The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform

John J Kavanagh - One of the best experts on this subject based on the ideXlab platform.

  • metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor response to hormone therapy
    International Journal of Gynecological Cancer, 2006
    Co-Authors: Michael T Deavers, J I Hughes, John J Kavanagh
    Abstract:

    .  Lee E-J, Deavers MT, Hughes JI, Lee J-H, Kavanagh JJ. Metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor: response to hormone therapy. Int J Gynecol Cancer 2006;16(Suppl. 1):295–299. Distant metastasis to sites other than lymph nodes of borderline ovarian tumor is rare. We describe a case metastasized to sigmoid Colon Mucosa and subMucosa. The metastatic lesion was detected incidentally by screening Colonoscopy 7 years after the patient was treated for the primary tumor. The metastatic lesion responded well to treatment with oral Arimidex 1 mg/day. A follow-up Colonoscopy with biopsy and imaging studies after 3 months of treatment revealed no evidence of disease in the sigmoid Colon. This case showed that the sigmoid Colon Mucosa and subMucosa should be considered as one of distant metastatic sites of a serous borderline ovarian tumor and the favorable response to Arimidex provides support the use of hormone therapy in women with serous borderline ovarian tumor.

  • Metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor: response to hormone therapy
    International Journal of Gynecologic Cancer, 2006
    Co-Authors: Michael T Deavers, J I Hughes, John J Kavanagh
    Abstract:

    Distant metastasis to sites other than lymph nodes of borderline ovarian tumor is rare. We describe a case metastasized to sigmoid Colon Mucosa and subMucosa. The metastatic lesion was detected incidentally by screening Colonoscopy 7 years after the patient was treated for the primary tumor. The metastatic lesion responded well to treatment with oral Arimidex 1 mg/day. A follow-up Colonoscopy with biopsy and imaging studies after 3 months of treatment revealed no evidence of disease in the sigmoid Colon. This case showed that the sigmoid Colon Mucosa and subMucosa should be considered as one of distant metastatic sites of a serous borderline ovarian tumor and the favorable response to Arimidex provides support the use of hormone therapy in women with serous borderline ovarian tumor.

Michael T Deavers - One of the best experts on this subject based on the ideXlab platform.

  • metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor response to hormone therapy
    International Journal of Gynecological Cancer, 2006
    Co-Authors: Michael T Deavers, J I Hughes, John J Kavanagh
    Abstract:

    .  Lee E-J, Deavers MT, Hughes JI, Lee J-H, Kavanagh JJ. Metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor: response to hormone therapy. Int J Gynecol Cancer 2006;16(Suppl. 1):295–299. Distant metastasis to sites other than lymph nodes of borderline ovarian tumor is rare. We describe a case metastasized to sigmoid Colon Mucosa and subMucosa. The metastatic lesion was detected incidentally by screening Colonoscopy 7 years after the patient was treated for the primary tumor. The metastatic lesion responded well to treatment with oral Arimidex 1 mg/day. A follow-up Colonoscopy with biopsy and imaging studies after 3 months of treatment revealed no evidence of disease in the sigmoid Colon. This case showed that the sigmoid Colon Mucosa and subMucosa should be considered as one of distant metastatic sites of a serous borderline ovarian tumor and the favorable response to Arimidex provides support the use of hormone therapy in women with serous borderline ovarian tumor.

  • Metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor: response to hormone therapy
    International Journal of Gynecologic Cancer, 2006
    Co-Authors: Michael T Deavers, J I Hughes, John J Kavanagh
    Abstract:

    Distant metastasis to sites other than lymph nodes of borderline ovarian tumor is rare. We describe a case metastasized to sigmoid Colon Mucosa and subMucosa. The metastatic lesion was detected incidentally by screening Colonoscopy 7 years after the patient was treated for the primary tumor. The metastatic lesion responded well to treatment with oral Arimidex 1 mg/day. A follow-up Colonoscopy with biopsy and imaging studies after 3 months of treatment revealed no evidence of disease in the sigmoid Colon. This case showed that the sigmoid Colon Mucosa and subMucosa should be considered as one of distant metastatic sites of a serous borderline ovarian tumor and the favorable response to Arimidex provides support the use of hormone therapy in women with serous borderline ovarian tumor.

Peter R Jungblut - One of the best experts on this subject based on the ideXlab platform.

  • protein abundance alterations in matched sets of macroscopically normal Colon Mucosa and colorectal carcinoma
    Electrophoresis, 1999
    Co-Authors: Jiri Stulik, Kamila Koupilova, Jan Osterreicher, Jiri Knizek, Ales Macela, J Bures, P Jandik, Frantisek Langr, Karel Dedic, Peter R Jungblut
    Abstract:

    : Our current results, aimed at the detection of protein abundance alterations that could be associated with the process of Colon tumorigenesis, are summarized. The matched sets of macroscopically normal Colon Mucosa and colorectal carcinoma were examined by a one- or two-dimensional electrophoretic approach and proteins were identified using immunoblotting or mass spectrometry. The following results were observed: The levels of liver fatty acid-binding protein, actin-binding protein/smooth muscle protein 22-alpha and cyclooxygenase 2 were downregulated in colorectal carcinoma compared to normal Colon Mucosa. Conversely, the expression of a novel variant of heat shock protein70 and several members of the S100 protein family of calcium-binding proteins (two isoforms of S100A9, S100A8, S100A11 and S100A6) were upregulated in transformed Colon Mucosa. Despite the variations of the levels of expression of given protein among analyzed samples, all quantitative changes were found to be statistically significant (Mann-Whitney test assuming p < or = 0.05). We conclude that the proteomic approach is useful for the study of complex biological events underlying the process of colorectal tumorigenesis.

  • the analysis of s100a9 and s100a8 expression in matched sets of macroscopically normal Colon Mucosa and colorectal carcinoma the s100a9 and s100a8 positive cells underlie and invade tumor mass
    Electrophoresis, 1999
    Co-Authors: Jiri Stulik, Kamila Koupilova, Jan Osterreicher, Jiri Knizek, Ales Macela, J Bures, P Jandik, Frantisek Langr, Karel Dedic, Peter R Jungblut
    Abstract:

    The expression of calcium-binding protein S100A9 was investigated in 23 matched sets of colorectal carcinoma and normal Colon Mucosa using two-dimensional gel electrophoresis. We found that, from a group of 23 patients, the level of S100A9 protein, in comparison with matched normal Colon Mucosa, was significantly increased in malignant tissues of 16 patients (70%). Furthermore, an additional protein, identified by matrix-assisted laser desorption/ionization - mass spectrometry (MALDI-MS) as S100A8, exhibited an increased expression in the same specimens of malignant tissues as the S100A9 protein. The immunohistological analysis revealed the accumulation of S100A9 positive cells, macrophages and polymorphonuclear leukocytes along the invasive margin of colorectal carcinoma. The S100A8 protein was found to be produced in the same location. The possible participation of both proteins and, especially, its heterodimeric complex calprotectin in colorectal carcinoma regression could be taken into account.

J I Hughes - One of the best experts on this subject based on the ideXlab platform.

  • metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor response to hormone therapy
    International Journal of Gynecological Cancer, 2006
    Co-Authors: Michael T Deavers, J I Hughes, John J Kavanagh
    Abstract:

    .  Lee E-J, Deavers MT, Hughes JI, Lee J-H, Kavanagh JJ. Metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor: response to hormone therapy. Int J Gynecol Cancer 2006;16(Suppl. 1):295–299. Distant metastasis to sites other than lymph nodes of borderline ovarian tumor is rare. We describe a case metastasized to sigmoid Colon Mucosa and subMucosa. The metastatic lesion was detected incidentally by screening Colonoscopy 7 years after the patient was treated for the primary tumor. The metastatic lesion responded well to treatment with oral Arimidex 1 mg/day. A follow-up Colonoscopy with biopsy and imaging studies after 3 months of treatment revealed no evidence of disease in the sigmoid Colon. This case showed that the sigmoid Colon Mucosa and subMucosa should be considered as one of distant metastatic sites of a serous borderline ovarian tumor and the favorable response to Arimidex provides support the use of hormone therapy in women with serous borderline ovarian tumor.

  • Metastasis to sigmoid Colon Mucosa and subMucosa from serous borderline ovarian tumor: response to hormone therapy
    International Journal of Gynecologic Cancer, 2006
    Co-Authors: Michael T Deavers, J I Hughes, John J Kavanagh
    Abstract:

    Distant metastasis to sites other than lymph nodes of borderline ovarian tumor is rare. We describe a case metastasized to sigmoid Colon Mucosa and subMucosa. The metastatic lesion was detected incidentally by screening Colonoscopy 7 years after the patient was treated for the primary tumor. The metastatic lesion responded well to treatment with oral Arimidex 1 mg/day. A follow-up Colonoscopy with biopsy and imaging studies after 3 months of treatment revealed no evidence of disease in the sigmoid Colon. This case showed that the sigmoid Colon Mucosa and subMucosa should be considered as one of distant metastatic sites of a serous borderline ovarian tumor and the favorable response to Arimidex provides support the use of hormone therapy in women with serous borderline ovarian tumor.

Jiri Stulik - One of the best experts on this subject based on the ideXlab platform.

  • protein abundance alterations in matched sets of macroscopically normal Colon Mucosa and colorectal carcinoma
    Electrophoresis, 1999
    Co-Authors: Jiri Stulik, Kamila Koupilova, Jan Osterreicher, Jiri Knizek, Ales Macela, J Bures, P Jandik, Frantisek Langr, Karel Dedic, Peter R Jungblut
    Abstract:

    : Our current results, aimed at the detection of protein abundance alterations that could be associated with the process of Colon tumorigenesis, are summarized. The matched sets of macroscopically normal Colon Mucosa and colorectal carcinoma were examined by a one- or two-dimensional electrophoretic approach and proteins were identified using immunoblotting or mass spectrometry. The following results were observed: The levels of liver fatty acid-binding protein, actin-binding protein/smooth muscle protein 22-alpha and cyclooxygenase 2 were downregulated in colorectal carcinoma compared to normal Colon Mucosa. Conversely, the expression of a novel variant of heat shock protein70 and several members of the S100 protein family of calcium-binding proteins (two isoforms of S100A9, S100A8, S100A11 and S100A6) were upregulated in transformed Colon Mucosa. Despite the variations of the levels of expression of given protein among analyzed samples, all quantitative changes were found to be statistically significant (Mann-Whitney test assuming p < or = 0.05). We conclude that the proteomic approach is useful for the study of complex biological events underlying the process of colorectal tumorigenesis.

  • the analysis of s100a9 and s100a8 expression in matched sets of macroscopically normal Colon Mucosa and colorectal carcinoma the s100a9 and s100a8 positive cells underlie and invade tumor mass
    Electrophoresis, 1999
    Co-Authors: Jiri Stulik, Kamila Koupilova, Jan Osterreicher, Jiri Knizek, Ales Macela, J Bures, P Jandik, Frantisek Langr, Karel Dedic, Peter R Jungblut
    Abstract:

    The expression of calcium-binding protein S100A9 was investigated in 23 matched sets of colorectal carcinoma and normal Colon Mucosa using two-dimensional gel electrophoresis. We found that, from a group of 23 patients, the level of S100A9 protein, in comparison with matched normal Colon Mucosa, was significantly increased in malignant tissues of 16 patients (70%). Furthermore, an additional protein, identified by matrix-assisted laser desorption/ionization - mass spectrometry (MALDI-MS) as S100A8, exhibited an increased expression in the same specimens of malignant tissues as the S100A9 protein. The immunohistological analysis revealed the accumulation of S100A9 positive cells, macrophages and polymorphonuclear leukocytes along the invasive margin of colorectal carcinoma. The S100A8 protein was found to be produced in the same location. The possible participation of both proteins and, especially, its heterodimeric complex calprotectin in colorectal carcinoma regression could be taken into account.