The Experts below are selected from a list of 126252 Experts worldwide ranked by ideXlab platform
Ian Dunham - One of the best experts on this subject based on the ideXlab platform.
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eLS - Chromosome 22: Sequencing
Encyclopedia of Life Sciences, 2005Co-Authors: Ian DunhamAbstract:The method of sequencing of Human Chromosome 22 has implications for sequencing the rest of the Human genome. Keywords: DNA sequencing; Chromosome 22; Human genome; genes
Heui-soo Kim - One of the best experts on this subject based on the ideXlab platform.
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Analysis of newly identified low copy AluYj subfamily.
Genes & genetic systems, 2005Co-Authors: Eun-sil Park, Jae-won Huh, Tae-hong Kim, Kyoung-don Kwak, Wook Kim, Heui-soo KimAbstract:Human specific AluY elements were investigated by comparative analysis between Human Chromosome 21 and chimpanzee Chromosome 22. Human specific AluY element was identified on Human Chromosome 21q22 (accession no. AL163282), and then that was a new member of AluYj subfamily. From the bioinformatic analysis, AluYj subfamily was investigated in Human whole genome using AluYj4 consensus sequence (accession no. AL163282). Thirteen members of the AluYj4 elements (4 diagnostic mutations) and eight members of the AluYj3 elements (3 diagnostic mutations) were identified with distinct diagnostic mutation from AluY consensus sequence. The results of the molecular clock calculation of non-CpG region substitution indicated that, AluYj4 elements (2.1 million years old) may be proliferated more recent time than AluYj3 elements (14.1 million years old). For the verification of recent insertion time, four of AluYj4 elements (ch2-AC017101, ch10-AC044786, ch12-AC007656 and ch21-AL163282) from Human Chromosomes 2, 10, 12, 21 were analyzed by PCR amplification using various Human and primate DNA samples. Though, no polymorphism was detected in Human population, we identified the new AluYj4 subfamily as the Human specific elements.
Eun-sil Park - One of the best experts on this subject based on the ideXlab platform.
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Analysis of newly identified low copy AluYj subfamily.
Genes & genetic systems, 2005Co-Authors: Eun-sil Park, Jae-won Huh, Tae-hong Kim, Kyoung-don Kwak, Wook Kim, Heui-soo KimAbstract:Human specific AluY elements were investigated by comparative analysis between Human Chromosome 21 and chimpanzee Chromosome 22. Human specific AluY element was identified on Human Chromosome 21q22 (accession no. AL163282), and then that was a new member of AluYj subfamily. From the bioinformatic analysis, AluYj subfamily was investigated in Human whole genome using AluYj4 consensus sequence (accession no. AL163282). Thirteen members of the AluYj4 elements (4 diagnostic mutations) and eight members of the AluYj3 elements (3 diagnostic mutations) were identified with distinct diagnostic mutation from AluY consensus sequence. The results of the molecular clock calculation of non-CpG region substitution indicated that, AluYj4 elements (2.1 million years old) may be proliferated more recent time than AluYj3 elements (14.1 million years old). For the verification of recent insertion time, four of AluYj4 elements (ch2-AC017101, ch10-AC044786, ch12-AC007656 and ch21-AL163282) from Human Chromosomes 2, 10, 12, 21 were analyzed by PCR amplification using various Human and primate DNA samples. Though, no polymorphism was detected in Human population, we identified the new AluYj4 subfamily as the Human specific elements.
Jae-won Huh - One of the best experts on this subject based on the ideXlab platform.
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Analysis of newly identified low copy AluYj subfamily.
Genes & genetic systems, 2005Co-Authors: Eun-sil Park, Jae-won Huh, Tae-hong Kim, Kyoung-don Kwak, Wook Kim, Heui-soo KimAbstract:Human specific AluY elements were investigated by comparative analysis between Human Chromosome 21 and chimpanzee Chromosome 22. Human specific AluY element was identified on Human Chromosome 21q22 (accession no. AL163282), and then that was a new member of AluYj subfamily. From the bioinformatic analysis, AluYj subfamily was investigated in Human whole genome using AluYj4 consensus sequence (accession no. AL163282). Thirteen members of the AluYj4 elements (4 diagnostic mutations) and eight members of the AluYj3 elements (3 diagnostic mutations) were identified with distinct diagnostic mutation from AluY consensus sequence. The results of the molecular clock calculation of non-CpG region substitution indicated that, AluYj4 elements (2.1 million years old) may be proliferated more recent time than AluYj3 elements (14.1 million years old). For the verification of recent insertion time, four of AluYj4 elements (ch2-AC017101, ch10-AC044786, ch12-AC007656 and ch21-AL163282) from Human Chromosomes 2, 10, 12, 21 were analyzed by PCR amplification using various Human and primate DNA samples. Though, no polymorphism was detected in Human population, we identified the new AluYj4 subfamily as the Human specific elements.
Tae-hong Kim - One of the best experts on this subject based on the ideXlab platform.
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Analysis of newly identified low copy AluYj subfamily.
Genes & genetic systems, 2005Co-Authors: Eun-sil Park, Jae-won Huh, Tae-hong Kim, Kyoung-don Kwak, Wook Kim, Heui-soo KimAbstract:Human specific AluY elements were investigated by comparative analysis between Human Chromosome 21 and chimpanzee Chromosome 22. Human specific AluY element was identified on Human Chromosome 21q22 (accession no. AL163282), and then that was a new member of AluYj subfamily. From the bioinformatic analysis, AluYj subfamily was investigated in Human whole genome using AluYj4 consensus sequence (accession no. AL163282). Thirteen members of the AluYj4 elements (4 diagnostic mutations) and eight members of the AluYj3 elements (3 diagnostic mutations) were identified with distinct diagnostic mutation from AluY consensus sequence. The results of the molecular clock calculation of non-CpG region substitution indicated that, AluYj4 elements (2.1 million years old) may be proliferated more recent time than AluYj3 elements (14.1 million years old). For the verification of recent insertion time, four of AluYj4 elements (ch2-AC017101, ch10-AC044786, ch12-AC007656 and ch21-AL163282) from Human Chromosomes 2, 10, 12, 21 were analyzed by PCR amplification using various Human and primate DNA samples. Though, no polymorphism was detected in Human population, we identified the new AluYj4 subfamily as the Human specific elements.