The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Krista A. Varady - One of the best experts on this subject based on the ideXlab platform.
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the effect of 4 h versus 6 h time Restricted Feeding on sleep quality duration insomnia severity and obstructive sleep apnea in adults with obesity
Nutrition and Health, 2021Co-Authors: Sofia Cienfuegos, Kelsey Gabel, Faiza Kalam, Mark Ezpeleta, Eric Wiseman, Shuhao Lin, Vicky Pavlou, Krista A. VaradyAbstract:Background:Time Restricted Feeding (TRF) involves deliberately restricting the times during which energy is ingested. Preliminary findings suggest that 8–10-h TRF improves sleep. However, the effec...
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Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Cell metabolism, 2020Co-Authors: Sofia Cienfuegos, Kelsey Gabel, Faiza Kalam, Mark Ezpeleta, Eric Wiseman, Vasiliki Pavlou, Shuhao Lin, Manoela Lima Oliveira, Krista A. VaradyAbstract:Summary Time-Restricted Feeding (TRF) regimens have grown in popularity; however, very few studies have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF (4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity were randomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between 1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4- and 6-h TRF produced comparable reductions in body weight (∼3%), insulin resistance, and oxidative stress, versus controls. Energy intake was reduced by ∼550 kcal/day in both TRF groups, without calorie counting. These findings suggest that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss. These diets may also improve some aspects of cardiometabolic health.
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effect of time Restricted Feeding on the gut microbiome in adults with obesity a pilot study
Nutrition and Health, 2020Co-Authors: Kelsey Gabel, Sofia Cienfuegos, Faiza Kalam, Mark Ezpeleta, Jarrad Marcell, Kate Cares, Krista A. VaradyAbstract:Background:Time Restricted Feeding is a form of intermittent fasting where participants shorten the daily window in which they eat.Aim:This is the first study to examine the effects of intermittent...
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Effect of 8-h time-Restricted Feeding on sleep quality and duration in adults with obesity.
Applied physiology nutrition and metabolism = Physiologie appliquee nutrition et metabolisme, 2019Co-Authors: Kelsey Gabel, Kristin K. Hoddy, Helen J. Burgess, Krista A. VaradyAbstract:This study examined the effects of time-Restricted Feeding (TRF; 8-h Feeding window/16-h fasting window daily) on sleep. Obese adults (n = 23) followed 8-h TRF for 12 weeks. Pittsburgh Sleep Quality Index (PSQI) total score was below 5 at week 1 (4.7 ± 0.5) and week 12 (4.8 ± 0.7), indicating good sleep quality throughout the trial. Subjective measures of wake time, bedtime, and sleep duration remained unchanged. Findings from this secondary analysis indicate that TRF does not alter sleep quality or duration in subjects with obesity. Novelty This study is the first to show that TRF (8-h Feeding window/16-h fasting window daily) does not alter sleep quality or duration in subjects with obesity.
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Safety of 8-h time Restricted Feeding in adults with obesity
Applied physiology nutrition and metabolism = Physiologie appliquee nutrition et metabolisme, 2018Co-Authors: Kelsey Gabel, Kristin K. Hoddy, Krista A. VaradyAbstract:This study examines the safety of time Restricted Feeding (TRF; 8-h Feeding window/16-h fasting window daily) in obese adults. Twenty-three subjects participated in an 8-h TRF intervention for 12 weeks. Self-reported adverse events, body image perception, complete blood count, and disordered eating patterns did not change from baseline to week 12. These findings suggest that consuming food within an 8-h window can safely facilitate weight loss in subjects with obesity.
Satchidananda Panda - One of the best experts on this subject based on the ideXlab platform.
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Time-Restricted Feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption.
Nature communications, 2019Co-Authors: Jesús E Villanueva, Satchidananda Panda, Christopher Livelo, Adriana S. Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Uri Manor, Girish C. MelkaniAbstract:Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of body mass. Behavioral intervention that can counteract obesity arising from genetic, diet or circadian disruption and can improve muscle function holds untapped potential to combat the obesity epidemic. Here we show that Drosophila melanogaster (fruit fly) subject to obesogenic challenges exhibits metabolic disease phenotypes in skeletal muscle; sarcomere disorganization, mitochondrial deformation, upregulation of Phospho-AKT level, aberrant intramuscular lipid infiltration, and insulin resistance. Imposing time-Restricted Feeding (TRF) paradigm in which flies were fed for 12 h during the day counteracts obesity-induced dysmetabolism and improves muscle performance by suppressing intramuscular fat deposits, Phospho-AKT level, mitochondrial aberrations, and markers of insulin resistance. Importantly, TRF was effective even in an irregular lighting schedule mimicking shiftwork. Hence, TRF is an effective dietary intervention for combating metabolic dysfunction arising from multiple causes.
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Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.
Obesity (Silver Spring Md.), 2019Co-Authors: Amy T. Hutchison, Satchidananda Panda, Gary A. Wittert, Prashant Regmi, Emily N. C. Manoogian, Jason G. Fleischer, Leonie K. HeilbronnAbstract:Objective This study aimed to assess the effects of 9-hour time-Restricted Feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes. Methods Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m2 ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd). Results TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions. Conclusions While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.
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Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
Cell metabolism, 2018Co-Authors: Amandine Chaix, Terry Lin, Max W. Chang, Satchidananda PandaAbstract:Summary Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the idea that a molecular clock is necessary for metabolic homeostasis. However, these mice often lack a normal Feeding-fasting cycle. We tested whether time-Restricted Feeding (TRF) could prevent obesity and metabolic syndrome in whole-body Cry1;Cry2 and in liver-specific Bmal1 and Rev-erbα/β knockout mice. When provided access to food ad libitum , these mice rapidly gained weight and showed genotype-specific metabolic defects. However, when fed the same diet under TRF (food access Restricted to 10 hr during the dark phase) they were protected from excessive weight gain and metabolic diseases. Transcriptome and metabolome analyses showed that TRF reduced the accumulation of hepatic lipids and enhanced cellular defenses against metabolic stress. These results suggest that the circadian clock maintains metabolic homeostasis by sustaining daily rhythms in Feeding and fasting and by maintaining balance between nutrient and cellular stress responses.
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effects of 8 hour time Restricted Feeding on body weight and metabolic disease risk factors in obese adults a pilot study
Nutrition and Healthy Aging, 2018Co-Authors: Kelsey Gabel, Kristin K. Hoddy, Nicole Haggerty, Jeehee Song, Cynthia M Kroeger, John F Trepanowski, Satchidananda Panda, Krista A. VaradyAbstract:BACKGROUND Time Restricted Feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined. OBJECTIVE This study investigated the effects of 8-h time Restricted Feeding on body weight and metabolic disease risk factors in obese adults. DESIGN Obese subjects (n = 23) participated in an 8-h time Restricted Feeding intervention (ad libitum Feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Weight loss and other outcomes were compared to a matched historical control group (n = 23). RESULTS Body weight and energy intake decreased in the time Restricted group (-2.6% ± 0.5; -341 ± 53 kcal/d) relative to controls over 12 weeks (P < 0.05). Systolic blood pressure decreased in the time Restricted Feeding group (-7 ± 2 mm Hg) versus controls (P < 0.05). Fat mass, lean mass, visceral fat mass, diastolic blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, fasting insulin, HOMA-IR, and homocysteine were not significantly different from controls after 12 weeks (no group×time interaction). CONCLUSION These findings suggest that 8-h time Restricted Feeding produces mild caloric restriction and weight loss, without calorie counting. It may also offer clinical benefits by reducing blood pressure.
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time Restricted Feeding for prevention and treatment of cardiometabolic disorders
The Journal of Physiology, 2017Co-Authors: Girish C. Melkani, Satchidananda PandaAbstract:The soaring prevalence of obesity and diabetes is associated with an increase in comorbidities, including elevated risk for cardiovascular diseases (CVDs). CVDs continue to be among the leading causes of death and disability in the United States. While increased nutritional intake from an energy-dense diet is known to disrupt metabolic homeostasis and contributes to the disease risk, circadian rhythm disruption is emerging as a new risk factor for CVD. Circadian rhythms coordinate cardiovascular health via temporal control of organismal metabolism and physiology. Thus, interventions that improve circadian rhythms are prospective entry points to mitigate cardiometabolic disease risk. Although light is a strong modulator of the neural circadian clock, time of food intake is emerging as a dominant agent that affects circadian clocks in metabolic organs. We discovered that imposing a time-Restricted Feeding (TRF) regimen in which all caloric intakes occur consistently within ≤ 12 h every day exerts many cardiometabolic benefits. TRF prevents excessive body weight gain, improves sleep, and attenuates age- and diet-induced deterioration in cardiac performance. Using an integrative approach that combines Drosophila melanogaster (fruit fly) genetics with transcriptome analyses it was found that the beneficial effects of TRF are mediated by circadian clock, ATP-dependent TCP/TRiC/CCT chaperonin and mitochondrial electron transport chain components. Parallel studies in rodents have shown TRF reduces metabolic disease risks by maintaining metabolic homeostasis. As modern humans continue to live under extended periods of wakefulness and ingestion events, daily eating pattern offers a new potential target for lifestyle intervention to reduce CVD risk.
F A S Silva - One of the best experts on this subject based on the ideXlab platform.
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effect of Restricted Feeding strategies on blood concentrations of hormones metabolites and minerals in holstein zebu finishing steers
Ciência Animal Brasileira, 2020Co-Authors: F A S Silva, Sebastiao De Campos Valadares Filho, Luciana Navajas Renno, Nathalia Veloso Tropia, Caio William Magalhaes Souza, H M Alhadas, Erica Garcia Mafort, T L FelixAbstract:The objectives were to determine the effects of Restricted-Feeding strategies on blood concentrations of hormones, metabolites, and minerals in Holstein × Zebu finishing steers. Twenty steers (body weight = 319 ± 16.2 kg; age = 19 ± 1 months) were randomly allotted in 4 groups of 5 steers, which were Restricted to 85% ad libitum feed intake for either 0 (R0; n = 5), 28 (R28; n = 5), 42 (R42; n = 5) or 84 (R84; n = 5) days of an 84-d finishing period. Steers were individually housed and considered the experimental unit. Blood samples were collected on d 0, 21, 42, 63, and 84, and were assayed for insulin-like growth factor 1 (IGF-1), thyroid hormones (T3 and T4), albumin, creatinine, urea, total protein, glucose, triglycerides, calcium, and phosphorus. Steers had increasing IGF-1 concentrations until d 42 when Restricted-fed. Steers fed R84 had the greatest IGF-1 concentrations on d 84. Urea concentrations were greatest in steers fed R0 and least in steers fed R28; steers fed R42 and R84 were intermediate and not different from one another. Concentrations of IGF-1, urea, albumin, and calcium, but not T3, T4, glucose, triglycerides, creatinine, total protein, and phosphorus were affected by Restricted-Feeding strategies in Holstein × Zebu finishing steers.Keywords: Crossbred Cattle; Mineral Balance; Restricted Intake
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effect of duration of Restricted Feeding on nutrient excretion animal performance and carcass characteristics of holstein zebu finishing steers
Animal Production Science, 2020Co-Authors: F A S Silva, S Valadares C Filho, L A Godoi, B C Silva, M V C Pacheco, D Zanetti, Pedro D B Benedeti, F F Silva, T L FelixAbstract:Restricted-Feeding may be a useful management tool available to reduce environmental impact in feedlots. Therefore, the objectives of the present study were to determine the effects of the duration of Restricted-Feeding on nitrogen (N) and phosphorus (P) excretion, growth performance and carcass characteristics of finishing steers. Twenty-five Holstein × Zebu steers (average initial bodyweight (BW) = 319 ± 16.2 kg; age = 19 ± 1 months) were used. Five steers were slaughtered to provide baseline empty BW (EBW) and empty body composition at Day 0. The remaining steers were randomly allotted to four groups of five steers, which were Restricted to 85% ad libitum feed intake for either 0 (R0), 28 (R28), 42 (R42) or 84 (R84) days of an 84-day finishing period. All steers were fed a diet of 40% corn silage and 60% concentrate (DM basis) for 84 days. Total excretion of faeces and urine were collected during two periods: Days 25 to 27 (period 1) and Days 73 to 75 (period 2). The DM intake, average daily gain (ADG) and gain-to-feed ratio (G : F) were evaluated in three blocks, Days 0 to 28, Days 28 to 42 and Days 42 to 84. As expected, DM, N and P intakes were greater (P 0.05) DM, N and P intakes compared with R0 steers. Faecal N and urinary P excretions did not differ (P ≥ 0.40) among Restricted and ad libitum-fed steers in either period evaluated. However, greater (P 0.05). Final BW, overall ADG, G : F and carcass characteristics were not affected (P ≥ 0.11) by treatments. Restricted-Feeding Holstein × Zebu steers to 85% of ad libitum intake for 84 days in the feedlot reduced DM intake and P excretion, without impairing steer growth performance or carcass characteristics. Nevertheless, it is important to highlight that the small sample size was one limitation of this present experiment.
Courtney M. Peterson - One of the best experts on this subject based on the ideXlab platform.
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Early Time-Restricted Feeding Reduces Appetite and Increases Fat Oxidation But Does Not Affect Energy Expenditure in Humans.
Obesity (Silver Spring Md.), 2019Co-Authors: Eric Ravussin, Robbie A Beyl, Eleonora Poggiogalle, Daniel S. Hsia, Courtney M. PetersonAbstract:Objective Eating earlier in the daytime to align with circadian rhythms in metabolism enhances weight loss. However, it is unknown whether these benefits are mediated through increased energy expenditure or decreased food intake. Therefore, this study performed the first randomized trial to determine how meal timing affects 24-hour energy metabolism when food intake and meal frequency are matched. Methods Eleven adults with overweight practiced both early time-Restricted Feeding (eTRF) (eating from 8 am to 2 pm) and a control schedule (eating from 8 am to 8 pm) for 4 days each. On the fourth day, 24-hour energy expenditure and substrate oxidation were measured by whole-room indirect calorimetry, in conjunction with appetite and metabolic hormones. Results eTRF did not affect 24-hour energy expenditure (Δ = 10 ± 16 kcal/d; P = 0.55). Despite the longer daily fast (intermittent fasting), eTRF decreased mean ghrelin levels by 32 ± 10 pg/mL (P = 0.006), made hunger more even-keeled (P = 0.006), and tended to increase fullness (P = 0.06-0.10) and decrease the desire to eat (P = 0.08). eTRF also increased metabolic flexibility (P = 0.0006) and decreased the 24-hour nonprotein respiratory quotient (Δ = -0.021 ± 0.010; P = 0.05). Conclusions Meal-timing interventions facilitate weight loss primarily by decreasing appetite rather than by increasing energy expenditure. eTRF may also increase fat loss by increasing fat oxidation.
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early time Restricted Feeding improves insulin sensitivity blood pressure and oxidative stress even without weight loss in men with prediabetes
Cell Metabolism, 2018Co-Authors: Elizabeth F Sutton, Courtney M. Peterson, Robbie A Beyl, Kate S Early, William T Cefalu, Eric RavussinAbstract:Summary Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled Feeding trial to test whether IF has benefits independent of weight loss by Feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of early time-Restricted Feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism. Men with prediabetes were randomized to eTRF (6-hr Feeding period, with dinner before 3 p.m.) or a control schedule (12-hr Feeding period) for 5 weeks and later crossed over to the other schedule. eTRF improved insulin sensitivity, β cell responsiveness, blood pressure, oxidative stress, and appetite. We demonstrate for the first time in humans that eTRF improves some aspects of cardiometabolic health and that IF's effects are not solely due to weight loss.
T L Felix - One of the best experts on this subject based on the ideXlab platform.
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effect of Restricted Feeding strategies on blood concentrations of hormones metabolites and minerals in holstein zebu finishing steers
Ciência Animal Brasileira, 2020Co-Authors: F A S Silva, Sebastiao De Campos Valadares Filho, Luciana Navajas Renno, Nathalia Veloso Tropia, Caio William Magalhaes Souza, H M Alhadas, Erica Garcia Mafort, T L FelixAbstract:The objectives were to determine the effects of Restricted-Feeding strategies on blood concentrations of hormones, metabolites, and minerals in Holstein × Zebu finishing steers. Twenty steers (body weight = 319 ± 16.2 kg; age = 19 ± 1 months) were randomly allotted in 4 groups of 5 steers, which were Restricted to 85% ad libitum feed intake for either 0 (R0; n = 5), 28 (R28; n = 5), 42 (R42; n = 5) or 84 (R84; n = 5) days of an 84-d finishing period. Steers were individually housed and considered the experimental unit. Blood samples were collected on d 0, 21, 42, 63, and 84, and were assayed for insulin-like growth factor 1 (IGF-1), thyroid hormones (T3 and T4), albumin, creatinine, urea, total protein, glucose, triglycerides, calcium, and phosphorus. Steers had increasing IGF-1 concentrations until d 42 when Restricted-fed. Steers fed R84 had the greatest IGF-1 concentrations on d 84. Urea concentrations were greatest in steers fed R0 and least in steers fed R28; steers fed R42 and R84 were intermediate and not different from one another. Concentrations of IGF-1, urea, albumin, and calcium, but not T3, T4, glucose, triglycerides, creatinine, total protein, and phosphorus were affected by Restricted-Feeding strategies in Holstein × Zebu finishing steers.Keywords: Crossbred Cattle; Mineral Balance; Restricted Intake
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effect of duration of Restricted Feeding on nutrient excretion animal performance and carcass characteristics of holstein zebu finishing steers
Animal Production Science, 2020Co-Authors: F A S Silva, S Valadares C Filho, L A Godoi, B C Silva, M V C Pacheco, D Zanetti, Pedro D B Benedeti, F F Silva, T L FelixAbstract:Restricted-Feeding may be a useful management tool available to reduce environmental impact in feedlots. Therefore, the objectives of the present study were to determine the effects of the duration of Restricted-Feeding on nitrogen (N) and phosphorus (P) excretion, growth performance and carcass characteristics of finishing steers. Twenty-five Holstein × Zebu steers (average initial bodyweight (BW) = 319 ± 16.2 kg; age = 19 ± 1 months) were used. Five steers were slaughtered to provide baseline empty BW (EBW) and empty body composition at Day 0. The remaining steers were randomly allotted to four groups of five steers, which were Restricted to 85% ad libitum feed intake for either 0 (R0), 28 (R28), 42 (R42) or 84 (R84) days of an 84-day finishing period. All steers were fed a diet of 40% corn silage and 60% concentrate (DM basis) for 84 days. Total excretion of faeces and urine were collected during two periods: Days 25 to 27 (period 1) and Days 73 to 75 (period 2). The DM intake, average daily gain (ADG) and gain-to-feed ratio (G : F) were evaluated in three blocks, Days 0 to 28, Days 28 to 42 and Days 42 to 84. As expected, DM, N and P intakes were greater (P 0.05) DM, N and P intakes compared with R0 steers. Faecal N and urinary P excretions did not differ (P ≥ 0.40) among Restricted and ad libitum-fed steers in either period evaluated. However, greater (P 0.05). Final BW, overall ADG, G : F and carcass characteristics were not affected (P ≥ 0.11) by treatments. Restricted-Feeding Holstein × Zebu steers to 85% of ad libitum intake for 84 days in the feedlot reduced DM intake and P excretion, without impairing steer growth performance or carcass characteristics. Nevertheless, it is important to highlight that the small sample size was one limitation of this present experiment.
