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Nazirah Hasnan - One of the best experts on this subject based on the ideXlab platform.

  • electrical stimulation evoked contractions blunt orthostatic hypotension in sub acute spinal cord injured individuals two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies

  • Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Study design: Prospective study of two Cases. Objectives: To describe the effects of electrical stimulation (ES) therapy in the 4-week management of two sub-acute spinal cord-injured (SCI) individuals (C7 American Spinal Injury Association Impairment Scale (AIS) B and T9 AIS (B)). Setting: University Malaya Medical Centre, Kuala Lumpur, Malaysia. Methods: A diagnostic tilt-table test was conducted to confirm the presence of orthostatic hypotension (OH) based on the current Clinical definitions. Following initial assessment, subjects underwent 4 weeks of ES therapy 4 times weekly for 1 h per day. Post-tests tilt table challenge, both with and without ES on their rectus abdominis, quadriceps, hamstrings and gastrocnemius muscles, was conducted at the end of the study (week 5). Subjects’ blood pressures (BP) and heart rates (HR) were recorded every minute during pre-test and post-tests. Orthostatic symptoms, as well as the maximum tolerance time that the subjects could withstand head up tilt at 60°, were recorded. Results: Subject A improved his orthostatic symptoms, but did not recover from Clinically defined OH based on the 20-min duration requirement. With concurrent ES therapy, 60° head up tilt BP was 89/62 mm Hg compared with baseline BP of 115/71 mm Hg. Subject B fully recovered from OH demonstrated by BP of 105/71 mm Hg during the 60° head up tilt compared with baseline BP of 124/77 mm Hg. Both patients demonstrated longer tolerance time during head up tilt with concomitant ES (subject A: pre-test 4 min, post-test without ES 6 min, post-test with ES 12 min; subject B: pre-test 4 min, post-test without ES 28 min, post-test with ES 60 min). Conclusions: Weekly ES therapy had positive effect on OH management in sub-acute SCI individuals.

Glen M Davis - One of the best experts on this subject based on the ideXlab platform.

  • electrical stimulation evoked contractions blunt orthostatic hypotension in sub acute spinal cord injured individuals two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies

  • Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Study design: Prospective study of two Cases. Objectives: To describe the effects of electrical stimulation (ES) therapy in the 4-week management of two sub-acute spinal cord-injured (SCI) individuals (C7 American Spinal Injury Association Impairment Scale (AIS) B and T9 AIS (B)). Setting: University Malaya Medical Centre, Kuala Lumpur, Malaysia. Methods: A diagnostic tilt-table test was conducted to confirm the presence of orthostatic hypotension (OH) based on the current Clinical definitions. Following initial assessment, subjects underwent 4 weeks of ES therapy 4 times weekly for 1 h per day. Post-tests tilt table challenge, both with and without ES on their rectus abdominis, quadriceps, hamstrings and gastrocnemius muscles, was conducted at the end of the study (week 5). Subjects’ blood pressures (BP) and heart rates (HR) were recorded every minute during pre-test and post-tests. Orthostatic symptoms, as well as the maximum tolerance time that the subjects could withstand head up tilt at 60°, were recorded. Results: Subject A improved his orthostatic symptoms, but did not recover from Clinically defined OH based on the 20-min duration requirement. With concurrent ES therapy, 60° head up tilt BP was 89/62 mm Hg compared with baseline BP of 115/71 mm Hg. Subject B fully recovered from OH demonstrated by BP of 105/71 mm Hg during the 60° head up tilt compared with baseline BP of 124/77 mm Hg. Both patients demonstrated longer tolerance time during head up tilt with concomitant ES (subject A: pre-test 4 min, post-test without ES 6 min, post-test with ES 12 min; subject B: pre-test 4 min, post-test without ES 28 min, post-test with ES 60 min). Conclusions: Weekly ES therapy had positive effect on OH management in sub-acute SCI individuals.

Nur Azah Hamzaid - One of the best experts on this subject based on the ideXlab platform.

  • electrical stimulation evoked contractions blunt orthostatic hypotension in sub acute spinal cord injured individuals two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies

  • Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Study design: Prospective study of two Cases. Objectives: To describe the effects of electrical stimulation (ES) therapy in the 4-week management of two sub-acute spinal cord-injured (SCI) individuals (C7 American Spinal Injury Association Impairment Scale (AIS) B and T9 AIS (B)). Setting: University Malaya Medical Centre, Kuala Lumpur, Malaysia. Methods: A diagnostic tilt-table test was conducted to confirm the presence of orthostatic hypotension (OH) based on the current Clinical definitions. Following initial assessment, subjects underwent 4 weeks of ES therapy 4 times weekly for 1 h per day. Post-tests tilt table challenge, both with and without ES on their rectus abdominis, quadriceps, hamstrings and gastrocnemius muscles, was conducted at the end of the study (week 5). Subjects’ blood pressures (BP) and heart rates (HR) were recorded every minute during pre-test and post-tests. Orthostatic symptoms, as well as the maximum tolerance time that the subjects could withstand head up tilt at 60°, were recorded. Results: Subject A improved his orthostatic symptoms, but did not recover from Clinically defined OH based on the 20-min duration requirement. With concurrent ES therapy, 60° head up tilt BP was 89/62 mm Hg compared with baseline BP of 115/71 mm Hg. Subject B fully recovered from OH demonstrated by BP of 105/71 mm Hg during the 60° head up tilt compared with baseline BP of 124/77 mm Hg. Both patients demonstrated longer tolerance time during head up tilt with concomitant ES (subject A: pre-test 4 min, post-test without ES 6 min, post-test with ES 12 min; subject B: pre-test 4 min, post-test without ES 28 min, post-test with ES 60 min). Conclusions: Weekly ES therapy had positive effect on OH management in sub-acute SCI individuals.

Mark Watson - One of the best experts on this subject based on the ideXlab platform.

  • pharmacogenomic data submissions to the fda Clinical Case Studies
    Pharmacogenomics, 2004
    Co-Authors: William L Trepicchio, Grant A Williams, David Essayan, Susan T Hall, Lea Harty, Peter Shaw, Brian B Spear, Sue Jane Wang, Mark Watson
    Abstract:

    William L Trepicchio†1, Grant A Williams2, David Essayan3, Sue T Hall4, Lea C Harty5, Peter M Shaw6, Brian B Spear7, Sue Jane Wang8 & Mark L Watson9 †Author for correspondence 1Director, Clinical Research and Pharmacogenomics, Millennium Pharmaceuticals, 40 Landsdowne Street Cambridge, MA 02139, USA E-mail: wtrepicchio @mpi.com 2Deputy Director, Division of Oncology Drug Products, Medical Officer, CDER, FDA, USA 3Director, Regulatory Affairs, Amgen, USA 4Director, US Regulatory Affairs, GlaxoSmithKline, USA 5Associate Director, Clinical Pharmacogenomics, Pfizer, USA 6Director, Pharmacogenomics and Human Genetics, Bristol-Myers Squibb, USA 7Director, Pharmacogenomics, Abbott Laboratories, USA 8Lead Senior Mathematical Statistician – FDA Inter-Center Pharmacogenomics/ Pharmacogenetics Initiative, USA 9Director, Pharmacogenomics, GlaxoSmithKline, USA

Anwar Suhaimi - One of the best experts on this subject based on the ideXlab platform.

  • electrical stimulation evoked contractions blunt orthostatic hypotension in sub acute spinal cord injured individuals two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies

  • Electrical stimulation-evoked contractions blunt orthostatic hypotension in sub-acute spinal cord-injured individuals: two Clinical Case Studies
    Spinal Cord, 2015
    Co-Authors: Nur Azah Hamzaid, L T Tean, Glen M Davis, Anwar Suhaimi, Nazirah Hasnan
    Abstract:

    Study design: Prospective study of two Cases. Objectives: To describe the effects of electrical stimulation (ES) therapy in the 4-week management of two sub-acute spinal cord-injured (SCI) individuals (C7 American Spinal Injury Association Impairment Scale (AIS) B and T9 AIS (B)). Setting: University Malaya Medical Centre, Kuala Lumpur, Malaysia. Methods: A diagnostic tilt-table test was conducted to confirm the presence of orthostatic hypotension (OH) based on the current Clinical definitions. Following initial assessment, subjects underwent 4 weeks of ES therapy 4 times weekly for 1 h per day. Post-tests tilt table challenge, both with and without ES on their rectus abdominis, quadriceps, hamstrings and gastrocnemius muscles, was conducted at the end of the study (week 5). Subjects’ blood pressures (BP) and heart rates (HR) were recorded every minute during pre-test and post-tests. Orthostatic symptoms, as well as the maximum tolerance time that the subjects could withstand head up tilt at 60°, were recorded. Results: Subject A improved his orthostatic symptoms, but did not recover from Clinically defined OH based on the 20-min duration requirement. With concurrent ES therapy, 60° head up tilt BP was 89/62 mm Hg compared with baseline BP of 115/71 mm Hg. Subject B fully recovered from OH demonstrated by BP of 105/71 mm Hg during the 60° head up tilt compared with baseline BP of 124/77 mm Hg. Both patients demonstrated longer tolerance time during head up tilt with concomitant ES (subject A: pre-test 4 min, post-test without ES 6 min, post-test with ES 12 min; subject B: pre-test 4 min, post-test without ES 28 min, post-test with ES 60 min). Conclusions: Weekly ES therapy had positive effect on OH management in sub-acute SCI individuals.