The Experts below are selected from a list of 81594 Experts worldwide ranked by ideXlab platform

Chengkai Zhai - One of the best experts on this subject based on the ideXlab platform.

  • effects of Dietary carbohydrate replaced with wild rice zizania latifolia griseb turcz on insulin resistance in rats fed with a high fat Cholesterol Diet
    Nutrients, 2013
    Co-Authors: Shufen Han, Hong Zhang, Liqiang Qin, Chengkai Zhai
    Abstract:

    Wild rice (WR) is a very nutritious grain that has been used to treat diabetes in Chinese medicinal practice. City Diet (CD) is based on the Diet consumed by Asian area residents in modern society, which is rich in saturated fats, Cholesterol and carbohydrates. The present study was aimed at evaluating the effects of replacing white rice and processed wheat starch of CD with WR as the chief source of Dietary carbohydrates on insulin resistance in rats fed with a high-fat/Cholesterol Diet. Except the rats of the low-fat (LF) Diet group, the rats of the other three groups, including to high-fat/Cholesterol (HFC) Diet, CD and WR Diet, were fed with high-fat/Cholesterol Diets for eight weeks. The rats fed with CD exhibited higher weight gain and lower insulin sensitivity compared to the rats consuming a HFC Diet. However, WR suppressed high-fat/Cholesterol Diet-induced insulin resistance. WR decreased liver homogenate triglyceride and free fatty acids levels, raised serum adiponectin concentration and reduced serum lipocalin-2 and visfatin concentrations. In addition, the WR Diet potently augmented the relative expressions of adiponectin receptor 2, peroxisome proliferator-activated receptors, alpha and gamma, and abated relative expressions of leptin and lipocalin-2 in the tissues of interest. These findings indicate that WR is effective in ameliorating abnormal glucose metabolism and insulin resistance in rats, even when the Diet consumed is high in fat and Cholesterol.

  • protective potentials of wild rice zizania latifolia griseb turcz against obesity and lipotoxicity induced by a high fat Cholesterol Diet in rats
    Food and Chemical Toxicology, 2012
    Co-Authors: Shufen Han, Hong Zhang, Chengkai Zhai
    Abstract:

    The study evaluates the protective potentials of wild rice against obesity and lipotoxicity induced by a high-fat/Cholesterol Diet in rats. In addition to the rats of low-fat Diet group, others animals were exposed to a high-fat/Cholesterol Diet condition for 8 weeks. The city Diet (CD) is based on the Diet consumed by urban residents in modern China, which is rich in fat/Cholesterol and high in carbohydrates from white rice and processed wheat starch. The chief source of Dietary carbohydrates of wild rice Diet (WRD) is from Chinese wild rice and other compositions are the same with CD. Rats fed CD showed elevated body and liver organ weights, lipid profiles, free fatty acids (FFA) and leptin comparable with rats fed high-fat/Cholesterol Diet (HFD) known to induce obesity and hyperlipidaemia in this species. However, rats consuming WRD suppressed the increase of lipid droplets accumulation, FFA, and leptin, and the decrease of lipoprotein lipase and adipose triglyceride lipase. Meanwhile, WRD prevented high-fat/Cholesterol Diet-induced elevation in protein expression of sterol-regulatory element binding protein-1c, and gene expression of fatty acid synthase and acetyl-CoA carboxylase. These findings indicate that wild rice as a natural food has the potentials of preventing obesity and liver lipotoxicity induced by a high-fat/Cholesterol Diet in rats.

  • wild rice zizania latifolia griseb turcz improves the serum lipid profile and antioxidant status of rats fed with a high fat Cholesterol Diet
    British Journal of Nutrition, 2009
    Co-Authors: Hong Zhang, Pei Cao, Luis B Agellon, Chengkai Zhai
    Abstract:

    The Diet consumed by urban residents in modern China has become rich in saturated fats and Cholesterol. In addition, the Diet is high in carbohydrates from white rice and processed wheat starch. The aim of the present study was to determine the effects of replacing white rice and processed wheat starch with wild rice (WR) as the chief source of Dietary carbohydrates. Rats fed with the Diet patterned after the Diet consumed by city residents of modern China showed elevated serum lipid levels comparable with rats consuming a high fat/Cholesterol Diet known to induce hyperlipidaemia in this species. Meanwhile, rats consuming the city Diet with WR as the carbohydrate source suppressed the increase in serum TAG and total Cholesterol, and the decrease in HDL Cholesterol level. In addition, the rats fed the WR Diet suppressed the build-up of oxidative stress by improving antioxidant capacity, increasing superoxide dismutase activity and reducing malondialdehyde concentration, both in the serum and liver. These findings illustrate that WR is effective in suppressing hyperlipidaemia and oxidative stress in rats even when the Diet consumed is high in fat and Cholesterol.

Hong Zhang - One of the best experts on this subject based on the ideXlab platform.

  • effects of Dietary carbohydrate replaced with wild rice zizania latifolia griseb turcz on insulin resistance in rats fed with a high fat Cholesterol Diet
    Nutrients, 2013
    Co-Authors: Shufen Han, Hong Zhang, Liqiang Qin, Chengkai Zhai
    Abstract:

    Wild rice (WR) is a very nutritious grain that has been used to treat diabetes in Chinese medicinal practice. City Diet (CD) is based on the Diet consumed by Asian area residents in modern society, which is rich in saturated fats, Cholesterol and carbohydrates. The present study was aimed at evaluating the effects of replacing white rice and processed wheat starch of CD with WR as the chief source of Dietary carbohydrates on insulin resistance in rats fed with a high-fat/Cholesterol Diet. Except the rats of the low-fat (LF) Diet group, the rats of the other three groups, including to high-fat/Cholesterol (HFC) Diet, CD and WR Diet, were fed with high-fat/Cholesterol Diets for eight weeks. The rats fed with CD exhibited higher weight gain and lower insulin sensitivity compared to the rats consuming a HFC Diet. However, WR suppressed high-fat/Cholesterol Diet-induced insulin resistance. WR decreased liver homogenate triglyceride and free fatty acids levels, raised serum adiponectin concentration and reduced serum lipocalin-2 and visfatin concentrations. In addition, the WR Diet potently augmented the relative expressions of adiponectin receptor 2, peroxisome proliferator-activated receptors, alpha and gamma, and abated relative expressions of leptin and lipocalin-2 in the tissues of interest. These findings indicate that WR is effective in ameliorating abnormal glucose metabolism and insulin resistance in rats, even when the Diet consumed is high in fat and Cholesterol.

  • protective potentials of wild rice zizania latifolia griseb turcz against obesity and lipotoxicity induced by a high fat Cholesterol Diet in rats
    Food and Chemical Toxicology, 2012
    Co-Authors: Shufen Han, Hong Zhang, Chengkai Zhai
    Abstract:

    The study evaluates the protective potentials of wild rice against obesity and lipotoxicity induced by a high-fat/Cholesterol Diet in rats. In addition to the rats of low-fat Diet group, others animals were exposed to a high-fat/Cholesterol Diet condition for 8 weeks. The city Diet (CD) is based on the Diet consumed by urban residents in modern China, which is rich in fat/Cholesterol and high in carbohydrates from white rice and processed wheat starch. The chief source of Dietary carbohydrates of wild rice Diet (WRD) is from Chinese wild rice and other compositions are the same with CD. Rats fed CD showed elevated body and liver organ weights, lipid profiles, free fatty acids (FFA) and leptin comparable with rats fed high-fat/Cholesterol Diet (HFD) known to induce obesity and hyperlipidaemia in this species. However, rats consuming WRD suppressed the increase of lipid droplets accumulation, FFA, and leptin, and the decrease of lipoprotein lipase and adipose triglyceride lipase. Meanwhile, WRD prevented high-fat/Cholesterol Diet-induced elevation in protein expression of sterol-regulatory element binding protein-1c, and gene expression of fatty acid synthase and acetyl-CoA carboxylase. These findings indicate that wild rice as a natural food has the potentials of preventing obesity and liver lipotoxicity induced by a high-fat/Cholesterol Diet in rats.

  • wild rice zizania latifolia griseb turcz improves the serum lipid profile and antioxidant status of rats fed with a high fat Cholesterol Diet
    British Journal of Nutrition, 2009
    Co-Authors: Hong Zhang, Pei Cao, Luis B Agellon, Chengkai Zhai
    Abstract:

    The Diet consumed by urban residents in modern China has become rich in saturated fats and Cholesterol. In addition, the Diet is high in carbohydrates from white rice and processed wheat starch. The aim of the present study was to determine the effects of replacing white rice and processed wheat starch with wild rice (WR) as the chief source of Dietary carbohydrates. Rats fed with the Diet patterned after the Diet consumed by city residents of modern China showed elevated serum lipid levels comparable with rats consuming a high fat/Cholesterol Diet known to induce hyperlipidaemia in this species. Meanwhile, rats consuming the city Diet with WR as the carbohydrate source suppressed the increase in serum TAG and total Cholesterol, and the decrease in HDL Cholesterol level. In addition, the rats fed the WR Diet suppressed the build-up of oxidative stress by improving antioxidant capacity, increasing superoxide dismutase activity and reducing malondialdehyde concentration, both in the serum and liver. These findings illustrate that WR is effective in suppressing hyperlipidaemia and oxidative stress in rats even when the Diet consumed is high in fat and Cholesterol.

Shufen Han - One of the best experts on this subject based on the ideXlab platform.

  • effects of cereal fiber on leptin resistance and sensitivity in c57bl 6j mice fed a high fat Cholesterol Diet
    Food & Nutrition Research, 2016
    Co-Authors: Ru Zhang, Liqiang Qin, Jun Jiao, Wei Zhang, Zheng Zhang, Weiguo Zhang, Shufen Han
    Abstract:

    Background : Cereal fiber is reported to be associated with obesity and metabolic diseases. However, whether cereal fiber improves leptin resistance and sensitivity remains unclear. Design : For 24 weeks, 48 male C57BL/6J mice were randomly given a normal chow Diet (Chow), high-fat/Cholesterol Diet (HFD), HFD with 0.8% oat fiber (H-oat) or HFD with 0.8% wheat bran fiber (H-wheat). At the end of feeding period, both the serum insulin and leptin levels were determined by ELISA kits. Western blotting was used to assess the protein expressions of the leptin receptor (LepR) and the leptin-signaling pathway in the adipose tissues. Results : Our results suggested that mice fed oat or wheat bran fiber exhibited lower body weight, serum lipids, as well as insulin and leptin levels. The two cereal fibers potently increased the protein expressions of LepR in the adipose tissue. In addition, protein expressions of Janus kinase 2 (JAK2) and transcription 3 (STAT3) (induced by LepR), which enhances leptin signaling, were significantly higher and the expression of cytokine signaling-3 (SOCS3), which inhibits leptin signaling, was significantly lower in the two cereal fiber groups than in the HFD group. Conclusion : Taken together, our findings suggest that cereal fiber can improve leptin resistance and sensitivity by the JAK2/STAT3 pathway in C57BL/6J mice fed a HFD; furthermore, oat fiber is more effective in the improvement of leptin sensitivity than wheat bran fiber, in this murine model. Keywords: cereal fiber; leptin resistance; leptin signaling; high-fat/Cholesterol Diet (Published: 16 August 2016) Citation: Food & Nutrition Research 2016, 60: 31690 - http://dx.doi.org/10.3402/fnr.v60.31690

  • effects of Dietary carbohydrate replaced with wild rice zizania latifolia griseb turcz on insulin resistance in rats fed with a high fat Cholesterol Diet
    Nutrients, 2013
    Co-Authors: Shufen Han, Hong Zhang, Liqiang Qin, Chengkai Zhai
    Abstract:

    Wild rice (WR) is a very nutritious grain that has been used to treat diabetes in Chinese medicinal practice. City Diet (CD) is based on the Diet consumed by Asian area residents in modern society, which is rich in saturated fats, Cholesterol and carbohydrates. The present study was aimed at evaluating the effects of replacing white rice and processed wheat starch of CD with WR as the chief source of Dietary carbohydrates on insulin resistance in rats fed with a high-fat/Cholesterol Diet. Except the rats of the low-fat (LF) Diet group, the rats of the other three groups, including to high-fat/Cholesterol (HFC) Diet, CD and WR Diet, were fed with high-fat/Cholesterol Diets for eight weeks. The rats fed with CD exhibited higher weight gain and lower insulin sensitivity compared to the rats consuming a HFC Diet. However, WR suppressed high-fat/Cholesterol Diet-induced insulin resistance. WR decreased liver homogenate triglyceride and free fatty acids levels, raised serum adiponectin concentration and reduced serum lipocalin-2 and visfatin concentrations. In addition, the WR Diet potently augmented the relative expressions of adiponectin receptor 2, peroxisome proliferator-activated receptors, alpha and gamma, and abated relative expressions of leptin and lipocalin-2 in the tissues of interest. These findings indicate that WR is effective in ameliorating abnormal glucose metabolism and insulin resistance in rats, even when the Diet consumed is high in fat and Cholesterol.

  • protective potentials of wild rice zizania latifolia griseb turcz against obesity and lipotoxicity induced by a high fat Cholesterol Diet in rats
    Food and Chemical Toxicology, 2012
    Co-Authors: Shufen Han, Hong Zhang, Chengkai Zhai
    Abstract:

    The study evaluates the protective potentials of wild rice against obesity and lipotoxicity induced by a high-fat/Cholesterol Diet in rats. In addition to the rats of low-fat Diet group, others animals were exposed to a high-fat/Cholesterol Diet condition for 8 weeks. The city Diet (CD) is based on the Diet consumed by urban residents in modern China, which is rich in fat/Cholesterol and high in carbohydrates from white rice and processed wheat starch. The chief source of Dietary carbohydrates of wild rice Diet (WRD) is from Chinese wild rice and other compositions are the same with CD. Rats fed CD showed elevated body and liver organ weights, lipid profiles, free fatty acids (FFA) and leptin comparable with rats fed high-fat/Cholesterol Diet (HFD) known to induce obesity and hyperlipidaemia in this species. However, rats consuming WRD suppressed the increase of lipid droplets accumulation, FFA, and leptin, and the decrease of lipoprotein lipase and adipose triglyceride lipase. Meanwhile, WRD prevented high-fat/Cholesterol Diet-induced elevation in protein expression of sterol-regulatory element binding protein-1c, and gene expression of fatty acid synthase and acetyl-CoA carboxylase. These findings indicate that wild rice as a natural food has the potentials of preventing obesity and liver lipotoxicity induced by a high-fat/Cholesterol Diet in rats.

Jun Kusunoki - One of the best experts on this subject based on the ideXlab platform.

  • effect of f 1394 an acyl coa Cholesterol acyltransferase inhibitor on atherosclerosis induced by high Cholesterol Diet in rabbits
    Atherosclerosis, 2001
    Co-Authors: Katsumi Aragane, Kazuhiro Kojima, Koji Fujinami, Junzo Kamei, Jun Kusunoki
    Abstract:

    Cholesterol-fed rabbits were used to study the anti-atherosclerotic effect of (1S ,2 S)-2-[3-(2,2-dimethylpropyl)-3-nonylureido]cyclohexane-1-yl 3-[(4R)-N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (F-1394), an acylCoA:Cholesterol acyltransferase (ACAT) inhibitor. To test its effect on the development of atherosclerosis, rabbits were fed a high-Cholesterol Diet (HCD) for 6 weeks, followed by regular chow (RC) for 12 weeks plus 0 or 100 mg/kg per day F-1394. Serum total Cholesterol (TC) rose to approximately 2000 mg/dl on HCD and then declined gradually after the change in Diet in both groups. F-1394 significantly reduced the extent of the atherosclerotic lesions and the total and esterified Cholesterol contents of the aorta (by 57, 38, and 59%, respectively), without affecting the serum TC level. To clarify whether F-1394 accelerates the regression of preexisting atherosclerosis, rabbits were fed HCD for the first 6 weeks and then RC for the next 6 weeks. Then, the rabbits were given 0 or 100 × 2m g/kg per day F-1394 for another 12 weeks while on RC. F-1394 significantly reduced the extent of the atherosclerotic lesions and the total and esterified Cholesterol content in the aorta (by 31, 31, and 43%, respectively), without affecting the serum TC level. These results demonstrate that F-1394 both prevents the formation of atherosclerosis and accelerates its regression without affecting the serum TC level, indicating that F-1394 acts directly on the arterial wall. © 2001 Elsevier Science Ireland Ltd. All rights reserved.

  • hypoCholesterolemic action and prevention of Cholesterol absorption via the gut by f 1394 a potent acyl coa Cholesterol acyltransferase acat inhibitor in Cholesterol Diet fed rats
    Japanese Journal of Pharmacology, 1995
    Co-Authors: Jun Kusunoki, Tetsuya Kitamine, Tetsuaki Yamaura, Katsumi Aragane, Sakiko Higashinakagawa, Noriko Kase, Haruo Ohnishi
    Abstract:

    In the present study, we investigated the hypoCholesterolemic effect of F-1394 ((ls, 2s)-2-[3-(2, 2-dimethylpropyl)-3-nonylureido]aminocyclohexane-1-yl 3-[N-(2, 2, 5, 5-tetramethyl-1, 3-dioxane-4-carbonyl)amino]propionate), a potent and selective inhibitor of acyl-CoA:Cholesterol acyltransferase (ACAT), and the effect on Cholesterol absorption via the gut in rats fed a 1 % Cholesterol Diet. Single administration of F-1394 to the Cholesterol Diet-fed rats at the doses of 3-30 mg/kg, p.o. decreased the serum Cholesterol levels by 16 - 54% 3 hr after the administration. The ACAT activity in the small intestinal mucosa of the rats given orally F-1394 (30 mg/kg) was significantly inhibited 3 hr after the administration. The hypoCholesterolemic action of F-1394 had a faster onset than that of DL-melinamide or CL-277, 082. The study by the dual isotope ratio method showed that F-1394 (30 mg/kg, p.o.) significantly suppressed the Dietary Cholesterol absorption. Furthermore, in the determination of Cholesterol absorption by using 14C-Cholesterol as the oral tracer, the administration of F-1394 (30 mg/kg, p.o.) 1 or 2 hr before or immediately after the application of the oral tracer significantly prevented the appearance of the radioactivity in the circulation by around 90%. These results indicate that oral administration of F-1394 inhibits the ACAT activity in the small intestinal mucosa and subsequently contributes much to the prevention of Cholesterol absorption via the gut, resulting in the decrease in serum Cholesterol levels in the Cholesterol Diet-fed rats. Furthermore, the effect of F-1394 appears immediately after its administration in contrast to that of DL-melinamide or CL-277, 082.

Shun Wan Chan - One of the best experts on this subject based on the ideXlab platform.

  • chlorogenic acid exhibits Cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hyperCholesterolemic rats induced with a high Cholesterol Diet
    Phytotherapy Research, 2013
    Co-Authors: Candy Ngaiyan Wong, Chingyee Kwok, Marcus Ho Yin Wong, Robbie Yatkan Chan, Peter Hoifu Yu, Shun Wan Chan
    Abstract:

    HyperCholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum Cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the hypoCholesterolemic and hepatoprotective effects of the Dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total Cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague–Dawley rats fed with a normal Diet, a high-Cholesterol Diet or a high-Cholesterol Diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total Cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hyperCholesterolemic Diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hyperCholesterolemic animals supplemented with chlorogenic acid. It is postulated that hypoCholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The hypoCholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd.

  • chlorogenic acid exhibits Cholesterol lowering and fatty liver attenuating properties by up regulating the gene expression of ppar α in hyperCholesterolemic rats induced with a high Cholesterol Diet
    Phytotherapy Research, 2013
    Co-Authors: Chunwai Wan, Chingyee Kwok, Candy Ngaiyan Wong, Wingkwan Pin, Marcus Ho Yin Wong, Robbie Yatkan Chan, Shun Wan Chan
    Abstract:

    HyperCholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum Cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the hypoCholesterolemic and hepatoprotective effects of the Dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total Cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein) in Sprague-Dawley rats fed with a normal Diet, a high-Cholesterol Diet or a high-Cholesterol Diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total Cholesterol and low-density lipoprotein but decreased high-density lipoprotein induced by a hyperCholesterolemic Diet with a dose-dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hyperCholesterolemic animals supplemented with chlorogenic acid. It is postulated that hypoCholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The hypoCholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up-regulation of peroxisome proliferation-activated receptor α mRNA.

  • consumption of dried fruit of crataegus pinnatifida hawthorn suppresses high Cholesterol Diet induced hyperCholesterolemia in rats
    Journal of Functional Foods, 2010
    Co-Authors: Chingyee Kwok, Candy Ngaiyan Wong, Mabel Yinchun Yau, Christina Chui Wa Poon, Sai Wang Seto, Tsz Yan Lam, Yiu Wa Kwan, Shun Wan Chan
    Abstract:

    Abstract The hypoCholesterolemic and atheroscleroprotective potentials of Dietary consumption of hawthorn (dried fruit of Crataegus pinnatifida , Shan Zha) were investigated by monitoring plasma lipid profiles and aortic relaxation in Sprague–Dawley rats fed with either normal Diet, high-Cholesterol Diet (HCD) or HCD supplemented with hawthorn powder (2%, w/w) (4 weeks). In HCD-fed rats, an increased plasma total Cholesterol and LDL-Cholesterol with a decreased HDL-Cholesterol was observed, and consumption of hawthorn markedly suppressed the elevated total Cholesterol and LDL-lipoprotein levels plus an increased HDL-Cholesterol level. The blunted acetylcholine-induced, endothelium-dependent relaxation of isolated aortas of HCD-fed rats was improved by hawthorn. The development of fatty liver, an increased nitric oxide synthase (NOS) activity and an elevated oxidative stress (as estimated by the attenuated levels of anti-oxidant enzymes) associated with HCD were attenuated by hawthorn. Thus, the results demonstrated that hawthorn consumption provides overall beneficial effects on reversing HCD associated detrimental changes.