The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform

Enrique Baca-garcia - One of the best experts on this subject based on the ideXlab platform.

  • Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications
    PLoS ONE, 2016
    Co-Authors: Sofian Berrouiguet, Maria Luisa Barrigón, Sara A. Brandt, Santiago Ovejero-garcía, Raquel Álvarez-garcía, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Study Group Memind, Enrique Baca-garcia
    Abstract:

    PURPOSE: The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS. METHOD: A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014. The web-application reported average daily dose prescribed for antipsychotics, prescribed daily dose (PDD), and the PDD to defined daily dose (DDD) ratio. RESULTS: The MEmind web-application reported that antipsychotics were used in 1116 patients out of the total sample, mostly in 486 (44%) patients with schizophrenia related disorders but also in other diagnoses. Second generation antipsychotics (quetiapine, aripiprazole and long-acting paliperidone) were preferably employed. Low doses were more frequently used than high doses. Long acting paliperidone and ziprasidone however, were the only two antipsychotics used at excessive dosing. Antipsychotic polypharmacy was used in 287 (26%) patients with classic depot drugs, Clotiapine, amisulpride and clozapine. CONCLUSIONS: In this study we describe the first step of the development of a web application that is able to make polypharmacy, high dose usage and off label usage of antipsychotics visible to clinicians. Current development of the MEmind web application may help to improve prescription security via momentary feedback of prescription and clinical decision support system.

  • Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications.
    Public Library of Science (PLoS), 2026
    Co-Authors: Sofian Berrouiguet, Maria Luisa Barrigón, Sara A. Brandt, Santiago Ovejero-garcía, Raquel Álvarez-garcía, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Enrique Baca-garcia
    Abstract:

    The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS.A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014. The web-application reported average daily dose prescribed for antipsychotics, prescribed daily dose (PDD), and the PDD to defined daily dose (DDD) ratio.The MEmind web-application reported that antipsychotics were used in 1116 patients out of the total sample, mostly in 486 (44%) patients with schizophrenia related disorders but also in other diagnoses. Second generation antipsychotics (quetiapine, aripiprazole and long-acting paliperidone) were preferably employed. Low doses were more frequently used than high doses. Long acting paliperidone and ziprasidone however, were the only two antipsychotics used at excessive dosing. Antipsychotic polypharmacy was used in 287 (26%) patients with classic depot drugs, Clotiapine, amisulpride and clozapine.In this study we describe the first step of the development of a web application that is able to make polypharmacy, high dose usage and off label usage of antipsychotics visible to clinicians. Current development of the MEmind web application may help to improve prescription security via momentary feedback of prescription and clinical decision support system

Sofian Berrouiguet - One of the best experts on this subject based on the ideXlab platform.

  • Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications
    PLoS ONE, 2016
    Co-Authors: Sofian Berrouiguet, Maria Luisa Barrigón, Sara A. Brandt, Santiago Ovejero-garcía, Raquel Álvarez-garcía, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Study Group Memind, Enrique Baca-garcia
    Abstract:

    PURPOSE: The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS. METHOD: A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014. The web-application reported average daily dose prescribed for antipsychotics, prescribed daily dose (PDD), and the PDD to defined daily dose (DDD) ratio. RESULTS: The MEmind web-application reported that antipsychotics were used in 1116 patients out of the total sample, mostly in 486 (44%) patients with schizophrenia related disorders but also in other diagnoses. Second generation antipsychotics (quetiapine, aripiprazole and long-acting paliperidone) were preferably employed. Low doses were more frequently used than high doses. Long acting paliperidone and ziprasidone however, were the only two antipsychotics used at excessive dosing. Antipsychotic polypharmacy was used in 287 (26%) patients with classic depot drugs, Clotiapine, amisulpride and clozapine. CONCLUSIONS: In this study we describe the first step of the development of a web application that is able to make polypharmacy, high dose usage and off label usage of antipsychotics visible to clinicians. Current development of the MEmind web application may help to improve prescription security via momentary feedback of prescription and clinical decision support system.

  • Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications.
    Public Library of Science (PLoS), 2026
    Co-Authors: Sofian Berrouiguet, Maria Luisa Barrigón, Sara A. Brandt, Santiago Ovejero-garcía, Raquel Álvarez-garcía, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Enrique Baca-garcia
    Abstract:

    The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS.A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014. The web-application reported average daily dose prescribed for antipsychotics, prescribed daily dose (PDD), and the PDD to defined daily dose (DDD) ratio.The MEmind web-application reported that antipsychotics were used in 1116 patients out of the total sample, mostly in 486 (44%) patients with schizophrenia related disorders but also in other diagnoses. Second generation antipsychotics (quetiapine, aripiprazole and long-acting paliperidone) were preferably employed. Low doses were more frequently used than high doses. Long acting paliperidone and ziprasidone however, were the only two antipsychotics used at excessive dosing. Antipsychotic polypharmacy was used in 287 (26%) patients with classic depot drugs, Clotiapine, amisulpride and clozapine.In this study we describe the first step of the development of a web application that is able to make polypharmacy, high dose usage and off label usage of antipsychotics visible to clinicians. Current development of the MEmind web application may help to improve prescription security via momentary feedback of prescription and clinical decision support system

Dilly Sébastien - One of the best experts on this subject based on the ideXlab platform.

  • Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study
    2011
    Co-Authors: Dilly Sébastien, Liégeois Jean-françois
    Abstract:

    The interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine derivatives, the oxidative mixture had low impact on the affinity of oxa- and thiazepine derivatives such as loxapine, clothiapine or JL13 for the D2 receptor. Molecular docking simulations revealed a huge difference between the mode of interaction of clozapine nitrenium ion and the parent drug. Electronic and geometric changes of the tricyclic ring system caused by the oxidation appeared to prevent the compound finding the correct binding mode and could therefore explain the difference observed in binding affinities.Peer reviewe

  • Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study
    'Springer Science and Business Media LLC', 2011
    Co-Authors: Dilly Sébastien, Liégeois Jean-françois
    Abstract:

    peer reviewedaudience: researcher, professional, studentThe interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine derivatives, the oxidative mixture had low impact on the affinity of oxa- and thiazepine derivatives such as loxapine, clothiapine or JL13 for the D2 receptor. Molecular docking simulations revealed a huge difference between the mode of interaction of clozapine nitrenium ion and the parent drug. Electronic and geometric changes of the tricyclic ring system caused by the oxidation appeared to prevent the compound finding the correct binding mode and could therefore explain the difference observed in binding affinities

  • Binding properties of clozapine and related compounds on native D2 dopamine receptors in normal and oxidative medium
    2010
    Co-Authors: Liégeois Jean-françois, Dilly Sébastien
    Abstract:

    Despite the presence of several side effects, clozapine remains a valuable drug in treating schizophrenia. The presence of haematological toxicity was proposed to be related to the formation of nitrenium species (1). Indeed, nitrogen derivatives like clozapine or olanzapine are very sensitive to oxidation while oxygen or sulphur isosteres such as loxapine, clothiapine and JL13, possess a very low sensitivity to oxidation (2-4). In the present study, we explore the impact of oxidation conditions on the binding of these drugs on native rat dopamine D2 receptors. Rats brains were quickly removed after cerebral dislocation and dissected on ice to get striata. After weighting, tissues were homogenized in buffer and washed three times by centrifugation. The final pellet was dispersed in the appropriate volume of incubation buffer (Tris 50 mM, MgCl2 5 mM, EDTA (Na2) 1 mM buffered at pH 7.4 with 4N HCl) depending on the experimental conditions. In oxidative conditions, horseradish peroxidase (1.25 µg/tube) and H2O2 (50 µM) were added to the incubation buffer. [3H]-Spiperone was used as radioligand and the non specific binding was determined in the presence of haloperidol (10 µM). Incubation temperature and time were 27°C and 60 min respectively. Competition experiments were done with different molecules such as haloperidol and various tricyclic derivatives. In our previous studies (2,3), we had observed that compounds like clozapine or olanzapine are significantly affected by oxidative conditions. In the present report, we show that this sensitivity is also associated with a dramatic decrease of binding affinity. Unlike such diazepine analogues, the binding of loxapine and JL13, two oxygen isosteres is slightly affected in oxidative conditions. Firstly, these results show that the distal nitrogen is not affected by the oxidative conditions. Secondly, the nitrenium formation (1) might lead to a tridimensional change that would reduce the interactions in the binding pocket. The oxidative effect of HRP/H2O2 mixture can be prevented by addition of ascorbic acid to the incubation medium. Thus depending on the oxidant character of the extracellular medium in physiological or pathophysiological conditions, interaction of molecules with different targets can be modified significantly

  • Binding properties of clozapine and related compounds on native D2 dopamine receptors in normal and oxidative medium
    2010
    Co-Authors: Liégeois Jean-françois, Dilly Sébastien
    Abstract:

    audience: researcher, professional, studentDespite the presence of several side effects, clozapine remains a valuable drug in treating schizophrenia. The presence of haematological toxicity was proposed to be related to the formation of nitrenium species (1). Indeed, nitrogen derivatives like clozapine or olanzapine are very sensitive to oxidation while oxygen or sulphur isosteres such as loxapine, clothiapine and JL13, possess a very low sensitivity to oxidation (2-4). In the present study, we explore the impact of oxidation conditions on the binding of these drugs on native rat dopamine D2 receptors. Rats brains were quickly removed after cerebral dislocation and dissected on ice to get striata. After weighting, tissues were homogenized in buffer and washed three times by centrifugation. The final pellet was dispersed in the appropriate volume of incubation buffer (Tris 50 mM, MgCl2 5 mM, EDTA (Na2) 1 mM buffered at pH 7.4 with 4N HCl) depending on the experimental conditions. In oxidative conditions, horseradish peroxidase (1.25 µg/tube) and H2O2 (50 µM) were added to the incubation buffer. [3H]-Spiperone was used as radioligand and the non specific binding was determined in the presence of haloperidol (10 µM). Incubation temperature and time were 27°C and 60 min respectively. Competition experiments were done with different molecules such as haloperidol and various tricyclic derivatives. In our previous studies (2,3), we had observed that compounds like clozapine or olanzapine are significantly affected by oxidative conditions. In the present report, we show that this sensitivity is also associated with a dramatic decrease of binding affinity. Unlike such diazepine analogues, the binding of loxapine and JL13, two oxygen isosteres is slightly affected in oxidative conditions. Firstly, these results show that the distal nitrogen is not affected by the oxidative conditions. Secondly, the nitrenium formation (1) might lead to a tridimensional change that would reduce the interactions in the binding pocket. The oxidative effect of HRP/H2O2 mixture can be prevented by addition of ascorbic acid to the incubation medium. Thus depending on the oxidant character of the extracellular medium in physiological or pathophysiological conditions, interaction of molecules with different targets can be modified significantly

Liégeois Jean-françois - One of the best experts on this subject based on the ideXlab platform.

  • Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study
    2011
    Co-Authors: Dilly Sébastien, Liégeois Jean-françois
    Abstract:

    The interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine derivatives, the oxidative mixture had low impact on the affinity of oxa- and thiazepine derivatives such as loxapine, clothiapine or JL13 for the D2 receptor. Molecular docking simulations revealed a huge difference between the mode of interaction of clozapine nitrenium ion and the parent drug. Electronic and geometric changes of the tricyclic ring system caused by the oxidation appeared to prevent the compound finding the correct binding mode and could therefore explain the difference observed in binding affinities.Peer reviewe

  • Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study
    'Springer Science and Business Media LLC', 2011
    Co-Authors: Dilly Sébastien, Liégeois Jean-françois
    Abstract:

    peer reviewedaudience: researcher, professional, studentThe interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine derivatives, the oxidative mixture had low impact on the affinity of oxa- and thiazepine derivatives such as loxapine, clothiapine or JL13 for the D2 receptor. Molecular docking simulations revealed a huge difference between the mode of interaction of clozapine nitrenium ion and the parent drug. Electronic and geometric changes of the tricyclic ring system caused by the oxidation appeared to prevent the compound finding the correct binding mode and could therefore explain the difference observed in binding affinities

  • Binding properties of clozapine and related compounds on native D2 dopamine receptors in normal and oxidative medium
    2010
    Co-Authors: Liégeois Jean-françois, Dilly Sébastien
    Abstract:

    Despite the presence of several side effects, clozapine remains a valuable drug in treating schizophrenia. The presence of haematological toxicity was proposed to be related to the formation of nitrenium species (1). Indeed, nitrogen derivatives like clozapine or olanzapine are very sensitive to oxidation while oxygen or sulphur isosteres such as loxapine, clothiapine and JL13, possess a very low sensitivity to oxidation (2-4). In the present study, we explore the impact of oxidation conditions on the binding of these drugs on native rat dopamine D2 receptors. Rats brains were quickly removed after cerebral dislocation and dissected on ice to get striata. After weighting, tissues were homogenized in buffer and washed three times by centrifugation. The final pellet was dispersed in the appropriate volume of incubation buffer (Tris 50 mM, MgCl2 5 mM, EDTA (Na2) 1 mM buffered at pH 7.4 with 4N HCl) depending on the experimental conditions. In oxidative conditions, horseradish peroxidase (1.25 µg/tube) and H2O2 (50 µM) were added to the incubation buffer. [3H]-Spiperone was used as radioligand and the non specific binding was determined in the presence of haloperidol (10 µM). Incubation temperature and time were 27°C and 60 min respectively. Competition experiments were done with different molecules such as haloperidol and various tricyclic derivatives. In our previous studies (2,3), we had observed that compounds like clozapine or olanzapine are significantly affected by oxidative conditions. In the present report, we show that this sensitivity is also associated with a dramatic decrease of binding affinity. Unlike such diazepine analogues, the binding of loxapine and JL13, two oxygen isosteres is slightly affected in oxidative conditions. Firstly, these results show that the distal nitrogen is not affected by the oxidative conditions. Secondly, the nitrenium formation (1) might lead to a tridimensional change that would reduce the interactions in the binding pocket. The oxidative effect of HRP/H2O2 mixture can be prevented by addition of ascorbic acid to the incubation medium. Thus depending on the oxidant character of the extracellular medium in physiological or pathophysiological conditions, interaction of molecules with different targets can be modified significantly

  • Binding properties of clozapine and related compounds on native D2 dopamine receptors in normal and oxidative medium
    2010
    Co-Authors: Liégeois Jean-françois, Dilly Sébastien
    Abstract:

    audience: researcher, professional, studentDespite the presence of several side effects, clozapine remains a valuable drug in treating schizophrenia. The presence of haematological toxicity was proposed to be related to the formation of nitrenium species (1). Indeed, nitrogen derivatives like clozapine or olanzapine are very sensitive to oxidation while oxygen or sulphur isosteres such as loxapine, clothiapine and JL13, possess a very low sensitivity to oxidation (2-4). In the present study, we explore the impact of oxidation conditions on the binding of these drugs on native rat dopamine D2 receptors. Rats brains were quickly removed after cerebral dislocation and dissected on ice to get striata. After weighting, tissues were homogenized in buffer and washed three times by centrifugation. The final pellet was dispersed in the appropriate volume of incubation buffer (Tris 50 mM, MgCl2 5 mM, EDTA (Na2) 1 mM buffered at pH 7.4 with 4N HCl) depending on the experimental conditions. In oxidative conditions, horseradish peroxidase (1.25 µg/tube) and H2O2 (50 µM) were added to the incubation buffer. [3H]-Spiperone was used as radioligand and the non specific binding was determined in the presence of haloperidol (10 µM). Incubation temperature and time were 27°C and 60 min respectively. Competition experiments were done with different molecules such as haloperidol and various tricyclic derivatives. In our previous studies (2,3), we had observed that compounds like clozapine or olanzapine are significantly affected by oxidative conditions. In the present report, we show that this sensitivity is also associated with a dramatic decrease of binding affinity. Unlike such diazepine analogues, the binding of loxapine and JL13, two oxygen isosteres is slightly affected in oxidative conditions. Firstly, these results show that the distal nitrogen is not affected by the oxidative conditions. Secondly, the nitrenium formation (1) might lead to a tridimensional change that would reduce the interactions in the binding pocket. The oxidative effect of HRP/H2O2 mixture can be prevented by addition of ascorbic acid to the incubation medium. Thus depending on the oxidant character of the extracellular medium in physiological or pathophysiological conditions, interaction of molecules with different targets can be modified significantly

Maria Luisa Barrigón - One of the best experts on this subject based on the ideXlab platform.

  • Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications
    PLoS ONE, 2016
    Co-Authors: Sofian Berrouiguet, Maria Luisa Barrigón, Sara A. Brandt, Santiago Ovejero-garcía, Raquel Álvarez-garcía, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Study Group Memind, Enrique Baca-garcia
    Abstract:

    PURPOSE: The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS. METHOD: A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014. The web-application reported average daily dose prescribed for antipsychotics, prescribed daily dose (PDD), and the PDD to defined daily dose (DDD) ratio. RESULTS: The MEmind web-application reported that antipsychotics were used in 1116 patients out of the total sample, mostly in 486 (44%) patients with schizophrenia related disorders but also in other diagnoses. Second generation antipsychotics (quetiapine, aripiprazole and long-acting paliperidone) were preferably employed. Low doses were more frequently used than high doses. Long acting paliperidone and ziprasidone however, were the only two antipsychotics used at excessive dosing. Antipsychotic polypharmacy was used in 287 (26%) patients with classic depot drugs, Clotiapine, amisulpride and clozapine. CONCLUSIONS: In this study we describe the first step of the development of a web application that is able to make polypharmacy, high dose usage and off label usage of antipsychotics visible to clinicians. Current development of the MEmind web application may help to improve prescription security via momentary feedback of prescription and clinical decision support system.

  • Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications.
    Public Library of Science (PLoS), 2026
    Co-Authors: Sofian Berrouiguet, Maria Luisa Barrigón, Sara A. Brandt, Santiago Ovejero-garcía, Raquel Álvarez-garcía, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Enrique Baca-garcia
    Abstract:

    The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS.A web application (www.MEmind.net) was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014. The web-application reported average daily dose prescribed for antipsychotics, prescribed daily dose (PDD), and the PDD to defined daily dose (DDD) ratio.The MEmind web-application reported that antipsychotics were used in 1116 patients out of the total sample, mostly in 486 (44%) patients with schizophrenia related disorders but also in other diagnoses. Second generation antipsychotics (quetiapine, aripiprazole and long-acting paliperidone) were preferably employed. Low doses were more frequently used than high doses. Long acting paliperidone and ziprasidone however, were the only two antipsychotics used at excessive dosing. Antipsychotic polypharmacy was used in 287 (26%) patients with classic depot drugs, Clotiapine, amisulpride and clozapine.In this study we describe the first step of the development of a web application that is able to make polypharmacy, high dose usage and off label usage of antipsychotics visible to clinicians. Current development of the MEmind web application may help to improve prescription security via momentary feedback of prescription and clinical decision support system