The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform

D P Dearnaley - One of the best experts on this subject based on the ideXlab platform.

  • cardiovascular disease as a long term Complication of Treatment for testicular cancer
    Journal of Clinical Oncology, 2003
    Co-Authors: R A Huddart, A Norman, M Shahidi, A Horwich, D Coward, J Nicholls, D P Dearnaley
    Abstract:

    Effective multi-agent chemotherapy means that most patients with testicular cancer are now cured and have a long potential life expectancy. Long term toxicity is therefore an important consideration. Some groups have reported an increased risk of cardiovascular disease in testicular cancer survivors. We have investigated whether such a risk exists by undertaking a cross sectional study of cardiovascular morbidity and risk factors in patients treated at our institution between 1982 and 1992.

  • cardiovascular disease as a long term Complication of Treatment for testicular cancer
    Journal of Clinical Oncology, 2003
    Co-Authors: R A Huddart, A Norman, M Shahidi, A Horwich, D Coward, J Nicholls, D P Dearnaley
    Abstract:

    Purpose: To assess the risk of cardiovascular morbidity and cardiac risk factors in long-term survivors of testicular cancer according to Treatment received. Patients and Methods: All resident male patients registered in the United Kingdom between 1982 and 1992 attending for follow-up were eligible for recruitment. Patients completed a current health questionnaire and underwent clinical review, along with hematologic, biochemical, and hormonal profiles. For patients not under routine review, follow-up information was sought from their general practitioner and mortality data were sought from the office of National Statistics. Descriptive analysis was performed on all variables and comparisons were made among patients treated by orchidectomy and follow-up only, chemotherapy alone (C), radiotherapy alone (RT), and radiotherapy and chemotherapy (C/RT). Results: Data on cardiovascular events were available on 992 patients. After a median follow-up of 10.2 years, 68 events had been reported, including 18 deaths...

R A Huddart - One of the best experts on this subject based on the ideXlab platform.

  • cardiovascular disease as a long term Complication of Treatment for testicular cancer
    Journal of Clinical Oncology, 2003
    Co-Authors: R A Huddart, A Norman, M Shahidi, A Horwich, D Coward, J Nicholls, D P Dearnaley
    Abstract:

    Effective multi-agent chemotherapy means that most patients with testicular cancer are now cured and have a long potential life expectancy. Long term toxicity is therefore an important consideration. Some groups have reported an increased risk of cardiovascular disease in testicular cancer survivors. We have investigated whether such a risk exists by undertaking a cross sectional study of cardiovascular morbidity and risk factors in patients treated at our institution between 1982 and 1992.

  • cardiovascular disease as a long term Complication of Treatment for testicular cancer
    Journal of Clinical Oncology, 2003
    Co-Authors: R A Huddart, A Norman, M Shahidi, A Horwich, D Coward, J Nicholls, D P Dearnaley
    Abstract:

    Purpose: To assess the risk of cardiovascular morbidity and cardiac risk factors in long-term survivors of testicular cancer according to Treatment received. Patients and Methods: All resident male patients registered in the United Kingdom between 1982 and 1992 attending for follow-up were eligible for recruitment. Patients completed a current health questionnaire and underwent clinical review, along with hematologic, biochemical, and hormonal profiles. For patients not under routine review, follow-up information was sought from their general practitioner and mortality data were sought from the office of National Statistics. Descriptive analysis was performed on all variables and comparisons were made among patients treated by orchidectomy and follow-up only, chemotherapy alone (C), radiotherapy alone (RT), and radiotherapy and chemotherapy (C/RT). Results: Data on cardiovascular events were available on 992 patients. After a median follow-up of 10.2 years, 68 events had been reported, including 18 deaths...

Samuel J Mann - One of the best experts on this subject based on the ideXlab platform.

  • the silent epidemic of thiazide induced hyponatremia
    Journal of Clinical Hypertension, 2008
    Co-Authors: Samuel J Mann
    Abstract:

    Hyponatremia is a recognized Complication of Treatment with thiazide diuretics, particularly in patients older than 70 years. Severe and symptomatic hyponatremia requires urgent management, usually requiring infusion of normal or hypertonic saline. Milder, asymptomatic, thiazide-induced hyponatremia requires steps to manage the hyponatremia as well as to prevent its future recurrence. This is a particular problem in patients who despite a history of thiazide-induced hyponatremia might require a diuretic in the management of their hypertension. In this review, the acute management of symptomatic and asymptomatic thiazide-induced hyponatremia is reviewed. Emphasis is also placed on the chronic management of patients who have experienced mild hyponatremia, in whom decisions about Treatment with diuretic and nondiuretic antihypertensive agents must be made to satisfy the twin goals of controlling hypertension and avoiding recurrent hyponatremia.

A Horwich - One of the best experts on this subject based on the ideXlab platform.

  • cardiovascular disease as a long term Complication of Treatment for testicular cancer
    Journal of Clinical Oncology, 2003
    Co-Authors: R A Huddart, A Norman, M Shahidi, A Horwich, D Coward, J Nicholls, D P Dearnaley
    Abstract:

    Effective multi-agent chemotherapy means that most patients with testicular cancer are now cured and have a long potential life expectancy. Long term toxicity is therefore an important consideration. Some groups have reported an increased risk of cardiovascular disease in testicular cancer survivors. We have investigated whether such a risk exists by undertaking a cross sectional study of cardiovascular morbidity and risk factors in patients treated at our institution between 1982 and 1992.

  • cardiovascular disease as a long term Complication of Treatment for testicular cancer
    Journal of Clinical Oncology, 2003
    Co-Authors: R A Huddart, A Norman, M Shahidi, A Horwich, D Coward, J Nicholls, D P Dearnaley
    Abstract:

    Purpose: To assess the risk of cardiovascular morbidity and cardiac risk factors in long-term survivors of testicular cancer according to Treatment received. Patients and Methods: All resident male patients registered in the United Kingdom between 1982 and 1992 attending for follow-up were eligible for recruitment. Patients completed a current health questionnaire and underwent clinical review, along with hematologic, biochemical, and hormonal profiles. For patients not under routine review, follow-up information was sought from their general practitioner and mortality data were sought from the office of National Statistics. Descriptive analysis was performed on all variables and comparisons were made among patients treated by orchidectomy and follow-up only, chemotherapy alone (C), radiotherapy alone (RT), and radiotherapy and chemotherapy (C/RT). Results: Data on cardiovascular events were available on 992 patients. After a median follow-up of 10.2 years, 68 events had been reported, including 18 deaths...

David W. Bates - One of the best experts on this subject based on the ideXlab platform.

  • risk of thiazide induced hyponatremia in patients with hypertension
    The American Journal of Medicine, 2011
    Co-Authors: Alexander A. Leung, Andrew S Karson, Valeria Pazo, Adam Wright, David W. Bates
    Abstract:

    Abstract Background Although hyponatremia is a well-recognized Complication of Treatment with thiazide diuretics, the risk of thiazide-induced hyponatremia remains uncertain in routine care. Methods We conducted a retrospective cohort study using a multicenter clinical research registry to identify 2613 adult outpatients that were newly treated for hypertension between January 1, 2000 and December 31, 2005 at 2 teaching hospitals in Boston, Massachusetts, and followed them for up to 10 years. Results Two hundred twenty patients exposed to ongoing thiazide therapy were compared with 2393 patients who were not exposed. In the exposed group, 66 (30%) developed hyponatremia (sodium ≤130 mmol/L). The adjusted incidence rate of hyponatremia was 140 cases per 1000 person-years for patients treated with thiazides, compared with 87 cases per 1000 person-years in those without thiazides. Patients exposed to thiazides were more likely to develop hyponatremia (adjusted incidence rate ratio, 1.61; 95% confidence interval [CI], 1.15-2.25). There was no significant difference in the risk of hospitalizations associated with hyponatremia (adjusted rate ratio, 1.04; 95% CI, 0.46-2.32) or mortality (adjusted rate ratio, 0.41; 95% CI, 0.12-1.42). The number needed to harm (to result in one excess case of incident hyponatremia in 5 years) was 15.02 (95% CI, 7.88-160.30). Conclusions Approximately 3 in 10 patients exposed to thiazides who continue to take them develop hyponatremia.