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Bruce W Hollis - One of the best experts on this subject based on the ideXlab platform.

  • assessment and interpretation of circulating 25 hydroxyvitamin d and 1 25 dihydroxyvitamin d in the Clinical Environment
    Rheumatic Diseases Clinics of North America, 2012
    Co-Authors: Bruce W Hollis
    Abstract:

    The assessment of circulating 25(OH)D and, to a lesser degree, 1,25(OH)2D is rapidly becoming an important Clinical tool in the diagnosis and management of many diverse pathologies. At present, the reference ranges for circulating 25(OH)D and 1,25(OH)2D are 32 to 100 ng/mL and 16 to 56 ng/mL, respectively, and are largely based on Clinical data derived from the FDA-cleared DiaSorin assay procedures.

  • Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the Clinical Environment.
    Endocrinology and metabolism clinics of North America, 2010
    Co-Authors: Bruce W Hollis
    Abstract:

    The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation, ultraviolet (UV) light-induced conformational changes, heat-induced conformational changes, and attacks by free radicals. Vitamin D(2) is much less bioactive than vitamin D(3) in humans. Metabolic activation and inactivation of vitamin D are well characterized and result in a plethora of metabolites, of which only 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) provide any Clinically relevant information. 25(OH)D(2) and 25(OH)D(3) are commonly known as calcifediol and the 1,25(OH)(2)D metabolites as calcitriol. In this review the current state of the science on the Clinical assessment of circulating 25(OH)D and 1,25(OH)(2)D is described.

  • measuring 25 hydroxyvitamin d in a Clinical Environment challenges and needs
    The American Journal of Clinical Nutrition, 2008
    Co-Authors: Bruce W Hollis
    Abstract:

    The number of assessments of circulating 25-hydroxy vitamin D [25(OH)D] for diagnostic purposes has increased significantly during the past 5 y. Over the years, techniques for quantifying 25(OH)D have increased and evolved. Some changes have been for the better and some have not. Most current methods appear to provide valid results as long as the operator of the given technique is properly trained and motivated. In addition, any laboratory that assesses circulating 25(OH)D for Clinical diagnosis needs to participate in the Vitamin D External Quality Assessment Scheme. Finally, research has shown that circulating 25(OH)D is extremely stable in stored serum or plasma samples; this characteristic makes accurate, long-term epidemiologic studies of circulating 25(OH)D possible. In this article, I provide an overview of the techniques available for measuring 25(OH)D, compare these techniques with one another, and assess their Clinical utility. I also briefly discuss the stability of 25(OH)D in biological media and present an overview of the Vitamin D External Quality Assessment Scheme.

Maria Kaariainen - One of the best experts on this subject based on the ideXlab platform.

  • culturally and linguistically diverse healthcare students experiences of learning in a Clinical Environment a systematic review of qualitative studies
    International Journal of Nursing Studies, 2016
    Co-Authors: Kristina Mikkonen, Satu Elo, Helimaria Kuivila, Annamaria Tuomikoski, Maria Kaariainen
    Abstract:

    Abstract Context Learning in the Clinical Environment of healthcare students plays a significant part in higher education. The greatest challenges for culturally and linguistically diverse healthcare students were found in Clinical placements, where differences in language and culture have been shown to cause learning obstacles for students. There has been no systematic review conducted to examine culturally and linguistically diverse healthcare students' experiences of their learning in the Clinical Environment. Objective This systematic review aims to identify culturally and linguistically diverse healthcare students' experiences of learning in a Clinical Environment. Methods The search strategy followed the guidelines of the Centre of Reviews and Dissemination. The original studies were identified from seven databases (CINAHL, Medline Ovid, Scopus, Web of Science, Academic Search Premiere, Eric and Cochrane Library) for the period 2000–2014. Two researchers selected studies based on titles, abstracts and full texts using inclusion criteria and assessed the quality of studies independently. Twelve original studies were chosen for the review. Results The culturally and linguistically diverse healthcare students' learning experiences were divided into three influential aspects of learning in a Clinical Environment: experiences with implementation processes and provision; experiences with peers and mentors; and experiences with university support and instructions. The main findings indicate that culturally and linguistically diverse healthcare students embarking on Clinical placements initially find integration stressful. Implementing the process of learning in a Clinical Environment requires additional time, well prepared pedagogical orientation, prior cultural and language education, and support for students and Clinical staff. Barriers to learning by culturally and linguistically diverse healthcare students were not being recognized and individuals were not considered motivated; learners experienced the strain of being different, and faced language difficulties. Clinical staff attitudes influenced students' Clinical learning experiences and outcomes. Conclusion Additional education in culture and language for students and Clinical staff is considered essential to improve the Clinical learning experiences of culturally and linguistically diverse healthcare students. Further studies of culturally and linguistically diverse healthcare students' learning experiences in the Clinical Environment need to be conducted in order to examine influential aspects on the Clinical learning found in the review.

Albert J J A Scherpbier - One of the best experts on this subject based on the ideXlab platform.

  • how can medical students learn in a self directed way in the Clinical Environment design based research
    Medical Education, 2005
    Co-Authors: Tim Dornan, Judy Hadfield, M Brown, Henny P A Boshuizen, Albert J J A Scherpbier
    Abstract:

    Aim  This study aimed to establish whether and under what conditions medical students can learn in a self-directed manner in the Clinical Environment. Method  A web-based learning management system brought 66 placement students, in a problem-based learning (PBL) medical curriculum, into closer touch with their Clinical learning objectives and ways of achieving them. Free response comments from 16 of them during the 7 weeks they used it, transcripts of group discussions before and after the period of use, and responses from all 66 students to a questionnaire were analysed qualitatively. Results  Students were rarely fully autonomous or subservient. They valued affective and pedagogic support, and relied on teachers to manage their learning Environment. With support, they were motivated and able to choose how and when to meet their learning needs. The new system was a useful adjunct. Conclusions  Self-direction, interpreted literally, was a method of learning that students defaulted to when support and guidance were lacking. They found ‘supported participation’ more valuable. Learning in the Clinical Environment was a social process with as many differences from, as similarities to, PBL.

James W Tysinger - One of the best experts on this subject based on the ideXlab platform.

Rickard Claire - One of the best experts on this subject based on the ideXlab platform.

  • Microorganisms present on peripheral intravenous needleless connectors in the Clinical Environment
    Elsevier, 2017
    Co-Authors: Slater Karen, Cooke Marie, Whitby Michael, Fullerton Fiona, Douglas Joel, Hay Jennine, Rickard Claire
    Abstract:

    The aim of this study was to quantify culturable microorganisms on needleless connectors (NCs) attached to peripheral intravenous catheters in hospitalized adult medical patients. Half (50%) of 40 NCs were contaminated with microorganisms commonly found on the skin or mouth. Staphylococcus capitis and Staphylococcus epidermidis were most commonly isolated. Emergency department insertion and higher patient dependency were statistically associated with positive NC microorganism growth. These results reaffirm the need for NC decontamination prior to access.Griffith Health, Menzies Health InstituteNo Full Tex

  • Microorganisms present on peripheral intravenous needleless connectors in the Clinical Environment
    'Elsevier BV', 2017
    Co-Authors: Slater Karen, Cooke Marie, Whitby Michael, Fullerton Fiona, Douglas Joel, Hay Jennine, Rickard Claire
    Abstract:

    The aim of this study was to quantify culturable microorganisms on needleless connectors (NCs) attached to peripheral intravenous catheters in hospitalized adult medical patients. Half (50%) of 40 NCs were contaminated with microorganisms commonly found on the skin or mouth. Staphylococcus capitis and Staphylococcus epidermidis were most commonly isolated. Emergency department insertion and higher patient dependency were statistically associated with positive NC microorganism growth. These results reaffirm the need for NC decontamination prior to access