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Norbert Quadflieg - One of the best experts on this subject based on the ideXlab platform.

  • The Upper Bavarian longitudinal Community Study 1975–2004. 2. Long-term course and outcome of depression
    European Archives of Psychiatry and Clinical Neuroscience, 2008
    Co-Authors: Manfred M. Fichter, Gabriele Kohlboeck, Norbert Quadflieg
    Abstract:

    Objective The Study describes course and outcome over 25 years in depressed and non-depressed men and women from a large Community Study. Outcome measures covered psychopathology, disability, and impaired functioning. Method A depressive syndrome (depressed mood and three additional depressive symptoms) was defined and compared to a control condition without depressive symptoms in the seven days preceding baseline assessment. Assessments focused on three time points: baseline survey, 5-year follow-up, and 25-year follow-up. Self-rating scales as well as expert-rating interviews yielded data on a wide range of social and psychopathological risk factors and outcome measures. Results Among participants of all three waves ( N  = 838), the baseline prevalence for depressive syndrome was 18.1%. Depressive symptoms manifest at the first wave had substantial impact over the 25-year Study. Subjects with a depressive syndrome were predisposed for later adverse mental health outcomes, more disability in social domains and reduced functionality. No long-term increase or decrease of the prevalence of the depressive syndrome was observed. Conclusion There is a persistent and long lasting impact of depressive syndrome, irrespective of diagnostic status, in the general population. Our results underscore the importance of sub-syndromal depressive syndrome when estimating the risk of future mental disorders and functional impairment in the long-term.

  • The Upper Bavarian longitudinal Community Study on psychopathology 1975–2004: 1. Methods and first results
    European Archives of Psychiatry and Clinical Neuroscience, 2008
    Co-Authors: Manfred M. Fichter, Gabriele Kohlboeck, Norbert Quadflieg, Horst Dilling, Thomas Niedermeier
    Abstract:

    Objective This paper presents background information on the methods and first results of the 25-years follow-up of the prospective longitudinal Upper Bavarian Study in the Community. Longitudinal epidemiological studies which cover very long time spans require special methods. Issues concerning these requirements are discussed using design and experiences from the Upper Bavarian Study. Method Assessments focused on three time points: baseline survey, five-year follow-up, and 25-year follow-up. Self-rating scales as well as expert-rating interviews yielded data on a wide range of social and psychopathological risk factors and outcome measures. Results Of the 1,342 Study participants in the original sample, 390 had died during the 25-year follow-up period. Participation rate was 88% of those alive. At all three time points, a total of 838 participants were interviewed. Data on this unselected sample over a quarter century will be presented in forthcoming papers. Because of their mobility young individuals from our original sample were more difficult to follow up. We analyzed in detail data of subjects interviewed at t3 (and earlier time points) as compared to data from subjects not traced or reached, and subjects who refused to participate at wave t3. We found no evidence that the long-term outcome was biased by drop-out due to gender or earlier mental illness. Conclusion Methodological possibilities and limitations concerning long-term epidemiological studies across decades are presented and discussed.

Manfred M. Fichter - One of the best experts on this subject based on the ideXlab platform.

  • The Upper Bavarian longitudinal Community Study 1975–2004. 2. Long-term course and outcome of depression
    European Archives of Psychiatry and Clinical Neuroscience, 2008
    Co-Authors: Manfred M. Fichter, Gabriele Kohlboeck, Norbert Quadflieg
    Abstract:

    Objective The Study describes course and outcome over 25 years in depressed and non-depressed men and women from a large Community Study. Outcome measures covered psychopathology, disability, and impaired functioning. Method A depressive syndrome (depressed mood and three additional depressive symptoms) was defined and compared to a control condition without depressive symptoms in the seven days preceding baseline assessment. Assessments focused on three time points: baseline survey, 5-year follow-up, and 25-year follow-up. Self-rating scales as well as expert-rating interviews yielded data on a wide range of social and psychopathological risk factors and outcome measures. Results Among participants of all three waves ( N  = 838), the baseline prevalence for depressive syndrome was 18.1%. Depressive symptoms manifest at the first wave had substantial impact over the 25-year Study. Subjects with a depressive syndrome were predisposed for later adverse mental health outcomes, more disability in social domains and reduced functionality. No long-term increase or decrease of the prevalence of the depressive syndrome was observed. Conclusion There is a persistent and long lasting impact of depressive syndrome, irrespective of diagnostic status, in the general population. Our results underscore the importance of sub-syndromal depressive syndrome when estimating the risk of future mental disorders and functional impairment in the long-term.

  • The Upper Bavarian longitudinal Community Study on psychopathology 1975–2004: 1. Methods and first results
    European Archives of Psychiatry and Clinical Neuroscience, 2008
    Co-Authors: Manfred M. Fichter, Gabriele Kohlboeck, Norbert Quadflieg, Horst Dilling, Thomas Niedermeier
    Abstract:

    Objective This paper presents background information on the methods and first results of the 25-years follow-up of the prospective longitudinal Upper Bavarian Study in the Community. Longitudinal epidemiological studies which cover very long time spans require special methods. Issues concerning these requirements are discussed using design and experiences from the Upper Bavarian Study. Method Assessments focused on three time points: baseline survey, five-year follow-up, and 25-year follow-up. Self-rating scales as well as expert-rating interviews yielded data on a wide range of social and psychopathological risk factors and outcome measures. Results Of the 1,342 Study participants in the original sample, 390 had died during the 25-year follow-up period. Participation rate was 88% of those alive. At all three time points, a total of 838 participants were interviewed. Data on this unselected sample over a quarter century will be presented in forthcoming papers. Because of their mobility young individuals from our original sample were more difficult to follow up. We analyzed in detail data of subjects interviewed at t3 (and earlier time points) as compared to data from subjects not traced or reached, and subjects who refused to participate at wave t3. We found no evidence that the long-term outcome was biased by drop-out due to gender or earlier mental illness. Conclusion Methodological possibilities and limitations concerning long-term epidemiological studies across decades are presented and discussed.

Birthe Høgh - One of the best experts on this subject based on the ideXlab platform.

  • A Community Study of clinical traits and risk factors for human metapneumovirus and respiratory syncytial virus infection during the first year of life
    European Journal of Pediatrics, 2008
    Co-Authors: Marie-louise Von Linstow, Jesper Eugen-olsen, Mette Høgh, Svein Arne Nordbø, Anders Koch, Birthe Høgh
    Abstract:

    Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are important respiratory pathogens with similar symptomatology. The aim of this prospective birth cohort Study was to identify risk factors for an hMPV or RSV infection during the first year of life in unselected healthy children. We followed 217 children from birth to 1 year of age. Nasal swabs and symptom diaries were collected monthly. Anti-hMPV and anti-RSV IgG antibodies by age 1 year were detected by ELISA, and nasal swabs were analysed for hMPV and RSV by RT-PCR. Logistic regression was used for risk factor analysis. Anti-hMPV IgG was found in 38 children (17.5%), and anti-RSV IgG in 172 children (79%). Risk factors for being anti-hMPV IgG-positive were: (1) being born in the spring (OR = 2.36; 95% CI:1.06–5.27), and (2) having older siblings (OR = 3.82; 95% CI:1.75–8.34). Risk factors for being anti-RSV IgG-positive were: (1) gestational age

  • a Community Study of clinical traits and risk factors for human metapneumovirus and respiratory syncytial virus infection during the first year of life
    European Journal of Pediatrics, 2008
    Co-Authors: Marielouise Von Linstow, Mette Høgh, Svein Arne Nordbø, Anders Koch, Jesper Eugenolsen, Birthe Høgh
    Abstract:

    Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are important respiratory pathogens with similar symptomatology. The aim of this prospective birth cohort Study was to identify risk factors for an hMPV or RSV infection during the first year of life in unselected healthy children. We followed 217 children from birth to 1 year of age. Nasal swabs and symptom diaries were collected monthly. Anti-hMPV and anti-RSV IgG antibodies by age 1 year were detected by ELISA, and nasal swabs were analysed for hMPV and RSV by RT-PCR. Logistic regression was used for risk factor analysis. Anti-hMPV IgG was found in 38 children (17.5%), and anti-RSV IgG in 172 children (79%). Risk factors for being anti-hMPV IgG-positive were: (1) being born in the spring (OR = 2.36; 95% CI:1.06–5.27), and (2) having older siblings (OR = 3.82; 95% CI:1.75–8.34). Risk factors for being anti-RSV IgG-positive were: (1) gestational age <38 weeks (OR = 3.39; 95% CI:1.42–8.05), (2) increasing paternal age (OR = 1.85 per 5 yrs; 95% CI:1.28–2.68), and (3) wall-to-wall carpeting (OR = 3.15; 95% CI:1.29–7.68). Being born in the spring was associated with decreased odds of being anti-RSV IgG-positive (OR = 0.27, 95% CI:0.09–0.85). Risk factors for RSV hospitalisation (n = 11) were: (1) older siblings (OR = 4.49; 95% CI: 1.08–18.73) and (2) smoking in the household (OR = 5.06; 95% CI: 1.36–18.76). Exclusive breastfeeding for the first 14 days of life protected against hospitalisation (OR = 0.21; 95% CI:0.06–0.79). In conclusion, this Study identifies risk factors for mild and asymptomatic hMPV infections in infancy.

Thomas Niedermeier - One of the best experts on this subject based on the ideXlab platform.

  • The Upper Bavarian longitudinal Community Study on psychopathology 1975–2004: 1. Methods and first results
    European Archives of Psychiatry and Clinical Neuroscience, 2008
    Co-Authors: Manfred M. Fichter, Gabriele Kohlboeck, Norbert Quadflieg, Horst Dilling, Thomas Niedermeier
    Abstract:

    Objective This paper presents background information on the methods and first results of the 25-years follow-up of the prospective longitudinal Upper Bavarian Study in the Community. Longitudinal epidemiological studies which cover very long time spans require special methods. Issues concerning these requirements are discussed using design and experiences from the Upper Bavarian Study. Method Assessments focused on three time points: baseline survey, five-year follow-up, and 25-year follow-up. Self-rating scales as well as expert-rating interviews yielded data on a wide range of social and psychopathological risk factors and outcome measures. Results Of the 1,342 Study participants in the original sample, 390 had died during the 25-year follow-up period. Participation rate was 88% of those alive. At all three time points, a total of 838 participants were interviewed. Data on this unselected sample over a quarter century will be presented in forthcoming papers. Because of their mobility young individuals from our original sample were more difficult to follow up. We analyzed in detail data of subjects interviewed at t3 (and earlier time points) as compared to data from subjects not traced or reached, and subjects who refused to participate at wave t3. We found no evidence that the long-term outcome was biased by drop-out due to gender or earlier mental illness. Conclusion Methodological possibilities and limitations concerning long-term epidemiological studies across decades are presented and discussed.

Gabriele Kohlboeck - One of the best experts on this subject based on the ideXlab platform.

  • The Upper Bavarian longitudinal Community Study 1975–2004. 2. Long-term course and outcome of depression
    European Archives of Psychiatry and Clinical Neuroscience, 2008
    Co-Authors: Manfred M. Fichter, Gabriele Kohlboeck, Norbert Quadflieg
    Abstract:

    Objective The Study describes course and outcome over 25 years in depressed and non-depressed men and women from a large Community Study. Outcome measures covered psychopathology, disability, and impaired functioning. Method A depressive syndrome (depressed mood and three additional depressive symptoms) was defined and compared to a control condition without depressive symptoms in the seven days preceding baseline assessment. Assessments focused on three time points: baseline survey, 5-year follow-up, and 25-year follow-up. Self-rating scales as well as expert-rating interviews yielded data on a wide range of social and psychopathological risk factors and outcome measures. Results Among participants of all three waves ( N  = 838), the baseline prevalence for depressive syndrome was 18.1%. Depressive symptoms manifest at the first wave had substantial impact over the 25-year Study. Subjects with a depressive syndrome were predisposed for later adverse mental health outcomes, more disability in social domains and reduced functionality. No long-term increase or decrease of the prevalence of the depressive syndrome was observed. Conclusion There is a persistent and long lasting impact of depressive syndrome, irrespective of diagnostic status, in the general population. Our results underscore the importance of sub-syndromal depressive syndrome when estimating the risk of future mental disorders and functional impairment in the long-term.

  • The Upper Bavarian longitudinal Community Study on psychopathology 1975–2004: 1. Methods and first results
    European Archives of Psychiatry and Clinical Neuroscience, 2008
    Co-Authors: Manfred M. Fichter, Gabriele Kohlboeck, Norbert Quadflieg, Horst Dilling, Thomas Niedermeier
    Abstract:

    Objective This paper presents background information on the methods and first results of the 25-years follow-up of the prospective longitudinal Upper Bavarian Study in the Community. Longitudinal epidemiological studies which cover very long time spans require special methods. Issues concerning these requirements are discussed using design and experiences from the Upper Bavarian Study. Method Assessments focused on three time points: baseline survey, five-year follow-up, and 25-year follow-up. Self-rating scales as well as expert-rating interviews yielded data on a wide range of social and psychopathological risk factors and outcome measures. Results Of the 1,342 Study participants in the original sample, 390 had died during the 25-year follow-up period. Participation rate was 88% of those alive. At all three time points, a total of 838 participants were interviewed. Data on this unselected sample over a quarter century will be presented in forthcoming papers. Because of their mobility young individuals from our original sample were more difficult to follow up. We analyzed in detail data of subjects interviewed at t3 (and earlier time points) as compared to data from subjects not traced or reached, and subjects who refused to participate at wave t3. We found no evidence that the long-term outcome was biased by drop-out due to gender or earlier mental illness. Conclusion Methodological possibilities and limitations concerning long-term epidemiological studies across decades are presented and discussed.