The Experts below are selected from a list of 1122 Experts worldwide ranked by ideXlab platform

Young-hoon Joo - One of the best experts on this subject based on the ideXlab platform.

Kyungdo Han - One of the best experts on this subject based on the ideXlab platform.

  • Insulin Resistance is Associated with Chronic Laryngitis in Korean Women
    The journal of nutrition health & aging, 2018
    Co-Authors: Ju-hyun Cho, Kyungdo Han, S.-s. Lee, Young-hoon Joo
    Abstract:

    Objectives The aim of this study was to investigate the association between Chronic Laryngitis (CL) and insulin resistance (IR) in South Korea using data from the 2010 Korea National Health and Nutrition Examination Surveys (KNHANES). Design, setting and participants Cross-sectional data of 4,261 adults who completed KNHANES were analyzed. CL was considered when participants experienced a voice change and demonstrated flexible laryngoscopic findings of diffuse laryngeal inflammation. All participants were assessed for IR using the homeostasis model assessment of insulin resistance (HOMA-IR). Results Among the Korean population older than 19 years, the prevalence of Chronic Laryngitis was 3.8±0.7%. Univariate analysis demonstrated that CL was significantly associated with smoking and systolic and diastolic blood pressure in men and with age, diastolic blood pressure, HDL cholesterol, insulin, and HOMA-IR in women. Multiple regression analysis demonstrated that the mean value of HOMA-IR was significantly associated with CL in women only. In addition, CL was more prevalent in the highest compared with the lowest HOMA-IR quartile (OR [95% CI]: 2.268 [1.053-4.884] after adjusting for age, OR [95% CI]: 2.235 [1.040-6.181] after adjusting for confounding factors of age, body mass index, smoking status, alcohol intake, regular exercise, education, and income). Conclusions These findings indicate that IR characterized by HOMA-IR is significantly associated with CL in Korean women only. Our results suggest that HOMA-IR could be an early predictive factor of increased risk of CL in Korean women.

  • Korean survey data reveals an association of Chronic Laryngitis with tinnitus in men.
    PLOS ONE, 2018
    Co-Authors: Myung Jin Ban, Won Shik Kim, Ki Nam Park, Jae Wook Kim, Seung Won Lee, Kyungdo Han, Jae Won Chang, Hyung Kwon Byeon, Yoon Woo Koh, Jae Hong Park
    Abstract:

    The association between Chronic Laryngitis and tinnitus is not a well-studied topic, unlike the association of these two conditions with many other disorders. Cross-sectional data of 11,347 adults (males: 4,934; females: 6,413), who completed the Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2012 were used to investigate this association. Lifestyle patterns, including smoking and alcohol habits, regular exercise, physical and mental health status, socioeconomic status, nutritional status, and other Chronic diseases, were analyzed. Chronic Laryngitis and tinnitus were diagnosed by field survey teams, which included otolaryngologists, who conducted Chronic disease surveillance using a health status interview, a nutritional status questionnaire, and a physical examination. Chronic Laryngitis was significantly associated with age, education beyond high school, depressed mood, voice change, metabolic syndrome, and tinnitus in men. In women, Chronic Laryngitis was associated with body mass index and diabetes mellitus. Chronic Laryngitis in men was significantly associated with tinnitus (odds ratio 1.671, [95% confidence interval: 1.167-2.393]) after adjusting for age, body mass index, smoking status, alcohol intake, regular exercise, metabolic syndrome, education beyond high school, and depressed mood. Additionally, the prevalence of Chronic Laryngitis increased with increasing severity of tinnitus in men alone (P = 0.002). The study revealed a significant association between Chronic Laryngitis and tinnitus.

  • Logistic regression models of tinnitus for Chronic Laryngitis.
    2018
    Co-Authors: Myung Jin Ban, Won Shik Kim, Ki Nam Park, Jae Wook Kim, Seung Won Lee, Kyungdo Han, Jae Won Chang, Hyung Kwon Byeon, Yoon Woo Koh, Jae Hong Park
    Abstract:

    Logistic regression models of tinnitus for Chronic Laryngitis.

  • Analysis of factors associated with Chronic Laryngitis, according to sex.
    2018
    Co-Authors: Myung Jin Ban, Won Shik Kim, Ki Nam Park, Jae Wook Kim, Seung Won Lee, Kyungdo Han, Jae Won Chang, Hyung Kwon Byeon, Yoon Woo Koh, Jae Hong Park
    Abstract:

    Analysis of factors associated with Chronic Laryngitis, according to sex.

  • Analysis of potential factors associated with Chronic Laryngitis and tinnitus.
    2018
    Co-Authors: Myung Jin Ban, Won Shik Kim, Ki Nam Park, Jae Wook Kim, Seung Won Lee, Kyungdo Han, Jae Won Chang, Hyung Kwon Byeon, Yoon Woo Koh, Jae Hong Park
    Abstract:

    Analysis of potential factors associated with Chronic Laryngitis and tinnitus.

Min Hu Chen - One of the best experts on this subject based on the ideXlab platform.

  • comparison of patients of Chronic Laryngitis with and without troublesome reflux symptoms
    Journal of Gastroenterology and Hepatology, 2012
    Co-Authors: An Jiang Wang, Mao Jin Liang, Ai Yun Jiang, Jin Kun Lin, Ying Lian Xiao, Sui Peng, Jie Chen, Wei Ping Wen, Min Hu Chen
    Abstract:

    Background and Aim:  Little is known about the difference between patients of Chronic Laryngitis with and without troublesome reflux symptoms. The aim of this study was to compare the clinical characteristics and response to acid suppression between patients of Chronic Laryngitis with and without troublesome reflux symptoms. Methods:  Consecutive patients with Chronic Laryngitis were enrolled. The frequency and severity of reflux and laryngeal symptoms were scored. All the patients underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Mild typical reflux symptoms (heartburn or regurgitation) occurring ≥ 2 days/week or moderate/severe symptoms occurring ≥ 1 day/week were defined as troublesome reflux symptoms. Results:  Compared to patients without troublesome reflux symptoms, those with troublesome reflux symptoms were older and had more episodes of acid and liquid gastroesophageal reflux (GER) and acid and weakly acidic laryngopharyngeal reflux (LPR). They also had higher percentages of both bolus exposure time and acid exposure time of GER and LPR. Patients with troublesome reflux symptoms responded to acid suppression more often at 12 weeks (67.3% vs 20.9%, P < 0.001) and more rapidly (40.8% vs 14.0%, 3 weeks after the start of acid suppression; P = 0.004) compared to those without. Conclusion:  Difference in reflux profile of GER and LPR between patients with and without troublesome reflux symptoms could partly explain the discrepancy of response to acid suppression among patients with Chronic Laryngitis. Acid suppression therapy may provide limited therapeutic benefits to patients of Chronic Laryngitis without troublesome reflux symptoms.

  • Comparison of patients of Chronic Laryngitis with and without troublesome reflux symptoms.
    Journal of gastroenterology and hepatology, 2012
    Co-Authors: An Jiang Wang, Mao Jin Liang, Ai Yun Jiang, Jin Kun Lin, Ying Lian Xiao, Sui Peng, Jie Chen, Wei Ping Wen, Min Hu Chen
    Abstract:

    Background and Aim:  Little is known about the difference between patients of Chronic Laryngitis with and without troublesome reflux symptoms. The aim of this study was to compare the clinical characteristics and response to acid suppression between patients of Chronic Laryngitis with and without troublesome reflux symptoms. Methods:  Consecutive patients with Chronic Laryngitis were enrolled. The frequency and severity of reflux and laryngeal symptoms were scored. All the patients underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Mild typical reflux symptoms (heartburn or regurgitation) occurring ≥ 2 days/week or moderate/severe symptoms occurring ≥ 1 day/week were defined as troublesome reflux symptoms. Results:  Compared to patients without troublesome reflux symptoms, those with troublesome reflux symptoms were older and had more episodes of acid and liquid gastroesophageal reflux (GER) and acid and weakly acidic laryngopharyngeal reflux (LPR). They also had higher percentages of both bolus exposure time and acid exposure time of GER and LPR. Patients with troublesome reflux symptoms responded to acid suppression more often at 12 weeks (67.3% vs 20.9%, P 

  • Predictors of acid suppression success in patients with Chronic Laryngitis.
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2012
    Co-Authors: An Jiang Wang, Mao Jin Liang, Ai Yun Jiang, Jin Kun Lin, Ying Lian Xiao, Sui Peng, Jie Chen, Wei Ping Wen, Min Hu Chen
    Abstract:

    Background  Up to 50% of the patients suspected of reflux Laryngitis syndrome failed to respond to acid suppression therapy. However, predictors of acid suppression success have not been determined. Methods  Consecutive patients with Chronic Laryngitis were enrolled prospectively. All the patients underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH (MII-pH) monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Patient was considered as a responder to acid suppression if the chief laryngeal complaint score during the last week since last interview had decreased by at least 50% after the start of therapy compared with baseline. Cox regression analysis was used to determine the independent predictors of acid suppression success. Key Results  Of 92 patients (age 42.4 ± 14.3 years, 50 women), 42 (45.7%) responded to acid suppression after 3 months. Gastroesophageal reflux disease was defined in 22 patients, of whom 19 patients had pathological distal esophageal acid exposure and 5 were defined as erosive esophagitis. The time to response showed a significant hazard ratio for patients with increased distal esophageal acid exposure time (β: 0.93; HR: 2.55; 95% CI: 1.24–5.24; P = 0.011) and increased laryngopharyngeal bolus exposure time (BET; β: 0.96; HR: 2.61; 95% CI: 1.36–5.00; P = 0.004). The latter had the best Youden Index (0.34) and accuracy (68.5%). Conclusions & Inferences  The success of acid suppression on Chronic Laryngitis could be predicted using reflux parameters detected by MII-pH, among which increased laryngopharyngeal BET is the best.

An Jiang Wang - One of the best experts on this subject based on the ideXlab platform.

  • comparison of patients of Chronic Laryngitis with and without troublesome reflux symptoms
    Journal of Gastroenterology and Hepatology, 2012
    Co-Authors: An Jiang Wang, Mao Jin Liang, Ai Yun Jiang, Jin Kun Lin, Ying Lian Xiao, Sui Peng, Jie Chen, Wei Ping Wen, Min Hu Chen
    Abstract:

    Background and Aim:  Little is known about the difference between patients of Chronic Laryngitis with and without troublesome reflux symptoms. The aim of this study was to compare the clinical characteristics and response to acid suppression between patients of Chronic Laryngitis with and without troublesome reflux symptoms. Methods:  Consecutive patients with Chronic Laryngitis were enrolled. The frequency and severity of reflux and laryngeal symptoms were scored. All the patients underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Mild typical reflux symptoms (heartburn or regurgitation) occurring ≥ 2 days/week or moderate/severe symptoms occurring ≥ 1 day/week were defined as troublesome reflux symptoms. Results:  Compared to patients without troublesome reflux symptoms, those with troublesome reflux symptoms were older and had more episodes of acid and liquid gastroesophageal reflux (GER) and acid and weakly acidic laryngopharyngeal reflux (LPR). They also had higher percentages of both bolus exposure time and acid exposure time of GER and LPR. Patients with troublesome reflux symptoms responded to acid suppression more often at 12 weeks (67.3% vs 20.9%, P < 0.001) and more rapidly (40.8% vs 14.0%, 3 weeks after the start of acid suppression; P = 0.004) compared to those without. Conclusion:  Difference in reflux profile of GER and LPR between patients with and without troublesome reflux symptoms could partly explain the discrepancy of response to acid suppression among patients with Chronic Laryngitis. Acid suppression therapy may provide limited therapeutic benefits to patients of Chronic Laryngitis without troublesome reflux symptoms.

  • Comparison of patients of Chronic Laryngitis with and without troublesome reflux symptoms.
    Journal of gastroenterology and hepatology, 2012
    Co-Authors: An Jiang Wang, Mao Jin Liang, Ai Yun Jiang, Jin Kun Lin, Ying Lian Xiao, Sui Peng, Jie Chen, Wei Ping Wen, Min Hu Chen
    Abstract:

    Background and Aim:  Little is known about the difference between patients of Chronic Laryngitis with and without troublesome reflux symptoms. The aim of this study was to compare the clinical characteristics and response to acid suppression between patients of Chronic Laryngitis with and without troublesome reflux symptoms. Methods:  Consecutive patients with Chronic Laryngitis were enrolled. The frequency and severity of reflux and laryngeal symptoms were scored. All the patients underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Mild typical reflux symptoms (heartburn or regurgitation) occurring ≥ 2 days/week or moderate/severe symptoms occurring ≥ 1 day/week were defined as troublesome reflux symptoms. Results:  Compared to patients without troublesome reflux symptoms, those with troublesome reflux symptoms were older and had more episodes of acid and liquid gastroesophageal reflux (GER) and acid and weakly acidic laryngopharyngeal reflux (LPR). They also had higher percentages of both bolus exposure time and acid exposure time of GER and LPR. Patients with troublesome reflux symptoms responded to acid suppression more often at 12 weeks (67.3% vs 20.9%, P 

  • Predictors of acid suppression success in patients with Chronic Laryngitis.
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2012
    Co-Authors: An Jiang Wang, Mao Jin Liang, Ai Yun Jiang, Jin Kun Lin, Ying Lian Xiao, Sui Peng, Jie Chen, Wei Ping Wen, Min Hu Chen
    Abstract:

    Background  Up to 50% of the patients suspected of reflux Laryngitis syndrome failed to respond to acid suppression therapy. However, predictors of acid suppression success have not been determined. Methods  Consecutive patients with Chronic Laryngitis were enrolled prospectively. All the patients underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance and pH (MII-pH) monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Patient was considered as a responder to acid suppression if the chief laryngeal complaint score during the last week since last interview had decreased by at least 50% after the start of therapy compared with baseline. Cox regression analysis was used to determine the independent predictors of acid suppression success. Key Results  Of 92 patients (age 42.4 ± 14.3 years, 50 women), 42 (45.7%) responded to acid suppression after 3 months. Gastroesophageal reflux disease was defined in 22 patients, of whom 19 patients had pathological distal esophageal acid exposure and 5 were defined as erosive esophagitis. The time to response showed a significant hazard ratio for patients with increased distal esophageal acid exposure time (β: 0.93; HR: 2.55; 95% CI: 1.24–5.24; P = 0.011) and increased laryngopharyngeal bolus exposure time (BET; β: 0.96; HR: 2.61; 95% CI: 1.36–5.00; P = 0.004). The latter had the best Youden Index (0.34) and accuracy (68.5%). Conclusions & Inferences  The success of acid suppression on Chronic Laryngitis could be predicted using reflux parameters detected by MII-pH, among which increased laryngopharyngeal BET is the best.

Michael F Vaezi - One of the best experts on this subject based on the ideXlab platform.

  • an oropharyngeal ph monitoring device to evaluate patients with Chronic Laryngitis
    Neurogastroenterology and Motility, 2013
    Co-Authors: Elif Saritas Yuksel, James C Slaughter, Marion Goutte, N Mukhtar, M Ochieng, George Sun, Srikant Muddana, Gaelyn C Garrett, Michael F Vaezi
    Abstract:

    Background Diagnostics for gastro-esophageal reflux disease (GERD) are suboptimal because of limited sensitivity. We performed in vitro and in vivo studies to systematically assess the performance characteristics of an oropharyngeal pH probe. Methods In vitro studies compared the oropharyngeal probe with a standard pH catheter in liquid and aerosolized solutions, pH 1–7. The accuracy of measurements, deviation from target pH, and time to equilibrium pH were determined. Simultaneous distal esophageal pH measurements were obtained in 11 patients with GERD. Oropharyngeal and distal esophageal reflux parameters were measured for controls (n = 20), patients with GERD (n = 17), and patients with Chronic Laryngitis (n = 10). Key Results In the liquid phase, at pH 4–5, the oropharyngeal probe had less deviation from the target value than the standard catheter; deviation in the vapor phase was similar (0.4 pH units). Median (interquartile) time to reach equilibrium pH was significantly (P < 0.001) faster with the oropharyngeal than the standard probe. In comparing simultaneous distal esophageal pH characteristics, 96% of recordings with the new and standard probes were in agreement to within ±1.0 pH unit; 71% of recordings were in agreement within ±0.5 pH units. Patients with Chronic Laryngitis had significantly higher levels of oropharyngeal acid exposure at pH <4, <5, and <6, in the upright position than patients with GERD or controls (P < .001). Conclusions & Inferences Oropharyngeal pH monitoring appears to be more sensitive than traditional pH monitoring in evaluation of patients with extraesophageal reflux. It is a promising tool in evaluation of this difficult group of patients.

  • An oropharyngeal pH monitoring device to evaluate patients with Chronic Laryngitis.
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2013
    Co-Authors: Elif Saritas Yuksel, James C Slaughter, Marion Goutte, N Mukhtar, M Ochieng, George Sun, Srikant Muddana, C. Gaelyn Garrett, Michael F Vaezi
    Abstract:

    Background Diagnostics for gastro-esophageal reflux disease (GERD) are suboptimal because of limited sensitivity. We performed in vitro and in vivo studies to systematically assess the performance characteristics of an oropharyngeal pH probe. Methods In vitro studies compared the oropharyngeal probe with a standard pH catheter in liquid and aerosolized solutions, pH 1–7. The accuracy of measurements, deviation from target pH, and time to equilibrium pH were determined. Simultaneous distal esophageal pH measurements were obtained in 11 patients with GERD. Oropharyngeal and distal esophageal reflux parameters were measured for controls (n = 20), patients with GERD (n = 17), and patients with Chronic Laryngitis (n = 10). Key Results In the liquid phase, at pH 4–5, the oropharyngeal probe had less deviation from the target value than the standard catheter; deviation in the vapor phase was similar (0.4 pH units). Median (interquartile) time to reach equilibrium pH was significantly (P 

  • dilated intercellular space in Chronic Laryngitis and gastro oesophageal reflux disease at baseline and post lansoprazole therapy
    Alimentary Pharmacology & Therapeutics, 2010
    Co-Authors: Michael F Vaezi, James C Slaughter, B S Smith, Mary Kay Washington, W G Jerome, C G Garrett, David Hagaman, Marion Goutte
    Abstract:

    SUMMARY Background Dilation of intercellular spaces is reported to be an early morphological marker in gastro-oesophageal reflux. It remains unknown if this marker is useful in diagnosing reflux-related Chronic Laryngitis. Aim To determine histopathology and electron microscopic changes in oesophageal and laryngeal epithelium in Chronic Laryngitis. Methods In this prospective blinded study, we enrolled 53 participants: 15 controls, 20 patients with GERD and 18 patients with Chronic Laryngitis. The latter two groups were subsequently treated with lansoprazole 30 mg bid for 12weeks. Baseline and postacid suppressive therapy biopsies were obtained from distal oesophagus and laryngeal postcricoid areas. Biopsy specimens were evaluated for histopathology and dilated intercellular space changes.

  • proton pump inhibitor therapy for suspected gerd related Chronic Laryngitis a meta analysis of randomized controlled trials
    The American Journal of Gastroenterology, 2006
    Co-Authors: Mohammed A Qadeer, Pieter J Noordzij, Christopher O Phillips, Rocio A Lopez, David L Steward, Maria V Suurna, Thomas Havas, Colin W Howden, Michael F Vaezi
    Abstract:

    Proton Pump Inhibitor Therapy for Suspected GERD-Related Chronic Laryngitis: A Meta-Analysis of Randomized Controlled Trials

  • Chronic Laryngitis associated with gastroesophageal reflux prospective assessment of differences in practice patterns between gastroenterologists and ent physicians
    The American Journal of Gastroenterology, 2006
    Co-Authors: Tasneem Ahmed, Farah Khandwala, Tom I Abelson, Douglas M Hicks, Joel E Richter, Claudio F Milstein, Michael F Vaezi
    Abstract:

    Chronic Laryngitis Associated with Gastroesophageal Reflux: Prospective Assessment of Differences in Practice Patterns Between Gastroenterologists and ENT Physicians