The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
A. Ohnishi - One of the best experts on this subject based on the ideXlab platform.
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pharmacokinetics and adverse events following 5 day repeated administration of lenograstim a recombinant human granulocyte colony stimulating Factor in healthy subjects
Bone Marrow Transplantation, 2000Co-Authors: Setsuko Akizuki, F Mizorogi, K. Sudo, T. Inoue, A. OhnishiAbstract:Pharmacokinetics and adverse events following 5-day repeated administration of lenograstim, a recombinant human granulocyte Colony-Stimulating Factor, in healthy subjects
Arturo J Vegas - One of the best experts on this subject based on the ideXlab platform.
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colony stimulating Factor 1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non human primates
Nature Materials, 2017Co-Authors: Joshua C Doloff, Omid Veiseh, Arturo J Vegas, Hok Hei Tam, Shady Farah, Jie LiAbstract:By studying the immune responses of animals to different types of biomaterial implants, colony stimulating Factor-1 receptor is revealed as an important mediator of the foreign body reaction and a possible target for fibrosis inhibition.
Joshua C Doloff - One of the best experts on this subject based on the ideXlab platform.
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colony stimulating Factor 1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non human primates
Nature Materials, 2017Co-Authors: Joshua C Doloff, Omid Veiseh, Arturo J Vegas, Hok Hei Tam, Shady Farah, Jie LiAbstract:By studying the immune responses of animals to different types of biomaterial implants, colony stimulating Factor-1 receptor is revealed as an important mediator of the foreign body reaction and a possible target for fibrosis inhibition.
John F Dipersio - One of the best experts on this subject based on the ideXlab platform.
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granulocyte macrophage colony stimulating Factor gm csf and granulocyte colony stimulating Factor g csf receptor biology signal transduction and neutrophil activation
Blood Reviews, 1992Co-Authors: Aaron P Rapoport, Camille N. Abboud, John F DipersioAbstract:Abstract Granulocyte-macrophage Colony-Stimulating Factor (GM-CSF) and granulocyte Colony-Stimulating Factor (G-CSF) are two of the growing number of recognized cytokines involved in the regulation of hematopoiesis. The purification of these Factors and the subsequent cloning of the cDNAs which encode these proteins have led to their widespread clinical use in the setting of therapy or disease-induced myelosuppression. Although originally purified on the basis of their Colony-Stimulating properties, GM-CSF and G-CSF may also play important roles in the regulation of effector cell function. The mechanisms underlying progenitor cell proliferation and effector cell stimulation remain poorly understood. However, the characterization of the GM-CSF and G-CSF receptors and recent work in signal transduction are helping to elucidate these mechanisms. This paper will review the biology of the GM-CSF and G-CSF receptors, the mechanisms of post-receptor signal transduction, and the resultant effects on neutrophil function. In addition, the current and potential clinical uses of these Factors will be examined in light of their ability to activate and perhaps enhance the function of neutrophils.
Minshu Li - One of the best experts on this subject based on the ideXlab platform.
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colony stimulating Factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage
Journal of Cerebral Blood Flow and Metabolism, 2017Co-Authors: Minshu Li, Zhiguo Li, Kristofer Wood, Kevin N ShethAbstract:Microglia are the first responders to intracerebral hemorrhage, but their precise role in intracerebral hemorrhage remains to be defined. Microglia are the only type of brain cells expressing the Colony-Stimulating Factor 1 receptor, a key regulator for myeloid lineage cells. Here, we determined the effects of a Colony-Stimulating Factor 1 receptor inhibitor (PLX3397) on microglia and the outcome in the context of experimental mouse intracerebral hemorrhage. We show that PLX3397 effectively depleted microglia, and the depletion of microglia was sustained after intracerebral hemorrhage. Importantly, Colony-Stimulating Factor 1 receptor inhibition attenuated neurodeficits and brain edema in two experimental models of intracerebral hemorrhage induced by injection of collagenase or autologous blood. The benefit of Colony-Stimulating Factor 1 receptor inhibition was associated with reduced leukocyte infiltration in the brain and improved blood–brain barrier integrity after intracerebral hemorrhage, and each ob...