The Experts below are selected from a list of 195 Experts worldwide ranked by ideXlab platform
Saima Amin - One of the best experts on this subject based on the ideXlab platform.
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effect of oil and co surfactant on the formation of solutol hs 15 based Colloidal Drug Carrier by box behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
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Effect of oil and co-surfactant on the formation of Solutol HS 15 based Colloidal Drug Carrier by Box–Behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
Javed Ahmad - One of the best experts on this subject based on the ideXlab platform.
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effect of oil and co surfactant on the formation of solutol hs 15 based Colloidal Drug Carrier by box behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
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Effect of oil and co-surfactant on the formation of Solutol HS 15 based Colloidal Drug Carrier by Box–Behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
Jean-christophe Leroux - One of the best experts on this subject based on the ideXlab platform.
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Long Circulating Poly(Ethylene Glycol)-Decorated Lipid Nanocapsules Deliver Docetaxel to Solid Tumors
Pharmaceutical Research, 2006Co-Authors: Mohamed Nabil Khalid, Pierre Simard, Didier Hoarau, Alice Dragomir, Jean-christophe LerouxAbstract:Purpose The purpose of this study was to evaluate the ability of poly(ethylene glycol)-coated lipid nanocapsules (LN) to deliver the highly potent hydrophobic anticancer Drug docetaxel to solid tumors. Methods Docetaxel-loaded nanocapsules (80–120 nm) were produced by a solvent-free phase inversion process and were coated with polyethylene glycol distearoylphosphatidylethanolamine conjugate by a postinsertion step. In vivo studies were conducted in mice bearing subcutaneously implanted C26 colon adenocarcinoma to assess the pharmacokinetics and biodistribution of both the Drug and LN. Results Incorporation of docetaxel into the LN dramatically increased the Drug's biological half-life while providing substantial accumulation at the tumoral site. The pharmacokinetics and biodistribution pattern were found to depend on the specific surface area and shell composition of the nanocapsules. Conclusion This study demonstrates that docetaxel physically entrapped into a lipid Colloidal Drug Carrier can be efficiently targeted to neoplastic tissues.
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Long Circulating Poly(Ethylene Glycol)-Decorated Lipid Nanocapsules Deliver Docetaxel to Solid Tumors
Pharmaceutical research, 2006Co-Authors: Mohamed Khalid, Pierre Simard, Didier Hoarau, Alice Dragomir, Jean-christophe LerouxAbstract:The purpose of this study was to evaluate the ability of poly(ethylene glycol)-coated lipid nanocapsules (LN) to deliver the highly potent hydrophobic anticancer Drug docetaxel to solid tumors. Docetaxel-loaded nanocapsules (80–120 nm) were produced by a solvent-free phase inversion process and were coated with polyethylene glycol distearoylphosphatidylethanolamine conjugate by a postinsertion step. In vivo studies were conducted in mice bearing subcutaneously implanted C26 colon adenocarcinoma to assess the pharmacokinetics and biodistribution of both the Drug and LN. Incorporation of docetaxel into the LN dramatically increased the Drug's biological half-life while providing substantial accumulation at the tumoral site. The pharmacokinetics and biodistribution pattern were found to depend on the specific surface area and shell composition of the nanocapsules. This study demonstrates that docetaxel physically entrapped into a lipid Colloidal Drug Carrier can be efficiently targeted to neoplastic tissues.
Showkat R. Mir - One of the best experts on this subject based on the ideXlab platform.
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effect of oil and co surfactant on the formation of solutol hs 15 based Colloidal Drug Carrier by box behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
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Effect of oil and co-surfactant on the formation of Solutol HS 15 based Colloidal Drug Carrier by Box–Behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
Kanchan Kohli - One of the best experts on this subject based on the ideXlab platform.
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effect of oil and co surfactant on the formation of solutol hs 15 based Colloidal Drug Carrier by box behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).
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Effect of oil and co-surfactant on the formation of Solutol HS 15 based Colloidal Drug Carrier by Box–Behnken statistical design
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014Co-Authors: Javed Ahmad, Showkat R. Mir, Kanchan Kohli, Saima AminAbstract:Abstract The present study provides an overview to design and optimize self-emulsifying system as Colloidal Drug Carrier for oral delivery of hydrophobic Drug using a new surfactant Solutol HS15. The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram. Box–Behnken experimental design was employed as statistical tool to optimize the formulation variables, X 1 (Propylene glycol monocaprylate as oil), X 2 (Solutol HS15 as surfactant), and X 3 (Transcutol HP as cosurfactant). Formulations were assessed for percentage transmittance, droplet size and emulsification efficacy. Transcutol HP was found to be better than other investigated cosurfactants with Solutol HS15, to solubilize the aqueous and the oil phase. Furthermore, the results revealed the significant influence of the surfactant/cosurfactant mass ratio ( Km ) to form self-emulsifying system of Colloidal dimension. Km value 2 was observed to exert a synergistic effect. There was a good correlation between percentage transmittance of diluted self-emulsifying system and droplet size analysis ( R 2 = 0.951).