The Experts below are selected from a list of 31536 Experts worldwide ranked by ideXlab platform

Linda D Ferrell - One of the best experts on this subject based on the ideXlab platform.

  • glycogenic hepatopathy an underrecognized hepatic Complication of Diabetes mellitus
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Michael Torbenson, Yunn Yi Chen, Elizabeth M Brunt, Oscar W Cummings, Marcia R Gottfried, Shriram Jakate, Linda D Ferrell
    Abstract:

    Reported are the clinical and pathologic features of glycogenic hepatopathy, a pathologic overloading of hepatocytes with glycogen that is associated with poorly controlled Diabetes mellitus. Fourteen cases were studied by stains, including hematoxylin and eosin, trichrome, periodic acid–Schiff, and

  • glycogenic hepatopathy an underrecognized hepatic Complication of Diabetes mellitus
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Michael Torbenson, Yunn Yi Chen, Elizabeth M Brunt, Oscar W Cummings, Marcia R Gottfried, Shriram Jakate, Yao Chang Liu, Matthew M Yeh, Linda D Ferrell
    Abstract:

    Reported are the clinical and pathologic features of glycogenic hepatopathy, a pathologic overloading of hepatocytes with glycogen that is associated with poorly controlled Diabetes mellitus. Fourteen cases were studied by stains, including hematoxylin and eosin, trichrome, periodic acid-Schiff, and periodic acid-Schiff with diastase. Ultrastructural analysis was performed in 2 cases. Medical records were reviewed for clinical presentations, laboratory findings, and clinical outcomes. The individuals ranged from 8 to 25 years of age. All had type I Diabetes mellitus with poor glycemic control. The clinical presentations included hepatomegaly, abdominal pain, and elevated transaminases (range, 50-1600 IU/L). The transaminases were dramatically elevated in 3 cases to greater than 10 times the upper limit of normal. All biopsies showed diffusely pale staining hepatocytes on hematoxylin and eosin stains, with excessive glycogen accumulation demonstrated by periodic acid-Schiff stains. Ultrastructural examination revealed marked glycogen accumulation in the cytoplasm and nuclei. Most cases showed no evidence for fatty liver disease: steatosis was absent in 12 of 14 cases, simple steatosis was seen in 1 of 14 cases, and mild steatohepatitis was present in 1 of 14 cases. Mallory hyaline was absent in all cases, acidophil bodies were only rarely seen, and inflammation was absent or minimally present. Fibrosis was typically absent, with only 2 cases demonstrating focal mild fibrosis. Three patients had adequate follow-up and demonstrated improvement of liver enzyme levels with control of blood glucose. We conclude that glycogenic hepatopathy can cause hepatomegaly and significant transaminase elevations in individuals with type I Diabetes mellitus. The pathology is distinct from steatohepatitis.

Atiye Cengel - One of the best experts on this subject based on the ideXlab platform.

Dorothy J Becker - One of the best experts on this subject based on the ideXlab platform.

  • hypoglycemia a Complication of Diabetes therapy in children
    Pediatric Clinics of North America, 2005
    Co-Authors: Christopher M Ryan, Nursen Gurtunca, Dorothy J Becker
    Abstract:

    The experience of hypoglycemia is probably the most feared and hated consequence of life with type 1 Diabetes among pediatric patients and their parents. Although transient detrimental effects are clearly disturbing and may have severe results, there is surprisingly little evidence of long-term CNS damage, even after multiple hypoglycemic episodes, except in rare instances. Despite the latter evidence, we advocate that every treatment regimen be designed to prevent hypoglycemia without inducing unacceptable hyperglycemia and increasing the risk of micro- and macrovascular Complications.

  • hypoglycemia a Complication of Diabetes therapy in children
    Seminars in Pediatric Neurology, 2005
    Co-Authors: Christopher M Ryan, Nursen Gurtunca, Dorothy J Becker
    Abstract:

    Hypoglycemia is the most common acute Complication associated with the treatment of type 1 Diabetes. At the very least, it can be an unpleasant experience for many children, because they begin to experience symptoms such as shakiness and emotional lability when their blood glucose levels fall. Many children and their parents find that hypoglycemia can be a terrifying event because under certain circumstances, more severe hypoglycemia leads to seizures or loss of consciousness and the possible development of permanent brain dysfunction, an uncertain area currently under intense investigation. For these reasons, iatrogenic hypoglycemia remains the major limiting factor in attempts to achieve the glycemic level required to prevent chronic micro- and macrovascular Complications.

  • hypoglycemia a Complication of Diabetes therapy in children
    Trends in Endocrinology and Metabolism, 2000
    Co-Authors: Dorothy J Becker, Christopher M Ryan
    Abstract:

    Hypoglycemia is the most common acute Complication in insulin-treated type 1 diabetic patients. Most surveys have demonstrated that the tighter the glycemic control, and the younger the patient, the greater the frequency of both mild and severe hypoglycemia. However, people in poor metabolic control, with high glycosylated hemoglobin levels, are not protected from experiencing severe hypoglycemia. Focusing on the pediatric population, we review new or controversial issues surrounding the prevalence of hypoglycemia, its causes, its consequences and preventive strategies, and discuss possible mechanisms underlying the variability of responses to hypoglycemia.

Michael Torbenson - One of the best experts on this subject based on the ideXlab platform.

  • glycogenic hepatopathy an underrecognized hepatic Complication of Diabetes mellitus
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Michael Torbenson, Yunn Yi Chen, Elizabeth M Brunt, Oscar W Cummings, Marcia R Gottfried, Shriram Jakate, Linda D Ferrell
    Abstract:

    Reported are the clinical and pathologic features of glycogenic hepatopathy, a pathologic overloading of hepatocytes with glycogen that is associated with poorly controlled Diabetes mellitus. Fourteen cases were studied by stains, including hematoxylin and eosin, trichrome, periodic acid–Schiff, and

  • glycogenic hepatopathy an underrecognized hepatic Complication of Diabetes mellitus
    The American Journal of Surgical Pathology, 2006
    Co-Authors: Michael Torbenson, Yunn Yi Chen, Elizabeth M Brunt, Oscar W Cummings, Marcia R Gottfried, Shriram Jakate, Yao Chang Liu, Matthew M Yeh, Linda D Ferrell
    Abstract:

    Reported are the clinical and pathologic features of glycogenic hepatopathy, a pathologic overloading of hepatocytes with glycogen that is associated with poorly controlled Diabetes mellitus. Fourteen cases were studied by stains, including hematoxylin and eosin, trichrome, periodic acid-Schiff, and periodic acid-Schiff with diastase. Ultrastructural analysis was performed in 2 cases. Medical records were reviewed for clinical presentations, laboratory findings, and clinical outcomes. The individuals ranged from 8 to 25 years of age. All had type I Diabetes mellitus with poor glycemic control. The clinical presentations included hepatomegaly, abdominal pain, and elevated transaminases (range, 50-1600 IU/L). The transaminases were dramatically elevated in 3 cases to greater than 10 times the upper limit of normal. All biopsies showed diffusely pale staining hepatocytes on hematoxylin and eosin stains, with excessive glycogen accumulation demonstrated by periodic acid-Schiff stains. Ultrastructural examination revealed marked glycogen accumulation in the cytoplasm and nuclei. Most cases showed no evidence for fatty liver disease: steatosis was absent in 12 of 14 cases, simple steatosis was seen in 1 of 14 cases, and mild steatohepatitis was present in 1 of 14 cases. Mallory hyaline was absent in all cases, acidophil bodies were only rarely seen, and inflammation was absent or minimally present. Fibrosis was typically absent, with only 2 cases demonstrating focal mild fibrosis. Three patients had adequate follow-up and demonstrated improvement of liver enzyme levels with control of blood glucose. We conclude that glycogenic hepatopathy can cause hepatomegaly and significant transaminase elevations in individuals with type I Diabetes mellitus. The pathology is distinct from steatohepatitis.

Christopher M Ryan - One of the best experts on this subject based on the ideXlab platform.

  • hypoglycemia a Complication of Diabetes therapy in children
    Pediatric Clinics of North America, 2005
    Co-Authors: Christopher M Ryan, Nursen Gurtunca, Dorothy J Becker
    Abstract:

    The experience of hypoglycemia is probably the most feared and hated consequence of life with type 1 Diabetes among pediatric patients and their parents. Although transient detrimental effects are clearly disturbing and may have severe results, there is surprisingly little evidence of long-term CNS damage, even after multiple hypoglycemic episodes, except in rare instances. Despite the latter evidence, we advocate that every treatment regimen be designed to prevent hypoglycemia without inducing unacceptable hyperglycemia and increasing the risk of micro- and macrovascular Complications.

  • hypoglycemia a Complication of Diabetes therapy in children
    Seminars in Pediatric Neurology, 2005
    Co-Authors: Christopher M Ryan, Nursen Gurtunca, Dorothy J Becker
    Abstract:

    Hypoglycemia is the most common acute Complication associated with the treatment of type 1 Diabetes. At the very least, it can be an unpleasant experience for many children, because they begin to experience symptoms such as shakiness and emotional lability when their blood glucose levels fall. Many children and their parents find that hypoglycemia can be a terrifying event because under certain circumstances, more severe hypoglycemia leads to seizures or loss of consciousness and the possible development of permanent brain dysfunction, an uncertain area currently under intense investigation. For these reasons, iatrogenic hypoglycemia remains the major limiting factor in attempts to achieve the glycemic level required to prevent chronic micro- and macrovascular Complications.

  • hypoglycemia a Complication of Diabetes therapy in children
    Trends in Endocrinology and Metabolism, 2000
    Co-Authors: Dorothy J Becker, Christopher M Ryan
    Abstract:

    Hypoglycemia is the most common acute Complication in insulin-treated type 1 diabetic patients. Most surveys have demonstrated that the tighter the glycemic control, and the younger the patient, the greater the frequency of both mild and severe hypoglycemia. However, people in poor metabolic control, with high glycosylated hemoglobin levels, are not protected from experiencing severe hypoglycemia. Focusing on the pediatric population, we review new or controversial issues surrounding the prevalence of hypoglycemia, its causes, its consequences and preventive strategies, and discuss possible mechanisms underlying the variability of responses to hypoglycemia.