The Experts below are selected from a list of 15720 Experts worldwide ranked by ideXlab platform
Jhijoung Wang - One of the best experts on this subject based on the ideXlab platform.
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caramiphen induced block of sodium currents and Spinal Anesthesia
European Journal of Pharmacology, 2015Co-Authors: Yukman Leung, Yu Wen Chen, Janninn Tzeng, Chili Gong, Yuwen Wang, Jhijoung WangAbstract:The underlying mechanisms for the action of caramiphen used in local Anesthesia are not well understood. The purpose of this study was to evaluate the block of caramiphen on voltage-gated Na+ channels and in Spinal Anesthesia. We investigated the effect of caramiphen on voltage-gated sodium channels in differentiated neuronal NG108-15 cells as well as on rat motor function, proprioception, and pain behavior (when administered intrathecally). In in vitro experiments, lidocaine produced concentration- and state-dependent effects on tonic block of voltage-gated Na+ currents (IC50 of 66.2 and 212.9 µM at holding potentials of −70 and −100 mV, respectively). Caramiphen exhibited a milder state-dependence of block (IC50 of 52.1 and 99.5 µM at holding potentials of −70 and −100 mV, respectively). Lidocaine showed a much stronger frequency-dependence of block than caramiphen: with high frequency stimulation (3.33 Hz), 50 µM caramiphen elicited an additional 20% blockade, whereas the same concentration of lidocaine produced 50% more block. In in vivo experiments, caramiphen with a more sensory-selective action over motor blockade was more potent than lidocaine (P<0.05) in Spinal Anesthesia. On an equipotent basis (25% effective dose (ED25), ED50, and ED75), the duration of caramiphen at producing Spinal Anesthesia was longer than that of lidocaine (P<0.01). Our data revealed that caramiphen had a more potent, prolonged Spinal blockade with a more sensory/nociceptive-selective action over motor blockade in comparison with lidocaine. Spinal Anesthesia with caramiphen could be through the suppression of voltage-gated Na+ currents.
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promazine and chlorpromazine for prolonged Spinal Anesthesia in rats
Neuroscience Letters, 2012Co-Authors: Yu Wen Chen, Yu-chung Chen, Jhijoung WangAbstract:Abstract Though promazine and chlorpromazine elicited cutaneous Anesthesia, no study of Spinal Anesthesia with chlorpromazine and promazine has been reported. This study was to examine whether chlorpromazine and promazine produce Spinal Anesthesia. Using a rat model via intrathecal injection, we tested Spinal blockades of motor function and nociception by promazine, chlorpromazine or bupivacaine, and so were dose–response studies and durations. We demonstrated that chlorpromazine and promazine elicited dose-dependent Spinal blockades in motor function and nociception. On the 50% effective dose (ED50) basis, the rank of potency of these drugs was bupivacaine > promazine > chlorpromazine (P
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Spinal Anesthesia with diphenhydramine and pheniramine in rats.
European Journal of Pharmacology, 2011Co-Authors: Ching Hsia Hung, Yu Wen Chen, Yu-chung Chen, Chin-chen Chu, Jhijoung WangAbstract:Abstract The aim of this study was to evaluate the local anesthetic effects of pheniramine and diphenhydramine, two histamine H 1 receptor antagonists, on Spinal Anesthesia and their comparison with lidocaine, a commonly used local anesthetic. After rats were injected intrathecally with diphenhydramine and pheniramine, the dose–response curves were obtained. The potency and duration of diphenhydramine and pheniramine on Spinal Anesthesia were compared with lidocaine. We showed that diphenhydramine and pheniramine produced dose-dependent Spinal blockades in motor function, proprioception, and nociception. On a 50% effective dose (ED 50 ) basis, the rank of potency of drugs was diphenhydramine = pheniramine > lidocaine ( p 25 , ED 50 , and ED 75 ), the block duration caused by diphenhydramine was longer than that caused by pheniramine or lidocaine ( p
Jurgen Drewe - One of the best experts on this subject based on the ideXlab platform.
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transient neurologic symptoms after Spinal Anesthesia
Anesthesia & Analgesia, 1996Co-Authors: K F Hampl, M C Schneider, Wolfgang Ummenhofer, Jurgen DreweAbstract:We recently reported several cases consistent with transient radicular irritation after Spinal Anesthesia with hyperbaric 5% lidocaine. The present prospective, blind, nonrandomized study was performed to determine the incidence of these transient neurologic symptoms and to identify factors that might be associated with their occurrence. We studied 270 patients scheduled for gynecologic or obstetric procedures under Spinal Anesthesia. For Spinal Anesthesia, either 5% lidocaine in 7.5% glucose or 0.5% bupivacaine in 8.5% glucose was used. Patients were evaluated on postoperative day 3 by a quality assurance nurse who was unaware of the drug given or details of the anesthetic technique. Transient neurologic symptoms were observed in 37% of patients receiving 5% lidocaine, whereas only one patient receiving 0.5% bupivacaine had transient hypesthesia of the lateral aspect of the right foot. These results suggest that symptoms were the result of a specific drug effect. However, because of the limitations of the study one cannot conclude that lidocaine per se was the cause.
Shi-qing Feng - One of the best experts on this subject based on the ideXlab platform.
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lower incidence of postdural puncture headache using whitacre Spinal needles after Spinal Anesthesia a meta analysis
Headache, 2016Co-Authors: Di Zhang, Ling-xiao Chen, Xing-yu Chen, Xiao-bo Wang, Guang-zhi Ning, Shi-qing FengAbstract:Objective The aim of this meta-analysis was to evaluate the postdural puncture headache after Spinal Anesthesia with Whitacre Spinal needles compared with Quincke spine needles. Methods We searched several databases, including PubMed, Embase, ISI Web of Knowledge, and Cochrane Central Register of Controlled Trials until October 10th, 2014, for randomized controlled trials that compared Spinal Anesthesia with Whitacre Spinal needles or Quincke spine needles for postdural puncture headache. Two reviewers independently screened the literature, assessed the risk for bias and extracted data. We used RevMan 5.3 software to perform the meta-analysis. Studies were included for the main end points if they addressed the following: frequency of postdural puncture headache, severity of postdural puncture headache as assessed by limitation of activities, and frequency of epidural blood patch. Results Nine randomized controlled trials were included for meta-analysis. The meta-analysis showed that Spinal Anesthesia with Whitacre Spinal needles achieved lower incidence of postdural puncture headache(RR 0.34; 95% CI [0.22, 0.52]; P Conclusion We suggest the Whitacre Spinal needles as a superior choice for Spinal Anesthesia compared with Quincke spine needles.
Lucian Sulica - One of the best experts on this subject based on the ideXlab platform.
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vocal fold paralysis following Spinal Anesthesia
Archives of Otolaryngology-head & Neck Surgery, 2014Co-Authors: Elizabeth Guardiani, Lucian SulicaAbstract:Importance Transient upper cranial neuropathy is a well-described complication of Spinal Anesthesia. Lower cranial neuropathies, in particular vagal neuropathies, have not been described. We present 4 cases of vocal fold paralysis (VFP) in 3 patients following Spinal Anesthesia and discuss a proposed mechanism. Observations Three women presented with dysphonia following Spinal Anesthesia and were found to have unilateral VFP. Patient 1 presented with dysphonia immediately after knee surgery. Patient 2 developed right VFP 1 week after vaginal delivery with Spinal epidural Anesthesia. Two years later, she presented with sudden onset of dysphonia 3 days after another vaginal delivery with Spinal and epidural Anesthesia; a contralateral VFP was found. Patient 3 noted dysphonia 4 days after knee surgery and was found to have left VFP. No patient had undergone intubation, and none had a central line on the side of the weakness. Imaging ruled out a relevant lesion. All 3 women had evidence of substantial recovery of motion at 6-month follow-up. Conclusions and Relevance Intracranial hypotension resulting in vagal neuropathy is a possible complication of Spinal Anesthesia and appears to be the cause of transient vocal fold palsy in these 4 cases.
Ayla Tur - One of the best experts on this subject based on the ideXlab platform.
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subdural hematoma as a late complication of Spinal Anesthesia
Journal of Neurosurgical Anesthesiology, 2003Co-Authors: Ebru Kelsaka, Binnur Sarihasan, Sibel Baris, Ayla TurAbstract:Subdural hematoma is a rare complication of Spinal Anesthesia. This patient underwent bilateral inguinal herniorrhaphy under Spinal Anesthesia 40 days prior to admission. Two days after Spinal Anesthesia, the patient described a typical postdural puncture headache. Oral analgesics, fluid therapy, and lying flat were recommended. Because of prolonged headache, computed tomography scan was performed and demonstrated chronic subdural hematoma in the left fronto-temporo-parietal region. After surgical drainage, the patient fully recovered. Prolonged headache should be regarded as a warning sign of subdural hematoma.
