The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Yahya Açil - One of the best experts on this subject based on the ideXlab platform.
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Amelogenesis Imperfecta in a New Animal Model—a Mutation in Chromosome 5 (Human 4q21)
Journal of Dental Research, 2004Co-Authors: Hartwig Seedorf, I.n. Springer, Elisabeth Grundner-Culemann, H.-k. Albers, M. Hrabé De Angelis, Helmut Fuchs, André Reis, Yahya AçilAbstract:Candidate genes for amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI) are located on 4q21 in Humans. We tested our hypothesis that mutations in the portion of mouse Chromosome 5 corresponding to Human Chromosome 4q21 would cause enamel and dentin abnormalities. Male C3H mice were injected with ethylnitrosourea (ENU). Within a dominant ENU mutagenesis screen, a mouse mutant was isolated with an abnormal tooth enamel (ATE) phenotype. The structure and ultrastructure of teeth were studied. The mutation was located on mouse Chromosome 5 in an interval of 9 cM between markers D5Mit18 and D5Mit10. Homozygotic mutants showed total enamel aplasia with exposed dentinal tubules, while heterozygotic mutants showed a significant reduction in enamel width. Dentin of mutant mice showed a reduced content of mature collagen cross-links. We were able to demonstrate that a mutation on Chromosome 5 corresponding to Human Chromosome 4q21 can cause amelogenesis imperfecta and changes in dentin composition.
Hartwig Seedorf - One of the best experts on this subject based on the ideXlab platform.
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Amelogenesis Imperfecta in a New Animal Model—a Mutation in Chromosome 5 (Human 4q21)
Journal of Dental Research, 2004Co-Authors: Hartwig Seedorf, I.n. Springer, Elisabeth Grundner-Culemann, H.-k. Albers, M. Hrabé De Angelis, Helmut Fuchs, André Reis, Yahya AçilAbstract:Candidate genes for amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI) are located on 4q21 in Humans. We tested our hypothesis that mutations in the portion of mouse Chromosome 5 corresponding to Human Chromosome 4q21 would cause enamel and dentin abnormalities. Male C3H mice were injected with ethylnitrosourea (ENU). Within a dominant ENU mutagenesis screen, a mouse mutant was isolated with an abnormal tooth enamel (ATE) phenotype. The structure and ultrastructure of teeth were studied. The mutation was located on mouse Chromosome 5 in an interval of 9 cM between markers D5Mit18 and D5Mit10. Homozygotic mutants showed total enamel aplasia with exposed dentinal tubules, while heterozygotic mutants showed a significant reduction in enamel width. Dentin of mutant mice showed a reduced content of mature collagen cross-links. We were able to demonstrate that a mutation on Chromosome 5 corresponding to Human Chromosome 4q21 can cause amelogenesis imperfecta and changes in dentin composition.
I.n. Springer - One of the best experts on this subject based on the ideXlab platform.
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Amelogenesis Imperfecta in a New Animal Model—a Mutation in Chromosome 5 (Human 4q21)
Journal of Dental Research, 2004Co-Authors: Hartwig Seedorf, I.n. Springer, Elisabeth Grundner-Culemann, H.-k. Albers, M. Hrabé De Angelis, Helmut Fuchs, André Reis, Yahya AçilAbstract:Candidate genes for amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI) are located on 4q21 in Humans. We tested our hypothesis that mutations in the portion of mouse Chromosome 5 corresponding to Human Chromosome 4q21 would cause enamel and dentin abnormalities. Male C3H mice were injected with ethylnitrosourea (ENU). Within a dominant ENU mutagenesis screen, a mouse mutant was isolated with an abnormal tooth enamel (ATE) phenotype. The structure and ultrastructure of teeth were studied. The mutation was located on mouse Chromosome 5 in an interval of 9 cM between markers D5Mit18 and D5Mit10. Homozygotic mutants showed total enamel aplasia with exposed dentinal tubules, while heterozygotic mutants showed a significant reduction in enamel width. Dentin of mutant mice showed a reduced content of mature collagen cross-links. We were able to demonstrate that a mutation on Chromosome 5 corresponding to Human Chromosome 4q21 can cause amelogenesis imperfecta and changes in dentin composition.
Elisabeth Grundner-Culemann - One of the best experts on this subject based on the ideXlab platform.
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Amelogenesis Imperfecta in a New Animal Model—a Mutation in Chromosome 5 (Human 4q21)
Journal of Dental Research, 2004Co-Authors: Hartwig Seedorf, I.n. Springer, Elisabeth Grundner-Culemann, H.-k. Albers, M. Hrabé De Angelis, Helmut Fuchs, André Reis, Yahya AçilAbstract:Candidate genes for amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI) are located on 4q21 in Humans. We tested our hypothesis that mutations in the portion of mouse Chromosome 5 corresponding to Human Chromosome 4q21 would cause enamel and dentin abnormalities. Male C3H mice were injected with ethylnitrosourea (ENU). Within a dominant ENU mutagenesis screen, a mouse mutant was isolated with an abnormal tooth enamel (ATE) phenotype. The structure and ultrastructure of teeth were studied. The mutation was located on mouse Chromosome 5 in an interval of 9 cM between markers D5Mit18 and D5Mit10. Homozygotic mutants showed total enamel aplasia with exposed dentinal tubules, while heterozygotic mutants showed a significant reduction in enamel width. Dentin of mutant mice showed a reduced content of mature collagen cross-links. We were able to demonstrate that a mutation on Chromosome 5 corresponding to Human Chromosome 4q21 can cause amelogenesis imperfecta and changes in dentin composition.
H.-k. Albers - One of the best experts on this subject based on the ideXlab platform.
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Amelogenesis Imperfecta in a New Animal Model—a Mutation in Chromosome 5 (Human 4q21)
Journal of Dental Research, 2004Co-Authors: Hartwig Seedorf, I.n. Springer, Elisabeth Grundner-Culemann, H.-k. Albers, M. Hrabé De Angelis, Helmut Fuchs, André Reis, Yahya AçilAbstract:Candidate genes for amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI) are located on 4q21 in Humans. We tested our hypothesis that mutations in the portion of mouse Chromosome 5 corresponding to Human Chromosome 4q21 would cause enamel and dentin abnormalities. Male C3H mice were injected with ethylnitrosourea (ENU). Within a dominant ENU mutagenesis screen, a mouse mutant was isolated with an abnormal tooth enamel (ATE) phenotype. The structure and ultrastructure of teeth were studied. The mutation was located on mouse Chromosome 5 in an interval of 9 cM between markers D5Mit18 and D5Mit10. Homozygotic mutants showed total enamel aplasia with exposed dentinal tubules, while heterozygotic mutants showed a significant reduction in enamel width. Dentin of mutant mice showed a reduced content of mature collagen cross-links. We were able to demonstrate that a mutation on Chromosome 5 corresponding to Human Chromosome 4q21 can cause amelogenesis imperfecta and changes in dentin composition.