The Experts below are selected from a list of 3405 Experts worldwide ranked by ideXlab platform

Jeffrey Robbins - One of the best experts on this subject based on the ideXlab platform.

  • alpha tropomyosin knockouts a blow against transcriptional Chauvinism
    Circulation Research, 1998
    Co-Authors: Jeffrey Robbins
    Abstract:

    The pace at which the protein complement of the heart is precisely remodeled by either gene targeting or transgenesis in animal models continues to accelerate.1 A logical focus of these approaches has been to establish structure-function relationships of the proteins present in the terminally differentiated cardiomyocyte. Rather unexpectedly, these experiments have also highlighted the importance of multiple control points, both at the transcriptional and posttranscriptional levels, which are able to regulate the overall stoichiometry of the cardiac thick and thin filament proteins. Several recent articles in Circulation Research illustrate these points for the thin filament protein, α-tropomyosin (α-TM).2 3 4 In striated muscle, the thin filament consists largely of actin, tropomyosin (TM), and the troponin complex (troponins I, C, and T) and is responsible for mediating Ca2+ control of contraction and relaxation. TM is a rigid rod-shaped protein that binds along the length of the actin filament and is intimately associated with troponin. It both stabilizes and stiffens the filament.5 In the absence of Ca2+ binding to troponin C, TM blocks the myosin binding site of actin. TM is a small polypeptide, ≈284 amino acids, depending on the particular isoform, and dimerizes to form a head-to-tail coiled-coil structure that lies in the major groove of the actin filament. The placement of the TM dimer is consistent with one of its important roles, which is to help mediate cooperativity of Ca2+ activation along the length of the myofilament.6 7 Like other sarcomeric proteins, TM exists as a set of isoforms; these are generated as a result of both differential transcription of the four members of the gene family (α-TM, β-TM, TM-4, and TM-30) and by alternative splicing patterns from the primary transcripts. The α- and β-TMs are the two striated muscle isoforms and are …

Baker Nicholas - One of the best experts on this subject based on the ideXlab platform.

  • Book review: contentious rituals: parading the nation in Northern Ireland by Jonathan S. Blake
    London School of Economics and Political Science, 2020
    Co-Authors: Baker Nicholas
    Abstract:

    In Contentious Rituals: Parading the Nation in Northern Ireland, Jonathan S. Blake offers a new examination of the complex phenomenon of Protestant parading in Northern Ireland, drawing on carefully compiled sociological and ethnographic data to argue that, in the words of his participants, what motivates the majority of paraders, musicians and spectators is not political, ethnic or religious Chauvinism, but rather commitment to a longstanding cultural practice positioned as antipolitical. This is a nuanced and rich study, writes Nicholas Baker, that will be of great value to anyone interested in contemporary politics in Northern Ireland

  • Book review: contentious rituals: parading the nation in Northern Ireland
    London School of Economics and Political Science, 2020
    Co-Authors: Baker Nicholas
    Abstract:

    In Contentious Rituals: Parading the Nation in Northern Ireland, Jonathan S. Blake offers a new examination of the complex phenomenon of Protestant parading in Northern Ireland, drawing on carefully compiled sociological and ethnographic data to argue that, in the words of his participants, what motivates the majority of paraders, musicians and spectators is not political, ethnic or religious Chauvinism, but rather commitment to a longstanding cultural practice positioned as antipolitical. This is a nuanced and rich study, writes Nicholas Baker, that will be of great value to anyone interested in contemporary politics in Northern Ireland

Helga Kristin Hallgrimsdottir - One of the best experts on this subject based on the ideXlab platform.

  • welfare state chauvinists gender citizenship and anti democratic politics in the welfare state paradise
    Frontiers in Sociology, 2019
    Co-Authors: Maria Finnsdottir, Helga Kristin Hallgrimsdottir
    Abstract:

    The rise of the far-right poses a pressing challenge to democratic politics and the democratization of political participation in Western Europe. This paper addresses this issue in the Scandinavian context, examining the importance of welfare Chauvinism and gendered citizenship claims in the political rhetoric of the far-right. In so doing, we contribute to a need to examine closely the interplay between gender, citizenship, and welfare politics and the rise of exclusionary and anti-democratic politics. The paper draws on an examination of the party platforms of the three principle far-right-wing parties currently active in Scandinavia: the Danish People’s Party, the Norwegian Progress Party, and the Sweden Democrats as well as descriptive statistics on ethnonationalist tendencies among the Scandinavian populations in recent years, retrieved from the International Social Survey Programme’s (ISSP) 2013 survey on nationalism. We conclude that the far-right in Scandinavia uses gender and ethno-nationalist claims to simultaneously valorize and challenge egalitarianism in the welfare state while also shoring up exclusionary and anti-democratic claims to citizenship and belonging in the Nordic welfare state.

Eric Schwitzgebel - One of the best experts on this subject based on the ideXlab platform.

  • If materialism is true, the United States is probably conscious
    Philosophical Studies, 2015
    Co-Authors: Eric Schwitzgebel
    Abstract:

    If you’re a materialist, you probably think that rabbits are conscious. And you ought to think that. After all, rabbits are a lot like us, biologically and neurophysiologically. If you’re a materialist, you probably also think that conscious experience would be present in a wide range of naturally-evolved alien beings behaviorally very similar to us even if they are physiologically very different. And you ought to think that. After all, to deny it seems insupportable Earthly Chauvinism. But a materialist who accepts consciousness in weirdly formed aliens ought also to accept consciousness in spatially distributed group entities. If she then also accepts rabbit consciousness, she ought to accept the possibility of consciousness even in rather dumb group entities. Finally, the United States would seem to be a rather dumb group entity of the relevant sort. If we set aside our morphological prejudices against spatially distributed group entities, we can see that the United States has all the types of properties that materialists tend to regard as characteristic of conscious beings.

Nicolai J. Foss - One of the best experts on this subject based on the ideXlab platform.

  • The (proper) microfoundations of routines and capabilities: a response to Winter, Pentland, Hodgson and Knudsen
    Journal of Institutional Economics, 2011
    Co-Authors: Teppo Felin, Nicolai J. Foss
    Abstract:

    Abstract:Sidney Winter (2011), Brian Pentland (2011), and Geoffrey Hodgson and Thorbjørn Knudsen (2011) take issue with the arguments in Teppo Felin and Nicolai J. Foss (2011), along with more generally critiquing the ‘microfoundations project’ related to routines and capabilities. In this rejoinder we argue that the responses of our critics reinforce a number of the points stated in our writings on the routines and capabilities literature. In response to their many points we address the following key issues in the debate: (1) lack of construct clarity; (2) universal mechanisms or comparative Chauvinism; (3) models of mind and man; (4) levels of analysis; (5) agency and uncaused causes; and then further discuss (6) a rationalist alternative.

  • the proper microfoundations of routines and capabilities a response to winter pentland hodgson and knudsen
    2011
    Co-Authors: Teppo Felin, Nicolai J. Foss
    Abstract:

    Winter (2011), Pentland (2011), and Hodgson and Knudsen (2011) take issue with the arguments in Felin and Foss (2011), along with more generally critiquing the “microfoundations project” related to routines and capabilities. In this rejoinder we argue that the responses of our critics reinforce a number of the points stated in our writings on the routines and capabilities literature. In response to their many points we address the following key issues in the debate: 1) lack of construct clarity, 2) universal mechanisms or comparative Chauvinism, 3) models of mind and man, 4) levels of analysis, 5) agency and uncaused causes, and then further discuss 6) a rationalist alternative.