The Experts below are selected from a list of 2460 Experts worldwide ranked by ideXlab platform
Paul M George - One of the best experts on this subject based on the ideXlab platform.
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modulating the electrical and mechanical microenvironment to guide neuronal stem cell differentiation
Advanced Science, 2021Co-Authors: Vishal Swaminathan, Vivek Lam, Jun B Ding, Paul M GeorgeAbstract:The application of induced pluripotent stem cells (iPSCs) in disease modeling and regenerative medicine can be limited by the prolonged times required for functional human neuronal differentiation and traditional 2D culture techniques. Here, a conductive graphene scaffold (Cgs) to modulate mechanical and electrical signals to promote human iPSC-derived neurons is presented. The soft Cgs with cortex-like stiffness (≈3 kPa) and electrical stimulation (±800 mV/100 Hz for 1 h) incurs a fivefold improvement in the rate (14d) of generating iPSC-derived neurons over some traditional protocols, with an increase in mature cellular markers and electrophysiological characteristics. Consistent with other culture conditions, it is found that the pro-neurogenic effects of mechanical and electrical stimuli rely on RhoA/ROCK signaling and de novo ciliary neurotrophic factor (CNTF) production respectively. Thus, the Cgs System creates a combined physical and continuously modifiable, electrical niche to efficiently and quickly generate iPSC-derived neurons.
Vishal Swaminathan - One of the best experts on this subject based on the ideXlab platform.
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modulating the electrical and mechanical microenvironment to guide neuronal stem cell differentiation
Advanced Science, 2021Co-Authors: Vishal Swaminathan, Vivek Lam, Jun B Ding, Paul M GeorgeAbstract:The application of induced pluripotent stem cells (iPSCs) in disease modeling and regenerative medicine can be limited by the prolonged times required for functional human neuronal differentiation and traditional 2D culture techniques. Here, a conductive graphene scaffold (Cgs) to modulate mechanical and electrical signals to promote human iPSC-derived neurons is presented. The soft Cgs with cortex-like stiffness (≈3 kPa) and electrical stimulation (±800 mV/100 Hz for 1 h) incurs a fivefold improvement in the rate (14d) of generating iPSC-derived neurons over some traditional protocols, with an increase in mature cellular markers and electrophysiological characteristics. Consistent with other culture conditions, it is found that the pro-neurogenic effects of mechanical and electrical stimuli rely on RhoA/ROCK signaling and de novo ciliary neurotrophic factor (CNTF) production respectively. Thus, the Cgs System creates a combined physical and continuously modifiable, electrical niche to efficiently and quickly generate iPSC-derived neurons.
Lloyd Dixon - One of the best experts on this subject based on the ideXlab platform.
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Qci 94 An Electrical Circuit Model for Magnetic Cores
2015Co-Authors: Lloyd DixonAbstract:A brief tutorial on magnetic fundamentals leads into a discussion of magnetic core properties. A modified version of lntusoft ' s magnetic core model is presented. Low1requency hysteresis is added to the model, making it suitable for magnetic amplifier applications. Fig I.-Magnetic Core B-H Characteristic surface of Fig. 1 represents energy per unit volume. The area enclosed by the hysteresis loop is unre-coverable energy (loss). The area between the hysteresis loop and the vertical axis is recoverable stored energy: W!m 3 = fBdH In Figure 2, the shape is the same as Fig. I, but the axis labels and values have been changed. Figure 2 shows the characteristic of a specific core made from the material of Figure I. The flux density axis Magnetic Fundamentals: Units commonly used in magnetics design are given in Table I, along with conversion factors from the older Cgs System to the SI System (sys-feme infernational- rationalized MKS). SI units are used almost universally throughout the world. Equations used for magnetics design in the SI System are much simpler and therefore more intu-itive than their Cgs equivalents. Unfortunately, much of the published magnetics data is in the Cgs System, especially in the United States, requiring conversion to use the SI equations
Subir K Banerjee - One of the best experts on this subject based on the ideXlab platform.
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magnetic properties of rocks and minerals
Rock Physics & Phase Relations: A Handbook of Physical Constants, 2013Co-Authors: Christopher P Hunt, Bruce M Moskowitz, Subir K BanerjeeAbstract:This is an updated collation of magnetic parameters of rocks and minerals for geologists, geochemists, and geophysicists. Since the publication of the previous edition of Handbook of Physical Constants [74], two other collations have appeared [16, 18]. In addition, selected magnetic parameters have also been assembled [19, 22, 38, 41, 88]. Rather than produce a fully comprehensive collection, we have aimed for high-precision data obtained from wellcharacterized samples. Both tables and figures have been used for presenting the data, and best-fit equations have been provided for some of the displayed ata so that interpolations can be made easily. In an attempt to discourage the use of the outdated Cgs System, all values are in the SI System (see Moskowitz, this volume). References have been cited for the sources used here. However, a more comprehensive bibliography has also been provided from which information can be extracted for samples which have not been included. The single-crystal constants and their variation with temperature and composition are for use by rock magnetists. Paleomagnetists and magnetic anomaly modelers have been provided with the magnetic properties of rocks and polycrystalline mineral samples. Lastly, we have made an effort to address the needs of environmental magnetism, a new group of researchers who require the values of sizeand
Jun B Ding - One of the best experts on this subject based on the ideXlab platform.
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modulating the electrical and mechanical microenvironment to guide neuronal stem cell differentiation
Advanced Science, 2021Co-Authors: Vishal Swaminathan, Vivek Lam, Jun B Ding, Paul M GeorgeAbstract:The application of induced pluripotent stem cells (iPSCs) in disease modeling and regenerative medicine can be limited by the prolonged times required for functional human neuronal differentiation and traditional 2D culture techniques. Here, a conductive graphene scaffold (Cgs) to modulate mechanical and electrical signals to promote human iPSC-derived neurons is presented. The soft Cgs with cortex-like stiffness (≈3 kPa) and electrical stimulation (±800 mV/100 Hz for 1 h) incurs a fivefold improvement in the rate (14d) of generating iPSC-derived neurons over some traditional protocols, with an increase in mature cellular markers and electrophysiological characteristics. Consistent with other culture conditions, it is found that the pro-neurogenic effects of mechanical and electrical stimuli rely on RhoA/ROCK signaling and de novo ciliary neurotrophic factor (CNTF) production respectively. Thus, the Cgs System creates a combined physical and continuously modifiable, electrical niche to efficiently and quickly generate iPSC-derived neurons.