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Piero Portincasa - One of the best experts on this subject based on the ideXlab platform.

  • Measurement of hepatic functional mass by means of ^13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease： Comparison with Child-Pugh Score and serum bile acid levels
    World journal of gastroenterology, 2005
    Co-Authors: Davide Festi, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels

  • and 13 C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels
    2005
    Co-Authors: Festi D, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    AIM: To evaluate and compare the clinical usefulness of 13 C-phenylalanine and 13 C-methacetin breath tests in quantitating functional hepatic mass in patients with chronic liver disease and to further compare these results with those of conventional tests, Child-Pugh Score and serum bile acid levels. METHODS: One hundred and forty patients (50 HCVrelated chronic hepatitis, 90 liver cirrhosis patients) and 40 matched healthy controls were studied. Both breath test and routine liver test, serum levels of cholic and chenodeoxycholic acid conjugates were evaluated. RESULTS: Methacetin breath test, expressed as 60 min cumulative percent of oxidation, discriminated the hepatic functional capacity not only between controls and liver disease patients, but also between different categories of chronic liver disease patients. Methacetin breath test was correlated with liver function tests and serum bile acids. Furthermore, methacetin breath test, as well as serum bile acids, were highly predictive of Child-Pugh Scores. The diagnostic power of phenylalanine breath test was always less than that of methacetin breath test. CONCLUSION: Methacetin breath test represents a safe and accurate diagnostic tool in the evaluation of hepatic functional mass in chronic liver disease patients.

Angelo Gatta - One of the best experts on this subject based on the ideXlab platform.

  • Neuropsychological-neurophysiological alterations and brain atrophy in cirrhotic patients.
    Metabolic Brain Disease, 2003
    Co-Authors: Piero Amodio, P. Amistà, Carmine Musto, Pietro Valenti, Francesco Piccolo, A. Pellegrini, S. Di Luise, Daniela Mapelli, Sara Montagnese, Angelo Gatta
    Abstract:

    Psychometric performance has been reported to be related to brain atrophy in cirrhotics, but the relationship between brain atrophy and EEG findings is still unknown. The aim of this study was to ascertain the relationship among brain atrophy, EEG, and cognitive performance in cirrhotics. Sixty-eight cirrhotics (age = 55 ± 10 years; males-66%) underwent psychometric evaluation (Symbol Digit Test, Trail Making Test—Part A, Scan test), EEG recording and spectral analysis (S-EEG), and brain CT scan. Central brain atrophy was ascertained by the following indexes of brain atrophy: the Evans' index, the bicaudate index, the cella media index, the bifrontal index, and the ventricular index; cortical brain atrophy by the sulci index. The severity of liver failure was assessed by the Child–Pugh Score: 18% of patients were Child–Pugh Class A, 50% Class B, and 32% Class C. Central and cortical atrophies were found to be correlated with age, but not with the Child–Pugh Score. Psychometric performance and the EEG mean dominant frequency (MDF) were found to be correlated with brain atrophy. Multivariate analysis showed that a poor psychometric performance was independently predicted by EEG slowing (MDF: p < 0.01) and by central brain atrophy (cella media index: p < 0.01). In conclusion, brain atrophy was associated with a poor psychometric performance and EEG alterations in cirrhosis. Both brain atrophy and EEG alterations independently predicted cognitive dysfunction in cirrhotic patients.

  • Updating prognosis of cirrhosis by Cox's regression model using Child-Pugh Score and aminopyrine breath test as time-dependent covariates.
    Italian journal of gastroenterology and hepatology, 1998
    Co-Authors: Carlo Merkel, A Morabito, David Sacerdoti, Massimo Bolognesi, Paolo Angeli, Angelo Gatta
    Abstract:

    BACKGROUND AND AIMS: The determination of aminopyrine breath test on entry into the study was recently shown to improve the accuracy of prediction of death based on the Child-Pugh classification, but the possible usefulness of serial determinations of both parameters has not been assessed. In the present study, we aimed at evaluating whether serial determinations of aminopyrine breath test and Child-Pugh Score improve prognostic accuracy in patients with cirrhosis, compared with determinations obtained only on admission. PATIENTS: In 74 patients with liver cirrhosis aminopyrine breath test and Child-Pugh Score were obtained upon entry into the study. Patients were followed with sequential aminopyrine breath tests and assessments of the Child-Pugh Score every 4-6 months. A total number of 232 determinations were obtained. During follow-up 45 patients died, on average after 12 months of follow-up. RESULTS: Child-Pugh Score improved in the beginning of follow-up, and then remained fairly constant; aminopyrine breath test showed no improvement in the beginning of follow-up, but rather a slowly progressive decline. In patients who died, both the Child-Pugh Score and the metabolism of aminopyrine were significantly more impaired in the last year preceding death (p < 0.05). Applying Cox's regression model with time-dependent covariates, Child-Pugh Score and aminopyrine breath test were independent significant predictors of survival. The model with time-dependent covariates explained the observed survival much better than the model with time-fixed covariates (chi-sq. explained by regression = 31.45 vs 11.97; d.f. = 2; p = 0.0000001 vs 0.003). CONCLUSIONS: These data suggest that serial determinations of Child-Pugh Score and aminopyrine breath test can be used to efficiently update prognosis of cirrhosis.

Giuseppe Mazzella - One of the best experts on this subject based on the ideXlab platform.

  • Measurement of hepatic functional mass by means of ^13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease： Comparison with Child-Pugh Score and serum bile acid levels
    World journal of gastroenterology, 2005
    Co-Authors: Davide Festi, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels

  • and 13 C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels
    2005
    Co-Authors: Festi D, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    AIM: To evaluate and compare the clinical usefulness of 13 C-phenylalanine and 13 C-methacetin breath tests in quantitating functional hepatic mass in patients with chronic liver disease and to further compare these results with those of conventional tests, Child-Pugh Score and serum bile acid levels. METHODS: One hundred and forty patients (50 HCVrelated chronic hepatitis, 90 liver cirrhosis patients) and 40 matched healthy controls were studied. Both breath test and routine liver test, serum levels of cholic and chenodeoxycholic acid conjugates were evaluated. RESULTS: Methacetin breath test, expressed as 60 min cumulative percent of oxidation, discriminated the hepatic functional capacity not only between controls and liver disease patients, but also between different categories of chronic liver disease patients. Methacetin breath test was correlated with liver function tests and serum bile acids. Furthermore, methacetin breath test, as well as serum bile acids, were highly predictive of Child-Pugh Scores. The diagnostic power of phenylalanine breath test was always less than that of methacetin breath test. CONCLUSION: Methacetin breath test represents a safe and accurate diagnostic tool in the evaluation of hepatic functional mass in chronic liver disease patients.

Amanda Vestito - One of the best experts on this subject based on the ideXlab platform.

  • Measurement of hepatic functional mass by means of ^13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease： Comparison with Child-Pugh Score and serum bile acid levels
    World journal of gastroenterology, 2005
    Co-Authors: Davide Festi, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels

  • and 13 C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels
    2005
    Co-Authors: Festi D, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    AIM: To evaluate and compare the clinical usefulness of 13 C-phenylalanine and 13 C-methacetin breath tests in quantitating functional hepatic mass in patients with chronic liver disease and to further compare these results with those of conventional tests, Child-Pugh Score and serum bile acid levels. METHODS: One hundred and forty patients (50 HCVrelated chronic hepatitis, 90 liver cirrhosis patients) and 40 matched healthy controls were studied. Both breath test and routine liver test, serum levels of cholic and chenodeoxycholic acid conjugates were evaluated. RESULTS: Methacetin breath test, expressed as 60 min cumulative percent of oxidation, discriminated the hepatic functional capacity not only between controls and liver disease patients, but also between different categories of chronic liver disease patients. Methacetin breath test was correlated with liver function tests and serum bile acids. Furthermore, methacetin breath test, as well as serum bile acids, were highly predictive of Child-Pugh Scores. The diagnostic power of phenylalanine breath test was always less than that of methacetin breath test. CONCLUSION: Methacetin breath test represents a safe and accurate diagnostic tool in the evaluation of hepatic functional mass in chronic liver disease patients.

E. Vitacolonna - One of the best experts on this subject based on the ideXlab platform.

  • Measurement of hepatic functional mass by means of ^13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease： Comparison with Child-Pugh Score and serum bile acid levels
    World journal of gastroenterology, 2005
    Co-Authors: Davide Festi, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels

  • and 13 C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh Score and serum bile acid levels
    2005
    Co-Authors: Festi D, S Capodicasa, L. Sandri, L. Colaiocco-ferrante, Tommaso Staniscia, E. Vitacolonna, Amanda Vestito, Patrizia Simoni, Giuseppe Mazzella, Piero Portincasa
    Abstract:

    AIM: To evaluate and compare the clinical usefulness of 13 C-phenylalanine and 13 C-methacetin breath tests in quantitating functional hepatic mass in patients with chronic liver disease and to further compare these results with those of conventional tests, Child-Pugh Score and serum bile acid levels. METHODS: One hundred and forty patients (50 HCVrelated chronic hepatitis, 90 liver cirrhosis patients) and 40 matched healthy controls were studied. Both breath test and routine liver test, serum levels of cholic and chenodeoxycholic acid conjugates were evaluated. RESULTS: Methacetin breath test, expressed as 60 min cumulative percent of oxidation, discriminated the hepatic functional capacity not only between controls and liver disease patients, but also between different categories of chronic liver disease patients. Methacetin breath test was correlated with liver function tests and serum bile acids. Furthermore, methacetin breath test, as well as serum bile acids, were highly predictive of Child-Pugh Scores. The diagnostic power of phenylalanine breath test was always less than that of methacetin breath test. CONCLUSION: Methacetin breath test represents a safe and accurate diagnostic tool in the evaluation of hepatic functional mass in chronic liver disease patients.