The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform
Raja R. Seethala - One of the best experts on this subject based on the ideXlab platform.
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Clear Cell odontogenic carcinomas show ewsr1 rearrangements a novel finding and a biological link to salivary Clear Cell carcinomas
The American Journal of Surgical Pathology, 2013Co-Authors: Elizabeth A. Bilodeau, Ilan Weinreb, Cristina R Antonescu, Lei Zhang, Sanja Dacic, Susan Muller, Bruce Barker, Raja R. SeethalaAbstract:Clear Cell odontogenic carcinomas (CCOCs) are a rare tumor of the jaws, which have considerable morphologic and immunophenotypic overlap with (hyalinizing) Clear Cell carcinomas (CCCs) of salivary origin. Fluorescence in situ hybridization for EWSR1 was performed on 12 CCOCs, 14 CCCs, and a control
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Clear Cell Carcinoma and Clear Cell Odontogenic Carcinoma: a Comparative Clinicopathologic and Immunohistochemical Study
Head and Neck Pathology, 2011Co-Authors: Elizabeth A. Bilodeau, Aaron P. Hoschar, E. Leon Barnes, Jennifer L. Hunt, Raja R. SeethalaAbstract:Clear Cell carcinoma or hyalinizing Clear Cell carcinoma (CCC) and Clear Cell odontogenic carcinoma (CCOC) are rare, low-grade and typically indolent malignancies that can be diagnostically challenging. In this study the clinicopathologic, histologic, and immunohistochemical features of 17 CCCs and 12 CCOCs are examined. The differential diagnosis of Clear Cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other Clear Cell tumors on the basis of their immunohistochemical staining patterns is postulated.
Pedram Argani - One of the best experts on this subject based on the ideXlab platform.
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renal Cell carcinoma with Clear Cell and papillary features
Archives of Pathology & Laboratory Medicine, 2012Co-Authors: Hillary M Ross, Guido Martignoni, Pedram ArganiAbstract:Context.—The diagnosis of primary renal Cell carcinomas (RCCs) with both papillary architecture and Cells with Clear cytoplasm can be diagnostically challenging for practicing pathologists. The 4 main neoplasms in the differential diagnosis are Clear Cell RCC, papillary RCC, Clear Cell papillary RCC, and Xp11 translocation RCC. Accurate diagnosis has both prognostic and therapeutic implications. Objective.—To highlight the helpful cytomorphologic, immunohistochemical, and cytogenetic features of each of these entities to enable reproducible classification. Data Sources.—Published peer-reviewed literature was reviewed, accompanied by the authors' personal experiences. Conclusions.—Key morphologic clues and a focused immunohistochemical panel, including CK7, α-methylacyl coenzyme A racemase (AMACR), TFE3, cathepsin K, and carbonic anhydrase IX (CAIX), now allow most resected RCCs with papillary architecture and Clear Cells to be accurately classified. In other cases, cytogenetic and molecular findings can e...
Elizabeth A. Bilodeau - One of the best experts on this subject based on the ideXlab platform.
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Clear Cell odontogenic carcinomas show ewsr1 rearrangements a novel finding and a biological link to salivary Clear Cell carcinomas
The American Journal of Surgical Pathology, 2013Co-Authors: Elizabeth A. Bilodeau, Ilan Weinreb, Cristina R Antonescu, Lei Zhang, Sanja Dacic, Susan Muller, Bruce Barker, Raja R. SeethalaAbstract:Clear Cell odontogenic carcinomas (CCOCs) are a rare tumor of the jaws, which have considerable morphologic and immunophenotypic overlap with (hyalinizing) Clear Cell carcinomas (CCCs) of salivary origin. Fluorescence in situ hybridization for EWSR1 was performed on 12 CCOCs, 14 CCCs, and a control
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Clear Cell Carcinoma and Clear Cell Odontogenic Carcinoma: a Comparative Clinicopathologic and Immunohistochemical Study
Head and Neck Pathology, 2011Co-Authors: Elizabeth A. Bilodeau, Aaron P. Hoschar, E. Leon Barnes, Jennifer L. Hunt, Raja R. SeethalaAbstract:Clear Cell carcinoma or hyalinizing Clear Cell carcinoma (CCC) and Clear Cell odontogenic carcinoma (CCOC) are rare, low-grade and typically indolent malignancies that can be diagnostically challenging. In this study the clinicopathologic, histologic, and immunohistochemical features of 17 CCCs and 12 CCOCs are examined. The differential diagnosis of Clear Cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other Clear Cell tumors on the basis of their immunohistochemical staining patterns is postulated.
Ilan Weinreb - One of the best experts on this subject based on the ideXlab platform.
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hyalinizing Clear Cell carcinoma of salivary gland a review and update
Head and Neck Pathology, 2013Co-Authors: Ilan WeinrebAbstract:Hyalinizing Clear Cell carcinoma (HCCC) is a rare minor salivary gland tumor made up of Clear Cells and forming cords and nests in a hyalinized stroma. The overall outcome is exCellent with only occasional metastatic spread. HCCC has a wide differential diagnosis including other Clear Cell-containing tumors, such as epithelial-myoepithelial carcinoma, mucoepidermoid carcinoma, and myoepithelial carcinoma. HCCC is currently classified as a “Clear Cell adenocarcinoma” by the AFIP and as “Clear Cell carcinoma, not otherwise specified (NOS)” by the World Health Organization (WHO). It is considered by the WHO to be a diagnosis of exclusion. Since the original description in 1994, there have been few new insights into HCCC, until recently. Dardick re-examined the features of HCCC, including the original electron microscopic images, and concluded that HCCC is a squamous lesion, at odds with the above nomenclature. Bilodeau et al. recently showed that this tumor essentially cannot be separated reliably from Clear Cell odontogenic carcinoma (CCOC) except by location. Antonescu et al. recently identified a consistent EWSR1-ATF1 fusion in HCCC. Bilodeau et al. subsequently argued a link between these two entities, with evidence of similar EWSR1 and ATF1 rearrangements in CCOC. This molecular signature is not present in other Clear Cell mimics. Cases with recurrence, metastasis, high-grade features and other alternative morphologies or presentations have also been seen and proven by molecular analysis to be HCCC. In the molecular era, HCCC can no longer be seen as a diagnosis of exclusion. It is neither an adenocarcinoma nor a “not otherwise specified” tumor, as the AFIP and WHO currently classify it. This review provides an in-depth look at the current state of knowledge of HCCC from morphology to molecular features. New developments and personal insights are provided that help identify and properly classify this lesion.
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Clear Cell odontogenic carcinomas show ewsr1 rearrangements a novel finding and a biological link to salivary Clear Cell carcinomas
The American Journal of Surgical Pathology, 2013Co-Authors: Elizabeth A. Bilodeau, Ilan Weinreb, Cristina R Antonescu, Lei Zhang, Sanja Dacic, Susan Muller, Bruce Barker, Raja R. SeethalaAbstract:Clear Cell odontogenic carcinomas (CCOCs) are a rare tumor of the jaws, which have considerable morphologic and immunophenotypic overlap with (hyalinizing) Clear Cell carcinomas (CCCs) of salivary origin. Fluorescence in situ hybridization for EWSR1 was performed on 12 CCOCs, 14 CCCs, and a control
Hillary M Ross - One of the best experts on this subject based on the ideXlab platform.
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renal Cell carcinoma with Clear Cell and papillary features
Archives of Pathology & Laboratory Medicine, 2012Co-Authors: Hillary M Ross, Guido Martignoni, Pedram ArganiAbstract:Context.—The diagnosis of primary renal Cell carcinomas (RCCs) with both papillary architecture and Cells with Clear cytoplasm can be diagnostically challenging for practicing pathologists. The 4 main neoplasms in the differential diagnosis are Clear Cell RCC, papillary RCC, Clear Cell papillary RCC, and Xp11 translocation RCC. Accurate diagnosis has both prognostic and therapeutic implications. Objective.—To highlight the helpful cytomorphologic, immunohistochemical, and cytogenetic features of each of these entities to enable reproducible classification. Data Sources.—Published peer-reviewed literature was reviewed, accompanied by the authors' personal experiences. Conclusions.—Key morphologic clues and a focused immunohistochemical panel, including CK7, α-methylacyl coenzyme A racemase (AMACR), TFE3, cathepsin K, and carbonic anhydrase IX (CAIX), now allow most resected RCCs with papillary architecture and Clear Cells to be accurately classified. In other cases, cytogenetic and molecular findings can e...