The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Ender Örnek - One of the best experts on this subject based on the ideXlab platform.
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Serum Sphingosine 1 Phosphate Levels in Patients with and without Coronary Collateral Circulation
Acta Cardiologica Sinica, 2018Co-Authors: Emrullah Kiziltunc, Harun Kundi, Turan Turhan, Mustafa Çetin, Canan Topcuoglu, Ender ÖrnekAbstract:Background Sphingosine 1 phosphate, an active sphingolipid metabolite, functions in both healthy and diseased cardiovascular systems. It has been reported to play a role in angiogenesis and arteriogenesis in various tissues, which are the proposed mechanisms for the development of coronary Collateral Circulation. To the best of our knowledge, no data exist regarding serum sphingosine 1 phosphate levels and the presence of coronary Collateral Circulation in the literature. Thus this study aimed to investigate serum sphingosine 1 phosphate levels in patients with and without coronary Collateral Circulation.
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Serum Sphingosine 1 Phosphate Levels in Patients with and without Coronary Collateral Circulation.
Acta Cardiologica Sinica, 2018Co-Authors: Emrullah Kiziltunc, Harun Kundi, Turan Turhan, Mustafa Çetin, Canan Topcuoglu, Murat Gök, Ender ÖrnekAbstract:Background Sphingosine 1 phosphate, an active sphingolipid metabolite, functions in both healthy and diseased cardiovascular systems. It has been reported to play a role in angiogenesis and arteriogenesis in various tissues, which are the proposed mechanisms for the development of coronary Collateral Circulation. To the best of our knowledge, no data exist regarding serum sphingosine 1 phosphate levels and the presence of coronary Collateral Circulation in the literature. Thus this study aimed to investigate serum sphingosine 1 phosphate levels in patients with and without coronary Collateral Circulation. Methods A total of 140 patients were included (70 with coronary Collateral Circulation and 70 with normal coronary arteries and stable coronary artery disease without Collaterals). Rentrop Collateral grade and the number of coronary arteries with Collateral Circulation were recorded. Results Serum sphingosine 1 phosphate levels were higher in the Collateral group than in the control group [186.6 (142.3-243.5) μg/l vs. 128.5 (105.0-161.6) μg/l, p < 0.001]. Multivariate logistic regression analysis revealed that the presence of multivessel disease, high serum sphingosine 1 phosphate levels and previous history of P2Y12 use were independent predictors of coronary Collateral Circulation. Median sphingosine 1 phosphate levels in different Rentrop grades in the Collateral group were similar, and there was no significant difference in median serum sphingosine 1 phosphate level with a higher number of coronary arteries with Collateral Circulation. Conclusions Our findings demonstrated higher levels of sphingosine 1 phosphate in the patients with coronary Collateral Circulation.
Marc I. Chimowitz - One of the best experts on this subject based on the ideXlab platform.
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Collateral Circulation in symptomatic intracranial atherosclerosis
Journal of Cerebral Blood Flow and Metabolism, 2011Co-Authors: David S. Liebeskind, George A. Cotsonis, Jeffrey L. Saver, Michael J. Lynn, Harry J. Cloft, Marc I. ChimowitzAbstract:Collateral Circulation in intracranial atherosclerosis has never been systematically characterized. We investigated Collaterals in a multicenter trial of symptomatic intracranial atherosclerotic disease. Baseline angiography was reviewed for information on Collaterals in stenoses of the internal carotid, middle cerebral, vertebral, and basilar arteries. A battery of angiographic scales was utilized to evaluate lesion site, arterial patency, antegrade flow, downstream territorial perfusion, and Collateral Circulation, blinded to all other data. Collateral Circulation was adequately available for analysis in 287/569 (50%) subjects with proximal arterial stenoses ranging from 50% to 99%. Extent of Collaterals was absent or none in 69%, slow or minimal in 10%, more rapid, yet incomplete perfusion of territory in 7%, complete but delayed perfusion in 11%, and rapid, complete Collateral perfusion in 4%. Extent of Collateral flow correlated with percentage of stenosis (P<0.0001), with more severe stenoses exhibiting greater compensation via Collaterals. Overall, Collateral grade increased with diminished antegrade flow across the lesion (thrombolysis in myocardial ischemia) and resultant downstream perfusion (thrombolysis in cerebral infarction) (both P<0.001). Our findings provide the initial detailed description of Collaterals across a variety of stenoses, suggesting that Collateral perfusion is a pivotal component in pathophysiology of intracranial atherosclerosis and implicating the need for further evaluation in ongoing studies.
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Collateral Circulation in symptomatic intracranial atherosclerosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010Co-Authors: David S. Liebeskind, George A. Cotsonis, Jeffrey L. Saver, Michael J. Lynn, Harry J. Cloft, Marc I. ChimowitzAbstract:Collateral Circulation in intracranial atherosclerosis has never been systematically characterized. We investigated Collaterals in a multicenter trial of symptomatic intracranial atherosclerotic disease. Baseline angiography was reviewed for information on Collaterals in stenoses of the internal carotid, middle cerebral, vertebral, and basilar arteries. A battery of angiographic scales was utilized to evaluate lesion site, arterial patency, antegrade flow, downstream territorial perfusion, and Collateral Circulation, blinded to all other data. Collateral Circulation was adequately available for analysis in 287/569 (50%) subjects with proximal arterial stenoses ranging from 50% to 99%. Extent of Collaterals was absent or none in 69%, slow or minimal in 10%, more rapid, yet incomplete perfusion of territory in 7%, complete but delayed perfusion in 11%, and rapid, complete Collateral perfusion in 4%. Extent of Collateral flow correlated with percentage of stenosis (P
Emrullah Kiziltunc - One of the best experts on this subject based on the ideXlab platform.
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Serum Sphingosine 1 Phosphate Levels in Patients with and without Coronary Collateral Circulation
Acta Cardiologica Sinica, 2018Co-Authors: Emrullah Kiziltunc, Harun Kundi, Turan Turhan, Mustafa Çetin, Canan Topcuoglu, Ender ÖrnekAbstract:Background Sphingosine 1 phosphate, an active sphingolipid metabolite, functions in both healthy and diseased cardiovascular systems. It has been reported to play a role in angiogenesis and arteriogenesis in various tissues, which are the proposed mechanisms for the development of coronary Collateral Circulation. To the best of our knowledge, no data exist regarding serum sphingosine 1 phosphate levels and the presence of coronary Collateral Circulation in the literature. Thus this study aimed to investigate serum sphingosine 1 phosphate levels in patients with and without coronary Collateral Circulation.
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Serum Sphingosine 1 Phosphate Levels in Patients with and without Coronary Collateral Circulation.
Acta Cardiologica Sinica, 2018Co-Authors: Emrullah Kiziltunc, Harun Kundi, Turan Turhan, Mustafa Çetin, Canan Topcuoglu, Murat Gök, Ender ÖrnekAbstract:Background Sphingosine 1 phosphate, an active sphingolipid metabolite, functions in both healthy and diseased cardiovascular systems. It has been reported to play a role in angiogenesis and arteriogenesis in various tissues, which are the proposed mechanisms for the development of coronary Collateral Circulation. To the best of our knowledge, no data exist regarding serum sphingosine 1 phosphate levels and the presence of coronary Collateral Circulation in the literature. Thus this study aimed to investigate serum sphingosine 1 phosphate levels in patients with and without coronary Collateral Circulation. Methods A total of 140 patients were included (70 with coronary Collateral Circulation and 70 with normal coronary arteries and stable coronary artery disease without Collaterals). Rentrop Collateral grade and the number of coronary arteries with Collateral Circulation were recorded. Results Serum sphingosine 1 phosphate levels were higher in the Collateral group than in the control group [186.6 (142.3-243.5) μg/l vs. 128.5 (105.0-161.6) μg/l, p < 0.001]. Multivariate logistic regression analysis revealed that the presence of multivessel disease, high serum sphingosine 1 phosphate levels and previous history of P2Y12 use were independent predictors of coronary Collateral Circulation. Median sphingosine 1 phosphate levels in different Rentrop grades in the Collateral group were similar, and there was no significant difference in median serum sphingosine 1 phosphate level with a higher number of coronary arteries with Collateral Circulation. Conclusions Our findings demonstrated higher levels of sphingosine 1 phosphate in the patients with coronary Collateral Circulation.
Ahmet Yilmaz - One of the best experts on this subject based on the ideXlab platform.
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Prognostic relevance of coronary Collateral Circulation: Clinical and epidemiological implications
International journal of cardiology, 2008Co-Authors: Okan Onur Turgut, Kenan Yalta, Mehmet Birhan Yilmaz, Izzet Tandogan, Ahmet YilmazAbstract:Coronary Collateral Circulation provides an important response to ischemic heart disease and partially determines the severity of ischemic myocardial damage. Practical significance of coronary Collateral Circulation has long been a matter of uncertainty due to concerns about the means for gauging coronary Collateral Circulation and the modest populations to be representative for all patients with ischemic heart disease. It is possible that prognosis may be defined by the balance between the harm of atherosclerotic burden, and the benefit from coronary Collateral Circulation. Atherosclerosis acts as a potent trigger for the formation of coronary Collateral Circulation, but at the same time it has deleterious effects on cardiovascular morbidity and mortality. Coronary Collateral Circulation has a complex role in modifying the risk of cardiovascular morbidity and mortality in ischemic heart disease. A more comprehensive insight into the exact determinants of coronary Collateral Circulation would help establish its potential implications in clinical and epidemiological realm.
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Coronary Collateral Circulation: any effect on P-wave dispersion?
Angiology, 2008Co-Authors: Halil Aslan, Okan Onur Turgut, Kenan Yalta, Mehmet Birhan Yilmaz, Ramazan Ozdemir, Necip Ermis, Alpay Turan Sezgin, Ertan Yetkin, Izzet Tandogan, Ahmet YilmazAbstract:Coronary Collateral Circulation determines the severity of ischemic myocardial damage. Increased P-wave dispersion is an independent predictor for atrial fibrillation. Consistent evidence is little about the relation between coronary Collateral Circulation and arrhythmia risk. In this article, the effect of coronary Collateral Circulation on P-wave dispersion was evaluated. Collateral grade and P-wave dispersion were ascertained in 100 patients with ≥85% diameter stenoses in left anterior descending or right coronary arteries. Left ventricular function score was also determined in all patients. Coronary Collateral Circulation was absent in 32 patients, whereas 68 patients had coronary Collateral Circulation. Patients with Collateral grade ≥1 had greater left ventricular function score than did patients with Collateral grade 0 (P = .048). However, there was no significant difference between P-wave dispersion of patients with and without coronary Collateral Circulation (P = .45). The presence of coronary co...
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The effect of Collateral Circulation on left ventricular systolic function.
Coronary artery disease, 2007Co-Authors: Filiz Karadas, Okan Onur Turgut, Kenan Yalta, Mehmet Birhan Yilmaz, Ahmet Yilmaz, Kasim Dogan, Izzet TandoganAbstract:Background Conflicting reports exist on the influence of coronary Collateral Circulation on preservation of left ventricular systolic function. The aim of this study was to assess the effect of coronary Collateral Circulation on left ventricular systolic function in coronary artery disease. Methods Seventy-one consecutive patients having left anterior descending arteries with proximal or near-proximal stenosis of at least 95% (excluding 100%) were included in the study. The coronary Collateral Circulation to left anterior descending artery was evaluated with regard to its effects on left ventricular systolic function. Results Among the 71 patients, 46 patients were found to have a coronary Collateral Circulation grade of >or=1 (group 1), whereas the remaining 25 patients had coronary Collateral Circulation grade of 0 (group 2). The mean value of left ventricular function score in group 1 was higher than that of group 2 (3.69+/-2.34 vs. 2.00+/-1.55, P=0.002), whereas the mean value of left ventricular ejection fraction in group 1 was lower than that of group 2 (44.67+/-12.05 vs. 54.32+/-10.22, P=0.001). The value of coronary Collateral Circulation grade was found to be positively correlated with the value of left ventricular function score (P=0.01, r=0.3), and negatively correlated with the value of left ventricular ejection fraction (P=0.01, r=-0.3). Conclusion Coronary Collateral Circulation to the severely stenotic left anterior descending artery was not found to have an improving effect on left ventricular systolic function. In contrast with the previous studies demonstrating the coronary Collateral Circulation-associated preservation of left ventricular systolic function, presence of coronary Collateral Circulation was found to accompany or be associated with impairment of left ventricular systolic function. The grade of coronary Collateral Circulation was also found to be positively correlated with the severity of left ventricular systolic dysfunction. Further research on larger patient populations based on a long-term follow-up is warranted to investigate this issue.
David S. Liebeskind - One of the best experts on this subject based on the ideXlab platform.
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Collateral Circulation in symptomatic intracranial atherosclerosis
Journal of Cerebral Blood Flow and Metabolism, 2011Co-Authors: David S. Liebeskind, George A. Cotsonis, Jeffrey L. Saver, Michael J. Lynn, Harry J. Cloft, Marc I. ChimowitzAbstract:Collateral Circulation in intracranial atherosclerosis has never been systematically characterized. We investigated Collaterals in a multicenter trial of symptomatic intracranial atherosclerotic disease. Baseline angiography was reviewed for information on Collaterals in stenoses of the internal carotid, middle cerebral, vertebral, and basilar arteries. A battery of angiographic scales was utilized to evaluate lesion site, arterial patency, antegrade flow, downstream territorial perfusion, and Collateral Circulation, blinded to all other data. Collateral Circulation was adequately available for analysis in 287/569 (50%) subjects with proximal arterial stenoses ranging from 50% to 99%. Extent of Collaterals was absent or none in 69%, slow or minimal in 10%, more rapid, yet incomplete perfusion of territory in 7%, complete but delayed perfusion in 11%, and rapid, complete Collateral perfusion in 4%. Extent of Collateral flow correlated with percentage of stenosis (P<0.0001), with more severe stenoses exhibiting greater compensation via Collaterals. Overall, Collateral grade increased with diminished antegrade flow across the lesion (thrombolysis in myocardial ischemia) and resultant downstream perfusion (thrombolysis in cerebral infarction) (both P<0.001). Our findings provide the initial detailed description of Collaterals across a variety of stenoses, suggesting that Collateral perfusion is a pivotal component in pathophysiology of intracranial atherosclerosis and implicating the need for further evaluation in ongoing studies.
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Collateral Circulation in symptomatic intracranial atherosclerosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010Co-Authors: David S. Liebeskind, George A. Cotsonis, Jeffrey L. Saver, Michael J. Lynn, Harry J. Cloft, Marc I. ChimowitzAbstract:Collateral Circulation in intracranial atherosclerosis has never been systematically characterized. We investigated Collaterals in a multicenter trial of symptomatic intracranial atherosclerotic disease. Baseline angiography was reviewed for information on Collaterals in stenoses of the internal carotid, middle cerebral, vertebral, and basilar arteries. A battery of angiographic scales was utilized to evaluate lesion site, arterial patency, antegrade flow, downstream territorial perfusion, and Collateral Circulation, blinded to all other data. Collateral Circulation was adequately available for analysis in 287/569 (50%) subjects with proximal arterial stenoses ranging from 50% to 99%. Extent of Collaterals was absent or none in 69%, slow or minimal in 10%, more rapid, yet incomplete perfusion of territory in 7%, complete but delayed perfusion in 11%, and rapid, complete Collateral perfusion in 4%. Extent of Collateral flow correlated with percentage of stenosis (P