The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform

Jhijoung Wang - One of the best experts on this subject based on the ideXlab platform.

Joanna Karpińska - One of the best experts on this subject based on the ideXlab platform.

  • Determination of Chlorprothixene and amitryptyline hydrochlorides by UV-derivative spectrophotometry and UV-solid-phase spectrophotometry
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2005
    Co-Authors: Joanna Karpińska, Jolanta Szostak
    Abstract:

    Abstract Two methods for spectrophotometric determination of Chlorprothixene and amitryptyline hydrochlorides were proposed. One of them is based on spectral analysis of their derivative spectra. The measurement of the value at 316.0 nm of first derivative was used for construction of calibration graph for Chlorprothixene. The Beer law was obeyed in the concentration range 0.5–50.0 μg ml−1. The amplitude of the second derivative at 261.4 nm was used for determination of amitryptyline in the range 0.5–75.0 μg ml−1. The second proposed method is utilized the use of solid sorbent for simultaneous preconcentration and assay of studied compounds. For this purpose the filtration gel Sephadex G100 was applied. The elaborated solid-phase spectrophotometric method was used for determination of Chlorprothixene at 268.0 nm in the range 2.5–75.0 μg ml−1 and amitryptyline at 238.0 nm in the concentration range 10.0–75.0 μg ml−1.

  • SPECTROPHOTOMETRIC DETERMINATION OF Chlorprothixene HYDROCHLORIDE BY PYROCATECHOL VIOLET AND CERIC(IV) IONS
    Journal of Trace and Microprobe Techniques, 2002
    Co-Authors: Barbara Starczewska, Joanna Karpińska
    Abstract:

    ABSTRACT Two methods for the determination of Chlorprothixene hydrochloride are presented. One of them employs the liability of the Chlorprothixene tertiary amine group nitrogen atom to form ion-association complexes with organic compounds. The formed complex is insoluble in water but well soluble in organic solvents. This property is the base of a new extractive-spectrophotometric method for Chlorprothixene determination. The second method applied the oxidation reaction of Chlorprothixene by Ce(IV) ions. Chlorprothixene hydrochloride is oxidised by ceric(IV) ions at room temperature with the formation of colourless products. Both reactions were followed spectrophotometrically by measuring the absorbance at 445 nm (extractive method) and at 268 nm (oxidative method). Extractive-spectrophotometric method allows to determine Chlorprothixene hydrochloride in the range of 3.5–32.0 µg/mL. The oxidative method obeys Beer's law in the range of 3.2–21.0 µg/mL. The methods were successfully applied to the determin...

  • Simultaneous LC determination of some antidepressants combined with neuroleptics.
    Journal of pharmaceutical and biomedical analysis, 2002
    Co-Authors: Joanna Karpińska, Barbara Starczewska
    Abstract:

    A reversed-phase HPLC method with UV detection at 252 nm is presented for the simultaneous determination of some tricyclic antidepressants (amitriptyline, imipramine) and neuroleptics (Chlorprothixene, thioridazine) in their quaternary mixtures. Sample analysis was performed on a bonded reversed phase C-18, 5 microm, 250 x 4.6 mm ID (Lichrospher 100RP-18) column using acetonitrile and 0.01 M aqueous solution of triethylamine (1:1) as the mobile phase at 0.9 ml/min. The pH was adjusted to 2.7 with concentrated phosphoric acid. The retention time was for imipramine, amitriptyline, Chlorprothixene, and thioridazine 5.8, 6.5, 8.3, 10.8 min, respectively. The linearity was obeyed up to 15 ppm for imipramine and amitriptyline, 12 ppm for Chlorprothixene and 10 ppm for thioridazine. The presented method also allows the determination of the mentioned drugs individually in their pharmaceutical preparations.

Yu Wen Chen - One of the best experts on this subject based on the ideXlab platform.

Jolanta Szostak - One of the best experts on this subject based on the ideXlab platform.

  • Determination of Chlorprothixene and amitryptyline hydrochlorides by UV-derivative spectrophotometry and UV-solid-phase spectrophotometry
    Spectrochimica acta. Part A Molecular and biomolecular spectroscopy, 2005
    Co-Authors: Joanna Karpińska, Jolanta Szostak
    Abstract:

    Abstract Two methods for spectrophotometric determination of Chlorprothixene and amitryptyline hydrochlorides were proposed. One of them is based on spectral analysis of their derivative spectra. The measurement of the value at 316.0 nm of first derivative was used for construction of calibration graph for Chlorprothixene. The Beer law was obeyed in the concentration range 0.5–50.0 μg ml−1. The amplitude of the second derivative at 261.4 nm was used for determination of amitryptyline in the range 0.5–75.0 μg ml−1. The second proposed method is utilized the use of solid sorbent for simultaneous preconcentration and assay of studied compounds. For this purpose the filtration gel Sephadex G100 was applied. The elaborated solid-phase spectrophotometric method was used for determination of Chlorprothixene at 268.0 nm in the range 2.5–75.0 μg ml−1 and amitryptyline at 238.0 nm in the concentration range 10.0–75.0 μg ml−1.

Barbara Starczewska - One of the best experts on this subject based on the ideXlab platform.

  • SPECTROPHOTOMETRIC DETERMINATION OF Chlorprothixene HYDROCHLORIDE BY PYROCATECHOL VIOLET AND CERIC(IV) IONS
    Journal of Trace and Microprobe Techniques, 2002
    Co-Authors: Barbara Starczewska, Joanna Karpińska
    Abstract:

    ABSTRACT Two methods for the determination of Chlorprothixene hydrochloride are presented. One of them employs the liability of the Chlorprothixene tertiary amine group nitrogen atom to form ion-association complexes with organic compounds. The formed complex is insoluble in water but well soluble in organic solvents. This property is the base of a new extractive-spectrophotometric method for Chlorprothixene determination. The second method applied the oxidation reaction of Chlorprothixene by Ce(IV) ions. Chlorprothixene hydrochloride is oxidised by ceric(IV) ions at room temperature with the formation of colourless products. Both reactions were followed spectrophotometrically by measuring the absorbance at 445 nm (extractive method) and at 268 nm (oxidative method). Extractive-spectrophotometric method allows to determine Chlorprothixene hydrochloride in the range of 3.5–32.0 µg/mL. The oxidative method obeys Beer's law in the range of 3.2–21.0 µg/mL. The methods were successfully applied to the determin...

  • spectrophotometric determination of vanadium iv by ternary complexes of chrome azurol s with imipramine and Chlorprothixene
    Journal of Trace and Microprobe Techniques, 2002
    Co-Authors: Barbara Starczewska
    Abstract:

    ABSTRACT Sensitive methods for the spectrophotometric determination of trace amounts of vanadium(IV) are described. The methods utilize the ternary complexes formed by reacting vanadium(IV) with imipramine or Chlorprothixene hydrochlorides in the presence of chrome azurol S and methylcellulose. The composition and the absorption spectra in the UV–VIS and IR regions of the ion association complexes are described.

  • Simultaneous LC determination of some antidepressants combined with neuroleptics.
    Journal of pharmaceutical and biomedical analysis, 2002
    Co-Authors: Joanna Karpińska, Barbara Starczewska
    Abstract:

    A reversed-phase HPLC method with UV detection at 252 nm is presented for the simultaneous determination of some tricyclic antidepressants (amitriptyline, imipramine) and neuroleptics (Chlorprothixene, thioridazine) in their quaternary mixtures. Sample analysis was performed on a bonded reversed phase C-18, 5 microm, 250 x 4.6 mm ID (Lichrospher 100RP-18) column using acetonitrile and 0.01 M aqueous solution of triethylamine (1:1) as the mobile phase at 0.9 ml/min. The pH was adjusted to 2.7 with concentrated phosphoric acid. The retention time was for imipramine, amitriptyline, Chlorprothixene, and thioridazine 5.8, 6.5, 8.3, 10.8 min, respectively. The linearity was obeyed up to 15 ppm for imipramine and amitriptyline, 12 ppm for Chlorprothixene and 10 ppm for thioridazine. The presented method also allows the determination of the mentioned drugs individually in their pharmaceutical preparations.

  • spectrophotometric determination of Chlorprothixene with eriochrome cyanine r
    Mikrochimica Acta, 2000
    Co-Authors: Barbara Starczewska, Agnieszka Purzynska
    Abstract:

    Two spectrophotometric methods are described for the determination of Chlorprothixene (CPT). The first method is based on the extraction of the ion-association compound of CPT with eriochrome cyanine R (ECR) into butanol. The extracted compound in the organic solvent obeys Beer’s law in the range 5–80 μg mL −1. The second method is based on the measuring of the absorbance of the aqueous solution of the compound of CPT with ECR in presence of methylcellulose. Conformity with Beer’s law was evident in the range 0.7–10 μg mL −1 of Chlorprothixene. The methods were applied for the determination of Chlorprothixene contents in pharmaceuticals.