The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform

Zonghui Yuan - One of the best experts on this subject based on the ideXlab platform.

  • acute and sub Chronic Toxicity Study of diaveridine in wistar rats
    Regulatory Toxicology and Pharmacology, 2015
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Zhenli Liu, Qin Huang, Dongmei Chen, Guyue Cheng, Zonghui Yuan
    Abstract:

    Abstract Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its Toxicity. To provide detailed Toxicity with a wide spectrum of doses for diaveridine, acute and sub-Chronic Toxicity studies were conducted. Calculated LD 50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-Chronic Study, diaveridine was fed to Wistar rats during 90 days at dietary levels of 0, 23, 230, 1150 and 2000 mg/kg, which were about 0, 2.0–2.3, 21.0–23.5, 115.2–126.9 and 212.4–217.9 mg/kg b.w., respectively. Significant decrease in body weights in both genders at 1150 and 2000 mg/kg groups and significant increases in relative weights of brain in both genders, liver in females, kidneys and testis in males, alkaline phosphatase and potassium in both genders at 2000 mg/kg diet were noted. Significant decrease in absolute weights of several organs, hemoglobin and red blood cell count in both genders, albumin and total protein in females were observed at 2000 mg/kg diet. Fibroblasts in the kidneys, cell swelling of the glomerular zone in the adrenals and inflammation in the liver were found at 2000 mg/kg group. The no-observed-adverse-effect level of diaveridine was 230 mg/kg diet (21.0–23.5 mg/kg b.w./day).

  • a Chronic Toxicity Study of cyadox in wistar rats
    Regulatory Toxicology and Pharmacology, 2011
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Lingli Huang, Wen Zhou, Zhenli Liu, Zonghui Yuan
    Abstract:

    To investigate the Chronic Toxicity of cyadox, a growth promoting agent, five groups of Wistar rats (30 rats/group/sex) were fed with the diets containing cyadox (0, 100, 400 and 2000 mg/kg) or olaquindox (400 mg/kg) for 78 weeks. There were significant decreases in body weights in both genders during most of the Study period in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats. Significant decreases in serum alkaline aminotransferase in the 2000 mg/kg cyadox rats at weeks 26, 52 and 78 were observed. Relative weights of liver and kidney were significantly increased in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats at weeks 26, 52 and 78. A significant increase in relative brain and heart weights in 2000 mg/kg cyadox males was observed. The histopathological examinations revealed that 2000 mg/kg cyadox diet or 400 mg/kg olaquindox diet could induce proliferation of bile canaliculi in the portal area of liver and swelling and fatty degeneration of the proximal renal tubular epithelial cells in kidneys. In conclusion, the target organs of cyadox for rats were liver and kidney. The no-observed-adverse-effect level of cyadox in this Study was estimated to be 400 mg/kg diet.

Xu Wang - One of the best experts on this subject based on the ideXlab platform.

  • acute and sub Chronic Toxicity Study of diaveridine in wistar rats
    Regulatory Toxicology and Pharmacology, 2015
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Zhenli Liu, Qin Huang, Dongmei Chen, Guyue Cheng, Zonghui Yuan
    Abstract:

    Abstract Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its Toxicity. To provide detailed Toxicity with a wide spectrum of doses for diaveridine, acute and sub-Chronic Toxicity studies were conducted. Calculated LD 50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-Chronic Study, diaveridine was fed to Wistar rats during 90 days at dietary levels of 0, 23, 230, 1150 and 2000 mg/kg, which were about 0, 2.0–2.3, 21.0–23.5, 115.2–126.9 and 212.4–217.9 mg/kg b.w., respectively. Significant decrease in body weights in both genders at 1150 and 2000 mg/kg groups and significant increases in relative weights of brain in both genders, liver in females, kidneys and testis in males, alkaline phosphatase and potassium in both genders at 2000 mg/kg diet were noted. Significant decrease in absolute weights of several organs, hemoglobin and red blood cell count in both genders, albumin and total protein in females were observed at 2000 mg/kg diet. Fibroblasts in the kidneys, cell swelling of the glomerular zone in the adrenals and inflammation in the liver were found at 2000 mg/kg group. The no-observed-adverse-effect level of diaveridine was 230 mg/kg diet (21.0–23.5 mg/kg b.w./day).

  • a Chronic Toxicity Study of cyadox in wistar rats
    Regulatory Toxicology and Pharmacology, 2011
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Lingli Huang, Wen Zhou, Zhenli Liu, Zonghui Yuan
    Abstract:

    To investigate the Chronic Toxicity of cyadox, a growth promoting agent, five groups of Wistar rats (30 rats/group/sex) were fed with the diets containing cyadox (0, 100, 400 and 2000 mg/kg) or olaquindox (400 mg/kg) for 78 weeks. There were significant decreases in body weights in both genders during most of the Study period in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats. Significant decreases in serum alkaline aminotransferase in the 2000 mg/kg cyadox rats at weeks 26, 52 and 78 were observed. Relative weights of liver and kidney were significantly increased in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats at weeks 26, 52 and 78. A significant increase in relative brain and heart weights in 2000 mg/kg cyadox males was observed. The histopathological examinations revealed that 2000 mg/kg cyadox diet or 400 mg/kg olaquindox diet could induce proliferation of bile canaliculi in the portal area of liver and swelling and fatty degeneration of the proximal renal tubular epithelial cells in kidneys. In conclusion, the target organs of cyadox for rats were liver and kidney. The no-observed-adverse-effect level of cyadox in this Study was estimated to be 400 mg/kg diet.

Yulian Wang - One of the best experts on this subject based on the ideXlab platform.

  • acute and sub Chronic Toxicity Study of diaveridine in wistar rats
    Regulatory Toxicology and Pharmacology, 2015
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Zhenli Liu, Qin Huang, Dongmei Chen, Guyue Cheng, Zonghui Yuan
    Abstract:

    Abstract Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its Toxicity. To provide detailed Toxicity with a wide spectrum of doses for diaveridine, acute and sub-Chronic Toxicity studies were conducted. Calculated LD 50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-Chronic Study, diaveridine was fed to Wistar rats during 90 days at dietary levels of 0, 23, 230, 1150 and 2000 mg/kg, which were about 0, 2.0–2.3, 21.0–23.5, 115.2–126.9 and 212.4–217.9 mg/kg b.w., respectively. Significant decrease in body weights in both genders at 1150 and 2000 mg/kg groups and significant increases in relative weights of brain in both genders, liver in females, kidneys and testis in males, alkaline phosphatase and potassium in both genders at 2000 mg/kg diet were noted. Significant decrease in absolute weights of several organs, hemoglobin and red blood cell count in both genders, albumin and total protein in females were observed at 2000 mg/kg diet. Fibroblasts in the kidneys, cell swelling of the glomerular zone in the adrenals and inflammation in the liver were found at 2000 mg/kg group. The no-observed-adverse-effect level of diaveridine was 230 mg/kg diet (21.0–23.5 mg/kg b.w./day).

  • a Chronic Toxicity Study of cyadox in wistar rats
    Regulatory Toxicology and Pharmacology, 2011
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Lingli Huang, Wen Zhou, Zhenli Liu, Zonghui Yuan
    Abstract:

    To investigate the Chronic Toxicity of cyadox, a growth promoting agent, five groups of Wistar rats (30 rats/group/sex) were fed with the diets containing cyadox (0, 100, 400 and 2000 mg/kg) or olaquindox (400 mg/kg) for 78 weeks. There were significant decreases in body weights in both genders during most of the Study period in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats. Significant decreases in serum alkaline aminotransferase in the 2000 mg/kg cyadox rats at weeks 26, 52 and 78 were observed. Relative weights of liver and kidney were significantly increased in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats at weeks 26, 52 and 78. A significant increase in relative brain and heart weights in 2000 mg/kg cyadox males was observed. The histopathological examinations revealed that 2000 mg/kg cyadox diet or 400 mg/kg olaquindox diet could induce proliferation of bile canaliculi in the portal area of liver and swelling and fatty degeneration of the proximal renal tubular epithelial cells in kidneys. In conclusion, the target organs of cyadox for rats were liver and kidney. The no-observed-adverse-effect level of cyadox in this Study was estimated to be 400 mg/kg diet.

Awais Ihsan - One of the best experts on this subject based on the ideXlab platform.

  • acute and sub Chronic Toxicity Study of diaveridine in wistar rats
    Regulatory Toxicology and Pharmacology, 2015
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Zhenli Liu, Qin Huang, Dongmei Chen, Guyue Cheng, Zonghui Yuan
    Abstract:

    Abstract Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its Toxicity. To provide detailed Toxicity with a wide spectrum of doses for diaveridine, acute and sub-Chronic Toxicity studies were conducted. Calculated LD 50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-Chronic Study, diaveridine was fed to Wistar rats during 90 days at dietary levels of 0, 23, 230, 1150 and 2000 mg/kg, which were about 0, 2.0–2.3, 21.0–23.5, 115.2–126.9 and 212.4–217.9 mg/kg b.w., respectively. Significant decrease in body weights in both genders at 1150 and 2000 mg/kg groups and significant increases in relative weights of brain in both genders, liver in females, kidneys and testis in males, alkaline phosphatase and potassium in both genders at 2000 mg/kg diet were noted. Significant decrease in absolute weights of several organs, hemoglobin and red blood cell count in both genders, albumin and total protein in females were observed at 2000 mg/kg diet. Fibroblasts in the kidneys, cell swelling of the glomerular zone in the adrenals and inflammation in the liver were found at 2000 mg/kg group. The no-observed-adverse-effect level of diaveridine was 230 mg/kg diet (21.0–23.5 mg/kg b.w./day).

  • a Chronic Toxicity Study of cyadox in wistar rats
    Regulatory Toxicology and Pharmacology, 2011
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Lingli Huang, Wen Zhou, Zhenli Liu, Zonghui Yuan
    Abstract:

    To investigate the Chronic Toxicity of cyadox, a growth promoting agent, five groups of Wistar rats (30 rats/group/sex) were fed with the diets containing cyadox (0, 100, 400 and 2000 mg/kg) or olaquindox (400 mg/kg) for 78 weeks. There were significant decreases in body weights in both genders during most of the Study period in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats. Significant decreases in serum alkaline aminotransferase in the 2000 mg/kg cyadox rats at weeks 26, 52 and 78 were observed. Relative weights of liver and kidney were significantly increased in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats at weeks 26, 52 and 78. A significant increase in relative brain and heart weights in 2000 mg/kg cyadox males was observed. The histopathological examinations revealed that 2000 mg/kg cyadox diet or 400 mg/kg olaquindox diet could induce proliferation of bile canaliculi in the portal area of liver and swelling and fatty degeneration of the proximal renal tubular epithelial cells in kidneys. In conclusion, the target organs of cyadox for rats were liver and kidney. The no-observed-adverse-effect level of cyadox in this Study was estimated to be 400 mg/kg diet.

Zhenli Liu - One of the best experts on this subject based on the ideXlab platform.

  • acute and sub Chronic Toxicity Study of diaveridine in wistar rats
    Regulatory Toxicology and Pharmacology, 2015
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Zhenli Liu, Qin Huang, Dongmei Chen, Guyue Cheng, Zonghui Yuan
    Abstract:

    Abstract Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its Toxicity. To provide detailed Toxicity with a wide spectrum of doses for diaveridine, acute and sub-Chronic Toxicity studies were conducted. Calculated LD 50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-Chronic Study, diaveridine was fed to Wistar rats during 90 days at dietary levels of 0, 23, 230, 1150 and 2000 mg/kg, which were about 0, 2.0–2.3, 21.0–23.5, 115.2–126.9 and 212.4–217.9 mg/kg b.w., respectively. Significant decrease in body weights in both genders at 1150 and 2000 mg/kg groups and significant increases in relative weights of brain in both genders, liver in females, kidneys and testis in males, alkaline phosphatase and potassium in both genders at 2000 mg/kg diet were noted. Significant decrease in absolute weights of several organs, hemoglobin and red blood cell count in both genders, albumin and total protein in females were observed at 2000 mg/kg diet. Fibroblasts in the kidneys, cell swelling of the glomerular zone in the adrenals and inflammation in the liver were found at 2000 mg/kg group. The no-observed-adverse-effect level of diaveridine was 230 mg/kg diet (21.0–23.5 mg/kg b.w./day).

  • a Chronic Toxicity Study of cyadox in wistar rats
    Regulatory Toxicology and Pharmacology, 2011
    Co-Authors: Xu Wang, Yulian Wang, Awais Ihsan, Lingli Huang, Wen Zhou, Zhenli Liu, Zonghui Yuan
    Abstract:

    To investigate the Chronic Toxicity of cyadox, a growth promoting agent, five groups of Wistar rats (30 rats/group/sex) were fed with the diets containing cyadox (0, 100, 400 and 2000 mg/kg) or olaquindox (400 mg/kg) for 78 weeks. There were significant decreases in body weights in both genders during most of the Study period in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats. Significant decreases in serum alkaline aminotransferase in the 2000 mg/kg cyadox rats at weeks 26, 52 and 78 were observed. Relative weights of liver and kidney were significantly increased in 2000 mg/kg cyadox and 400 mg/kg olaquindox rats at weeks 26, 52 and 78. A significant increase in relative brain and heart weights in 2000 mg/kg cyadox males was observed. The histopathological examinations revealed that 2000 mg/kg cyadox diet or 400 mg/kg olaquindox diet could induce proliferation of bile canaliculi in the portal area of liver and swelling and fatty degeneration of the proximal renal tubular epithelial cells in kidneys. In conclusion, the target organs of cyadox for rats were liver and kidney. The no-observed-adverse-effect level of cyadox in this Study was estimated to be 400 mg/kg diet.