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Cleverson Teixeira Soares - One of the best experts on this subject based on the ideXlab platform.
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loss of cytokeratin 10 indicates malignant transformation in actinic Cheilitis
Clinical Oral Investigations, 2016Co-Authors: Natalia Galvao Garcia, Eliana Maria Minicucci, Maria Aparecida Custódio Domingues, Jose Roberto Pereira Lauris, Denise Tostes Oliveira, Cleverson Teixeira SoaresAbstract:The aim of this study was to investigate the relationship the expression of cytokeratins (CK10 and CK13) and the cell proliferation index determined by Ki-67 of lip squamous cell carcinoma and actinic Cheilitis with different degrees of dysplasia. Forty-five paraffin-embedded actinic Cheilitis with and without dysplasia and 20 lip squamous cell carcinoma were analyzed by immunohistochemistry using anti-human anti-CK10, anti-CK13, and anti-Ki-67 antibodies. The majority of actinic Cheilitis showed immunopositivity for CK10 and CK13 with decrease or loss of expression in dysplastic areas. In lip squamous cell carcinoma of the lip, heterogeneous expression of CK13 and immunonegativity for CK10 were observed. There was a statistically significant difference between CK10 expression in lip squamous cell carcinoma and in actinic Cheilitis with or without dysplasia (p < 0.001). The cell proliferation index was higher in actinic Cheilitis with dysplasia and lip squamous cell carcinoma than in actinic Cheilitis without epithelial dysplasia. A significant correlation was found between the intensity of the epithelial dysplasia and the cell proliferation index (p < 0.001). These results provide evidence that there is a downregulation of CK10 expression in dysplastic areas of patients with actinic Cheilitis and in those with lip squamous cell carcinoma (LSCC) and that the index of cell proliferation, determined by Ki-67, is directly correlated with the intensity of the epithelial dysplasia. Altogether, these results suggest that CK10 expression and the epithelial cell proliferation index can help to identify malignant transformation in the lip region.
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Loss of cytokeratin 10 indicates malignant transformation in actinic Cheilitis
Clinical Oral Investigations, 2015Co-Authors: Natalia Galvao Garcia, Eliana Maria Minicucci, Maria Aparecida Custódio Domingues, Jose Roberto Pereira Lauris, Denise Tostes Oliveira, Cleverson Teixeira SoaresAbstract:The aim of this study was to investigate the relationship the expression of cytokeratins (CK10 and CK13) and the cell proliferation index determined by Ki-67 of lip squamous cell carcinoma and actinic Cheilitis with different degrees of dysplasia. Forty-five paraffin-embedded actinic Cheilitis with and without dysplasia and 20 lip squamous cell carcinoma were analyzed by immunohistochemistry using anti-human anti-CK10, anti-CK13, and anti-Ki-67 antibodies. The majority of actinic Cheilitis showed immunopositivity for CK10 and CK13 with decrease or loss of expression in dysplastic areas. In lip squamous cell carcinoma of the lip, heterogeneous expression of CK13 and immunonegativity for CK10 were observed. There was a statistically significant difference between CK10 expression in lip squamous cell carcinoma and in actinic Cheilitis with or without dysplasia (p
U Joos - One of the best experts on this subject based on the ideXlab platform.
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surgical treatment of persistent macrocheilia in patients with melkersson rosenthal syndrome and Cheilitis granulomatosa
Archives of Dermatology, 2005Co-Authors: Birgit Kruselosler, Dagmar Presser, Dieter Metze, U JoosAbstract:Background Various conservative methods for treatment of labial swelling in patients with Cheilitis granulomatosa have been attempted, often with only moderate success and sometimes with persistent disfiguring lip swelling. Severe macrocheilia can produce an unaesthetic facial deformity associated with functional disturbances. In patients with persistent macrocheilia, reduction cheiloplasty with excision of excess tissue may be indicated when conservative treatment has proven ineffective in reducing swelling but may have been successful in stabilizing disease. Objective To evaluate long-term results after reduction cheiloplasty in patients with macrocheilia caused by Melkersson-Rosenthal syndrome or Cheilitis granulomatosa. Design Follow-up study in 7 patients with severe persisting macrocheilia, including 3 patients with Melkersson-Rosenthal syndrome and 4 patients with Cheilitis granulomatosa in a stable state of disease, treated by reduction cheiloplasty at our hospital between January 1, 1987, and December 31, 2002. Preoperative and postoperative medical histories were obtained, and criteria for the success of surgical treatment were evaluated by clinical examination. Different techniques of reduction cheiloplasty are described and demonstrated in representative cases of severe macrocheilia. Results Surgical treatment in all 7 patients showed satisfying aesthetic and functional outcomes that persisted throughout follow-up (median follow-up, 6.5 years). Conclusions Reduction cheiloplasty is an effective method to correct persistent macrocheilia and improve lip aesthetics in patients with Melkersson-Rosenthal syndrome or granulomatous Cheilitis in the persistent state of disease. With careful planning, proper sequencing of treatment, and proficiency in the various surgical techniques, optimal results can be achieved.
Friederike Egberts - One of the best experts on this subject based on the ideXlab platform.
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treatment of actinic Cheilitis using photodynamic therapy with methylaminolevulinate report of three cases
Dermatologic Surgery, 2005Co-Authors: Axel Hauschild, S Lischner, Bernhard Langeasschenfeldt, Friederike EgbertsAbstract:Background. Patients with actinic Cheilitis should be treated to prevent transformation into invasive squamous cell carcinoma. Treatment options comprise, for instance, destructive approaches, such as vermilionectomy and carbon dioxide laser ablation. Photodynamic therapy (PDT) has demonstrated high efficacy in patients with epithelial skin cancers, but there is only one report on PDT with free d-aminolevulinic acid (ALA) and noncoherent light in the treatment of actinic Cheilitis. Objective. We report the treatment of three patients with actinic Cheilitis with PDT using the new photosensitizing agent methylaminolevulinate (methyl-5-amino-4-oxopenthanoate [MAOP]) combined with red light. Methods. MAOP was topically applied on the lower lip 3 hours before treatment with red light. Two consecutive treatments, 1 week apart, were administered. Clinical assessment was performed up to 13 months after the initial treatment. Results. A good clinical response with an excellent cosmetic outcome was observed in all three patients. Moderate to severe pain was associated with the application of the red light, and mild inflammation with edema of the lower lip occurred. Conclusion. This is the first use of PDT with MAOP and 634 mm wavelength red light in patients with actinic Cheilitis. The clinical results demonstrate that PDT might be an alternative for patients who refuse surgical procedures. However, further studies are needed to compare the efficacy and cosmetic outcome with conventional treatment modalities.
Natalia Galvao Garcia - One of the best experts on this subject based on the ideXlab platform.
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loss of cytokeratin 10 indicates malignant transformation in actinic Cheilitis
Clinical Oral Investigations, 2016Co-Authors: Natalia Galvao Garcia, Eliana Maria Minicucci, Maria Aparecida Custódio Domingues, Jose Roberto Pereira Lauris, Denise Tostes Oliveira, Cleverson Teixeira SoaresAbstract:The aim of this study was to investigate the relationship the expression of cytokeratins (CK10 and CK13) and the cell proliferation index determined by Ki-67 of lip squamous cell carcinoma and actinic Cheilitis with different degrees of dysplasia. Forty-five paraffin-embedded actinic Cheilitis with and without dysplasia and 20 lip squamous cell carcinoma were analyzed by immunohistochemistry using anti-human anti-CK10, anti-CK13, and anti-Ki-67 antibodies. The majority of actinic Cheilitis showed immunopositivity for CK10 and CK13 with decrease or loss of expression in dysplastic areas. In lip squamous cell carcinoma of the lip, heterogeneous expression of CK13 and immunonegativity for CK10 were observed. There was a statistically significant difference between CK10 expression in lip squamous cell carcinoma and in actinic Cheilitis with or without dysplasia (p < 0.001). The cell proliferation index was higher in actinic Cheilitis with dysplasia and lip squamous cell carcinoma than in actinic Cheilitis without epithelial dysplasia. A significant correlation was found between the intensity of the epithelial dysplasia and the cell proliferation index (p < 0.001). These results provide evidence that there is a downregulation of CK10 expression in dysplastic areas of patients with actinic Cheilitis and in those with lip squamous cell carcinoma (LSCC) and that the index of cell proliferation, determined by Ki-67, is directly correlated with the intensity of the epithelial dysplasia. Altogether, these results suggest that CK10 expression and the epithelial cell proliferation index can help to identify malignant transformation in the lip region.
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Loss of cytokeratin 10 indicates malignant transformation in actinic Cheilitis
Clinical Oral Investigations, 2015Co-Authors: Natalia Galvao Garcia, Eliana Maria Minicucci, Maria Aparecida Custódio Domingues, Jose Roberto Pereira Lauris, Denise Tostes Oliveira, Cleverson Teixeira SoaresAbstract:The aim of this study was to investigate the relationship the expression of cytokeratins (CK10 and CK13) and the cell proliferation index determined by Ki-67 of lip squamous cell carcinoma and actinic Cheilitis with different degrees of dysplasia. Forty-five paraffin-embedded actinic Cheilitis with and without dysplasia and 20 lip squamous cell carcinoma were analyzed by immunohistochemistry using anti-human anti-CK10, anti-CK13, and anti-Ki-67 antibodies. The majority of actinic Cheilitis showed immunopositivity for CK10 and CK13 with decrease or loss of expression in dysplastic areas. In lip squamous cell carcinoma of the lip, heterogeneous expression of CK13 and immunonegativity for CK10 were observed. There was a statistically significant difference between CK10 expression in lip squamous cell carcinoma and in actinic Cheilitis with or without dysplasia (p
Klaus Degitz - One of the best experts on this subject based on the ideXlab platform.
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the efficacy of photodynamic therapy in actinic Cheilitis of the lower lip a prospective study of 15 patients
Dermatologic Surgery, 2007Co-Authors: Carola Berking, Thomas Herzinger, Michael J Flaig, Michaela Brenner, Claudia Borelli, Klaus DegitzAbstract:BACKGROUND Photodynamic therapy (PDT) has been developed into a widely used method to treat actinic keratoses and basal cell carcinoma. OBJECTIVE The objective was to assess the efficacy of PDT in the treatment of actinic Cheilitis of the lower lip. METHODS In this prospective, uncontrolled study at a university dermatology department, 15 patients with actinic Cheilitis received two sessions of PDT of the lower lip at an interval of 1 week using methylaminoxopentanoate and red light. Clinical and histopathologic evaluation was performed 3 months after therapy. RESULTS Complete clinical cure was observed in 47% (7/15) and partial cure in another 47% (7/15) of the patients. By histopathologic analysis, residual disease was found in 62% (8/13). Cosmetic results and patients' satisfaction were good to excellent in most cases. Local pain was sufficiently controlled by local anesthesia. CONCLUSION PDT can be an effective noninvasive method to treat actinic Cheilitis of the lower lip.