The Experts below are selected from a list of 38727 Experts worldwide ranked by ideXlab platform

Ming C Gong - One of the best experts on this subject based on the ideXlab platform.

  • time restricted feeding protects the blood pressure Circadian Rhythm in diabetic mice
    Proceedings of the National Academy of Sciences of the United States of America, 2021
    Co-Authors: Tianfei Hou, Marilyn J Duncan, Vsevolozhskaya A Olga, Zhenheng Guo, Ming C Gong
    Abstract:

    The quantity and quality of food intake have been considered crucial for peoples' wellness. Only recently has it become appreciated that the timing of food intake is also critical. Nondipping blood pressure (BP) is prevalent in diabetic patients and is associated with increased cardiovascular events. However, the causes and mechanisms of nondipping BP in diabetes are not fully understood. Here, we report that food intake and BP were arRhythmic in diabetic db/db mice fed a normal chow diet ad libitum. Imposing a food intake diurnal Rhythm by time-restricted feeding (TRF; food was only available for 8 h during the active phase) prevented db/db mice from developing nondipping BP and effectively restored the already disrupted BP Circadian Rhythm in db/db mice. Interestingly, increasing the time of food availability from 8 h to 12 h during the active dark phase in db/db mice prompted isocaloric feeding and still provided robust protection of the BP Circadian Rhythm in db/db mice. In contrast, neither 8-h nor 12-h TRF affected BP dipping in wild-type mice. Mechanistically, we demonstrate that TRF protects the BP Circadian Rhythm in db/db mice via suppressing the sympathetic activity during the light phase when they are inactive and fasting. Collectively, these data reveal a potentially pivotal role of the timing of food intake in the prevention and treatment of nondipping BP in diabetes.

  • smooth muscle bmal1 participates in blood pressure Circadian Rhythm regulation
    Journal of Clinical Investigation, 2015
    Co-Authors: Zhongwen Xie, Zhenheng Guo, Shu Liu, Guogang Zhao, Karyn A Esser, Elizabeth A Schroder, Mellani Lefta, Harald M Stauss, Ming C Gong
    Abstract:

    As the central pacemaker, the suprachiasmatic nucleus (SCN) has long been considered the primary regulator of blood pressure Circadian Rhythm; however, this dogma has been challenged by the discovery that each of the clock genes present in the SCN is also expressed and functions in peripheral tissues. The involvement and contribution of these peripheral clock genes in the Circadian Rhythm of blood pressure remains uncertain. Here, we demonstrate that selective deletion of the Circadian clock transcriptional activator aryl hydrocarbon receptor nuclear translocator–like (Bmal1) from smooth muscle, but not from cardiomyocytes, compromised blood pressure Circadian Rhythm and decreased blood pressure without affecting SCN-controlled locomotor activity in murine models. In mesenteric arteries, BMAL1 bound to the promoter of and activated the transcription of Rho-kinase 2 (Rock2), and Bmal1 deletion abolished the time-of-day variations in response to agonist-induced vasoconstriction, myosin phosphorylation, and ROCK2 activation. Together, these data indicate that peripheral inputs contribute to the daily control of vasoconstriction and blood pressure and suggest that clock gene expression outside of the SCN should be further evaluated to elucidate pathogenic mechanisms of diseases involving blood pressure Circadian Rhythm disruption.

  • hypertension and disrupted blood pressure Circadian Rhythm in type 2 diabetic db db mice
    American Journal of Physiology-heart and Circulatory Physiology, 2008
    Co-Authors: Zhenheng Guo, David C Randall, Lisa A Cassis, David R Brown, Ming C Gong
    Abstract:

    Human Type 2 diabetes is associated with increased incidence of hypertension and disrupted blood pressure (BP) Circadian Rhythm. Db/db mice have been used extensively as a model of Type 2 diabetes,...

Evalotte Morelius - One of the best experts on this subject based on the ideXlab platform.

Zhenheng Guo - One of the best experts on this subject based on the ideXlab platform.

  • time restricted feeding protects the blood pressure Circadian Rhythm in diabetic mice
    Proceedings of the National Academy of Sciences of the United States of America, 2021
    Co-Authors: Tianfei Hou, Marilyn J Duncan, Vsevolozhskaya A Olga, Zhenheng Guo, Ming C Gong
    Abstract:

    The quantity and quality of food intake have been considered crucial for peoples' wellness. Only recently has it become appreciated that the timing of food intake is also critical. Nondipping blood pressure (BP) is prevalent in diabetic patients and is associated with increased cardiovascular events. However, the causes and mechanisms of nondipping BP in diabetes are not fully understood. Here, we report that food intake and BP were arRhythmic in diabetic db/db mice fed a normal chow diet ad libitum. Imposing a food intake diurnal Rhythm by time-restricted feeding (TRF; food was only available for 8 h during the active phase) prevented db/db mice from developing nondipping BP and effectively restored the already disrupted BP Circadian Rhythm in db/db mice. Interestingly, increasing the time of food availability from 8 h to 12 h during the active dark phase in db/db mice prompted isocaloric feeding and still provided robust protection of the BP Circadian Rhythm in db/db mice. In contrast, neither 8-h nor 12-h TRF affected BP dipping in wild-type mice. Mechanistically, we demonstrate that TRF protects the BP Circadian Rhythm in db/db mice via suppressing the sympathetic activity during the light phase when they are inactive and fasting. Collectively, these data reveal a potentially pivotal role of the timing of food intake in the prevention and treatment of nondipping BP in diabetes.

  • smooth muscle bmal1 participates in blood pressure Circadian Rhythm regulation
    Journal of Clinical Investigation, 2015
    Co-Authors: Zhongwen Xie, Zhenheng Guo, Shu Liu, Guogang Zhao, Karyn A Esser, Elizabeth A Schroder, Mellani Lefta, Harald M Stauss, Ming C Gong
    Abstract:

    As the central pacemaker, the suprachiasmatic nucleus (SCN) has long been considered the primary regulator of blood pressure Circadian Rhythm; however, this dogma has been challenged by the discovery that each of the clock genes present in the SCN is also expressed and functions in peripheral tissues. The involvement and contribution of these peripheral clock genes in the Circadian Rhythm of blood pressure remains uncertain. Here, we demonstrate that selective deletion of the Circadian clock transcriptional activator aryl hydrocarbon receptor nuclear translocator–like (Bmal1) from smooth muscle, but not from cardiomyocytes, compromised blood pressure Circadian Rhythm and decreased blood pressure without affecting SCN-controlled locomotor activity in murine models. In mesenteric arteries, BMAL1 bound to the promoter of and activated the transcription of Rho-kinase 2 (Rock2), and Bmal1 deletion abolished the time-of-day variations in response to agonist-induced vasoconstriction, myosin phosphorylation, and ROCK2 activation. Together, these data indicate that peripheral inputs contribute to the daily control of vasoconstriction and blood pressure and suggest that clock gene expression outside of the SCN should be further evaluated to elucidate pathogenic mechanisms of diseases involving blood pressure Circadian Rhythm disruption.

  • hypertension and disrupted blood pressure Circadian Rhythm in type 2 diabetic db db mice
    American Journal of Physiology-heart and Circulatory Physiology, 2008
    Co-Authors: Zhenheng Guo, David C Randall, Lisa A Cassis, David R Brown, Ming C Gong
    Abstract:

    Human Type 2 diabetes is associated with increased incidence of hypertension and disrupted blood pressure (BP) Circadian Rhythm. Db/db mice have been used extensively as a model of Type 2 diabetes,...

Katrin Ivars - One of the best experts on this subject based on the ideXlab platform.

Genjiro Kimura - One of the best experts on this subject based on the ideXlab platform.