The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Ronald I. Clyman - One of the best experts on this subject based on the ideXlab platform.

  • mechanisms regulating the ductus arteriosus
    Neonatology, 2006
    Co-Authors: Ronald I. Clyman
    Abstract:

    A patent ductus arteriosus (PDA) results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. In this review, Comparative Physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed.

  • patent ductus arteriosus pathoPhysiology and management
    Journal of Perinatology, 2006
    Co-Authors: Evelyn R Hermesdesantis, Ronald I. Clyman
    Abstract:

    Patent ductus arteriosus (PDA) in preterm newborns prior to 28 weeks of gestation has led to many challenges regarding the type and timing of treatment regimens. A PDA results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. The prostaglandin inhibitor, indomethacin, is effective in the treatment of PDA. Questions regarding the optimal timing of the intervention – early prophylaxis or treatment, once signs and symptoms become evident – have challenged physicians for decades. Both evidence and experience are explored in this article. Comparative Physiology between the full-term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed.

Bruno Gualano - One of the best experts on this subject based on the ideXlab platform.

  • a Comparative study of hummingbirds and chickens provides mechanistic insight on the histidine containing dipeptide role in skeletal muscle metabolism
    Scientific Reports, 2018
    Co-Authors: Eimear Dolan, Bryan Saunders, Wagner S Dantas, Igor Hisashi Murai, Hamilton Roschel, Guilherme Giannini Artioli, R C Harris, Jose Eduardo Pereira Wilken Bicudo, Craig Sale, Bruno Gualano
    Abstract:

    Histidine containing dipeptides (HCDs) have numerous ergogenic and therapeutic properties, but their primary role in skeletal muscle remains unclear. Potential functions include pH regulation, protection against reactive oxygen/nitrogen species, or Ca2+ regulation. In recognition of the challenge of isolating physiological processes in-vivo, we employed a Comparative Physiology approach to investigate the primary mechanism of HCD action in skeletal muscle. We selected two avian species (i.e., hummingbirds and chickens), who represented the extremes of the physiological processes in which HCDs are likely to function. Our findings indicate that HCDs are non-essential to the development of highly oxidative and contractile muscle, given their very low content in hummingbird skeletal tissue. In contrast, their abundance in the glycolytic chicken muscle, indicate that they are important in anaerobic bioenergetics as pH regulators. This evidence provides new insights on the HCD role in skeletal muscle, which could inform widespread interventions, from health to elite performance.

Irene Soderhall - One of the best experts on this subject based on the ideXlab platform.

  • retraction of a calreticulin gc1qr complex prevents cells from dying a conserved mechanism from arthropods to humans
    Journal of Molecular Cell Biology, 2015
    Co-Authors: Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, Irene Soderhall
    Abstract:

    Retraction of: A calreticulin/gC1qR complex prevents cells from dying: a conserved mechanism from arthropods to humans Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, and Irene Soderhall* 1 Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Norbyvagen 18A, Uppsala SE-75236, Sweden 2 Aquatic Molecular Genetics and Biotechnology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Paholyothin Rd., Klong 1, Klongluang, Pathumthani 12120, Thailand * Correspondence to: Irene Soderhall, E-mail: irene.soderhall@ebc.uu.se

  • retraction of a calreticulin gc1qr complex prevents cells from dying a conserved mechanism from arthropods to humans
    Journal of Molecular Cell Biology, 2015
    Co-Authors: Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, Irene Soderhall
    Abstract:

    Retraction of: A calreticulin/gC1qR complex prevents cells from dying: a conserved mechanism from arthropods to humans Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, and Irene Soderhall* 1 Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Norbyvagen 18A, Uppsala SE-75236, Sweden 2 Aquatic Molecular Genetics and Biotechnology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Paholyothin Rd., Klong 1, Klongluang, Pathumthani 12120, Thailand * Correspondence to: Irene Soderhall, E-mail: irene.soderhall@ebc.uu.se

Pikul Jiravanichpaisal - One of the best experts on this subject based on the ideXlab platform.

  • retraction of a calreticulin gc1qr complex prevents cells from dying a conserved mechanism from arthropods to humans
    Journal of Molecular Cell Biology, 2015
    Co-Authors: Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, Irene Soderhall
    Abstract:

    Retraction of: A calreticulin/gC1qR complex prevents cells from dying: a conserved mechanism from arthropods to humans Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, and Irene Soderhall* 1 Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Norbyvagen 18A, Uppsala SE-75236, Sweden 2 Aquatic Molecular Genetics and Biotechnology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Paholyothin Rd., Klong 1, Klongluang, Pathumthani 12120, Thailand * Correspondence to: Irene Soderhall, E-mail: irene.soderhall@ebc.uu.se

  • retraction of a calreticulin gc1qr complex prevents cells from dying a conserved mechanism from arthropods to humans
    Journal of Molecular Cell Biology, 2015
    Co-Authors: Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, Irene Soderhall
    Abstract:

    Retraction of: A calreticulin/gC1qR complex prevents cells from dying: a conserved mechanism from arthropods to humans Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Soderhall, and Irene Soderhall* 1 Department of Comparative Physiology, Evolutionary Biology Center, Uppsala University, Norbyvagen 18A, Uppsala SE-75236, Sweden 2 Aquatic Molecular Genetics and Biotechnology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Paholyothin Rd., Klong 1, Klongluang, Pathumthani 12120, Thailand * Correspondence to: Irene Soderhall, E-mail: irene.soderhall@ebc.uu.se

Kathleen M. Gilmour - One of the best experts on this subject based on the ideXlab platform.

  • The integration of behaviour into Comparative Physiology.
    Physiological and Biochemical Zoology, 2005
    Co-Authors: Kathleen M. Gilmour, Rod W. Wilson, Katherine A. Sloman
    Abstract:

    Abstract Comparative Physiology has traditionally focused on the physiological responses of animals to their physicochemical environment. In recent years, awareness has increased among physiologists of the potential for behavioural factors, such as the social environment of the animal, to affect physiological condition and responses. This recognition has led to an emerging trend within the field toward using multidisciplinary approaches that incorporate both behavioural and physiological techniques. Research areas in which the integrated study of behaviour and Physiology has been particularly fruitful include the Physiology of the social environment, sensory Physiology and behaviour, and physiological constraints on behavioural ecology. The manner in which incorporating behavioural considerations has informed the physiological data collected is discussed for each of these areas using specific examples.

  • cytoplasmic carbonic anhydrase isozymes in rainbow trout oncorhynchus mykiss Comparative Physiology and molecular evolution
    The Journal of Experimental Biology, 2005
    Co-Authors: Andrew J Esbaugh, Steve F Perry, M Bayaa, Tina Georgalis, J Nickerson, B L Tufts, Kathleen M. Gilmour
    Abstract:

    It is well established that the gills of teleost fish contain substantial levels of cytoplasmic carbonic anhydrase (CA), but it is unclear which CA isozyme(s) might be responsible for this activity. The objective of the current study was to determine if branchial CA activity in rainbow trout was the result of a general cytoplasmic CA isozyme, with kinetic properties, tissue distribution and physiological functions distinct from those of the red blood cell (rbc)-specific CA isozyme. Isolation and sequencing of a second trout cytoplasmic CA yielded a 780 bp coding region that was 76% identical with the trout rbc CA (TCAb), although the active sites differed by only 1 amino acid. Interestingly, phylogenetic analyses did not group these two isozymes closely together, suggesting that more fish species may have multiple cytoplasmic CA isozymes. In contrast to TCAb, the second cytoplasmic CA isozyme had a wide tissue distribution with high expression in the gills and brain, and lower expression in many tissues, including the red blood cells. Thus, unlike TCAb, the second isozyme lacks tissue specificity and may be expressed in the cytoplasm of all cells. For this reason, it is referred to hereafter as TCAc (trout cytoplasmic CA). The inhibitor properties of both cytoplasmic isozymes were similar (Ki acetazolamide 1.21+/-0.18 nmol l(-1) and 1.34+/-0.10 nmol l(-1) for TCAc and TCAb, respectively). However, the turnover of TCAb was over three times greater than that of TCAc (30.3+/-5.83 vs 8.90+/-1.95 e4 s(-1), respectively), indicating that the rbc-specific CA isoform was significantly faster than the general cytoplasmic isoform. Induction of anaemia revealed differential expression of the two isozymes in the red blood cell; whereas TCAc mRNA expression was unaffected, TCAb mRNA expression was significantly increased by 30- to 60-fold in anaemic trout.