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Ayla Celik - One of the best experts on this subject based on the ideXlab platform.
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genotoxicity of thimerosal in cultured human lymphocytes with and without metabolic activation sister Chromatid Exchange analysis proliferation index and mitotic index
Toxicology in Vitro, 2008Co-Authors: Dilek Eke, Ayla CelikAbstract:Abstract Thimerosal is an antiseptic containing 49.5% of ethyl mercury that has been used for years as a preservative in many infant vaccines and in flu vaccines. Thimerosal is an organic mercurial compound used as a preservative in biomedical preparations. In this study, we evaluated the genotoxic effect of thimerosal in cultured human peripheral blood lymphocytes using sister Chromatid Exchange analysis in culture conditions with and without S9 metabolic activation. This study is the first report investigating the genotoxic effects of thimerosal in cultured human peripheral blood lymphocyte cells using sister Chromatid Exchange analysis. An analysis of variance test (ANOVA) was performed to evaluate the results. Significant induction of sister Chromatid Exchanges was seen at concentrations between 0.2 and 0.6 μg/ml of thimerosal compared with negative control. A significant decrease (p
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evaluation of sister Chromatid Exchange and chromosomal aberration frequencies in peripheral blood lymphocytes of gasoline station attendants
Ecotoxicology and Environmental Safety, 2005Co-Authors: Ayla Celik, Etem AkbasAbstract:Petroleum derivatives constitute a complex mixture of chemicals which contain well-known genotoxicants, such as benzene. Thus, chronic occupational exposure to such derivatives may be considered to possess genotoxic risk. In the present study, frequencies of sister Chromatid Exchange (SCE); aberrant cells, including numerical and structural chromosomal aberrations; and chromosome aberrations were investigated in peripheral blood lymphocytes from 30 exposed workers (15 smokers and 15 nonsmokers) and 30 controls (15 smokers and 15 nonsmokers). The exposed subjects were employed at 12 different petrol pumping stations in the city of Mersin, Turkey. Urinary phenol levels of exposed workers were found to be significantly higher than those of control subjects. Benzene exposure and cigarette smoking decrease the replication index and mitotic index. There is an interaction between benzene exposure and cigarette smoking for replication index and mitotic index. There is no interaction between cigarette smoking and benzene exposure for chromosomal aberrations. The results indicate that there are significant differences in SCE values in the exposed workers compared to the control individuals (P 0.05). SCE frequency is higher in smokers than in nonsmokers.
Jeanmarc Lemaitre - One of the best experts on this subject based on the ideXlab platform.
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ipsc line derived from a bloom syndrome patient retains an increased disease specific sister Chromatid Exchange activity
Stem Cell Research, 2020Co-Authors: Vincent Gatinois, Romain Desprat, Fabienne Becker, Lydiane Pichard, Florence Bernex, Bertrand Isidor, Franck Pellestor, Jeanmarc LemaitreAbstract:Abstract Bloom syndrome is characterized by severe pre- and postnatal growth deficiency, immune abnormalities, sensitivity to sunlight, insulin resistance, and a high risk for many cancers that occur at an early age. The diagnosis is established on characteristic clinical features and/or presence of biallelic pathogenic variants in the BLM gene. An increased frequency of sister-Chromatid Exchanges is also observed and can be useful to diagnose BS patients with weak or no clinical features. For the first time, we derived an induced pluripotent cell line from a Bloom syndrome patient retaining the specific sister-Chromatid Exchange feature as a unique tool to model the pathology.
Romain Desprat - One of the best experts on this subject based on the ideXlab platform.
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ipsc line derived from a bloom syndrome patient retains an increased disease specific sister Chromatid Exchange activity
Stem Cell Research, 2020Co-Authors: Vincent Gatinois, Romain Desprat, Fabienne Becker, Lydiane Pichard, Florence Bernex, Bertrand Isidor, Franck Pellestor, Jeanmarc LemaitreAbstract:Abstract Bloom syndrome is characterized by severe pre- and postnatal growth deficiency, immune abnormalities, sensitivity to sunlight, insulin resistance, and a high risk for many cancers that occur at an early age. The diagnosis is established on characteristic clinical features and/or presence of biallelic pathogenic variants in the BLM gene. An increased frequency of sister-Chromatid Exchanges is also observed and can be useful to diagnose BS patients with weak or no clinical features. For the first time, we derived an induced pluripotent cell line from a Bloom syndrome patient retaining the specific sister-Chromatid Exchange feature as a unique tool to model the pathology.
Fabienne Becker - One of the best experts on this subject based on the ideXlab platform.
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ipsc line derived from a bloom syndrome patient retains an increased disease specific sister Chromatid Exchange activity
Stem Cell Research, 2020Co-Authors: Vincent Gatinois, Romain Desprat, Fabienne Becker, Lydiane Pichard, Florence Bernex, Bertrand Isidor, Franck Pellestor, Jeanmarc LemaitreAbstract:Abstract Bloom syndrome is characterized by severe pre- and postnatal growth deficiency, immune abnormalities, sensitivity to sunlight, insulin resistance, and a high risk for many cancers that occur at an early age. The diagnosis is established on characteristic clinical features and/or presence of biallelic pathogenic variants in the BLM gene. An increased frequency of sister-Chromatid Exchanges is also observed and can be useful to diagnose BS patients with weak or no clinical features. For the first time, we derived an induced pluripotent cell line from a Bloom syndrome patient retaining the specific sister-Chromatid Exchange feature as a unique tool to model the pathology.
Vincent Gatinois - One of the best experts on this subject based on the ideXlab platform.
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ipsc line derived from a bloom syndrome patient retains an increased disease specific sister Chromatid Exchange activity
Stem Cell Research, 2020Co-Authors: Vincent Gatinois, Romain Desprat, Fabienne Becker, Lydiane Pichard, Florence Bernex, Bertrand Isidor, Franck Pellestor, Jeanmarc LemaitreAbstract:Abstract Bloom syndrome is characterized by severe pre- and postnatal growth deficiency, immune abnormalities, sensitivity to sunlight, insulin resistance, and a high risk for many cancers that occur at an early age. The diagnosis is established on characteristic clinical features and/or presence of biallelic pathogenic variants in the BLM gene. An increased frequency of sister-Chromatid Exchanges is also observed and can be useful to diagnose BS patients with weak or no clinical features. For the first time, we derived an induced pluripotent cell line from a Bloom syndrome patient retaining the specific sister-Chromatid Exchange feature as a unique tool to model the pathology.