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Kenneth Javad Dale Allen - One of the best experts on this subject based on the ideXlab platform.

  • negative emotional action termination neat support for a Cognitive Mechanism underlying negative urgency in nonsuicidal self injury
    Behavior Therapy, 2019
    Co-Authors: Kenneth Javad Dale Allen, Jill M Hooley
    Abstract:

    Abstract Negative urgency, the self-reported tendency to act impulsively when distressed, increases risk for nonsuicidal self-injury (NSSI). NSSI is also associated with impaired negative emotional response inhibition (NERI), specifically negative emotional action termination (NEAT), a Cognitive process theoretically related to negative urgency. We previously found that adults with NSSI history had difficulty inhibiting behavioral responses to affective images depicting negative content (but not positive or neutral images) in an Emotional Stop-Signal Task. We sought to replicate this finding, determine whether this deficit extends to negative emotional action suppression (NEAS; an earlier stage of NERI), and explore whether impairment in these two stages of emotional response inhibition helps explain the relationship between negative urgency and NSSI. Eighty-eight adults with NSSI history (n = 45) and healthy control participants (n = 43) without NSSI history or psychopathology completed a clinical interview, symptom inventories, an impulsivity questionnaire, and behavioral assays of early and late NERI (NEAS and NEAT, respectively). The NSSI group had worse NEAT than the control group in the Emotional Stop-Signal Task, but no group differences in NEAS were observed in an Emotional Go/No-go task. However, both early and late stages of NERI accounted for independent variance in negative urgency. We additionally found that NEAT explained variance in the association between negative urgency and NSSI. These results suggest that impulsive behavior in NSSI may involve specifically impaired inhibitory control over initiated negative emotional impulses. This deficit in late response inhibition to negative emotional stimuli might reflect a Cognitive Mechanism or pathway to elevated negative urgency among people who self-injure.

  • negative emotional action termination neat support for a Cognitive Mechanism underlying negative urgency in nonsuicidal self injury
    Behavior Therapy, 2019
    Co-Authors: Kenneth Javad Dale Allen, Jill M Hooley
    Abstract:

    Abstract Negative urgency, the self-reported tendency to act impulsively when distressed, increases risk for nonsuicidal self-injury (NSSI). NSSI is also associated with impaired negative emotional response inhibition (NERI), specifically negative emotional action termination (NEAT), a Cognitive process theoretically related to negative urgency. We previously found that adults with NSSI history had difficulty inhibiting behavioral responses to affective images depicting negative content (but not positive or neutral images) in an Emotional Stop-Signal Task. We sought to replicate this finding, determine whether this deficit extends to negative emotional action suppression (NEAS; an earlier stage of NERI), and explore whether impairment in these two stages of emotional response inhibition helps explain the relationship between negative urgency and NSSI. Eighty-eight adults with NSSI history (n = 45) and healthy control participants (n = 43) without NSSI history or psychopathology completed a clinical interview, symptom inventories, an impulsivity questionnaire, and behavioral assays of early and late NERI (NEAS and NEAT, respectively). The NSSI group had worse NEAT than the control group in the Emotional Stop-Signal Task, but no group differences in NEAS were observed in an Emotional Go/No-go task. However, both early and late stages of NERI accounted for independent variance in negative urgency. We additionally found that NEAT explained variance in the association between negative urgency and NSSI. These results suggest that impulsive behavior in NSSI may involve specifically impaired inhibitory control over initiated negative emotional impulses. This deficit in late response inhibition to negative emotional stimuli might reflect a Cognitive Mechanism or pathway to elevated negative urgency among people who self-injure.

  • Negative Emotional Response Inhibition: Support for a Cognitive Mechanism underlying negative urgency in nonsuicidal self-injury
    2018
    Co-Authors: Kenneth Javad Dale Allen, D.phil. Jill Miranda Hooley
    Abstract:

    Negative urgency, the self-reported tendency to act impulsively when distressed, increases risk for nonsuicidal self-injury (NSSI). Prior research also suggests that NSSI is associated with impaired negative emotional response inhibition (NERI), a Cognitive process theoretically related to negative urgency. Specifically, individuals with a history of NSSI had difficulty inhibiting behavioral responses to negative affective images in an Emotional Stop-Signal Task, but not to those depicting positive or neutral content. The present study sought to replicate this finding, determine whether this deficit extends to an earlier stage of NERI, and explore whether impairment in these two stages of emotional inhibitory control helps explain the relationship between negative urgency and NSSI. To address these aims, 88 adults with NSSI histories (n = 45) and healthy control participants (n = 43) without NSSI history or psychopathology completed a clinical interview, symptom inventories, an impulsivity questionnaire, and behavioral impulsivity tasks measuring early and late emotional response inhibition. The NSSI group had worse late NERI than the control group on the Emotional Stop-Signal Task, but no group differences were observed in early NERI on an Emotional Go/no-go task. However, both early and late stages of NERI accounted for independent variance in negative urgency. We additionally found that late NERI explained variance in the association between negative urgency and NSSI. These results suggest that impulsive behavior in NSSI may involve specifically impaired inhibitory control over negative emotional impulses during late response inhibition, and that this Cognitive deficit might reflect one Mechanism or pathway to elevated negative urgency among people who self-injure.

Jill M Hooley - One of the best experts on this subject based on the ideXlab platform.

  • negative emotional action termination neat support for a Cognitive Mechanism underlying negative urgency in nonsuicidal self injury
    Behavior Therapy, 2019
    Co-Authors: Kenneth Javad Dale Allen, Jill M Hooley
    Abstract:

    Abstract Negative urgency, the self-reported tendency to act impulsively when distressed, increases risk for nonsuicidal self-injury (NSSI). NSSI is also associated with impaired negative emotional response inhibition (NERI), specifically negative emotional action termination (NEAT), a Cognitive process theoretically related to negative urgency. We previously found that adults with NSSI history had difficulty inhibiting behavioral responses to affective images depicting negative content (but not positive or neutral images) in an Emotional Stop-Signal Task. We sought to replicate this finding, determine whether this deficit extends to negative emotional action suppression (NEAS; an earlier stage of NERI), and explore whether impairment in these two stages of emotional response inhibition helps explain the relationship between negative urgency and NSSI. Eighty-eight adults with NSSI history (n = 45) and healthy control participants (n = 43) without NSSI history or psychopathology completed a clinical interview, symptom inventories, an impulsivity questionnaire, and behavioral assays of early and late NERI (NEAS and NEAT, respectively). The NSSI group had worse NEAT than the control group in the Emotional Stop-Signal Task, but no group differences in NEAS were observed in an Emotional Go/No-go task. However, both early and late stages of NERI accounted for independent variance in negative urgency. We additionally found that NEAT explained variance in the association between negative urgency and NSSI. These results suggest that impulsive behavior in NSSI may involve specifically impaired inhibitory control over initiated negative emotional impulses. This deficit in late response inhibition to negative emotional stimuli might reflect a Cognitive Mechanism or pathway to elevated negative urgency among people who self-injure.

  • negative emotional action termination neat support for a Cognitive Mechanism underlying negative urgency in nonsuicidal self injury
    Behavior Therapy, 2019
    Co-Authors: Kenneth Javad Dale Allen, Jill M Hooley
    Abstract:

    Abstract Negative urgency, the self-reported tendency to act impulsively when distressed, increases risk for nonsuicidal self-injury (NSSI). NSSI is also associated with impaired negative emotional response inhibition (NERI), specifically negative emotional action termination (NEAT), a Cognitive process theoretically related to negative urgency. We previously found that adults with NSSI history had difficulty inhibiting behavioral responses to affective images depicting negative content (but not positive or neutral images) in an Emotional Stop-Signal Task. We sought to replicate this finding, determine whether this deficit extends to negative emotional action suppression (NEAS; an earlier stage of NERI), and explore whether impairment in these two stages of emotional response inhibition helps explain the relationship between negative urgency and NSSI. Eighty-eight adults with NSSI history (n = 45) and healthy control participants (n = 43) without NSSI history or psychopathology completed a clinical interview, symptom inventories, an impulsivity questionnaire, and behavioral assays of early and late NERI (NEAS and NEAT, respectively). The NSSI group had worse NEAT than the control group in the Emotional Stop-Signal Task, but no group differences in NEAS were observed in an Emotional Go/No-go task. However, both early and late stages of NERI accounted for independent variance in negative urgency. We additionally found that NEAT explained variance in the association between negative urgency and NSSI. These results suggest that impulsive behavior in NSSI may involve specifically impaired inhibitory control over initiated negative emotional impulses. This deficit in late response inhibition to negative emotional stimuli might reflect a Cognitive Mechanism or pathway to elevated negative urgency among people who self-injure.

Herta Flor - One of the best experts on this subject based on the ideXlab platform.

  • Hippocampal-Dorsolateral Prefrontal Coupling as a Species-Conserved Cognitive Mechanism: A Human Translational Imaging Study.
    Journal of Investigative Dermatology, 2015
    Co-Authors: Florian Bähner, Kai Ueltzhöffer, Charmaine Demanuele, Janina I. Schweiger, Zamoscik, Patric Meyer, Tim Hahn, Martin Fungisai Gerchen, Herta Flor, Daniel Durstewitz
    Abstract:

    Abbreviations: CIU/CSU, chronic idiopathic/spontaneous urticaria; BHR, basophil histamine release; fMLP-N, formylmethionine-leucyl-phenylalanine

  • hippocampal dorsolateral prefrontal coupling as a species conserved Cognitive Mechanism a human translational imaging study
    Neuropsychopharmacology, 2015
    Co-Authors: Florian Bähner, Kai Ueltzhöffer, Charmaine Demanuele, Janina I. Schweiger, Patric Meyer, Tim Hahn, Martin Fungisai Gerchen, Vera Zamoscik, Herta Flor
    Abstract:

    Hippocampal–prefrontal cortex (HC–PFC) interactions are implicated in working memory (WM) and altered in psychiatric conditions with Cognitive impairment such as schizophrenia. While coupling between both structures is crucial for WM performance in rodents, evidence from human studies is conflicting and translation of findings is complicated by the use of differing paradigms across species. We therefore used functional magnetic resonance imaging together with a spatial WM paradigm adapted from rodent research to examine HC–PFC coupling in humans. A PFC–parietal network was functionally connected to hippocampus (HC) during task stages requiring high levels of executive control but not during a matched control condition. The magnitude of coupling in a network comprising HC, bilateral dorsolateral PFC (DLPFC), and right supramarginal gyrus explained one-fourth of the variability in an independent spatial WM task but was unrelated to visual WM performance. HC–DLPFC coupling may thus represent a systems-level Mechanism specific to spatial WM that is conserved across species, suggesting its utility for modeling Cognitive dysfunction in translational neuroscience.

Kai Ueltzhöffer - One of the best experts on this subject based on the ideXlab platform.

  • Hippocampal-Dorsolateral Prefrontal Coupling as a Species-Conserved Cognitive Mechanism: A Human Translational Imaging Study.
    Journal of Investigative Dermatology, 2015
    Co-Authors: Florian Bähner, Kai Ueltzhöffer, Charmaine Demanuele, Janina I. Schweiger, Zamoscik, Patric Meyer, Tim Hahn, Martin Fungisai Gerchen, Herta Flor, Daniel Durstewitz
    Abstract:

    Abbreviations: CIU/CSU, chronic idiopathic/spontaneous urticaria; BHR, basophil histamine release; fMLP-N, formylmethionine-leucyl-phenylalanine

  • hippocampal dorsolateral prefrontal coupling as a species conserved Cognitive Mechanism a human translational imaging study
    Neuropsychopharmacology, 2015
    Co-Authors: Florian Bähner, Kai Ueltzhöffer, Charmaine Demanuele, Janina I. Schweiger, Patric Meyer, Tim Hahn, Martin Fungisai Gerchen, Vera Zamoscik, Herta Flor
    Abstract:

    Hippocampal–prefrontal cortex (HC–PFC) interactions are implicated in working memory (WM) and altered in psychiatric conditions with Cognitive impairment such as schizophrenia. While coupling between both structures is crucial for WM performance in rodents, evidence from human studies is conflicting and translation of findings is complicated by the use of differing paradigms across species. We therefore used functional magnetic resonance imaging together with a spatial WM paradigm adapted from rodent research to examine HC–PFC coupling in humans. A PFC–parietal network was functionally connected to hippocampus (HC) during task stages requiring high levels of executive control but not during a matched control condition. The magnitude of coupling in a network comprising HC, bilateral dorsolateral PFC (DLPFC), and right supramarginal gyrus explained one-fourth of the variability in an independent spatial WM task but was unrelated to visual WM performance. HC–DLPFC coupling may thus represent a systems-level Mechanism specific to spatial WM that is conserved across species, suggesting its utility for modeling Cognitive dysfunction in translational neuroscience.

Florian Bähner - One of the best experts on this subject based on the ideXlab platform.

  • Hippocampal-Dorsolateral Prefrontal Coupling as a Species-Conserved Cognitive Mechanism: A Human Translational Imaging Study.
    Journal of Investigative Dermatology, 2015
    Co-Authors: Florian Bähner, Kai Ueltzhöffer, Charmaine Demanuele, Janina I. Schweiger, Zamoscik, Patric Meyer, Tim Hahn, Martin Fungisai Gerchen, Herta Flor, Daniel Durstewitz
    Abstract:

    Abbreviations: CIU/CSU, chronic idiopathic/spontaneous urticaria; BHR, basophil histamine release; fMLP-N, formylmethionine-leucyl-phenylalanine

  • hippocampal dorsolateral prefrontal coupling as a species conserved Cognitive Mechanism a human translational imaging study
    Neuropsychopharmacology, 2015
    Co-Authors: Florian Bähner, Kai Ueltzhöffer, Charmaine Demanuele, Janina I. Schweiger, Patric Meyer, Tim Hahn, Martin Fungisai Gerchen, Vera Zamoscik, Herta Flor
    Abstract:

    Hippocampal–prefrontal cortex (HC–PFC) interactions are implicated in working memory (WM) and altered in psychiatric conditions with Cognitive impairment such as schizophrenia. While coupling between both structures is crucial for WM performance in rodents, evidence from human studies is conflicting and translation of findings is complicated by the use of differing paradigms across species. We therefore used functional magnetic resonance imaging together with a spatial WM paradigm adapted from rodent research to examine HC–PFC coupling in humans. A PFC–parietal network was functionally connected to hippocampus (HC) during task stages requiring high levels of executive control but not during a matched control condition. The magnitude of coupling in a network comprising HC, bilateral dorsolateral PFC (DLPFC), and right supramarginal gyrus explained one-fourth of the variability in an independent spatial WM task but was unrelated to visual WM performance. HC–DLPFC coupling may thus represent a systems-level Mechanism specific to spatial WM that is conserved across species, suggesting its utility for modeling Cognitive dysfunction in translational neuroscience.