The Experts below are selected from a list of 79251 Experts worldwide ranked by ideXlab platform

Yuko Sato - One of the best experts on this subject based on the ideXlab platform.

  • catechin green tea Component Causes caspase independent necrosis like cell death in chronic myelogenous leukemia
    Cancer Science, 2009
    Co-Authors: Reo Iwasaki, Kinji Ito, Takaomi Ishida, Makoto Hamanoue, Souichi Adachi, Toshiki Watanabe, Yuko Sato
    Abstract:

    Management strategies of chronic phase chronic myelogenous leukemia (CML) have been revolutionized due to the discovery of a selective tyrosine kinase inhibitor, imatinib (Gleevec, STI571), which is substantially improving median survival. However, emergence of imatinib-resistance has put up a serious problem that requires novel treatment methods. Catechins, polyphenolic compounds in green tea, are gathering much attention due to their potential antitumor effects. So far (–)-epigallocatechin-3-gallate (EGCG), the most abundant Component of catechin, has been shown to cause typical apoptosis in several tumor cell lines in most cases through activation of caspases. In this study, we showed that EGCG predominantly caused necrosis-like cell death via a caspase-independent mechanism in CML cells, K562 and C2F8, whereas imatinib induced the typical apoptotic cell death. Moreover, this caspase-independent cell death partially mediated the release of apoptosis-inducing factor, AIF, and serine protease, HtrA2/Omi, from the mitochondria to cytosol. In addition, EGCG enhanced the imatinib-induced cell death (P < 0.01) resulting in additive cell death in K562 cells and EGCG alone, effectively reduced the viability of imatinib-resistant K562 cells (P < 0.01). Catechin is a possible candidate for an antitumor agent that Causes cell death in CML cells via a caspase-independent mechanism. (Cancer Sci 2009; 100: 349–356)

  • catechin green tea Component Causes caspase independent necrosis like cell death in chronic myelogenous leukemia
    Cancer Science, 2009
    Co-Authors: Reo Iwasaki, Kinji Ito, Takaomi Ishida, Makoto Hamanoue, Souichi Adachi, Toshiki Watanabe, Yuko Sato
    Abstract:

    Management strategies of chronic phase chronic myelogenous leukemia (CML) have been revolutionized due to the discovery of a selective tyrosine kinase inhibitor, imatinib (Gleevec, STI571), which is substantially improving median survival. However, emergence of imatinib-resistance has put up a serious problem that requires novel treatment methods. Catechins, polyphenolic compounds in green tea, are gathering much attention due to their potential antitumor effects. So far (-)-epigallocatechin-3-gallate (EGCG), the most abundant Component of catechin, has been shown to cause typical apoptosis in several tumor cell lines in most cases through activation of caspases. In this study, we showed that EGCG predominantly caused necrosis-like cell death via a caspase-independent mechanism in CML cells, K562 and C2F8, whereas imatinib induced the typical apoptotic cell death. Moreover, this caspase-independent cell death partially mediated the release of apoptosis-inducing factor, AIF, and serine protease, HtrA2/Omi, from the mitochondria to cytosol. In addition, EGCG enhanced the imatinib-induced cell death (P < 0.01) resulting in additive cell death in K562 cells and EGCG alone, effectively reduced the viability of imatinib-resistant K562 cells (P < 0.01). Catechin is a possible candidate for an antitumor agent that Causes cell death in CML cells via a caspase-independent mechanism.

Andre Fuzfa - One of the best experts on this subject based on the ideXlab platform.

  • imprints of dark energy on cosmic structure formation i realistic quintessence models and the non linear matter power spectrum
    Monthly Notices of the Royal Astronomical Society, 2010
    Co-Authors: Jeanmichel Alimi, Andre Fuzfa, Vincent Boucher, Yann Rasera, J Courtin, Pier Stefano Corasaniti
    Abstract:

    Quintessence has been proposed to account for dark energy (DE) in the Universe. This Component Causes a typical modification of the background cosmic expansion, which, in addition to its clustering properties, can leave a potentially distinctive signature on large-scale structures. Many previous studies have investigated this topic, particularly in relation to the non-linear regime of structure formation. However, no careful pre-selection of viable quintessence models with high precision cosmological data was performed. Here we show that this has led to a misinterpretation (and underestimation) of the imprint of quintessence on the distribution of large-scale structures. To this purpose, we perform a likelihood analysis of the combined Supernova Ia UNION data set and Wilkinson Microwave Anisotropy Probe 5-yr data to identify realistic quintessence models. These are specified by different model parameter values, but still statistically indistinguishable from the vanilla Lambda cold dark matter (Lambda CDM). Differences are especially manifest in the predicted amplitude and shape of the linear matter power spectrum though these remain within the uncertainties of the Sloan Digital Sky Survey data. We use these models as a benchmark for studying the clustering properties of dark matter haloes by performing a series of high-resolution N-body simulations. In this first paper, we specifically focus on the non-linear matter power spectrum. We find that realistic quintessence models allow for relevant differences of the dark matter distribution with respect to the Lambda CDM scenario well into the non-linear regime, with deviations of up to 40 per cent in the non-linear power spectrum. Such differences are shown to depend on the nature of DE, as well as the scale and epoch considered. At small scales (k similar to 1-5 h Mpc-1, depending on the redshift), the structure formation process is about 20 per cent more efficient than in Lambda CDM. We show that these imprints are a specific record of the cosmic structure formation history in DE cosmologies and therefore cannot be accounted for in standard fitting functions of the non-linear matter power spectrum.

  • imprints of dark energy on cosmic structure formation i realistic quintessence models and the non linear matter power spectrum
    arXiv: Cosmology and Nongalactic Astrophysics, 2009
    Co-Authors: Jeanmichel Alimi, Andre Fuzfa, Vincent Boucher, Yann Rasera, J Courtin, Pier Stefano Corasaniti
    Abstract:

    Dark energy as a quintessence Component Causes a typical modification of the background cosmic expansion, which in addition to its clustering properties, can leave a potentially distinctive signature on large scale structures. Many previous studies have investigated this topic, particularly in relation to the non-linear regime of structure formation. However, no careful pre-selection of viable quintessence models with high precision cosmological data was performed. Here we show that this has led to a misinterpretation (and underestimation) of the imprint of quintessence on the distribution of large scale structures. To this purpose we perform a likelihood analysis of the combined Supernova Ia UNION dataset and WMAP5-years data to identify realistic quintessence models. Differences from the vanilla LambdaCDM are especially manifest in the predicted amplitude and shape of the linear matter power spectrum, though these remain within the uncertainties of the SDSS data. We use these models as benchmark for studying the clustering properties of dark matter halos by performing a series of high resolution N-body simulations. We find that realistic quintessence models allow for relevant differences of the dark matter distribution with the respect to the LambdaCDM scenario well into the non-linear regime, with deviations up to 40% in the non-linear power spectrum. Such differences are shown to depend on the nature of DE, as well as the scale and epoch considered. At small scales (k~1-5 h Mpc^{-1}, depending on the redshift) the structure formation process is about 20% more efficient than in LambdaCDM. We show that these imprints are a specific record of the cosmic structure formation history in DE cosmologies and therefore cannot be accounted in standard fitting functions of the non-linear matter power spectrum.

Jeanmichel Alimi - One of the best experts on this subject based on the ideXlab platform.

  • imprints of dark energy on cosmic structure formation i realistic quintessence models and the non linear matter power spectrum
    Monthly Notices of the Royal Astronomical Society, 2010
    Co-Authors: Jeanmichel Alimi, Andre Fuzfa, Vincent Boucher, Yann Rasera, J Courtin, Pier Stefano Corasaniti
    Abstract:

    Quintessence has been proposed to account for dark energy (DE) in the Universe. This Component Causes a typical modification of the background cosmic expansion, which, in addition to its clustering properties, can leave a potentially distinctive signature on large-scale structures. Many previous studies have investigated this topic, particularly in relation to the non-linear regime of structure formation. However, no careful pre-selection of viable quintessence models with high precision cosmological data was performed. Here we show that this has led to a misinterpretation (and underestimation) of the imprint of quintessence on the distribution of large-scale structures. To this purpose, we perform a likelihood analysis of the combined Supernova Ia UNION data set and Wilkinson Microwave Anisotropy Probe 5-yr data to identify realistic quintessence models. These are specified by different model parameter values, but still statistically indistinguishable from the vanilla Lambda cold dark matter (Lambda CDM). Differences are especially manifest in the predicted amplitude and shape of the linear matter power spectrum though these remain within the uncertainties of the Sloan Digital Sky Survey data. We use these models as a benchmark for studying the clustering properties of dark matter haloes by performing a series of high-resolution N-body simulations. In this first paper, we specifically focus on the non-linear matter power spectrum. We find that realistic quintessence models allow for relevant differences of the dark matter distribution with respect to the Lambda CDM scenario well into the non-linear regime, with deviations of up to 40 per cent in the non-linear power spectrum. Such differences are shown to depend on the nature of DE, as well as the scale and epoch considered. At small scales (k similar to 1-5 h Mpc-1, depending on the redshift), the structure formation process is about 20 per cent more efficient than in Lambda CDM. We show that these imprints are a specific record of the cosmic structure formation history in DE cosmologies and therefore cannot be accounted for in standard fitting functions of the non-linear matter power spectrum.

  • imprints of dark energy on cosmic structure formation i realistic quintessence models and the non linear matter power spectrum
    arXiv: Cosmology and Nongalactic Astrophysics, 2009
    Co-Authors: Jeanmichel Alimi, Andre Fuzfa, Vincent Boucher, Yann Rasera, J Courtin, Pier Stefano Corasaniti
    Abstract:

    Dark energy as a quintessence Component Causes a typical modification of the background cosmic expansion, which in addition to its clustering properties, can leave a potentially distinctive signature on large scale structures. Many previous studies have investigated this topic, particularly in relation to the non-linear regime of structure formation. However, no careful pre-selection of viable quintessence models with high precision cosmological data was performed. Here we show that this has led to a misinterpretation (and underestimation) of the imprint of quintessence on the distribution of large scale structures. To this purpose we perform a likelihood analysis of the combined Supernova Ia UNION dataset and WMAP5-years data to identify realistic quintessence models. Differences from the vanilla LambdaCDM are especially manifest in the predicted amplitude and shape of the linear matter power spectrum, though these remain within the uncertainties of the SDSS data. We use these models as benchmark for studying the clustering properties of dark matter halos by performing a series of high resolution N-body simulations. We find that realistic quintessence models allow for relevant differences of the dark matter distribution with the respect to the LambdaCDM scenario well into the non-linear regime, with deviations up to 40% in the non-linear power spectrum. Such differences are shown to depend on the nature of DE, as well as the scale and epoch considered. At small scales (k~1-5 h Mpc^{-1}, depending on the redshift) the structure formation process is about 20% more efficient than in LambdaCDM. We show that these imprints are a specific record of the cosmic structure formation history in DE cosmologies and therefore cannot be accounted in standard fitting functions of the non-linear matter power spectrum.

Reo Iwasaki - One of the best experts on this subject based on the ideXlab platform.

  • catechin green tea Component Causes caspase independent necrosis like cell death in chronic myelogenous leukemia
    Cancer Science, 2009
    Co-Authors: Reo Iwasaki, Kinji Ito, Takaomi Ishida, Makoto Hamanoue, Souichi Adachi, Toshiki Watanabe, Yuko Sato
    Abstract:

    Management strategies of chronic phase chronic myelogenous leukemia (CML) have been revolutionized due to the discovery of a selective tyrosine kinase inhibitor, imatinib (Gleevec, STI571), which is substantially improving median survival. However, emergence of imatinib-resistance has put up a serious problem that requires novel treatment methods. Catechins, polyphenolic compounds in green tea, are gathering much attention due to their potential antitumor effects. So far (–)-epigallocatechin-3-gallate (EGCG), the most abundant Component of catechin, has been shown to cause typical apoptosis in several tumor cell lines in most cases through activation of caspases. In this study, we showed that EGCG predominantly caused necrosis-like cell death via a caspase-independent mechanism in CML cells, K562 and C2F8, whereas imatinib induced the typical apoptotic cell death. Moreover, this caspase-independent cell death partially mediated the release of apoptosis-inducing factor, AIF, and serine protease, HtrA2/Omi, from the mitochondria to cytosol. In addition, EGCG enhanced the imatinib-induced cell death (P < 0.01) resulting in additive cell death in K562 cells and EGCG alone, effectively reduced the viability of imatinib-resistant K562 cells (P < 0.01). Catechin is a possible candidate for an antitumor agent that Causes cell death in CML cells via a caspase-independent mechanism. (Cancer Sci 2009; 100: 349–356)

  • catechin green tea Component Causes caspase independent necrosis like cell death in chronic myelogenous leukemia
    Cancer Science, 2009
    Co-Authors: Reo Iwasaki, Kinji Ito, Takaomi Ishida, Makoto Hamanoue, Souichi Adachi, Toshiki Watanabe, Yuko Sato
    Abstract:

    Management strategies of chronic phase chronic myelogenous leukemia (CML) have been revolutionized due to the discovery of a selective tyrosine kinase inhibitor, imatinib (Gleevec, STI571), which is substantially improving median survival. However, emergence of imatinib-resistance has put up a serious problem that requires novel treatment methods. Catechins, polyphenolic compounds in green tea, are gathering much attention due to their potential antitumor effects. So far (-)-epigallocatechin-3-gallate (EGCG), the most abundant Component of catechin, has been shown to cause typical apoptosis in several tumor cell lines in most cases through activation of caspases. In this study, we showed that EGCG predominantly caused necrosis-like cell death via a caspase-independent mechanism in CML cells, K562 and C2F8, whereas imatinib induced the typical apoptotic cell death. Moreover, this caspase-independent cell death partially mediated the release of apoptosis-inducing factor, AIF, and serine protease, HtrA2/Omi, from the mitochondria to cytosol. In addition, EGCG enhanced the imatinib-induced cell death (P < 0.01) resulting in additive cell death in K562 cells and EGCG alone, effectively reduced the viability of imatinib-resistant K562 cells (P < 0.01). Catechin is a possible candidate for an antitumor agent that Causes cell death in CML cells via a caspase-independent mechanism.

Pier Stefano Corasaniti - One of the best experts on this subject based on the ideXlab platform.

  • imprints of dark energy on cosmic structure formation i realistic quintessence models and the non linear matter power spectrum
    Monthly Notices of the Royal Astronomical Society, 2010
    Co-Authors: Jeanmichel Alimi, Andre Fuzfa, Vincent Boucher, Yann Rasera, J Courtin, Pier Stefano Corasaniti
    Abstract:

    Quintessence has been proposed to account for dark energy (DE) in the Universe. This Component Causes a typical modification of the background cosmic expansion, which, in addition to its clustering properties, can leave a potentially distinctive signature on large-scale structures. Many previous studies have investigated this topic, particularly in relation to the non-linear regime of structure formation. However, no careful pre-selection of viable quintessence models with high precision cosmological data was performed. Here we show that this has led to a misinterpretation (and underestimation) of the imprint of quintessence on the distribution of large-scale structures. To this purpose, we perform a likelihood analysis of the combined Supernova Ia UNION data set and Wilkinson Microwave Anisotropy Probe 5-yr data to identify realistic quintessence models. These are specified by different model parameter values, but still statistically indistinguishable from the vanilla Lambda cold dark matter (Lambda CDM). Differences are especially manifest in the predicted amplitude and shape of the linear matter power spectrum though these remain within the uncertainties of the Sloan Digital Sky Survey data. We use these models as a benchmark for studying the clustering properties of dark matter haloes by performing a series of high-resolution N-body simulations. In this first paper, we specifically focus on the non-linear matter power spectrum. We find that realistic quintessence models allow for relevant differences of the dark matter distribution with respect to the Lambda CDM scenario well into the non-linear regime, with deviations of up to 40 per cent in the non-linear power spectrum. Such differences are shown to depend on the nature of DE, as well as the scale and epoch considered. At small scales (k similar to 1-5 h Mpc-1, depending on the redshift), the structure formation process is about 20 per cent more efficient than in Lambda CDM. We show that these imprints are a specific record of the cosmic structure formation history in DE cosmologies and therefore cannot be accounted for in standard fitting functions of the non-linear matter power spectrum.

  • imprints of dark energy on cosmic structure formation i realistic quintessence models and the non linear matter power spectrum
    arXiv: Cosmology and Nongalactic Astrophysics, 2009
    Co-Authors: Jeanmichel Alimi, Andre Fuzfa, Vincent Boucher, Yann Rasera, J Courtin, Pier Stefano Corasaniti
    Abstract:

    Dark energy as a quintessence Component Causes a typical modification of the background cosmic expansion, which in addition to its clustering properties, can leave a potentially distinctive signature on large scale structures. Many previous studies have investigated this topic, particularly in relation to the non-linear regime of structure formation. However, no careful pre-selection of viable quintessence models with high precision cosmological data was performed. Here we show that this has led to a misinterpretation (and underestimation) of the imprint of quintessence on the distribution of large scale structures. To this purpose we perform a likelihood analysis of the combined Supernova Ia UNION dataset and WMAP5-years data to identify realistic quintessence models. Differences from the vanilla LambdaCDM are especially manifest in the predicted amplitude and shape of the linear matter power spectrum, though these remain within the uncertainties of the SDSS data. We use these models as benchmark for studying the clustering properties of dark matter halos by performing a series of high resolution N-body simulations. We find that realistic quintessence models allow for relevant differences of the dark matter distribution with the respect to the LambdaCDM scenario well into the non-linear regime, with deviations up to 40% in the non-linear power spectrum. Such differences are shown to depend on the nature of DE, as well as the scale and epoch considered. At small scales (k~1-5 h Mpc^{-1}, depending on the redshift) the structure formation process is about 20% more efficient than in LambdaCDM. We show that these imprints are a specific record of the cosmic structure formation history in DE cosmologies and therefore cannot be accounted in standard fitting functions of the non-linear matter power spectrum.