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Tran Minh Ngoc - One of the best experts on this subject based on the ideXlab platform.
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xanthine oxidase inhibitory activity of constituents of Cinnamomum Cassia twigs
Bioorganic & Medicinal Chemistry Letters, 2012Co-Authors: Tran Minh Ngoc, Do Thi Ha, Nguyen Minh Khoi, Nguyen Xuan Nhiem, Hoang Van LuongAbstract:Abstract A methanol extract of the twigs of Cinnamomum Cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A–C ( 11–13 ), together with 10 known compounds ( 1 – 10 ). The structures of the three new compounds were determined by interpretation of spectroscopic data. Cinnamaldehyde derivatives 1 − 5 and 7 were significant inhibitors of xanthine oxidase, with IC 50 values ranging from 7.8 to 36.3 μg/mL. The results indicate that the acyl group of these cinnamaldehyde derivatives plays an important role in the inhibition of xanthine oxidase.
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2 methoxycinnamaldehyde from Cinnamomum Cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to ho 1 induction
Journal of Ethnopharmacology, 2012Co-Authors: Jeong Seok Hwa, Tran Minh Ngoc, Kihwan Bae, Yong Chun Jin, Young Soo Lee, Young Min Kim, Lian Yu Shi, Hye Jung Kim, Jae Heun Lee, Yeong Shik KimAbstract:Abstract Ethnopharmacological relevance Cinnamomum Cassia Blume has been used as a traditional Chinese herbal medicine for alleviation of fever, inflammation, chronic bronchitis, and to improve blood circulation. Aim of the study We addressed whether 2-methoxycinnamaldehyde (2-MCA), one of active ingredients of Cinnamomum Cassia , reduces vascular cell adhesion molecule-1 (VCAM-1) expression in tumor necrosis factor-alpha (TNF-α)-activated endothelial cells and protects ischemia/reperfusion (I/R)-injury due to heme oxygenase (HO)-1 induction. Materials and methods Adult male rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 24 h of reperfusion. Rats were randomized to receive vehicle or 2-MCA ( i.v. ) 10 min before reperfusion. Results Administration of 2-MCA significantly improved I/R-induced myocardial dysfunction by increasing the values of the first derivative (±d p /d t ) of left ventricular pressure and decreased infarct size. In addition, 2-MCA reduced the expression of high mobility group box 1 (HMGB1), an activator of the inflammatory cascade when released into the extracellular space, and VCAM-1 in I/R myocardium along with increase of HO-1 induction. The reduced injury was accompanied by significantly reduction of neutrophils infiltration and increased SOD activity in ischemic tissues and reduced serum level of cardiac troponin I (cTnI). Furthermore, 2-MCA significantly increased HO-1 induction by translocation of Nrf-2 from cytosol to nucleus in endothelial cells. Inhibition of VCAM-1 expression by 2-MCA was reversed both by SnPPIX, a HO-1 inhibitor and siHO-1 RNA trasfection in TNF-α-activated cells. In addition, 2-MCA significantly inhibited NF-κB luciferase activity in TNF-α-activated endothelial cells. As expected, 2-MCA significantly inhibited monocyte (U937) adhesion to endothelial cells. Conclusion We concluded that 2-MCA protects of myocardial I/R-injury due to antioxidant and anti-inflammatory action possibly by HO-1 induction which can be explained why Cinnamomum Cassia has been used in inflammatory disorders.
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platelet anti aggregation activities of compounds from Cinnamomum Cassia
Journal of Medicinal Food, 2010Co-Authors: Sun Young Kim, Tran Minh Ngoc, Kihwan Bae, Yean Kyoung Koo, Ja Yong Koo, Sam Sik Kang, Yeong Sik Kim, Hye Sook YunchoiAbstract:Abstract Cinnamomum Cassia is a well-known traditional medicine for improvement of blood circulation. An extract of this plant showed both platelet anti-aggregation and blood anti-coagulation effects in preliminary testing. Among the 13 compounds obtained from this plant, eugenol (2), amygdalactone (4), cinnamic alcohol (5), 2-hydroxycinnamaldehyde (7), 2-methoxycinnamaldehyde (8), and coniferaldehyde (9) showed 1.5–73-fold greater inhibitory effects than acetylsalicylic acid (ASA) on arachidonic acid (AA)-induced aggregation (50% inhibitory concentration [IC50] = 3.8, 5.16, 31.2, 40.0, 16.9, and 0.82 μM, respectively, vs. 60.3 μM) and 6.3–730-fold stronger effect than ASA on U46619 (a thromboxane A2 mimic)-induced aggregation (IC50 = 3.51, 33.9, 31.0, 51.3, 14.6, and 0.44 μM, respectively, vs. 321 μM). The other compounds, coumarin (3), cinnamaldehyde (6), cinnamic acid (10), icariside DC (11), and dihydrocinnacasside (12), also inhibited (2.5 to four times greater than ASA) U46619-induced aggregation. I...
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Tyrosinase-inhibitory constituents from the twigs of Cinnamomum Cassia.
Journal of natural products, 2009Co-Authors: Tran Minh Ngoc, Ik-soo Lee, Hongjin Kim, Byung-sun Min, Kihwan BaeAbstract:A methanol extract of the twigs of Cinnamomum Cassia was found to possess inhibitory activity against tyrosinase. Purification of the MeOH extract afforded four new phenolics, cassiferaldehyde (6), icariside DC (9), cinnacassinol (10), and dihydrocinnacasside (13), together with 10 known compounds (1−5, 7−12, and 14). The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 1−6 and 8−13 showed strong inhibitory activity against tyrosinase, with IC50 values ranging from 0.24 to 0.94 mM.
Kihwan Bae - One of the best experts on this subject based on the ideXlab platform.
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2 methoxycinnamaldehyde from Cinnamomum Cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to ho 1 induction
Journal of Ethnopharmacology, 2012Co-Authors: Jeong Seok Hwa, Tran Minh Ngoc, Kihwan Bae, Yong Chun Jin, Young Soo Lee, Young Min Kim, Lian Yu Shi, Hye Jung Kim, Jae Heun Lee, Yeong Shik KimAbstract:Abstract Ethnopharmacological relevance Cinnamomum Cassia Blume has been used as a traditional Chinese herbal medicine for alleviation of fever, inflammation, chronic bronchitis, and to improve blood circulation. Aim of the study We addressed whether 2-methoxycinnamaldehyde (2-MCA), one of active ingredients of Cinnamomum Cassia , reduces vascular cell adhesion molecule-1 (VCAM-1) expression in tumor necrosis factor-alpha (TNF-α)-activated endothelial cells and protects ischemia/reperfusion (I/R)-injury due to heme oxygenase (HO)-1 induction. Materials and methods Adult male rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 24 h of reperfusion. Rats were randomized to receive vehicle or 2-MCA ( i.v. ) 10 min before reperfusion. Results Administration of 2-MCA significantly improved I/R-induced myocardial dysfunction by increasing the values of the first derivative (±d p /d t ) of left ventricular pressure and decreased infarct size. In addition, 2-MCA reduced the expression of high mobility group box 1 (HMGB1), an activator of the inflammatory cascade when released into the extracellular space, and VCAM-1 in I/R myocardium along with increase of HO-1 induction. The reduced injury was accompanied by significantly reduction of neutrophils infiltration and increased SOD activity in ischemic tissues and reduced serum level of cardiac troponin I (cTnI). Furthermore, 2-MCA significantly increased HO-1 induction by translocation of Nrf-2 from cytosol to nucleus in endothelial cells. Inhibition of VCAM-1 expression by 2-MCA was reversed both by SnPPIX, a HO-1 inhibitor and siHO-1 RNA trasfection in TNF-α-activated cells. In addition, 2-MCA significantly inhibited NF-κB luciferase activity in TNF-α-activated endothelial cells. As expected, 2-MCA significantly inhibited monocyte (U937) adhesion to endothelial cells. Conclusion We concluded that 2-MCA protects of myocardial I/R-injury due to antioxidant and anti-inflammatory action possibly by HO-1 induction which can be explained why Cinnamomum Cassia has been used in inflammatory disorders.
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platelet anti aggregation activities of compounds from Cinnamomum Cassia
Journal of Medicinal Food, 2010Co-Authors: Sun Young Kim, Tran Minh Ngoc, Kihwan Bae, Yean Kyoung Koo, Ja Yong Koo, Sam Sik Kang, Yeong Sik Kim, Hye Sook YunchoiAbstract:Abstract Cinnamomum Cassia is a well-known traditional medicine for improvement of blood circulation. An extract of this plant showed both platelet anti-aggregation and blood anti-coagulation effects in preliminary testing. Among the 13 compounds obtained from this plant, eugenol (2), amygdalactone (4), cinnamic alcohol (5), 2-hydroxycinnamaldehyde (7), 2-methoxycinnamaldehyde (8), and coniferaldehyde (9) showed 1.5–73-fold greater inhibitory effects than acetylsalicylic acid (ASA) on arachidonic acid (AA)-induced aggregation (50% inhibitory concentration [IC50] = 3.8, 5.16, 31.2, 40.0, 16.9, and 0.82 μM, respectively, vs. 60.3 μM) and 6.3–730-fold stronger effect than ASA on U46619 (a thromboxane A2 mimic)-induced aggregation (IC50 = 3.51, 33.9, 31.0, 51.3, 14.6, and 0.44 μM, respectively, vs. 321 μM). The other compounds, coumarin (3), cinnamaldehyde (6), cinnamic acid (10), icariside DC (11), and dihydrocinnacasside (12), also inhibited (2.5 to four times greater than ASA) U46619-induced aggregation. I...
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Tyrosinase-inhibitory constituents from the twigs of Cinnamomum Cassia.
Journal of natural products, 2009Co-Authors: Tran Minh Ngoc, Ik-soo Lee, Hongjin Kim, Byung-sun Min, Kihwan BaeAbstract:A methanol extract of the twigs of Cinnamomum Cassia was found to possess inhibitory activity against tyrosinase. Purification of the MeOH extract afforded four new phenolics, cassiferaldehyde (6), icariside DC (9), cinnacassinol (10), and dihydrocinnacasside (13), together with 10 known compounds (1−5, 7−12, and 14). The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 1−6 and 8−13 showed strong inhibitory activity against tyrosinase, with IC50 values ranging from 0.24 to 0.94 mM.
Hoang Van Luong - One of the best experts on this subject based on the ideXlab platform.
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xanthine oxidase inhibitory activity of constituents of Cinnamomum Cassia twigs
Bioorganic & Medicinal Chemistry Letters, 2012Co-Authors: Tran Minh Ngoc, Do Thi Ha, Nguyen Minh Khoi, Nguyen Xuan Nhiem, Hoang Van LuongAbstract:Abstract A methanol extract of the twigs of Cinnamomum Cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A–C ( 11–13 ), together with 10 known compounds ( 1 – 10 ). The structures of the three new compounds were determined by interpretation of spectroscopic data. Cinnamaldehyde derivatives 1 − 5 and 7 were significant inhibitors of xanthine oxidase, with IC 50 values ranging from 7.8 to 36.3 μg/mL. The results indicate that the acyl group of these cinnamaldehyde derivatives plays an important role in the inhibition of xanthine oxidase.
Eckhard Neddermann - One of the best experts on this subject based on the ideXlab platform.
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Antidiabetic effect of Cinnamomum Cassia and Cinnamomum zeylanicum In vivo and In vitro
Phytotherapy research : PTR, 2005Co-Authors: Eugen J. Verspohl, Katrin Bauer, Eckhard NeddermannAbstract:Rats were given Cinnamomum Cassia bark or extracts from Cinnamomum Cassia and zeylanicum to evaluate blood glucose and plasma insulin levels in rats under various conditions. The Cassia extract was superior to the zeylanicum extract. The Cassia extract was slightly more efficacious than the equivalent amount of Cassia bark. A decrease in blood glucose levels was observed in a glucose tolerance test (GTT), whereas it was not obvious in rats that were not challenged by a glucose load. The elevation in plasma insulin was direct since a stimulatory in vitro effect of insulin release from INS-1 cells (an insulin secreting cell line) was observed. Thus the Cassia extract has a direct antidiabetic potency.
Cheng-hsiung Chang - One of the best experts on this subject based on the ideXlab platform.
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Antioxidant activity of Cinnamomum Cassia
Phytotherapy research : PTR, 2003Co-Authors: Chun-ching Lin, Cheng-hsiung ChangAbstract:The antioxidant activities of hot water extracts (HWECC) and ethanol extracts (EECC) from the dry bark of Cinnamomum Cassia Presl were evaluated in this study. Results showed that at 1.0 mg/mL, the ethanol extracts of C. Cassia (96.30%) exhibited a greater inhibition than the alpha-tocopherol (93.74%) on FeCl(2)-ascorbic acid induced lipid peroxidation of rat liver homogenate in vitro. From 0.05 to 1.0 mg/mL, the EECC demonstrated the highest superoxide anions scavenging activity and the strongest anti-superoxide formation activity (p < 0.05). The same extract also showed an excellent antioxidant activity in enzymatic and nonenzymatic liver tissue oxidative systems. EECC revealed the strongest antioxidant activity followed by alpha-tocopherol and HWECC. Compared to alpha-tocopherol, the IC(50) values of EECC were found to be lower in thiobarbituric acid test (IC(50) = 0.24 mg/mL vs 0.37 mg/mL), in cytochrome c test (IC(50) = 0.16 mg/mL vs 0.27 mg/mL) and in xanthine oxidase inhibition test (IC(50) = 0.09 mg/mL vs 0.19 mg/mL). The present study concludes that EECC could be used as a good source of antioxidant in the dietary supplement.