The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Roser Pleixats - One of the best experts on this subject based on the ideXlab platform.
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dehydroacetic acid triacetic acid lactone and related pyrones
Advances in Heterocyclic Chemistry, 1992Co-Authors: Marcial Morenomanas, Roser PleixatsAbstract:Publisher Summary This chapter focuses on dehydroacetic acid, triacetic acid lactone, and related pyrones. Dehydroacetic acid is mainly used to produce clopidol, a Coccidiostatic Agent. Small quantities are used as a preservative for fruits and vegetables as well as a stabilizer for plastics. Its sodium salt is also of interest for these applications. 4-Hydroxy-6-methyl-2-pyrone (triacetic acid lactone) is a natural product of polyketide origin. Its 3-acetyl derivative, 3-acetyl-4-hydroxyd-methyl-2-pyrone (dehydroacetic acid), has been isolated from natural sources and is industrially available by dimerization of diketene. Preparation of pyrones dealt with in the chapter can be achieved by modifying previously existing pyrones or by cyclizing open-chain compounds. Biogenetic formation of triacetic acid lactone has been considered a derailment from fatty acid biosynthesis promoted by the absence of the reductant NADPH. The pyrones react at their different ring positions.
Marcial Morenomanas - One of the best experts on this subject based on the ideXlab platform.
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dehydroacetic acid triacetic acid lactone and related pyrones
Advances in Heterocyclic Chemistry, 1992Co-Authors: Marcial Morenomanas, Roser PleixatsAbstract:Publisher Summary This chapter focuses on dehydroacetic acid, triacetic acid lactone, and related pyrones. Dehydroacetic acid is mainly used to produce clopidol, a Coccidiostatic Agent. Small quantities are used as a preservative for fruits and vegetables as well as a stabilizer for plastics. Its sodium salt is also of interest for these applications. 4-Hydroxy-6-methyl-2-pyrone (triacetic acid lactone) is a natural product of polyketide origin. Its 3-acetyl derivative, 3-acetyl-4-hydroxyd-methyl-2-pyrone (dehydroacetic acid), has been isolated from natural sources and is industrially available by dimerization of diketene. Preparation of pyrones dealt with in the chapter can be achieved by modifying previously existing pyrones or by cyclizing open-chain compounds. Biogenetic formation of triacetic acid lactone has been considered a derailment from fatty acid biosynthesis promoted by the absence of the reductant NADPH. The pyrones react at their different ring positions.
Wojciech Rzeski - One of the best experts on this subject based on the ideXlab platform.
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cytoprotective effect of silybin against lasalocid induced toxicity in hepg2 cells
Polish Journal of Veterinary Sciences, 2013Co-Authors: Lidia Radko, Wojciech Cybulski, Wojciech RzeskiAbstract:Lasalocid is an ionophore Coccidiostatic Agent frequently used in poultry. Its extensive use causes the formation of residues in edible tissues and eggs which may pose a risk to consumers. Silybin is the main compound extracted from the herb milk thistle Silybum marianum and its hepatoprotective effect has been reported in literature. The aim of the study was to compare lasalocid and silybin cytotoxic effects followed by their combined use in HepG2 cell line. A cytoprotective effect resulting from the interaction of both pharmacologically active substances was measured. In this study, an MTT test, coomassie brillant blue binding test, and LDH release test determined the effective concentration (EC50) of the compounds. The isobolograms and combination index were used to assess the nature of interaction. The lowest EC50-value for lasalocid was established via the MTT test. This study revealed a lack of silybin cytotoxic effect on the cells. Co-actions of the two drugs led to a significant decrease of lasalocid cytotoxicity. The isobolograms and combination index showed a remarkable antagonistic effect in the course of silybin and lasalocid interaction. The results indicate that silybin revealed a cytoprotective effect when incubated with lasalocid since its cytotoxic impact on HepG2 cells has been significantly diminished.
Lidia Radko - One of the best experts on this subject based on the ideXlab platform.
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cytoprotective effect of silybin against lasalocid induced toxicity in hepg2 cells
Polish Journal of Veterinary Sciences, 2013Co-Authors: Lidia Radko, Wojciech Cybulski, Wojciech RzeskiAbstract:Lasalocid is an ionophore Coccidiostatic Agent frequently used in poultry. Its extensive use causes the formation of residues in edible tissues and eggs which may pose a risk to consumers. Silybin is the main compound extracted from the herb milk thistle Silybum marianum and its hepatoprotective effect has been reported in literature. The aim of the study was to compare lasalocid and silybin cytotoxic effects followed by their combined use in HepG2 cell line. A cytoprotective effect resulting from the interaction of both pharmacologically active substances was measured. In this study, an MTT test, coomassie brillant blue binding test, and LDH release test determined the effective concentration (EC50) of the compounds. The isobolograms and combination index were used to assess the nature of interaction. The lowest EC50-value for lasalocid was established via the MTT test. This study revealed a lack of silybin cytotoxic effect on the cells. Co-actions of the two drugs led to a significant decrease of lasalocid cytotoxicity. The isobolograms and combination index showed a remarkable antagonistic effect in the course of silybin and lasalocid interaction. The results indicate that silybin revealed a cytoprotective effect when incubated with lasalocid since its cytotoxic impact on HepG2 cells has been significantly diminished.
Wojciech Cybulski - One of the best experts on this subject based on the ideXlab platform.
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cytoprotective effect of silybin against lasalocid induced toxicity in hepg2 cells
Polish Journal of Veterinary Sciences, 2013Co-Authors: Lidia Radko, Wojciech Cybulski, Wojciech RzeskiAbstract:Lasalocid is an ionophore Coccidiostatic Agent frequently used in poultry. Its extensive use causes the formation of residues in edible tissues and eggs which may pose a risk to consumers. Silybin is the main compound extracted from the herb milk thistle Silybum marianum and its hepatoprotective effect has been reported in literature. The aim of the study was to compare lasalocid and silybin cytotoxic effects followed by their combined use in HepG2 cell line. A cytoprotective effect resulting from the interaction of both pharmacologically active substances was measured. In this study, an MTT test, coomassie brillant blue binding test, and LDH release test determined the effective concentration (EC50) of the compounds. The isobolograms and combination index were used to assess the nature of interaction. The lowest EC50-value for lasalocid was established via the MTT test. This study revealed a lack of silybin cytotoxic effect on the cells. Co-actions of the two drugs led to a significant decrease of lasalocid cytotoxicity. The isobolograms and combination index showed a remarkable antagonistic effect in the course of silybin and lasalocid interaction. The results indicate that silybin revealed a cytoprotective effect when incubated with lasalocid since its cytotoxic impact on HepG2 cells has been significantly diminished.