The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Wanda Kisiel - One of the best experts on this subject based on the ideXlab platform.
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A new neolignan glucoside from hairy roots of Cichorium intybus
Phytochemistry Letters, 2013Co-Authors: J. Malarz, Anna Stojakowska, Edward Szneler, Wanda KisielAbstract:A new neolignan glucoside was isolated from hairy roots of Cichorium intybus. Its structure was determined as (7S, 8R)-3′-demethyl-dehydrodiconiferyl alcohol-3′-O-β-glucopyranoside based on a combination of 1D and 2D NMR techniques and CD data. In addition, further water soluble constituents, including four known phenolic compounds and one known sesquiterpene lactone glucoside, were isolated from the same source.
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Furofuran lignans from a callus culture of Cichorium intybus
Plant Cell Reports, 2005Co-Authors: J. Malarz, Anna Stojakowska, Edward Szneler, Wanda KisielAbstract:Three new and one known furofuran lignans—syringaresinol derivatives—along with the known phenylpropanoids cichoriin and syringin were isolated from a callus tissue of Cichorium intybus . The compounds were characterised by spectral methods. This is the first report on the presence of furofuran lignans in Cichorium species.
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Sesquiterpene Lactones in a Hairy Root Culture of Cichorium intybus
Zeitschrift fur Naturforschung. C Journal of biosciences, 2002Co-Authors: J. Malarz, Anna Stojakowska, Wanda KisielAbstract:A transformed root culture of Cichorium intybus L. (Asteraceae) was found to produce sesquiterpene lactones of guaiane and germacrane type. Lactucopicrin, 8-desoxylactucin and three sesquiterpene lactone glycosides: crepidiaside B, sonchuside A and ixerisoside D were isolated from the roots. The yield of 8-desoxylactucin reached 0.03 g l(-1) at the early stationary phase of the culture.
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Guaianolides from Cichorium intybus and structure revision of Cichorium sesquiterpene lactones.
Phytochemistry, 2001Co-Authors: Wanda Kisiel, Klaudia ZielińskaAbstract:The isolation and structure elucidation of a new lactucopicrin derivative from Cichorium intybus is described, together with the revised structures of several sesquiterpene lactones previously isolated from Cichorium species. The known eudesmanolide magnolialide and the known guaianolide ixerisoside D, reported for the first time from the plant material, along with the previously known chicory sesquiterpene lactones have been also isolated and identified.
Klaudia Zielińska - One of the best experts on this subject based on the ideXlab platform.
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Guaianolides from Cichorium intybus and structure revision of Cichorium sesquiterpene lactones.
Phytochemistry, 2001Co-Authors: Wanda Kisiel, Klaudia ZielińskaAbstract:The isolation and structure elucidation of a new lactucopicrin derivative from Cichorium intybus is described, together with the revised structures of several sesquiterpene lactones previously isolated from Cichorium species. The known eudesmanolide magnolialide and the known guaianolide ixerisoside D, reported for the first time from the plant material, along with the previously known chicory sesquiterpene lactones have been also isolated and identified.
Ali Awsat Mellati - One of the best experts on this subject based on the ideXlab platform.
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Inhibitory Effects of Cichorium intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells
International Journal of Cancer Management, 2018Co-Authors: Reza Mehrandish, Nasrin Dehghan-nayeri, Aliasghar Rahimian, Ali Toutounchi, Ali Awsat MellatiAbstract:Background: Fatty acid synthase (FASN) is a key enzyme in de novo lipogenesis pathway. FASN overexpression is a common feature of many human cancers like breast cancer. Furthermore, FASN expression in HER2 - positive cell lines like SKBR3 is more than other cell lines, such as MCF - 7, which are not HER2 - positive. Cichorium intybus is a medicinal herb and methanolic extract of this plant significantly suppressed cell viability and growth in some cancer cells. Objectives: In this study, we aimed at investigating the effect of methanolic extract of Cichorium intybus on the FASN expression and, therefore, lipogenesis pathway in human breast cancer SKBR3 cell line. Methods: We assessed the cytotoxicity effect of Chicorium intybus on the cell viability of SKBR3 cells, using MTT assay. In addition, apoptosis rate was assessed by annexinV/PI flow cytometry. Finally, Real time q - PCR was used for the analysis of FASN gene expression. Results: The results showed that the methanolic extract of Cichorium intybus caused a dose - dependent decrease in the cell viability of SKBR3 cells. Additionally, the treatment of confluent SKBR3 cells with extract led to reduced FASN expression at mRNA level. Conclusions: These results suggest that Chicorium intybus not only inhibits cell viability in a dose - dependent manner, but also presumably inhibits lipogenesis by markedly decreased FASN expression as a key lipogenic enzyme.
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Anti-Cancer Activity of Methanol Extracts of Cichorium intybus on Human Breast Cancer SKBR3 Cell Line
Razavi International Journal of Medicine, 2016Co-Authors: Reza Mehrandish, Ali Rahimipour, Ali Awsat Mellati, Nasrin Dehghan NayeriAbstract:Background Breast cancer is the most prevalent cancer and the second cause of death among women around the world. In many cancers, including breast cancer, Fatty acid synthase (FASN) gene expression is increased significantly. In breast cancer cell lines, expression of FASN is higher in HER2 positive cell line like SKBR3 than the others. FASN is the key enzyme for fatty acid synthesis de novo pathway and it is producing palmitate which is necessary for cell membrane formation. Cichorium intybus is a medicinal plant that effectively leads to inhibition of fatty acid synthase and thus reduces the percentage of survival of cancer cell lines. Objectives The aim of this study was to evaluate the effect of methanol extract of Chicorium intybus root on percentage of survival in SKBR3 cell line. Methods Human breast cancer SKBR3 cell line was cultured in DMEM medium. Methanol extract of Cichorium intybus root was extracted and different dilutions (200, 300, 400, 500 and 600µg/mL) were added to cell culture. Cell viability was quantitated by MTT assay after 24, 48 and 72 hours. Results Cichorium intybus could decrease cell viability. The effects of extract on cell viability were observed after 24, 48 and 72 hours on SKBR3 cell line and IC50 was 800, 400 and 300 after 24, 48 and 72 hours of treatment, respectively. Conclusions Our study shows that methanol extract of Cichorium intybus has cytotoxic effects on tumor cells. This is a pilot work for further evaluation in the future
Reza Mehrandish - One of the best experts on this subject based on the ideXlab platform.
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Inhibitory Effects of Cichorium intybus Root Extract on the Proliferation and Lipogenesis of the SKBR3 Cells
International Journal of Cancer Management, 2018Co-Authors: Reza Mehrandish, Nasrin Dehghan-nayeri, Aliasghar Rahimian, Ali Toutounchi, Ali Awsat MellatiAbstract:Background: Fatty acid synthase (FASN) is a key enzyme in de novo lipogenesis pathway. FASN overexpression is a common feature of many human cancers like breast cancer. Furthermore, FASN expression in HER2 - positive cell lines like SKBR3 is more than other cell lines, such as MCF - 7, which are not HER2 - positive. Cichorium intybus is a medicinal herb and methanolic extract of this plant significantly suppressed cell viability and growth in some cancer cells. Objectives: In this study, we aimed at investigating the effect of methanolic extract of Cichorium intybus on the FASN expression and, therefore, lipogenesis pathway in human breast cancer SKBR3 cell line. Methods: We assessed the cytotoxicity effect of Chicorium intybus on the cell viability of SKBR3 cells, using MTT assay. In addition, apoptosis rate was assessed by annexinV/PI flow cytometry. Finally, Real time q - PCR was used for the analysis of FASN gene expression. Results: The results showed that the methanolic extract of Cichorium intybus caused a dose - dependent decrease in the cell viability of SKBR3 cells. Additionally, the treatment of confluent SKBR3 cells with extract led to reduced FASN expression at mRNA level. Conclusions: These results suggest that Chicorium intybus not only inhibits cell viability in a dose - dependent manner, but also presumably inhibits lipogenesis by markedly decreased FASN expression as a key lipogenic enzyme.
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Anti-Cancer Activity of Methanol Extracts of Cichorium intybus on Human Breast Cancer SKBR3 Cell Line
Razavi International Journal of Medicine, 2016Co-Authors: Reza Mehrandish, Ali Rahimipour, Ali Awsat Mellati, Nasrin Dehghan NayeriAbstract:Background Breast cancer is the most prevalent cancer and the second cause of death among women around the world. In many cancers, including breast cancer, Fatty acid synthase (FASN) gene expression is increased significantly. In breast cancer cell lines, expression of FASN is higher in HER2 positive cell line like SKBR3 than the others. FASN is the key enzyme for fatty acid synthesis de novo pathway and it is producing palmitate which is necessary for cell membrane formation. Cichorium intybus is a medicinal plant that effectively leads to inhibition of fatty acid synthase and thus reduces the percentage of survival of cancer cell lines. Objectives The aim of this study was to evaluate the effect of methanol extract of Chicorium intybus root on percentage of survival in SKBR3 cell line. Methods Human breast cancer SKBR3 cell line was cultured in DMEM medium. Methanol extract of Cichorium intybus root was extracted and different dilutions (200, 300, 400, 500 and 600µg/mL) were added to cell culture. Cell viability was quantitated by MTT assay after 24, 48 and 72 hours. Results Cichorium intybus could decrease cell viability. The effects of extract on cell viability were observed after 24, 48 and 72 hours on SKBR3 cell line and IC50 was 800, 400 and 300 after 24, 48 and 72 hours of treatment, respectively. Conclusions Our study shows that methanol extract of Cichorium intybus has cytotoxic effects on tumor cells. This is a pilot work for further evaluation in the future
Wang Jinhui - One of the best experts on this subject based on the ideXlab platform.
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Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats.
World journal of gastroenterology, 2014Co-Authors: Li Guoyu, Jian Huang, Hong-ying Gao, Wang JinhuiAbstract:Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats