The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Huabao Xiong - One of the best experts on this subject based on the ideXlab platform.
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coagulation cascade and Complement system in systemic lupus erythematosus
Oncotarget, 2017Co-Authors: Yan Liang, Shangbo Xie, Qin Zhang, Yinguang Fan, Ruixue Leng, Haifeng Pan, Huabao XiongAbstract:This study was conducted to (1) characterize coagulation cascade and Complement system in systemic lupus erythematosus (SLE); (2) evaluate the associations between coagulation cascade, Complement system, inflammatory response and SLE disease severity; (3) test the diagnostic value of a combination of D-dimer and C4 for lupus activity. Transcriptomics, proteomics and metabolomics were performed in 24 SLE patients and 24 healthy controls. The levels of ten coagulations, seven Complements and three cytokines were measured in 112 SLE patients. Clinical data were collected from 2025 SLE patients. The analysis of multi-omics data revealed the common links for the components of coagulation cascade and Complement system. The results of ELISA showed coagulation cascade and Complement system had an interaction effect on SLE disease severity, this effect was pronounced among patients with excess inflammation. The analysis of clinical data revealed a combination of D-dimer and C4 provided good diagnostic performance for lupus activity. This study suggested that coagulation cascade and Complement system become 'partners in crime', contributing to SLE disease severity and identified the diagnostic value of D-dimer combined with C4for lupus activity.
Richard Festenstein - One of the best experts on this subject based on the ideXlab platform.
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sexual dimorphism in mammalian autosomal gene regulation is determined not only by sry but by sex chromosome Complement as well
Developmental Cell, 2010Co-Authors: Patrick J Wijchers, Cihangir Yandim, Eleni Panousopoulou, Mushfika Ahmad, Nicky Harker, Alexander Saveliev, Paul S Burgoyne, Richard FestensteinAbstract:Differences between males and females are normally attributed to developmental and hormonal differences between the sexes. Here, we demonstrate differences between males and females in gene silencing using a heterochromatin-sensitive reporter gene. Using "sex-reversal" mouse models with varying sex chromosome Complements, we found that this differential gene silencing was determined by X chromosome Complement, rather than sex. Genome-wide transcription profiling showed that the expression of hundreds of autosomal genes was also sensitive to sex chromosome Complement. These genome-wide analyses also uncovered a role for Sry in modulating autosomal gene expression in a sex chromosome Complement-specific manner. The identification of this additional layer in the establishment of sexual dimorphisms has implications for understanding sexual dimorphisms in physiology and disease.
Jason Low - One of the best experts on this subject based on the ideXlab platform.
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preschoolers implicit and explicit false belief understanding relations with complex syntactical mastery
Child Development, 2010Co-Authors: Jason LowAbstract:Three studies were carried out to investigate sentential Complements being the critical device that allows for false-belief understanding in 3- and 4-year-olds (N = 102). Participants across studies accurately gazed in anticipation of a character's mistaken belief in a predictive looking task despite erring on verbal responses for direct false-belief questions. Gaze was independent of Complement mastery. These patterns held when other low-verbal false-belief tasks were considered and the predictive looking task was presented as a time-controlled film. While implicit (gaze) knowledge predicted explicit (verbal) false-belief understanding, Complement mastery and cognitive flexibility also supported explicit reasoning. Overall, explicit false-belief understanding is complexly underpinned by implicit knowledge and input from higher-order systems of language and executive control.
Ximena E Caeiro - One of the best experts on this subject based on the ideXlab platform.
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sex differences in body fluid homeostasis sex chromosome Complement influences on bradycardic baroreflex response and sodium depletion induced neural activity
Physiology & Behavior, 2015Co-Authors: Laura Vivas, Florencia M Dadam, Ximena E CaeiroAbstract:Clinical and basic findings indicate that angiotensin II (ANG II) differentially modulates hydroelectrolyte and cardiovascular responses in male and female. But are only the activational and organizational hormonal effects to blame for such differences? Males and females not only differ in their sex (males are born with testes and females with ovaries) but also carry different sex chromosome Complements and are thus influenced throughout life by different genomes. In this review, we discuss our recent studies in order to evaluate whether sex chromosome Complement is in part responsible for gender differences previously observed in ANG II bradycardic-baroreflex response and sodium depletion-induced sodium appetite and neural activity. To test the hypothesis that XX or XY contributes to the dimorphic ANG II bradycardic-baroreflex response, we used the four core genotype mouse model, in which the effects of gonadal sex (testes or ovaries) and sex chromosome Complement (XX or XY) are dissociated. The results indicate that ANG II bradycardic-baroreflex sexual dimorphic response may be ascribed to differences in sex chromosomes, indicating an XX-sex chromosome Complement facilitatory bradycardic-baroreflex control of heart rate. Furthermore, we evaluated whether genetic differences within the sex chromosome Complement may differentially modulate the known sexually dimorphic sodium appetite as well as basal or induced brain activity due to physiological stimulation of the renin-angiotensin system by furosemide and low-sodium treatment. Our studies demonstrate an organizational hormonal effect on sexually dimorphic induced sodium intake in mice, while at the brain level (subfornical organ and area postrema) we showed a sex chromosome Complement effect in sodium-depleted mice, suggesting a sex chromosome gene participation in the modulation of neural pathways underlying regulatory response to renin-angiotensin stimulation.
Stephanie Durrleman - One of the best experts on this subject based on the ideXlab platform.
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exploring links between language and cognition in autism spectrum disorders Complement sentences false belief and executive functioning
Journal of Communication Disorders, 2015Co-Authors: Stephanie Durrleman, Julie FranckAbstract:Abstract A growing body of work indicates a close relation between Complement clause sentences and Theory of Mind (ToM) in children with autism (e.g., Tager-Flusberg, & Joseph (2005). In Astington, & Baird (Eds.), Why language matters for theory of mind (pp. 298 – 318). New York, NY, US: Oxford University Press, Lind, & Bowler (2009). Journal of Autism and Developmental Disorders , 39 (6), 929). However, this link is based primarily on success at a specific Complement clause task and a verbal false-belief (FB) task. One cannot exclude that the link found between these tasks may be a by-product of their both presupposing similar levels of language skills. It is also an open question if the role of Complementation in ToM success is a privileged one as compared to that of other abilities which have been claimed to be an important factor for ToM understanding in autism, namely executive functioning (EF) (Pellicano (2007). Developmental Psychology 43, 974). Indeed the role played by Complementation may be conceived of as an indirect one, mediated by some more general cognitive function related to EF. This study is the first to examine the relation between theory of mind assessed both verbally and non-verbally and various types of Complement clause sentences as well as executive functions in children with autism spectrum disorder (ASD). Our participants included 17 children and adolescents with ASD (aged 6 to 16) and a younger TD control group matched on non-verbal IQ (aged 4 to 9 years). Three tasks assessing Complements of verbs of cognition, verbs of communication and verbs of perception were conducted. ToM tasks involved a verbal ToM task (Sally-Anne, Baron-Cohen et al. (1985). Cognition , 21 (1), 37) as well as a non-verbal one (Colle et al. (2007). Journal of Autism and Developmental Disorders , 37 (4), 716). Indexes of executive functions were collected via a computerized version of the Dimensional Change Card-Sorting task ( Frye et al., 1995 ). Standardized measures of vocabulary, morphosyntax and non-verbal IQ were also administered. Results show similar performance by children with ASD and TD controls for the understanding of Complement sentences, for non-verbal ToM and for executive functions. However, children with ASD were significantly impaired for false belief when this was measured verbally. For both ASD and TD, correlations controlling for IQ were found between the verbal FB task and Complement sentences of verbs of communication and cognition, but not with verbs of perception. EF indexes did not significantly correlate with either of the ToM tasks, nor did any of the general language scores. These findings provide support for the view that knowledge of certain specific types of Complement clause may serve as a privileged means of ‘hacking out’ solutions to verbal false belief tasks for individuals on the autistic spectrum. More specifically, Complements with a truth-value that is independent of that of the matrix clause (i.e. those occurring with verbs of cognition and of communication, but not of perception) may describe a false event while the whole sentence remains true, making these linguistic structures particularly well suited for representing the minds of others ( de Villiers, 2007 ). Learning outcomes: Readers will be able to (1) describe and evaluate the hypothesis that Complement sentences play a privileged role in false belief task success in autism; (2) describe performance on Complement sentences, executive functioning and false belief tasks by children with autism as compared to IQ-matched peers; (3) explain which types of Complements specifically relate to false belief task performance and why; and (4) understand that differences in performance by children with autism at different types of false-belief tasks may be related to the nature of the task conducted and the underlying mechanisms involved.
