The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Amirali Toossi - One of the best experts on this subject based on the ideXlab platform.
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Comparative Neuroanatomy of the lumbosacral spinal cord of the rat cat pig monkey and human
Scientific Reports, 2021Co-Authors: Amirali Toossi, Bradley Bergin, Maedeh Marefatallah, Behdad Parhizi, Neil Tyreman, Dirk G. Everaert, Sabereh Rezaei, Peter Seres, Christopher J GatenbyAbstract:The overall goal of this work was to create a high-resolution MRI atlas of the lumbosacral enlargement of the spinal cord of the rat (Sprague-Dawley), cat, domestic pig, rhesus monkey, and human. These species were chosen because they are commonly used in basic and translational research in spinal cord injuries and diseases. Six spinal cord specimens from each of the studied species (total of 30 specimens) were fixed, extracted, and imaged. Sizes of the spinal cord segments, cross-sectional dimensions, and locations of the spinal cord gray and white matter were quantified and compared across species. The lumbar enlargement spans spinal cord levels L3-S1 in rats, L4-S1 in cats, L3-S1 in pigs, L2/L3-L7/S1 in monkeys, and T12/L1-S1/S2 in humans. The enlargements in pigs and humans are largest and most similar in size (length and cross-sectional area); followed by monkeys and cats; and followed by rats. The obtained atlas establishes a neuroanatomical reference for the intact lumbosacral spinal cord in these species. It can also be used to guide the planning of surgical procedures of the spinal cord and technology design and development of spinal cord neuroprostheses, as well as precise delivery of cells/drugs into target regions within the spinal cord parenchyma.
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Comparative Neuroanatomy of the Lumbosacral Spinal Cord of the Rat, Cat, Pig, Monkey, and Human
2020Co-Authors: Amirali Toossi, Bradley Bergin, Maedeh Marefatallah, Behdad Parhizi, Neil Tyreman, Dirk G. Everaert, Sabereh Rezaei, Peter Seres, J. Christopher Gatenby, Steve I. PerlmutterAbstract:Abstract The overall goal of this work was to create a high-resolution MRI atlas of the lumbosacral enlargement of the spinal cord of the rat (Sprague-Dawley), cat, domestic pig, rhesus monkey, and human. These species were chosen because they are commonly used in basic and translational research in spinal cord injuries and diseases. Six spinal cord specimens from each of the studied species (total of 30 specimens) were fixed, extracted, and imaged. Sizes of the spinal cord segments, cross-sectional dimensions, and locations of the spinal cord gray and white matter were quantified and compared across species. The obtained atlas establishes a reference for the Neuroanatomy of the intact lumbosacral spinal cord in these species. It can also be used to guide the planning of surgical procedures of the spinal cord, technology design and development of spinal cord neuroprostheses, and the precise delivery of cells/drugs into target regions within the spinal cord parenchyma.
Rogier B Mars - One of the best experts on this subject based on the ideXlab platform.
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XTRACT - Standardised protocols for automated tractography in the human and macaque brain.
NeuroImage, 2020Co-Authors: Shaun Warrington, Katherine L Bryant, Alexandre A Khrapitchev, Jerome Sallet, Gwenaelle Douaud, Saad Jbabdi, Rogier B Mars, Marina Charquero-ballester, Stamatios N. SotiropoulosAbstract:We present a new software package with a library of standardised tractography protocols devised for the robust automated extraction of white matter tracts both in the human and the macaque brain. Using in vivo data from the Human Connectome Project (HCP) and the UK Biobank and ex vivo data for the macaque brain datasets, we obtain white matter atlases, as well as atlases for tract endpoints on the white-grey matter boundary, for both species. We illustrate that our protocols are robust against data quality, generalisable across two species and reflect the known anatomy. We further demonstrate that they capture inter-subject variability by preserving tract lateralisation in humans and tract similarities stemming from twinship in the HCP cohort. Our results demonstrate that the presented toolbox will be useful for generating imaging-derived features in large cohorts, and in facilitating Comparative Neuroanatomy studies. The software, tractography protocols, and atlases are publicly released through FSL, allowing users to define their own tractography protocols in a standardised manner, further contributing to open science.
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xtract standardised protocols for automated tractography and connectivity blueprints in the human and macaque brain
bioRxiv, 2019Co-Authors: Shaun Warrington, Katherine L Bryant, Alexandre A Khrapitchev, Jerome Sallet, Marina Charqueroballester, Gwenaelle Douaud, Saad Jbabdi, Rogier B MarsAbstract:We present a new software package with a library of standardised tractography protocols devised for the robust automated extraction of white matter tracts both in the human and the macaque brain. Using in vivo data from the Human Connectome Project (HCP) and the UK Biobank and ex vivo data for the macaque brain datasets, we obtain white matter atlases, as well as atlases for tract endpoints on the white-grey matter boundary, for both species. We illustrate that our protocols are robust against data quality, generalisable across two species and reflect the known anatomy. We further demonstrate that they capture inter-subject variability by preserving tract lateralisation in humans and tract similarities stemming from twinship in the HCP cohort. Our results demonstrate that the presented toolbox will be useful for generating imaging-derived features in large cohorts, and in facilitating Comparative Neuroanatomy studies. The software, tractography protocols, and atlases are publicly released through FSL, allowing users to define their own tractography protocols in a standardised manner, further contributing to open science.
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xtract standardised protocols for automated tractography and connectivity blueprints in the human and macaque brain
bioRxiv, 2019Co-Authors: Shaun Warrington, Katherine L Bryant, Alexandre A Khrapitchev, Jerome Sallet, Marina Charqueroballester, Gwenaelle Douaud, Saad Jbabdi, Rogier B MarsAbstract:Abstract We present a new toolbox and library of standardised tractography protocols devised for the robust automated extraction of white matter tracts both in the human and the macaque brain. Using in vivo data from the Human Connectome Project (HCP) and the UK Biobank and ex vivo data for the macaque brain datasets, we obtain white matter atlases, as well as atlases for tract endpoints on the white-grey matter boundary, for both species. We illustrate that our protocols are robust against data quality, generalisable across two species and reflect the known anatomy. We further demonstrate that they capture inter-subject variability by preserving tract lateralisation in humans and tract similarities stemming from twinship in the HCP cohort. Our results demonstrate that the presented toolbox will be useful for generating imaging-derived features in large cohorts, and in facilitating Comparative Neuroanatomy studies. The software, tractography protocols, and atlases are publicly released through FSL, allowing users to define their own tractography protocols in a standardised manner, further contributing to open science.
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What is special about the human arcuate fasciculus? Lateralization, projections, and expansion
Cortex, 2019Co-Authors: Nicole Eichert, Alexandre A Khrapitchev, Jerome Sallet, Saad Jbabdi, Lennart Verhagen, Davide Folloni, Nicola R. Sibson, Dante Mantini, Rogier B MarsAbstract:Evolutionary adaptations of the human brain are the basis for our unique abilities such as language. An expansion of the arcuate fasciculus (AF), the dorsal language tract, in the human lineage involving left lateralization is considered canonical, but this hypothesis has not been tested in relation to other architectural adaptations in the human brain. Using diffusion-weighted MRI, we examined AF in the human and macaque and quantified species differences in white matter architecture and surface representations. To compare surface results in the two species, we transformed macaque representations to human space using a landmark-based monkey-to-human cortical expansion model. We found that the human dorsal AF, but not the ventral inferior fronto-occipital fasciculus (IFO), is left-lateralized. In the monkey AF is not lateralized. Moreover, compared to the macaque, human AF is relatively increased with respect to IFO. A comparison of human and transformed macaque surface representations suggests that cortical expansion alone cannot account for the species differences in the surface representation of AF. Our results show that the human AF has undergone critical anatomical modifications in comparison with the macaque AF. More generally, this work demonstrates that studies on the human brain specializations underlying the language connectome can benefit from current methodological advances in Comparative Neuroanatomy.
Jean-luc Picq - One of the best experts on this subject based on the ideXlab platform.
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A 3D population-based brain atlas of the mouse lemur primate with examples of applications in aging studies and Comparative anatomy.
NeuroImage, 2019Co-Authors: Nachiket A. Nadkarni, Salma Bougacha, Clément M. Garin, Marc Dhenain, Jean-luc PicqAbstract:The gray mouse lemur (Microcebus murinus) is a small prosimian of growing interest for studies of primate biology and evolution, and notably as a model organism of brain aging. As brain atlases are essential tools for brain investigation, the objective of the current work was to create the first 3D digital atlas of the mouse lemur brain. For this, a template image was constructed from in vivo magnetic resonance imaging (MRI) data of 34 animals. This template was then manually segmented into 40 cortical, 74 subcortical and 6 cerebro-spinal fluid (CSF) regions. Additionally, we generated probability maps of gray matter, white matter and CSF. The template, manual segmentation and probability maps, as well as imaging tools used to create and manipulate the template, can all be freely downloaded. The atlas was first used to automatically assess regional age-associated cerebral atrophy in a cohort of mouse lemurs previously studied by voxel based morphometry (VBM). Results based on the atlas were in good agreement with the VBM ones, showing age-associated atrophy in the same brain regions such as the insular, parietal or occipital cortices as well as the thalamus or hypothalamus. The atlas was also used as a tool for Comparative Neuroanatomy. To begin with, we compared measurements of brain regions in our MRI data with histology-based measures from a reference article largely used in previous Comparative Neuroanatomy studies. We found large discrepancies between our MRI-based data and those of the reference histology-based article. Next, regional brain volumes were compared amongst the mouse lemur and several other mammalian species where high quality volumetric MRI brain atlases were available, including rodents (mouse, rat) and primates (marmoset, macaque, and human). Unlike those based on histological atlases, measures from MRI atlases indicated similar cortical to cerebral volume indices in all primates, including in mouse lemurs, and lower values in mice. On the other hand, white matter to cerebral volume index increased from rodents to small primates (mouse lemurs and marmosets) to macaque, reaching their highest values in humans.
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Digital templates and brain atlas dataset for the mouse lemur primate
Elsevier, 2018Co-Authors: Nachiket A. Nadkarni, Salma Bougacha, Marc Dhenain, Clément Garin, Jean-luc PicqAbstract:We present a dataset made of 3D digital brain templates and of an atlas of the gray mouse lemur (Microcebus murinus), a small prosimian primate of growing interest for studies of primate biology and evolution. A template image was constructed from in vivo magnetic resonance imaging (MRI) data of 34 animals. This template was then manually segmented into 40 cortical, 74 subcortical and 6 cerebro-spinal fluid (CSF) regions. Additionally, the dataset contains probability maps of gray matter, white matter and CSF. The template, manual segmentation and probability maps can be downloaded in NIfTI-1 format at https://www.nitrc.org/projects/mouselemuratlas. Further construction and validation details are given in “A 3D population-based brain atlas of the mouse lemur primate with examples of applications in aging studies and Comparative anatomy” (Nadkarni et al., 2018) [1], which also presents applications of the atlas such as automatic assessment of regional age-associated cerebral atrophy and Comparative Neuroanatomy studies
Andrew N Iwaniuk - One of the best experts on this subject based on the ideXlab platform.
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the importance of scientific collecting and natural history museums for Comparative Neuroanatomy
Annals of the New York Academy of Sciences, 2011Co-Authors: Andrew N IwaniukAbstract:TheComparativestudyofvertebratebrainsisinherentlydependentuponaccesstoasufficientnumberofspeciesandspecimens to perform meaningful comparisons. Although many studies rely on compiling published information,continued specimen collection, in addition to more extensive use of existing brain collections and natural historymuseums,arecrucialfordetailedneuroanatomicalcomparisonsacrossspecies.Thisreviewhighlightstheimportanceof collecting species through a variety of means, details a marsupial brain collection, and stresses the potential ofnatural history museums as a resource for Comparative Neuroanatomy. By taking advantage of as many of theseresources as possible, researchers can rapidly increase species coverage and generate a better understanding of howthebrainevolves.Keywords: natural history museums; Comparative method; Neuroanatomy; marsupials; birds
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The importance of scientific collecting and natural history museums for Comparative Neuroanatomy.
Annals of the New York Academy of Sciences, 2011Co-Authors: Andrew N IwaniukAbstract:The Comparative study of vertebrate brains is inherently dependent upon access to a sufficient number of species and specimens to perform meaningful comparisons. Although many studies rely on compiling published information, continued specimen collection, in addition to more extensive use of existing brain collections and natural history museums, are crucial for detailed neuroanatomical comparisons across species. This review highlights the importance of collecting species through a variety of means, details a marsupial brain collection, and stresses the potential of natural history museums as a resource for Comparative Neuroanatomy. By taking advantage of as many of these resources as possible, researchers can rapidly increase species coverage and generate a better understanding of how the brain evolves.
Christopher J Gatenby - One of the best experts on this subject based on the ideXlab platform.
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Comparative Neuroanatomy of the lumbosacral spinal cord of the rat cat pig monkey and human
Scientific Reports, 2021Co-Authors: Amirali Toossi, Bradley Bergin, Maedeh Marefatallah, Behdad Parhizi, Neil Tyreman, Dirk G. Everaert, Sabereh Rezaei, Peter Seres, Christopher J GatenbyAbstract:The overall goal of this work was to create a high-resolution MRI atlas of the lumbosacral enlargement of the spinal cord of the rat (Sprague-Dawley), cat, domestic pig, rhesus monkey, and human. These species were chosen because they are commonly used in basic and translational research in spinal cord injuries and diseases. Six spinal cord specimens from each of the studied species (total of 30 specimens) were fixed, extracted, and imaged. Sizes of the spinal cord segments, cross-sectional dimensions, and locations of the spinal cord gray and white matter were quantified and compared across species. The lumbar enlargement spans spinal cord levels L3-S1 in rats, L4-S1 in cats, L3-S1 in pigs, L2/L3-L7/S1 in monkeys, and T12/L1-S1/S2 in humans. The enlargements in pigs and humans are largest and most similar in size (length and cross-sectional area); followed by monkeys and cats; and followed by rats. The obtained atlas establishes a neuroanatomical reference for the intact lumbosacral spinal cord in these species. It can also be used to guide the planning of surgical procedures of the spinal cord and technology design and development of spinal cord neuroprostheses, as well as precise delivery of cells/drugs into target regions within the spinal cord parenchyma.