The Experts below are selected from a list of 9630 Experts worldwide ranked by ideXlab platform
Erin B Lavik - One of the best experts on this subject based on the ideXlab platform.
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engineering angiogenesis following spinal cord injury a coculture of neural progenitor and endothelial cells in a degradable polymer Implant leads to an increase in vessel density and formation of the blood spinal cord barrier
2009Co-Authors: Millicent Ford Rauch, Sara Royce Hynes, James P Bertram, Andrew Redmond, Rebecca Robinson, Cicely A Williams, Hao Xu, Joseph A Madri, Erin B LavikAbstract:: Angiogenesis precedes recovery following spinal cord injury and its extent correlates with neural regeneration, suggesting that angiogenesis may play a role in repair. An important precondition for studying the role of angiogenesis is the ability to induce it in a controlled manner. Previously, we showed that a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) promoted the formation of stable tubes in vitro and stable, functional vascular networks in vivo in a subcutaneous model. We sought to test whether a similar coculture would lead to the formation of stable functional vessels in the spinal cord following injury. We created microvascular networks in a biodegradable two-Component Implant system and tested the ability of the coculture or controls (lesion control, Implant alone, Implant + ECs or Implant + NPCs) to promote angiogenesis in a rat hemisection model of spinal cord injury. The coculture Implant led to a fourfold increase in functional vessels compared with the lesion control, Implant alone or Implant + NPCs groups and a twofold increase in functional vessels over the Implant + ECs group. Furthermore, half of the vessels in the coculture Implant exhibited positive staining for the endothelial barrier antigen, a marker for the formation of the blood-spinal cord barrier. No other groups have shown positive staining for the blood-spinal cord barrier in the injury epicenter. This work provides a novel method to induce angiogenesis following spinal cord injury and a foundation for studying its role in repair.
Millicent Ford Rauch - One of the best experts on this subject based on the ideXlab platform.
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engineering angiogenesis following spinal cord injury a coculture of neural progenitor and endothelial cells in a degradable polymer Implant leads to an increase in vessel density and formation of the blood spinal cord barrier
2009Co-Authors: Millicent Ford Rauch, Sara Royce Hynes, James P Bertram, Andrew Redmond, Rebecca Robinson, Cicely A Williams, Hao Xu, Joseph A Madri, Erin B LavikAbstract:: Angiogenesis precedes recovery following spinal cord injury and its extent correlates with neural regeneration, suggesting that angiogenesis may play a role in repair. An important precondition for studying the role of angiogenesis is the ability to induce it in a controlled manner. Previously, we showed that a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) promoted the formation of stable tubes in vitro and stable, functional vascular networks in vivo in a subcutaneous model. We sought to test whether a similar coculture would lead to the formation of stable functional vessels in the spinal cord following injury. We created microvascular networks in a biodegradable two-Component Implant system and tested the ability of the coculture or controls (lesion control, Implant alone, Implant + ECs or Implant + NPCs) to promote angiogenesis in a rat hemisection model of spinal cord injury. The coculture Implant led to a fourfold increase in functional vessels compared with the lesion control, Implant alone or Implant + NPCs groups and a twofold increase in functional vessels over the Implant + ECs group. Furthermore, half of the vessels in the coculture Implant exhibited positive staining for the endothelial barrier antigen, a marker for the formation of the blood-spinal cord barrier. No other groups have shown positive staining for the blood-spinal cord barrier in the injury epicenter. This work provides a novel method to induce angiogenesis following spinal cord injury and a foundation for studying its role in repair.
Florian D Naal - One of the best experts on this subject based on the ideXlab platform.
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total ankle replacement with use of a new three Component Implant
2011Co-Authors: Pascal F Rippstein, Martin Huber, Chris J Coetzee, Florian D NaalAbstract:Background: Total ankle arthroplasty has evolved over the past decade, and newer three-Component Implants have demonstrated favorable clinical results and improved survivorship. The present study analyzed the clinical and radiographic results of the first 240 total ankle arthroplasties performed by the authors with one of these new three-Component prostheses. Methods: Two hundred and forty consecutive primary total ankle arthroplasties were performed in 233 patients (115 women and 118 men; mean age, 61.6 years) between November 2003 and October 2007 with the Mobility prosthesis. Intraoperative and postoperative complications, reoperations, and failures were recorded. The American Orthopaedic Foot & Ankle Society hindfoot score and a visual analog scale score assessment of pain were determined at each follow-up visit. Range of ankle motion was measured on functional radiographs, and the radiographs were studied to assess Component positioning, radiolucencies, new bone formation, and periprosthetic bone cysts. Results: Two hundred and thirty-three of the arthroplasties were available for follow-up at least one year after surgery. The mean duration of follow-up was 32.8 ± 15.3 months. There were ten intraoperative complications (4.2%) and twenty postoperative complications (8.6%). A reoperation was necessary in eighteen ankles (7.7%). Five arthroplasties (2.1%) failed at a mean of twenty-seven months after surgery. The mean American Orthopaedic Foot & Ankle Society hindfoot score improved from 48.2 to 84.1 points (p < 0.001). The mean pain level decreased from 7.7 to 1.7 points (p < 0.001). The mean total range of ankle motion improved from 19.8° to 21.9° (p < 0.001). The tibial Component had a mean of 2.1° of varus and a mean posterior slope of 6.0° relative to the tibial axis. The prevalence of nonprogressive radiolucency ranged from 1.8% to 37.3% in the ten zones surrounding the tibial Component, and from 0 to 2.2% in the three zones surrounding the talar Component. Conclusions: The short-term clinical and radiographic results after Mobility total ankle arthroplasty are encouraging and are at least comparable with those associated with other modern three-Component Implants. The minimum duration of follow-up of one year is short, and studies with longer follow-up are needed to confirm our findings. Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.
Joseph A Madri - One of the best experts on this subject based on the ideXlab platform.
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engineering angiogenesis following spinal cord injury a coculture of neural progenitor and endothelial cells in a degradable polymer Implant leads to an increase in vessel density and formation of the blood spinal cord barrier
2009Co-Authors: Millicent Ford Rauch, Sara Royce Hynes, James P Bertram, Andrew Redmond, Rebecca Robinson, Cicely A Williams, Hao Xu, Joseph A Madri, Erin B LavikAbstract:: Angiogenesis precedes recovery following spinal cord injury and its extent correlates with neural regeneration, suggesting that angiogenesis may play a role in repair. An important precondition for studying the role of angiogenesis is the ability to induce it in a controlled manner. Previously, we showed that a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) promoted the formation of stable tubes in vitro and stable, functional vascular networks in vivo in a subcutaneous model. We sought to test whether a similar coculture would lead to the formation of stable functional vessels in the spinal cord following injury. We created microvascular networks in a biodegradable two-Component Implant system and tested the ability of the coculture or controls (lesion control, Implant alone, Implant + ECs or Implant + NPCs) to promote angiogenesis in a rat hemisection model of spinal cord injury. The coculture Implant led to a fourfold increase in functional vessels compared with the lesion control, Implant alone or Implant + NPCs groups and a twofold increase in functional vessels over the Implant + ECs group. Furthermore, half of the vessels in the coculture Implant exhibited positive staining for the endothelial barrier antigen, a marker for the formation of the blood-spinal cord barrier. No other groups have shown positive staining for the blood-spinal cord barrier in the injury epicenter. This work provides a novel method to induce angiogenesis following spinal cord injury and a foundation for studying its role in repair.
Hao Xu - One of the best experts on this subject based on the ideXlab platform.
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engineering angiogenesis following spinal cord injury a coculture of neural progenitor and endothelial cells in a degradable polymer Implant leads to an increase in vessel density and formation of the blood spinal cord barrier
2009Co-Authors: Millicent Ford Rauch, Sara Royce Hynes, James P Bertram, Andrew Redmond, Rebecca Robinson, Cicely A Williams, Hao Xu, Joseph A Madri, Erin B LavikAbstract:: Angiogenesis precedes recovery following spinal cord injury and its extent correlates with neural regeneration, suggesting that angiogenesis may play a role in repair. An important precondition for studying the role of angiogenesis is the ability to induce it in a controlled manner. Previously, we showed that a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) promoted the formation of stable tubes in vitro and stable, functional vascular networks in vivo in a subcutaneous model. We sought to test whether a similar coculture would lead to the formation of stable functional vessels in the spinal cord following injury. We created microvascular networks in a biodegradable two-Component Implant system and tested the ability of the coculture or controls (lesion control, Implant alone, Implant + ECs or Implant + NPCs) to promote angiogenesis in a rat hemisection model of spinal cord injury. The coculture Implant led to a fourfold increase in functional vessels compared with the lesion control, Implant alone or Implant + NPCs groups and a twofold increase in functional vessels over the Implant + ECs group. Furthermore, half of the vessels in the coculture Implant exhibited positive staining for the endothelial barrier antigen, a marker for the formation of the blood-spinal cord barrier. No other groups have shown positive staining for the blood-spinal cord barrier in the injury epicenter. This work provides a novel method to induce angiogenesis following spinal cord injury and a foundation for studying its role in repair.