The Experts below are selected from a list of 285 Experts worldwide ranked by ideXlab platform

Magnus S Agren - One of the best experts on this subject based on the ideXlab platform.

  • A comparative study of three occlusive dressings in the treatment of full-thickness wounds in pigs☆☆☆★
    Journal of The American Academy of Dermatology, 2005
    Co-Authors: Magnus S Agren, Patricia M. Mertza, Lennart Franzén
    Abstract:

    Abstract Background: Little objective information is available on the influence of occlusive dressings on the healing of cutaneous full-thickness wounds. Objective: Our purpose was to examine the effects of three occlusive dressings—two hydrocolloid dressings (Comfeel Ulcer Dressing, Coloplast A/S, Espergaerder, Denmark [hydrocolloid dressing A] and DuoDERM; ConvaTec, Princeton, N.J. [hydrocolloid dressing B]) and one polyurethane film dressing (OpSite, Smith & Nephew, Hull, U.K. [film dressing])—on tissue reactions, degree of inflammation, wound contraction, and epithelialization in full-thickness wounds in domestic pigs. Methods: Standardized 20 mm full-thickness punch biopsy wounds were treated for 10 days. Healing was assessed by light microscopy and by planimetry. Results: Material from both hydrocolloid dressings was phagocytosed as indicated by the presence of foam cells in the granulation tissue. Granulomatous tissue reactions around extracellular vacuoles were found in 10 of 12 hydrocolloid dressing B–treated wounds compared with one in hydrocolloid dressing A–treated wounds and in none of the 10 film dressing–treated wounds ( p p p Conclusion: Wound tissue reactions to different hydrocolloid dressings vary depending on composition. The tissue reactions had no significant effect on wound contraction or epithelialization. (J Am Acad Dermatol 1997;36:53-8.)

  • Occlusion versus air exposure on full-thickness biopsy wounds
    Journal of Wound Care, 2001
    Co-Authors: Magnus S Agren, T. Karlsmark, J.b. Hansen, J. Rygaard
    Abstract:

    The benefits of moisture-retaining dressings on wound healing are well documented in experimental animal models but not in humans. To examine the effect of occlusion, the effects of three brands of synthetic occlusive dressings (Comfeel Plus, DuoDerm CGF, OpSite) were compared with air exposure in epithelial resurfacing and proliferation in acute, full-thickness skin wounds in humans.

  • a fibre free alginate dressing in the treatment of split thickness skin graft donor sites
    Journal of The European Academy of Dermatology and Venereology, 1998
    Co-Authors: H H Steenfos, Magnus S Agren
    Abstract:

    Background Alginate dressings are gaining acceptance in wound management although comparative published data with conventional treatment is inconclusive. Aims The aim of this randomised controlled study was to compare a fibre-free alginate dressing (Comfeel SeaSorb) with conventional treatment of standardised split-thickness skin graft donor sites in 17 patients regarding initial absorption of blood and healing. Results The alginate dressing absorbed 40% (P < 0.05) more blood, measured as total iron content of used dressings, during the first 10 post-wounding minutes than fine mesh gauze, resulting in less subsequent bleeding. Light microscopic examination of punch biopsies obtained from 10 wounds on post-operative day 6 demonstrated that nine wounds treated with the alginate dressing compared with seven wounds treated conventionally with paraffin-impregnated gauze (Jelonet8) were completely epithelialised, a statistically non-significant difference (P = 0.46). Conclusions In conclusion, the fibre-free alginate dressing showed increased initial blood absorption resulting in quicker haemostasis but showed no greater beneficial effect on epithelialisation of split-thickness skin graft donor sites compared with conventional topical treatment. 0 1998 Elsevier Science B.V. All rights reserved

  • Two hydrocolloid dressings evaluated in experimental full-thickness wounds in the skin.
    Acta Dermato-venereologica, 1997
    Co-Authors: Magnus S Agren, Everland H
    Abstract:

    : Hydrocolloid occlusive dressings are beneficial in wound management in many respects, although the adhesive matrix may disintegrate when in contact with wounds. The purpose of this study was to determine: (1) if material from two hydrocolloid dressings-Comfeel and Duoderm-showing differences in adhesive cohesion, can be chemically identified in granulation tissue; and (2) if the presence of this material influences cutaneous wound healing. In full-thickness skin wounds in rats, components from the two hydrocolloid dressings were phagocytosed as indicated by the presence of foam cells. Extracellular vacuoles (100-400 microns in size) occupied about 25% of the granulation tissue volume in the Duoderm group but less than 5% in the Comfeel group, a statistically significant difference (p < 0.001). The vacuoles contained hydrophobic polymers derived from the respective hydrocolloid dressing, as analyzed by Fourier Transform Infrared (FT-IR) microscopy. Wound contraction did not differ significantly between the two hydrocolloid dressings. Wounds treated with Comfeel were significantly (p < 0.05) more epithelialized (mean: 78%) than those treated with Duoderm (mean: 41%). The proliferative activity in wound epithelium, as measured immunohistochemically by bromodeoxyuridine incorporation, was similar for the two treatment groups, indicating that epithelial migration was impaired in Duoderm-treated wounds. In summary, extensive incorporation of hydrophobic dressing material from hydrocolloid dressings may render the wound bed less suitable for epithelial migration during acute secondary wound healing.

  • A comparative study of three occlusive dressings in the treatment of full-thickness wounds in pigs
    Journal of the American Academy of Dermatology, 1997
    Co-Authors: Magnus S Agren, P. M. Mertz, Léon Franzen
    Abstract:

    Background: Little objective information is available on the influence of occlusive dressings on the healing of cutaneous full-thickness wounds. Objective: Our purpose was to examine the effects of three occlusive dressings-two hydrocolloid dressings (Comfeel Ulcer Dressing, Coloplast A/S, Espergaerder, Denmark [hydrocolloid dressing A] and DuoDERM; ConvaTec, Princeton, N.J. [hydrocolloid dressing B]) and one polyurethane film dressing (OpSite, Smith and Nephew, Hull, U.K. [film dressing]) - on tissue reactions, degree of inflammation, wound contraction, and epithelialization in full- thickness wounds in domestic pigs. Methods: Standardized 20 mm full-thickness punch biopsy wounds were treated for 10 days. Healing was assessed by light microscopy and by planimetry. Results: Material from both hydrocolloid dressings was phagocytosed as indicated by the presence of foam cells in the granulation tissue. Granulomatous tissue reactions around extracellular vacuoles were found in 10 of 12 hydrocolloid dressing B treated wounds compared with one in hydrocolloid dressing A treated wounds and in none of the 10 film dressing treated wounds (p

A. Kursat Bozkurt - One of the best experts on this subject based on the ideXlab platform.

  • Combination of hydrocolloid dressing and medical compression stockings versus Unna's boot for the treatment of venous leg ulcers.
    Swiss medical weekly, 2003
    Co-Authors: Cengiz Koksal, A. Kursat Bozkurt
    Abstract:

    Various therapeutic approaches have been developed to manage venous ulcers. In this study the effectiveness of a hydrocolloid dressing (Comfeel Ulcer Dressing) in comparison to the Unna boot, the prototype of rigid bandages, was evaluated. Prospective, comparative study. University hospital. Sixty patients diagnosed with post-thrombotic chronic venous insufficiency with venous ulcers were randomly assigned to two groups of 30 patients. In group A, the Unna boot, and in group B, hydrocolloid dressing in addition to the elastic compression were used. The two groups were compared in terms of 1) complete healing, 2) weekly wound surface reduction, 3) time to complete healing, 4) performance characteristics (ease-of-use score), 5) pain during application and at home, 6) application time. The duration of the ulcers was 16.6 +/- 5.8 weeks in group A and 16.9 +/- 6.2 in group B (p >0.05). Previous ulcer recurrence was 74% (20/27 patients) in group A and 73% (19/26 patients) in group B (p >0.05). The initial ulcer size was 6.38 +/- 1.2 cm2 in group A and 6.19 +/- 0.8 cm2 in group B (p >0.05). The complete healing rates were 74.07% (20/27) in group A and 80. 76% (21/26) in group B (p >0.05). The weekly wound surface reductions were 1.28 +/- 0.72 cm2/week and 1.16 +/- 0.38 cm2/week in groups A and B, respectively (p >0.05). The ulcer healing time was 6.85 +/- 3.60 weeks in group A, whereas it was 6.65 +/- 3.31 weeks in group B (p >0.05). Ease-of-use score was 9.04 +/- 2.38 in group A and 17.27 +/- 3.27 in group B and the difference was significant (p <0.0001). A higher degree of pain was reported by the patients who were treated with the Unna boot, both during application (group A 3.69 +/- 1.35, group B 1.88 +/- 1.48, p <0.0001) and at home (group A, 3.27 +/- 1.08, group B, 1.88 +/- 1.11, p <0.0001). The average time spent on Unna boot changes was 150.59 +/- 34.73 min, compared to 134.54 +/- 43.39 min in group B (p >0.05). These results demonstrate the superiority of hydrocolloid dressing plus elastic compression treatment in terms of patient convenience.

  • combination of hydrocolloid dressing and medical compression stockings versus unna s boot for the treatment of venous leg ulcers
    Swiss Medical Weekly, 2003
    Co-Authors: Cengiz Koksal, A. Kursat Bozkurt
    Abstract:

    BACKGROUND: Various therapeutic approaches have been developed to manage venous ulcers. In this study the effectiveness of a hydrocolloid dressing (Comfeel Ulcer Dressing) in comparison to the Unna boot, the prototype of rigid bandages, was evaluated. DESIGN: Prospective, comparative study. SETTING: University hospital. PATIENTS: Sixty patients diagnosed with post-thrombotic chronic venous insufficiency with venous ulcers were randomly assigned to two groups of 30 patients. INTERVENTIONS: In group A, the Unna boot, and in group B, hydrocolloid dressing in addition to the elastic compression were used. MEASURES: The two groups were compared in terms of 1) complete healing, 2) weekly wound surface reduction, 3) time to complete healing, 4) performance characteristics (ease-of-use score), 5) pain during application and at home, 6) application time. RESULTS: The duration of the ulcers was 16.6 +/- 5.8 weeks in group A and 16.9 +/- 6.2 in group B (p >0.05). Previous ulcer recurrence was 74% (20/27 patients) in group A and 73% (19/26 patients) in group B (p >0.05). The initial ulcer size was 6.38 +/- 1.2 cm2 in group A and 6.19 +/- 0.8 cm2 in group B (p >0.05). The complete healing rates were 74.07% (20/27) in group A and 80. 76% (21/26) in group B (p >0.05). The weekly wound surface reductions were 1.28 +/- 0.72 cm2/week and 1.16 +/- 0.38 cm2/week in groups A and B, respectively (p >0.05). The ulcer healing time was 6.85 +/- 3.60 weeks in group A, whereas it was 6.65 +/- 3.31 weeks in group B (p >0.05). Ease-of-use score was 9.04 +/- 2.38 in group A and 17.27 +/- 3.27 in group B and the difference was significant (p 0.05). CONCLUSIONS: These results demonstrate the superiority of hydrocolloid dressing plus elastic compression treatment in terms of patient convenience.

  • Combination of hydrocolloid dressing and medical compression stocking versus Unna's boot for the treatment of venous leg ulcers
    Swiss Medical Weekly, 2003
    Co-Authors: Cengiz Koksal, A. Kursat Bozkurt
    Abstract:

    Various therapeutic approaches have been developed to manage venous ulcers. In this study the effectiveness of a hydrocolloid dressing (Comfeel Ulcer Dressing) in comparison to the Unna boot, the prototype of rigid bandages, was evaluated.

Ahmet Demir - One of the best experts on this subject based on the ideXlab platform.

  • management of split thickness skin graft donor site a prospective clinical trial for comparison of five different dressing materials
    Burns, 2010
    Co-Authors: Yener Demirtas, Caglayan Yagmur, Fatih Soylemez, Nuray Ozturk, Ahmet Demir
    Abstract:

    Abstract Introduction Split-thickness skin grafting (STSG) is a frequently used reconstructive technique but is associated with a large variation regarding the management of the donor site. The aim of this study is to compare five different dressings for management of the STSG donor site in a prospective trial. Patients and methods 100 consecutive patients, in whom reconstruction with STSG was performed, were included into the study. The grafts are harvested in a standard manner and the donor sites were dressed with one of the following materials: Aquacel ® Ag, Bactigras ® with Melolin ® , Comfeel ® Plus Transparent, Opsite ® Flexigrid and Adaptic ® . The materials are compared regarding to the time required for complete epithelialization, pain sensed by the patients, incidence of infection, scar formation, ease of application and the cost. Results The earliest complete epithelialization was observed for Aquacel ® Ag and the latest for Bactigras ® with Melolin ® ·Comfeel ® Plus Transparent was the most painless dressing and Bactigras ® with Melolin ® was the most painful. The incidence of infection was highest for Bactigras ® with Melolin ® ·Opsite ® Flexigrid was the most economical dressing and Aquacel ® Ag was the most expensive one. Conclusion The aim is to provide the earliest complete epithelialization with minimal patient discomfort and lower cost in management of the STSG donor sites. None of the tested materials were ideal regarding these criteria, but Comfeel ® Plus Transparent, as the least painful and one of the most economical materials, may be offered as the dressing of choice among the tested materials.

Cengiz Koksal - One of the best experts on this subject based on the ideXlab platform.

  • Combination of hydrocolloid dressing and medical compression stockings versus Unna's boot for the treatment of venous leg ulcers.
    Swiss medical weekly, 2003
    Co-Authors: Cengiz Koksal, A. Kursat Bozkurt
    Abstract:

    Various therapeutic approaches have been developed to manage venous ulcers. In this study the effectiveness of a hydrocolloid dressing (Comfeel Ulcer Dressing) in comparison to the Unna boot, the prototype of rigid bandages, was evaluated. Prospective, comparative study. University hospital. Sixty patients diagnosed with post-thrombotic chronic venous insufficiency with venous ulcers were randomly assigned to two groups of 30 patients. In group A, the Unna boot, and in group B, hydrocolloid dressing in addition to the elastic compression were used. The two groups were compared in terms of 1) complete healing, 2) weekly wound surface reduction, 3) time to complete healing, 4) performance characteristics (ease-of-use score), 5) pain during application and at home, 6) application time. The duration of the ulcers was 16.6 +/- 5.8 weeks in group A and 16.9 +/- 6.2 in group B (p >0.05). Previous ulcer recurrence was 74% (20/27 patients) in group A and 73% (19/26 patients) in group B (p >0.05). The initial ulcer size was 6.38 +/- 1.2 cm2 in group A and 6.19 +/- 0.8 cm2 in group B (p >0.05). The complete healing rates were 74.07% (20/27) in group A and 80. 76% (21/26) in group B (p >0.05). The weekly wound surface reductions were 1.28 +/- 0.72 cm2/week and 1.16 +/- 0.38 cm2/week in groups A and B, respectively (p >0.05). The ulcer healing time was 6.85 +/- 3.60 weeks in group A, whereas it was 6.65 +/- 3.31 weeks in group B (p >0.05). Ease-of-use score was 9.04 +/- 2.38 in group A and 17.27 +/- 3.27 in group B and the difference was significant (p <0.0001). A higher degree of pain was reported by the patients who were treated with the Unna boot, both during application (group A 3.69 +/- 1.35, group B 1.88 +/- 1.48, p <0.0001) and at home (group A, 3.27 +/- 1.08, group B, 1.88 +/- 1.11, p <0.0001). The average time spent on Unna boot changes was 150.59 +/- 34.73 min, compared to 134.54 +/- 43.39 min in group B (p >0.05). These results demonstrate the superiority of hydrocolloid dressing plus elastic compression treatment in terms of patient convenience.

  • combination of hydrocolloid dressing and medical compression stockings versus unna s boot for the treatment of venous leg ulcers
    Swiss Medical Weekly, 2003
    Co-Authors: Cengiz Koksal, A. Kursat Bozkurt
    Abstract:

    BACKGROUND: Various therapeutic approaches have been developed to manage venous ulcers. In this study the effectiveness of a hydrocolloid dressing (Comfeel Ulcer Dressing) in comparison to the Unna boot, the prototype of rigid bandages, was evaluated. DESIGN: Prospective, comparative study. SETTING: University hospital. PATIENTS: Sixty patients diagnosed with post-thrombotic chronic venous insufficiency with venous ulcers were randomly assigned to two groups of 30 patients. INTERVENTIONS: In group A, the Unna boot, and in group B, hydrocolloid dressing in addition to the elastic compression were used. MEASURES: The two groups were compared in terms of 1) complete healing, 2) weekly wound surface reduction, 3) time to complete healing, 4) performance characteristics (ease-of-use score), 5) pain during application and at home, 6) application time. RESULTS: The duration of the ulcers was 16.6 +/- 5.8 weeks in group A and 16.9 +/- 6.2 in group B (p >0.05). Previous ulcer recurrence was 74% (20/27 patients) in group A and 73% (19/26 patients) in group B (p >0.05). The initial ulcer size was 6.38 +/- 1.2 cm2 in group A and 6.19 +/- 0.8 cm2 in group B (p >0.05). The complete healing rates were 74.07% (20/27) in group A and 80. 76% (21/26) in group B (p >0.05). The weekly wound surface reductions were 1.28 +/- 0.72 cm2/week and 1.16 +/- 0.38 cm2/week in groups A and B, respectively (p >0.05). The ulcer healing time was 6.85 +/- 3.60 weeks in group A, whereas it was 6.65 +/- 3.31 weeks in group B (p >0.05). Ease-of-use score was 9.04 +/- 2.38 in group A and 17.27 +/- 3.27 in group B and the difference was significant (p 0.05). CONCLUSIONS: These results demonstrate the superiority of hydrocolloid dressing plus elastic compression treatment in terms of patient convenience.

  • Combination of hydrocolloid dressing and medical compression stocking versus Unna's boot for the treatment of venous leg ulcers
    Swiss Medical Weekly, 2003
    Co-Authors: Cengiz Koksal, A. Kursat Bozkurt
    Abstract:

    Various therapeutic approaches have been developed to manage venous ulcers. In this study the effectiveness of a hydrocolloid dressing (Comfeel Ulcer Dressing) in comparison to the Unna boot, the prototype of rigid bandages, was evaluated.

H H Steenfos - One of the best experts on this subject based on the ideXlab platform.

  • a fibre free alginate dressing in the treatment of split thickness skin graft donor sites
    Journal of The European Academy of Dermatology and Venereology, 1998
    Co-Authors: H H Steenfos, Magnus S Agren
    Abstract:

    Background Alginate dressings are gaining acceptance in wound management although comparative published data with conventional treatment is inconclusive. Aims The aim of this randomised controlled study was to compare a fibre-free alginate dressing (Comfeel SeaSorb) with conventional treatment of standardised split-thickness skin graft donor sites in 17 patients regarding initial absorption of blood and healing. Results The alginate dressing absorbed 40% (P < 0.05) more blood, measured as total iron content of used dressings, during the first 10 post-wounding minutes than fine mesh gauze, resulting in less subsequent bleeding. Light microscopic examination of punch biopsies obtained from 10 wounds on post-operative day 6 demonstrated that nine wounds treated with the alginate dressing compared with seven wounds treated conventionally with paraffin-impregnated gauze (Jelonet8) were completely epithelialised, a statistically non-significant difference (P = 0.46). Conclusions In conclusion, the fibre-free alginate dressing showed increased initial blood absorption resulting in quicker haemostasis but showed no greater beneficial effect on epithelialisation of split-thickness skin graft donor sites compared with conventional topical treatment. 0 1998 Elsevier Science B.V. All rights reserved