The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform
Murray W. Huff - One of the best experts on this subject based on the ideXlab platform.
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naringenin enhances the regression of atherosclerosis induced by a Chow Diet in ldlr mice
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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Naringenin enhances the regression of atherosclerosis induced by a Chow Diet in Ldlr-/- mice.
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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naringenin supplementation to a Chow Diet enhances energy expenditure and fatty acid oxidation and reduces adiposity in lean pair fed ldlr mice
Molecular Nutrition & Food Research, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:SCOPE: Naringenin is a citrus-derived flavonoid that has potent lipid-lowering and insulin-sensitizing effects in obese mouse models of metabolic dysfunction. However, in these models, a significant effect of naringenin supplementation is the prevention of weight gain, which in itself can confer metabolic protection. Therefore, in the present study, the effect of naringenin supplementation in lean, Chow-fed Ldlr-/- mice is investigated. METHODS AND RESULTS: In Ldlr-/- mice with isocaloric food consumption, treatment with naringenin for 8 weeks reduces body weight and adiposity compared to littermate controls pair-fed the Chow Diet alone. Furthermore, naringenin treatment reduces plasma lipids and enhances insulin sensitivity compared to Chow-fed controls. Metabolic cage studies reveal that naringenin-treated mice have elevated energy expenditure with no change in ambulatory activity. Additionally, naringenin-treated mice have an increased respiratory exchange ratio and food consumption during the dark cycle. Treatment increases the expression of fatty acid oxidation genes in liver, and increased β-hydroxybutyrate concentrations in plasma, indicating that one mechanism through which naringenin mediates metabolic improvement is enhanced hepatic fatty acid oxidation. CONCLUSIONS: These studies highlight the potential therapeutic utility of naringenin and suggest that this flavonoid maintains potent metabolic properties in the absence of obesity or a high-fat Diet.
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abstract 369 naringenin supplementation to a Chow Diet reduces plasma lipids and adiposity and suppresses rer in ldlr mice fed a Chow Diet
Arteriosclerosis Thrombosis and Vascular Biology, 2017Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Jane Y. Edwards, Murray W. HuffAbstract:Previously, we have shown that intervention by the addition of the citrus flavonoid naringenin to a Chow Diet enhances the reversal of Diet-induced metabolic dysregulation, obesity, and atheroscler...
Amy C. Burke - One of the best experts on this subject based on the ideXlab platform.
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naringenin enhances the regression of atherosclerosis induced by a Chow Diet in ldlr mice
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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Naringenin enhances the regression of atherosclerosis induced by a Chow Diet in Ldlr-/- mice.
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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naringenin supplementation to a Chow Diet enhances energy expenditure and fatty acid oxidation and reduces adiposity in lean pair fed ldlr mice
Molecular Nutrition & Food Research, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:SCOPE: Naringenin is a citrus-derived flavonoid that has potent lipid-lowering and insulin-sensitizing effects in obese mouse models of metabolic dysfunction. However, in these models, a significant effect of naringenin supplementation is the prevention of weight gain, which in itself can confer metabolic protection. Therefore, in the present study, the effect of naringenin supplementation in lean, Chow-fed Ldlr-/- mice is investigated. METHODS AND RESULTS: In Ldlr-/- mice with isocaloric food consumption, treatment with naringenin for 8 weeks reduces body weight and adiposity compared to littermate controls pair-fed the Chow Diet alone. Furthermore, naringenin treatment reduces plasma lipids and enhances insulin sensitivity compared to Chow-fed controls. Metabolic cage studies reveal that naringenin-treated mice have elevated energy expenditure with no change in ambulatory activity. Additionally, naringenin-treated mice have an increased respiratory exchange ratio and food consumption during the dark cycle. Treatment increases the expression of fatty acid oxidation genes in liver, and increased β-hydroxybutyrate concentrations in plasma, indicating that one mechanism through which naringenin mediates metabolic improvement is enhanced hepatic fatty acid oxidation. CONCLUSIONS: These studies highlight the potential therapeutic utility of naringenin and suggest that this flavonoid maintains potent metabolic properties in the absence of obesity or a high-fat Diet.
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abstract 369 naringenin supplementation to a Chow Diet reduces plasma lipids and adiposity and suppresses rer in ldlr mice fed a Chow Diet
Arteriosclerosis Thrombosis and Vascular Biology, 2017Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Jane Y. Edwards, Murray W. HuffAbstract:Previously, we have shown that intervention by the addition of the citrus flavonoid naringenin to a Chow Diet enhances the reversal of Diet-induced metabolic dysregulation, obesity, and atheroscler...
Brian G. Sutherland - One of the best experts on this subject based on the ideXlab platform.
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naringenin enhances the regression of atherosclerosis induced by a Chow Diet in ldlr mice
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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Naringenin enhances the regression of atherosclerosis induced by a Chow Diet in Ldlr-/- mice.
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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naringenin supplementation to a Chow Diet enhances energy expenditure and fatty acid oxidation and reduces adiposity in lean pair fed ldlr mice
Molecular Nutrition & Food Research, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:SCOPE: Naringenin is a citrus-derived flavonoid that has potent lipid-lowering and insulin-sensitizing effects in obese mouse models of metabolic dysfunction. However, in these models, a significant effect of naringenin supplementation is the prevention of weight gain, which in itself can confer metabolic protection. Therefore, in the present study, the effect of naringenin supplementation in lean, Chow-fed Ldlr-/- mice is investigated. METHODS AND RESULTS: In Ldlr-/- mice with isocaloric food consumption, treatment with naringenin for 8 weeks reduces body weight and adiposity compared to littermate controls pair-fed the Chow Diet alone. Furthermore, naringenin treatment reduces plasma lipids and enhances insulin sensitivity compared to Chow-fed controls. Metabolic cage studies reveal that naringenin-treated mice have elevated energy expenditure with no change in ambulatory activity. Additionally, naringenin-treated mice have an increased respiratory exchange ratio and food consumption during the dark cycle. Treatment increases the expression of fatty acid oxidation genes in liver, and increased β-hydroxybutyrate concentrations in plasma, indicating that one mechanism through which naringenin mediates metabolic improvement is enhanced hepatic fatty acid oxidation. CONCLUSIONS: These studies highlight the potential therapeutic utility of naringenin and suggest that this flavonoid maintains potent metabolic properties in the absence of obesity or a high-fat Diet.
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abstract 369 naringenin supplementation to a Chow Diet reduces plasma lipids and adiposity and suppresses rer in ldlr mice fed a Chow Diet
Arteriosclerosis Thrombosis and Vascular Biology, 2017Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Jane Y. Edwards, Murray W. HuffAbstract:Previously, we have shown that intervention by the addition of the citrus flavonoid naringenin to a Chow Diet enhances the reversal of Diet-induced metabolic dysregulation, obesity, and atheroscler...
Dawn E. Telford - One of the best experts on this subject based on the ideXlab platform.
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naringenin enhances the regression of atherosclerosis induced by a Chow Diet in ldlr mice
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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Naringenin enhances the regression of atherosclerosis induced by a Chow Diet in Ldlr-/- mice.
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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naringenin supplementation to a Chow Diet enhances energy expenditure and fatty acid oxidation and reduces adiposity in lean pair fed ldlr mice
Molecular Nutrition & Food Research, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:SCOPE: Naringenin is a citrus-derived flavonoid that has potent lipid-lowering and insulin-sensitizing effects in obese mouse models of metabolic dysfunction. However, in these models, a significant effect of naringenin supplementation is the prevention of weight gain, which in itself can confer metabolic protection. Therefore, in the present study, the effect of naringenin supplementation in lean, Chow-fed Ldlr-/- mice is investigated. METHODS AND RESULTS: In Ldlr-/- mice with isocaloric food consumption, treatment with naringenin for 8 weeks reduces body weight and adiposity compared to littermate controls pair-fed the Chow Diet alone. Furthermore, naringenin treatment reduces plasma lipids and enhances insulin sensitivity compared to Chow-fed controls. Metabolic cage studies reveal that naringenin-treated mice have elevated energy expenditure with no change in ambulatory activity. Additionally, naringenin-treated mice have an increased respiratory exchange ratio and food consumption during the dark cycle. Treatment increases the expression of fatty acid oxidation genes in liver, and increased β-hydroxybutyrate concentrations in plasma, indicating that one mechanism through which naringenin mediates metabolic improvement is enhanced hepatic fatty acid oxidation. CONCLUSIONS: These studies highlight the potential therapeutic utility of naringenin and suggest that this flavonoid maintains potent metabolic properties in the absence of obesity or a high-fat Diet.
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abstract 369 naringenin supplementation to a Chow Diet reduces plasma lipids and adiposity and suppresses rer in ldlr mice fed a Chow Diet
Arteriosclerosis Thrombosis and Vascular Biology, 2017Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Jane Y. Edwards, Murray W. HuffAbstract:Previously, we have shown that intervention by the addition of the citrus flavonoid naringenin to a Chow Diet enhances the reversal of Diet-induced metabolic dysregulation, obesity, and atheroscler...
Jane Y. Edwards - One of the best experts on this subject based on the ideXlab platform.
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naringenin enhances the regression of atherosclerosis induced by a Chow Diet in ldlr mice
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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Naringenin enhances the regression of atherosclerosis induced by a Chow Diet in Ldlr-/- mice.
Atherosclerosis, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:Abstract Background and aims Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr−/− mice fed a high-fat Diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In the present study, we assessed the capacity of naringenin to enhance regression in Ldlr−/− mice with Diet-induced intermediate atherosclerosis intervened with a Chow Diet. Methods Male Ldlr−/− mice were fed a high-fat, cholesterol-containing (HFHC) Diet for 12 weeks to induce intermediate atherosclerosis and metabolic dysfunction. Subsequently, a group of these mice were sacrificed for baseline analyses and the remainder either 1) continued on the HFHC Diet, 2) switched to a Chow Diet or 3) switched to Chow Diet supplemented with naringenin. Results After 12 weeks induction, intermediate lesions developed in the aortic sinus. Intervention with Chow alone slowed lesion growth, while intervention with naringenin-supplemented Chow completely halted lesion growth. Lesions were characterized by features of improved morphology. Compared to Chow alone, naringenin reduced plaque macrophages and modestly increased smooth muscle cells. Investigating processes that contributed to improved plaque morphology, we showed naringenin further reduced plasma triglycerides and cholesterol compared to Chow alone. Furthermore, elevated monocytosis and myelopoiesis were further corrected by intervention with naringenin compared to Chow alone. Metabolically, naringenin enhanced the correction of insulin resistance, hepatic steatosis and obesity compared to Chow alone, potentially contributing to enhanced regression. Conclusions Naringenin supplementation to Chow enhances atherosclerosis regression in male Ldlr−/− mice. These studies further underscore the potential therapeutic utility of naringenin.
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naringenin supplementation to a Chow Diet enhances energy expenditure and fatty acid oxidation and reduces adiposity in lean pair fed ldlr mice
Molecular Nutrition & Food Research, 2019Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Jane Y. Edwards, Murray W. HuffAbstract:SCOPE: Naringenin is a citrus-derived flavonoid that has potent lipid-lowering and insulin-sensitizing effects in obese mouse models of metabolic dysfunction. However, in these models, a significant effect of naringenin supplementation is the prevention of weight gain, which in itself can confer metabolic protection. Therefore, in the present study, the effect of naringenin supplementation in lean, Chow-fed Ldlr-/- mice is investigated. METHODS AND RESULTS: In Ldlr-/- mice with isocaloric food consumption, treatment with naringenin for 8 weeks reduces body weight and adiposity compared to littermate controls pair-fed the Chow Diet alone. Furthermore, naringenin treatment reduces plasma lipids and enhances insulin sensitivity compared to Chow-fed controls. Metabolic cage studies reveal that naringenin-treated mice have elevated energy expenditure with no change in ambulatory activity. Additionally, naringenin-treated mice have an increased respiratory exchange ratio and food consumption during the dark cycle. Treatment increases the expression of fatty acid oxidation genes in liver, and increased β-hydroxybutyrate concentrations in plasma, indicating that one mechanism through which naringenin mediates metabolic improvement is enhanced hepatic fatty acid oxidation. CONCLUSIONS: These studies highlight the potential therapeutic utility of naringenin and suggest that this flavonoid maintains potent metabolic properties in the absence of obesity or a high-fat Diet.
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abstract 369 naringenin supplementation to a Chow Diet reduces plasma lipids and adiposity and suppresses rer in ldlr mice fed a Chow Diet
Arteriosclerosis Thrombosis and Vascular Biology, 2017Co-Authors: Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Jane Y. Edwards, Murray W. HuffAbstract:Previously, we have shown that intervention by the addition of the citrus flavonoid naringenin to a Chow Diet enhances the reversal of Diet-induced metabolic dysregulation, obesity, and atheroscler...