The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform

Demosthenes Pappagianis - One of the best experts on this subject based on the ideXlab platform.

Suzanne M Johnson - One of the best experts on this subject based on the ideXlab platform.

Garry T. Cole - One of the best experts on this subject based on the ideXlab platform.

  • Gene-Finding in Coccidioides Immitis
    Pathogen Genomics, 2020
    Co-Authors: Theo N. Kirkland, Garry T. Cole
    Abstract:

    Coccidioides Immitis is a primary fungal pathogen that lives in the soil of the desert Southwest. Like most medically important fungi that cause systemic disease, C. Immitis exhibits different morphologies in its saprobic and parasitic phases, but is distinguished from other fungal pathogens by the unique morphogenetic features of its growth in host tissue (Fig. 1). Coccidioidomycosis, the disease caused by this pathogenic fungus, is also known as Valley Fever because the organism is prevalent in the San Joaquin Valley of Central California. C. Immitis infections are caused by inhalation of the organism. The clinical spectrum of disease is broad, ranging from an asymptomatic infection to a rapidly fatal mycosis (1).The most common clinical presentation is self-limited pneumonia, but in some cases the fungus can cause chronic cavitary pulmonary disease or disseminate beyond the lungs to the skin, bones, meninges, and other body organs. It has been estimated, primarily on the basis of skin tests, that there are between 25,000 and 100,000 new cases of human C. Immitis infections each year in the United States. Approximately 5% of these new cases progress to disseminated disease.

  • the parasitic cell wall of Coccidioides Immitis
    Medical Mycology, 2001
    Co-Authors: Garry T. Cole, C Y Hung
    Abstract:

    Coccidioides Immitis is a human respiratory pathogen characterized by a parasitic cycle that is unique among fungi that cause systemic mycoses. Biochemical, molecular and immunological studies of the cell wall of C. Immitis have focused on three distinct events of parasitic cell differentiation: isotropic growth, segmentation and endosporulation. Current investigations of each developmental phase in vitro include the identification, expression analysis, and disruption of synthase and hydrolase genes that are suspected to have key roles in morphogenesis. Temporal expression of families of β-glucosidase and chitinase genes are of particular interest because their products may participate in wall modification during both isotropic growth and endosporulation and, thereby, represent potential molecular targets for novel antifungal drugs. Furthermore, our immunological studies of these and other isolated parasitic cell-wall components have resulted in the identification of antigens with demonstrated impact on h...

  • isolation and characterization of the arginase encoding gene arg from Coccidioides Immitis
    Gene, 1995
    Co-Authors: Minzhi Zhang, Garry T. Cole
    Abstract:

    The arginase (ARG)-encoding gene (arg) of Coccidioides Immitis, a human fungal pathogen, was cloned and sequenced. Both the genomic and cDNA sequences are provided. The transcription start point and poly(A) sites were confirmed. The arg gene, which was located on chromosome II of C. Immitis by Southern hybridization, is a single-copy gene with two introns and a 966-bp ORF which translates a 322-aa protein of 35.1 kDa. The deduced ARG protein showed 44% identity and 68% similarity to the Saccharomyces cerevisiae ARG.

  • Cell Wall-Associated Proteinases of Coccidioides Immitis
    Fungal Cell Wall and Immune Response, 1991
    Co-Authors: Garry T. Cole, K. R. Seshan
    Abstract:

    Coccidioides Immitis is the causative agent of a human respiratory disease known as coccidioidomycosis (’cocci’ or valley fever), which is characterized by a multiplicity of clinical forms. Approximately 100,000 cases of this fungal disease are diagnosed annually in the United States, primarily on the basis of serological tests (Cole et al., 1990). Results of clinical studies of coccidioidomycosis have suggested that underlying immunological illnesses are not prerequisite to infection. On the other hand, immunocompromised patients such as those diagnosed with acquired immunodeficiency syndrome (AIDS) who have previously lived or currently reside in endemic areas have been reported to contract symptomatic coccidioidomycosis at an unpredicted high annual frequency (27%; Bronnimann et al., 1987). A large percentage of these cases may represent reactivation of an old infection. C. Immitis is apparently able to persist in body organs in the absence of overt illness. The nature of this persistent form of the pathogen in host tissue is not known.

C Y Hung - One of the best experts on this subject based on the ideXlab platform.

  • The parasitic cell wall of Coccidioides Immitis.
    Medical mycology, 2020
    Co-Authors: G T Cole, C Y Hung
    Abstract:

    Coccidioides Immitis is a human respiratory pathogen characterized by a parasitic cycle that is unique among fungi that cause systemic mycoses. Biochemical, molecular and immunological studies of the cell wall of C. Immitis have focused on three distinct events of parasitic cell differentiation: isotropic growth, segmentation and endosporulation. Current investigations of each developmental phase in vitro include the identification, expression analysis, and disruption of synthase and hydrolase genes that are suspected to have key roles in morphogenesis. Temporal expression of families of beta-glucosidase and chitinase genes are of particular interest because their products may participate in wall modification during both isotropic growth and endosporulation and, thereby, represent potential molecular targets for novel antifungal drugs. Furthermore, our immunological studies of these and other isolated parasitic cell-wall components have resulted in the identification of antigens with demonstrated impact on host response to coccidioidal infection. C. Immitis has proved to be an excellent model for fungal cell-wall research.

  • the parasitic cell wall of Coccidioides Immitis
    Medical Mycology, 2001
    Co-Authors: Garry T. Cole, C Y Hung
    Abstract:

    Coccidioides Immitis is a human respiratory pathogen characterized by a parasitic cycle that is unique among fungi that cause systemic mycoses. Biochemical, molecular and immunological studies of the cell wall of C. Immitis have focused on three distinct events of parasitic cell differentiation: isotropic growth, segmentation and endosporulation. Current investigations of each developmental phase in vitro include the identification, expression analysis, and disruption of synthase and hydrolase genes that are suspected to have key roles in morphogenesis. Temporal expression of families of β-glucosidase and chitinase genes are of particular interest because their products may participate in wall modification during both isotropic growth and endosporulation and, thereby, represent potential molecular targets for novel antifungal drugs. Furthermore, our immunological studies of these and other isolated parasitic cell-wall components have resulted in the identification of antigens with demonstrated impact on h...

C R Zimmermann - One of the best experts on this subject based on the ideXlab platform.