The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform
Feyyaz Onur - One of the best experts on this subject based on the ideXlab platform.
-
simultaneous spectrophotometric determination of Chlorphenoxamine hydrochloride and caffeine in a pharmaceutical preparation using first derivative of the ratio spectra and chemometric methods
Journal of Pharmaceutical and Biomedical Analysis, 2002Co-Authors: Erdal Dinc, Murat I Palabiyik, Ozgur Ustundag, Filiz Yurtsever, Feyyaz OnurAbstract:Three new methods are described for the simultaneous determination of Chlorphenoxamine hydrochloride (CP) and caffeine (CAF) in their combination. In the first method, ratio spectra derivative spectrophotometry, analytical signals were measured at the wavelenghts corresponding to either maxima and minima for both drugs in the first derivative spectra of the ratio spectra obtained by using each other spectra as divisor in their solution in 0.1 M HCl. In the other two methods, chemometric techniques, classical least-squares (CLS) and inverse least-squares (ILS), the concentration data matrix were prepared by using the synthetic mixtures containing these drugs in 0.1 M HCl. The absorbance data matrix corresponding to the concentration data matrix was obtained by the measurements of absorbances in the range 225–285 nm in the intervals with Δλ=5 nm at 13 wavelengths in their zero-order spectra, then, calibration or regression was obtained by using the absorbance data matrix and concentration data matrix for the prediction of the unknown concentrations of CP and CAF in their mixture. The numerical values were calculated by using maple v software in chemometric methods. The procedures do not require any separation step. The accuracy and the precision of the methods have been determined and they have been validated by analyzing synthetic mixtures containing title drugs. These three methods were successfully applied to a pharmaceutical formulation, sugar-coated tablet, and the results were compared with each other.
Erdal Dinc - One of the best experts on this subject based on the ideXlab platform.
-
simultaneous spectrophotometric determination of Chlorphenoxamine hydrochloride and caffeine in a pharmaceutical preparation using first derivative of the ratio spectra and chemometric methods
Journal of Pharmaceutical and Biomedical Analysis, 2002Co-Authors: Erdal Dinc, Murat I Palabiyik, Ozgur Ustundag, Filiz Yurtsever, Feyyaz OnurAbstract:Three new methods are described for the simultaneous determination of Chlorphenoxamine hydrochloride (CP) and caffeine (CAF) in their combination. In the first method, ratio spectra derivative spectrophotometry, analytical signals were measured at the wavelenghts corresponding to either maxima and minima for both drugs in the first derivative spectra of the ratio spectra obtained by using each other spectra as divisor in their solution in 0.1 M HCl. In the other two methods, chemometric techniques, classical least-squares (CLS) and inverse least-squares (ILS), the concentration data matrix were prepared by using the synthetic mixtures containing these drugs in 0.1 M HCl. The absorbance data matrix corresponding to the concentration data matrix was obtained by the measurements of absorbances in the range 225–285 nm in the intervals with Δλ=5 nm at 13 wavelengths in their zero-order spectra, then, calibration or regression was obtained by using the absorbance data matrix and concentration data matrix for the prediction of the unknown concentrations of CP and CAF in their mixture. The numerical values were calculated by using maple v software in chemometric methods. The procedures do not require any separation step. The accuracy and the precision of the methods have been determined and they have been validated by analyzing synthetic mixtures containing title drugs. These three methods were successfully applied to a pharmaceutical formulation, sugar-coated tablet, and the results were compared with each other.
Abdelaziz M Wahbi - One of the best experts on this subject based on the ideXlab platform.
-
spectrophotometric determination of chlorpheniramine maleate and chlor phenoxamine hydrochloride each in presence of caffeine as binary mixtures
Drug Development and Industrial Pharmacy, 1991Co-Authors: Magda H Barary, Abdelaziz M WahbiAbstract:AbstractThe dye-salt formation method was successfully applied to the determination of chlorpheniramine maleate and Chlorphenoxamine hydrochloride each in presence of caffeine. At pH 5, the chromogens (λmax=420 nm) produced with methyl orange in chloroform obeyed Beer's law over the range 5-15 ug/ml and with relative SD less than 1%.
Murat I Palabiyik - One of the best experts on this subject based on the ideXlab platform.
-
simultaneous spectrophotometric determination of Chlorphenoxamine hydrochloride and caffeine in a pharmaceutical preparation using first derivative of the ratio spectra and chemometric methods
Journal of Pharmaceutical and Biomedical Analysis, 2002Co-Authors: Erdal Dinc, Murat I Palabiyik, Ozgur Ustundag, Filiz Yurtsever, Feyyaz OnurAbstract:Three new methods are described for the simultaneous determination of Chlorphenoxamine hydrochloride (CP) and caffeine (CAF) in their combination. In the first method, ratio spectra derivative spectrophotometry, analytical signals were measured at the wavelenghts corresponding to either maxima and minima for both drugs in the first derivative spectra of the ratio spectra obtained by using each other spectra as divisor in their solution in 0.1 M HCl. In the other two methods, chemometric techniques, classical least-squares (CLS) and inverse least-squares (ILS), the concentration data matrix were prepared by using the synthetic mixtures containing these drugs in 0.1 M HCl. The absorbance data matrix corresponding to the concentration data matrix was obtained by the measurements of absorbances in the range 225–285 nm in the intervals with Δλ=5 nm at 13 wavelengths in their zero-order spectra, then, calibration or regression was obtained by using the absorbance data matrix and concentration data matrix for the prediction of the unknown concentrations of CP and CAF in their mixture. The numerical values were calculated by using maple v software in chemometric methods. The procedures do not require any separation step. The accuracy and the precision of the methods have been determined and they have been validated by analyzing synthetic mixtures containing title drugs. These three methods were successfully applied to a pharmaceutical formulation, sugar-coated tablet, and the results were compared with each other.
Ozgur Ustundag - One of the best experts on this subject based on the ideXlab platform.
-
simultaneous spectrophotometric determination of Chlorphenoxamine hydrochloride and caffeine in a pharmaceutical preparation using first derivative of the ratio spectra and chemometric methods
Journal of Pharmaceutical and Biomedical Analysis, 2002Co-Authors: Erdal Dinc, Murat I Palabiyik, Ozgur Ustundag, Filiz Yurtsever, Feyyaz OnurAbstract:Three new methods are described for the simultaneous determination of Chlorphenoxamine hydrochloride (CP) and caffeine (CAF) in their combination. In the first method, ratio spectra derivative spectrophotometry, analytical signals were measured at the wavelenghts corresponding to either maxima and minima for both drugs in the first derivative spectra of the ratio spectra obtained by using each other spectra as divisor in their solution in 0.1 M HCl. In the other two methods, chemometric techniques, classical least-squares (CLS) and inverse least-squares (ILS), the concentration data matrix were prepared by using the synthetic mixtures containing these drugs in 0.1 M HCl. The absorbance data matrix corresponding to the concentration data matrix was obtained by the measurements of absorbances in the range 225–285 nm in the intervals with Δλ=5 nm at 13 wavelengths in their zero-order spectra, then, calibration or regression was obtained by using the absorbance data matrix and concentration data matrix for the prediction of the unknown concentrations of CP and CAF in their mixture. The numerical values were calculated by using maple v software in chemometric methods. The procedures do not require any separation step. The accuracy and the precision of the methods have been determined and they have been validated by analyzing synthetic mixtures containing title drugs. These three methods were successfully applied to a pharmaceutical formulation, sugar-coated tablet, and the results were compared with each other.