% confidence interval 0.76–1.21) whereas for Cervical Intraepithelial Neoplasia, grade 1 patients treated with loop electrosurcigal excision procedure the risk for preterm birth was increased (odds ratios 1.45, 95% confidence interval 1.02–1.92). Conclusions Loop electrosurcigal excision procedure itself increases the risk for preterm birth. Cervical Intraepithelial Neoplasia, grade 1 as such does not increase the risk for preterm birth.

  • preterm delivery after surgical treatment for Cervical Intraepithelial Neoplasia
    Obstetrics & Gynecology, 2007
    Co-Authors: Maija Jakobsson, Mika Gissler, Jorma Paavonen, Susanna Sainio, Anna-maija Tapper
    Abstract:

    OBJECTIVE:To study whether a treatment of Cervical Intraepithelial Neoplasia (CIN) is associated with an adverse outcome in the subsequent pregnancies.METHODS:This study is a register-based retrospective cohort study from Finland. National data of 25,827 women having a surgical treatment of the cerv

Sonia Andersson - One of the best experts on this subject based on the ideXlab platform.

  • Follow-up after treatment of Cervical Intraepithelial Neoplasia by human papillomavirus genotyping.
    American Journal of Obstetrics and Gynecology, 2009
    Co-Authors: Sophia Brismar, Bo Johansson, Malin Borjesson, Marc Arbyn, Sonia Andersson
    Abstract:

    Objective To assess the use of human papillomavirus genotyping in Cervical Intraepithelial Neoplasia posttreatment follow-up. Study Design Prospective observational study. Ninety women underwent cytologic testing and human papillomavirus genotyping at the follow-up visit after conization. Cones were retrospectively genotyped. A second cytologic follow-up was performed. Results Margin status and presence of Cervical Intraepithelial Neoplasia 3+ in the cone were poor predictors of treatment outcome (sensitivity, P Conclusion Testing for high-risk human papillomavirus identified all recurrent/residual high-grade Cervical Intraepithelial Neoplasia. Focusing on women with persistent human papillomavirus types through genotyping substantially increased positive predictive value but at a loss in sensitivity.

R H Kaufman - One of the best experts on this subject based on the ideXlab platform.

  • Relevance of human papillomavirus screening in management of Cervical Intraepithelial Neoplasia.
    American journal of obstetrics and gynecology, 1997
    Co-Authors: R H Kaufman, E Adam, J Icenogle, H Lawson, N Lee, K O Reeves, J Irwin, T Simon, M Press, R Uhler
    Abstract:

    To evaluate the utility of human papillomavirus detection in identifying women with abnormal Papanicolaou smears who can be safely followed up with cytologic study only, we conducted a study to determine the sensitivity, specificity, and negative and positive predictive values of a Food and Drug Administration-approved human papillomavirus test kit for detection of Cervical Intraepithelial Neoplasia in colposcopically directed biopsy specimens. We enrolled women with abnormal Papanicolaou smears referred to a colposcopy clinic serving indigent patients. All 1128 women had a referral Papanicolaou smear, a clinic Papanicolaou smear, and a sample for human papillomavirus deoxyribonucleic acid test; 1075 underwent colposcopically directed biopsies and endoCervical curettage. We used the HPV Profile kit for human papillomavirus testing. Of 486 women with low-grade squamous Intraepithelial lesions on Papanicolaou smear, 35.4% had high-risk human papillomavirus deoxyribonucleic acid detected, and of 592 with high-grade lesions, 44.4% had high-risk human papillomavirus detected. Among 527 women with biopsy specimens showing Cervical Intraepithelial Neoplasia and in 267 with Cervical Intraepithelial Neoplasia grades 2 or 3, 38.7% and 56.2% had high-risk human papillomavirus deoxyribonucleic acid detected. However, the sensitivity of human papillomavirus deoxyribonucleic acid detection to identify biopsy-confirmed Cervical Intraepithelial Neoplasia grades 2 or 3 was 55.7%, and the positive predictive value of the test was only 34.9%. Human papillomavirus appears to be causally associated with Cervical cancer but human papillomavirus screening does not appear to be of value to identify women with abnormal Papanicolaou smears who can be safely followed up with cytologic study alone.

  • Relevance of human papillomavirus screening in management of Cervical Intraepithelial Neoplasia
    American Journal of Obstetrics and Gynecology, 1997
    Co-Authors: R H Kaufman, E Adam, J Icenogle, K O Reeves, T Simon, M Press, Herschel W. Lawson, Nancy C. Lee, John C. Irwin, R Uhler
    Abstract:

    Abstract OBJECTIVE: To evaluate the utility of human papillomavirus detection in identifying women with abnormal Papanicolaou smears who can be safely followed up with cytologic study only, we conducted a study to determine the sensitivity, specificity, and negative and positive predictive values of a Food and Drug Administration–approved human papillomavirus test kit for detection of Cervical Intraepithelial Neoplasia in colposcopically directed biopsy specimens. STUDY DESIGN: We enrolled women with abnormal Papanicolaou smears referred to a colposcopy clinic serving indigent patients. All 1128 women had a referral Papanicolaou smear, a clinic Papanicolaou smear, and a sample for human papillomavirus deoxyribonucleic acid test; 1075 underwent colposcopically directed biopsies and endoCervical curettage. We used the HPV Profile kit for human papillomavirus testing. RESULTS: Of 486 women with low-grade squamous Intraepithelial lesions on Papanicolaou smear, 35.4% had high-risk human papillomavirus deoxyribonucleic acid detected, and of 592 with high-grade lesions, 44.4% had high-risk human papillomavirus detected. Among 527 women with biopsy specimens showing Cervical Intraepithelial Neoplasia and in 267 with Cervical Intraepithelial Neoplasia grades 2 or 3, 38.7% and 56.2% had high-risk human papillomavirus deoxyribonucleic acid detected. However, the sensitivity of human papillomavirus deoxyribonucleic acid detection to identify biopsy-confirmed Cervical Intraepithelial Neoplasia grades 2 or 3 was 55.7%, and the positive predictive value of the test was only 34.9%. CONCLUSION: Human papillomavirus appears to be causally associated with Cervical cancer but human papillomavirus screening does not appear to be of value to identify women with abnormal Papanicolaou smears who can be safely followed up with cytologic study alone. (Am J Obstet Gynecol 1997;176:87-92.)