The Experts below are selected from a list of 12492 Experts worldwide ranked by ideXlab platform

Johannes Tolls - One of the best experts on this subject based on the ideXlab platform.

  • specific environmental release categories a tool for improving Chemical Safety Assessment in the ec report of a multi stakeholder workshop
    Integrated Environmental Assessment and Management, 2012
    Co-Authors: Daniel Sattler, Frank Schnoder, Nannett Aust, Andreas Ahrens, Christian Bogi, Theo Traas, Johannes Tolls
    Abstract:

    In April 2011, experts from industry and authorities met for a workshop to discuss experience and future developments regarding the use of specific environmental release categories (SPERCs) in Chemicals Safety Assessment (CSA) under the European Chemicals Regulation Registration, Evaluation and Authorization of Chemicals (REACH). This article provides a summary of the workshop. It briefly explains what a SPERC is, why SPERCs are needed, where the challenges of the concept are, and what improvements are needed to make SPERCs a useful tool for Assessments under REACH. Integr Environ Assess Manag 2012; 8: 580–585. © 2012 SETAC

  • specific environmental release categories a tool for improving Chemical Safety Assessment in the ec report of a multi stakeholder workshop
    Integrated Environmental Assessment and Management, 2012
    Co-Authors: Daniel Sattler, Frank Schnoder, Nannett Aust, Andreas Ahrens, Christian Bogi, Theo Traas, Johannes Tolls
    Abstract:

    In April 2011, experts from industry and authorities met for a workshop to discuss experience and future developments regarding the use of specific environmental release categories (SPERCs) in Chemicals Safety Assessment (CSA) under the European Chemicals Regulation Registration, Evaluation and Authorization of Chemicals (REACH). This article provides a summary of the workshop. It briefly explains what a SPERC is, why SPERCs are needed, where the challenges of the concept are, and what improvements are needed to make SPERCs a useful tool for Assessments under REACH.

Xuefang Liang - One of the best experts on this subject based on the ideXlab platform.

  • toxicogenomic applications of chinese rare minnow gobiocypris rarus in aquatic toxicology
    Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2016
    Co-Authors: Xuefang Liang
    Abstract:

    Abstract Rare minnow (Gobiocypris rarus), a Chinese native species, are an excellent emerging model organism for aquatic toxicity testing and Chemical Safety Assessment. “Big data” omics approaches (i.e., genomics, proteomics, and metabolomics) to inform mechanistic toxicology are now applied to studies in rare minnows to better understand toxicity and molecular pathways perturbed by Chemicals. This review highlights recent applications of toxicogenomics to study changes in the gene and protein expression profiles in rare minnows in response to Chemicals. Here we briefly describe studies that utilized cDNA microarrays in characterization of the cellular effects of rare minnows in single and mixed Chemical exposures. Then we compare gel-based proteomics studies in liver of rare minnows following treatment with endocrine disrupting Chemicals including 17β-estradiol, 17α-methyltestosterone, pentachlorophenol, and perfluorooctanoic acid. A total of 90 proteins identified in these studies were functionally annotated and categorized. These responsive proteins have roles in biological processes that include metabolism (37.8%), response to oxidation/Chemicals (16.7%), signal transduction (11.1%), transport (10%), cytoskeleton (6.7%) and others (17.8%). In addition, recent investigations of endocrine disrupting effects and neurotoxicity of benzotriazole, an emerging contaminant, are summarized. The objective is to continue to enrich genome and protein databases for this species and to integrate molecular datasets to consider temporal effects and complex regulation at the level of the genome and proteome.

Daniel Sattler - One of the best experts on this subject based on the ideXlab platform.

  • specific environmental release categories a tool for improving Chemical Safety Assessment in the ec report of a multi stakeholder workshop
    Integrated Environmental Assessment and Management, 2012
    Co-Authors: Daniel Sattler, Frank Schnoder, Nannett Aust, Andreas Ahrens, Christian Bogi, Theo Traas, Johannes Tolls
    Abstract:

    In April 2011, experts from industry and authorities met for a workshop to discuss experience and future developments regarding the use of specific environmental release categories (SPERCs) in Chemicals Safety Assessment (CSA) under the European Chemicals Regulation Registration, Evaluation and Authorization of Chemicals (REACH). This article provides a summary of the workshop. It briefly explains what a SPERC is, why SPERCs are needed, where the challenges of the concept are, and what improvements are needed to make SPERCs a useful tool for Assessments under REACH. Integr Environ Assess Manag 2012; 8: 580–585. © 2012 SETAC

  • specific environmental release categories a tool for improving Chemical Safety Assessment in the ec report of a multi stakeholder workshop
    Integrated Environmental Assessment and Management, 2012
    Co-Authors: Daniel Sattler, Frank Schnoder, Nannett Aust, Andreas Ahrens, Christian Bogi, Theo Traas, Johannes Tolls
    Abstract:

    In April 2011, experts from industry and authorities met for a workshop to discuss experience and future developments regarding the use of specific environmental release categories (SPERCs) in Chemicals Safety Assessment (CSA) under the European Chemicals Regulation Registration, Evaluation and Authorization of Chemicals (REACH). This article provides a summary of the workshop. It briefly explains what a SPERC is, why SPERCs are needed, where the challenges of the concept are, and what improvements are needed to make SPERCs a useful tool for Assessments under REACH.

Lorraine Irvine - One of the best experts on this subject based on the ideXlab platform.

  • a tiered approach to life stages testing for agricultural Chemical Safety Assessment
    Critical Reviews in Toxicology, 2006
    Co-Authors: Ralph L Cooper, Nancy G Doerrer, James C Lamb, Sue M Barlow, Karin S Bentley, Angela M Brady, David L Eisenbrandt, Penelope A Fennercrisp, Ronald N Hines, Lorraine Irvine
    Abstract:

    Aproposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the Safety of crop protection Chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk Assessment. The ACSA Life Stages Task Force proposes a tiered approach to toxicity testing that assesses a compound's potential to cause adverse effects on reproduction, and that assesses the nature and severity of effects during development and adolescence, with consideration of the sensitivity of the elderly. While incorporating many features from current guideline studies, the proposed approach includes a novel rat reproduction and developmental study with enhanced endpoints and a rabbit development study. All available data, including toxicokinetics, ADMEdata, ...

  • a tiered approach to life stages testing for agricultural Chemical Safety Assessment
    Critical Reviews in Toxicology, 2006
    Co-Authors: Ralph L Cooper, Nancy G Doerrer, James C Lamb, Sue M Barlow, Karin S Bentley, Angela M Brady, David L Eisenbrandt, Penelope A Fennercrisp, Ronald N Hines, Lorraine Irvine
    Abstract:

    A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the Safety of crop protection Chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk Assessment. The ACSA Life Stages Task Force proposes a tiered approach to toxicity testing that assesses a compound's potential to cause adverse effects on reproduction, and that assesses the nature and severity of effects during development and adolescence, with consideration of the sensitivity of the elderly. While incorporating many features from current guideline studies, the proposed approach includes a novel rat reproduction and developmental study with enhanced endpoints and a rabbit development study. All available data, including toxicokinetics, ADME data, and systemic toxicity information, are considered in the design and interpretation of studies. Compared to existing testing strategies, the proposed approach uses fewer animals, provides information on the young animal, and includes an estimation of human exposure potential for making decisions about the extent of testing required.

Ralph L Cooper - One of the best experts on this subject based on the ideXlab platform.

  • a tiered approach to life stages testing for agricultural Chemical Safety Assessment
    Critical Reviews in Toxicology, 2006
    Co-Authors: Ralph L Cooper, Nancy G Doerrer, James C Lamb, Sue M Barlow, Karin S Bentley, Angela M Brady, David L Eisenbrandt, Penelope A Fennercrisp, Ronald N Hines, Lorraine Irvine
    Abstract:

    Aproposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the Safety of crop protection Chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk Assessment. The ACSA Life Stages Task Force proposes a tiered approach to toxicity testing that assesses a compound's potential to cause adverse effects on reproduction, and that assesses the nature and severity of effects during development and adolescence, with consideration of the sensitivity of the elderly. While incorporating many features from current guideline studies, the proposed approach includes a novel rat reproduction and developmental study with enhanced endpoints and a rabbit development study. All available data, including toxicokinetics, ADMEdata, ...

  • a tiered approach to life stages testing for agricultural Chemical Safety Assessment
    Critical Reviews in Toxicology, 2006
    Co-Authors: Ralph L Cooper, Nancy G Doerrer, James C Lamb, Sue M Barlow, Karin S Bentley, Angela M Brady, David L Eisenbrandt, Penelope A Fennercrisp, Ronald N Hines, Lorraine Irvine
    Abstract:

    A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the Safety of crop protection Chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk Assessment. The ACSA Life Stages Task Force proposes a tiered approach to toxicity testing that assesses a compound's potential to cause adverse effects on reproduction, and that assesses the nature and severity of effects during development and adolescence, with consideration of the sensitivity of the elderly. While incorporating many features from current guideline studies, the proposed approach includes a novel rat reproduction and developmental study with enhanced endpoints and a rabbit development study. All available data, including toxicokinetics, ADME data, and systemic toxicity information, are considered in the design and interpretation of studies. Compared to existing testing strategies, the proposed approach uses fewer animals, provides information on the young animal, and includes an estimation of human exposure potential for making decisions about the extent of testing required.

  • agricultural Chemical Safety Assessment a multisector approach to the modernization of human Safety requirements
    Critical Reviews in Toxicology, 2006
    Co-Authors: Neil G Carmichael, John E Doe, Alan R Boobis, Vicki L Dellarco, Nancy G Doerrer, Ralph L Cooper, James C Lamb, Penelope A Fennercrisp, Hugh A Barton, Timothy P Pastoor
    Abstract:

    Better understanding of toxicological mechanisms, enhanced testing capabilities, and demands for more sophisticated data for Safety and health risk Assessment have generated international interest in improving the current testing paradigm for agricultural Chemicals. To address this need, the ILSI Health and Environmental Sciences Institute convened a large and diverse group of international experts to develop a credible and viable testing approach that includes scientifically appropriate studies that are necessary without being redundant, and that emphasize toxicological endpoints and exposure durations that are relevant for risk Assessment. Benefits of the proposed approach include improved data for risk Assessment, greater efficiency, use of fewer animals, and better use of resources. From the outset of this endeavor, it was unanimously agreed that a tiered approach should be designed to incorporate existing knowledge on the chemistry, toxicology, and actual human exposure scenarios of the compound, wit...