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Punam Pahwa - One of the best experts on this subject based on the ideXlab platform.
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a randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome Composite Score and bone mineral in older adults
Applied Physiology Nutrition and Metabolism, 2009Co-Authors: Stephen M Cornish, Philip D Chilibeck, Lisa Pausjennsenl Pausjennsen, Jay H Biem, Talaei Khozanit Khozani, Vijitha Senanayakev Senanayake, Hassanali Vatanparast, Jonathan P Little, Susan J Whiting, Punam PahwaAbstract:A randomized double-blind placebo controlled study design was used to assess the effects of flaxseed lignan complex supplementation during exercise training on a metabolic syndrome Composite Score ...
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a randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome Composite Score and bone mineral in older adults
Applied Physiology Nutrition and Metabolism, 2009Co-Authors: Stephen M Cornish, Philip D Chilibeck, Lisa Pausjennsenl Pausjennsen, Jay H Biem, Talaei Khozanit Khozani, Vijitha Senanayakev Senanayake, Hassanali Vatanparast, Jonathan P Little, Susan J Whiting, Punam PahwaAbstract:A randomized double-blind placebo controlled study design was used to assess the effects of flaxseed lignan complex supplementation during exercise training on a metabolic syndrome Composite Score and osteoporosis risk in older adults. A total of 100 subjects (≥50 years) were randomized to receive flaxseed lignan (543 mg·day–1 in a 4050 mg complex) or placebo while completing a 6 month walking program (30–60 min·day–1, 5–6 days·week–1). Fasting serum glucose, triacylglycerol (TAG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, total cholesterol, interleukin-6, and tumor necrosis factor-α were measured every 2 months, while body composition, bone mineral density, and resting blood pressure were assessed at baseline and at 6 months. A Composite Z Score of 6 risk factors for metabolic syndrome (fasting glucose, HDL cholesterol, TAG, abdominal adiposity, blood pressure, and inflammatory cytokines) was calculated at baseline and at 6 months. Men taking placebo increased metab...
Hung N Luu - One of the best experts on this subject based on the ideXlab platform.
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Composite Score of healthy lifestyle factors and the risk of pancreatic cancer in a prospective cohort study
Cancer Prevention Research, 2021Co-Authors: Hung N Luu, Renwei Wang, Aizhen Jin, Woonpuay Koh, Pedram Paragomi, Randall E Brand, Jianmin YuanAbstract:While the associations between individual lifestyle factors and risk of pancreatic cancer were studied extensively, their combined impact has not been examined. We evaluated the association of a Composite Score of healthy lifestyle factors, including body mass index, cigarette smoking, the Alternative Healthy Eating Index-2010 (AHEI-2010), sleep duration, and physical activity with pancreatic cancer risk in the Singapore Chinese Health Study, an on-going prospective cohort study of 63,257 Chinese aged 45-74 at enrollment in 1993-1998 with up to 25 years of follow-up. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI) with adjustment for multiple potential confounders. We identified 316 incident pancreatic cancer cases among the cohort participants after a mean 17 years of follow-up. Individuals with higher Composite Scores representing healthier lifestyle were at significantly lower risk of pancreatic cancer. The multivariate-adjusted HRs (95% CIs) of pancreatic cancer incidence for the Composite Scores 2, 3, 4, 5, 6-7 were 0.60 (0.50-0.91), 0.48 (0.32-0.71), 0.45 (0.31-0.67), 0.41 (0.27-0.62) and 0.38 (0.24-0.62), respectively, compared with the Scores 0-1 (Ptrend<0.0001). The inverse association was more apparent among participants without diabetes history and was robust in men and women as well as in alcohol drinkers and non-drinkers. In summary, the association for pancreatic cancer risk was stronger for the aggregated than individual healthy lifestyle factors. These findings suggest that a more comprehensive lifestyle modification strategy would be more effective for prevention of pancreatic cancer than the change of a single lifestyle factor.
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Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma findings from a prospective cohort study
Cancer Epidemiology Biomarkers & Prevention, 2021Co-Authors: Hung N Luu, Renwei Wang, Jaideep Behari, Andrew O Odegaard, Aizhen Jin, George Boonbee Goh, Claire E Thomas, Jose C Clemente, Woonpuay KohAbstract:Background. While the associations between individual lifestyle factors and risk of hepatocellular carcinoma (HCC) have been previously described, their combined impact on HCC risk is unknown. Methods. The association of a Composite Score of healthy lifestyle factors, including body mass index, alcohol consumption, cigarette smoking, alternative Mediterranean diet, and sleep duration, and HCC risk was examined in the Singapore Chinese Health Study, an on-going prospective cohort study of 63,257 Chinese. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI). Conditional logistic regression method was used to evaluate this Composite lifestyle Score-HCC risk association among a subset of individuals who tested negative for hepatitis B surface antigen (HBsAg) and anti-hepatitis C antibody. Results. After a mean follow-up of 17.7 years, 561 participants developed HCC. Individuals with higher Composite Scores representing healthier lifestyles (range 0-8) were at significantly lower risk of HCC. Compared to the lowest Composite Score category (0-4), the HRs (95% CIs) for the Composite Scores of 5, 6, 7, and 8 were 0.67 (0.62-0.85), 0.61 (0.48-0.77), 0.49 (0.37-0.65), and 0.13 (0.06-0.30), respectively (Ptrend<0.0001). A similar inverse association was observed in participants with negative HBsAg and anti-HCV negative serology (HR=0.38, 95% CI: 0.19-0.79; for the highest versus the lowest category of the Composite Scores (Ptrend=0.001). Conclusion. Healthy lifestyles protects against HCC development, especially for individuals without hepatitis B virus and hepatitis C infections. Impact. Our current study highlight the importance of a comprehensive lifestyle modification strategy for HCC primary prevention.
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abstract 2344 Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma findings from a prospective cohort study
Epidemiology, 2020Co-Authors: Hung N Luu, Renwei Wang, Jaideep Behari, Jennifer M Adamshaduch, Andrew O Odegaard, George Goh Bee, Aizhen Jin, Woonpuay Koh, Jianmin YuanAbstract:Background. While the associations between individual lifestyle factors and risk of hepatocellular carcinoma (HCC) were examined substantially, their combined impact on HCC risk has not been evaluated. Methods. The association of a Composite Score of healthy lifestyle factors, including body mass index, alcohol consumption, cigarette smoking, alternative Mediterranean Diet (aMED), and sleep duration, with the risk of developing HCC was examined in the Singapore Chinese Health Study (SCHS), an on-going prospective cohort of 63,257 Chinese men and women aged 45-74 at enrollment in 1993-1998 with up to 25 years of follow-up. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI) of HCC with the Composite Score after adjustment for multiple potential confounders. The unconditional logistic regression method was used to confirm the association between the Composite lifestyle Score and HCC risk among hepatitis B surface antigen (HBsAg) negative individuals to eliminate its potential confounding effect. Results. After a mean follow-up of 17.7 years, 561 participants of the SCHS developed HCC. Individuals with higher Composite Scores, which represented for healthier lifestyles, were at significantly lower risk of HCC. Compared with the lowest Composite Score (i.e., 0-4), the HRs (95% CIs) for 5, 6, 7 and 8 were 0.48 (0.36-0.64), 0.44 (0.34-0.67), 0.37 (0.28-0.48), and 0.26 (0.17-0.39), respectively (Ptrend Conclusion. Healthy lifestyles are protective against the development of HCC, especially for individuals without viral infection. This finding highlights the importance of a comprehensive lifestyle modification strategy for primary prevention of HCC. Funding: The Singapore Chinese Health Study was supported by the National Institutes of Health (NIH) of the United States (grants # R01 CA144034 and UM1 CA182876). Citation Format: Hung N. Luu, Renwei Wang, Jaideep Behari, Jennifer Adams-Haduch, Andrew O. Odegaard, George Goh Bee, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan. Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma: Findings from a prospective cohort study [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2344.
Woonpuay Koh - One of the best experts on this subject based on the ideXlab platform.
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Composite Score of healthy lifestyle factors and the risk of pancreatic cancer in a prospective cohort study
Cancer Prevention Research, 2021Co-Authors: Hung N Luu, Renwei Wang, Aizhen Jin, Woonpuay Koh, Pedram Paragomi, Randall E Brand, Jianmin YuanAbstract:While the associations between individual lifestyle factors and risk of pancreatic cancer were studied extensively, their combined impact has not been examined. We evaluated the association of a Composite Score of healthy lifestyle factors, including body mass index, cigarette smoking, the Alternative Healthy Eating Index-2010 (AHEI-2010), sleep duration, and physical activity with pancreatic cancer risk in the Singapore Chinese Health Study, an on-going prospective cohort study of 63,257 Chinese aged 45-74 at enrollment in 1993-1998 with up to 25 years of follow-up. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI) with adjustment for multiple potential confounders. We identified 316 incident pancreatic cancer cases among the cohort participants after a mean 17 years of follow-up. Individuals with higher Composite Scores representing healthier lifestyle were at significantly lower risk of pancreatic cancer. The multivariate-adjusted HRs (95% CIs) of pancreatic cancer incidence for the Composite Scores 2, 3, 4, 5, 6-7 were 0.60 (0.50-0.91), 0.48 (0.32-0.71), 0.45 (0.31-0.67), 0.41 (0.27-0.62) and 0.38 (0.24-0.62), respectively, compared with the Scores 0-1 (Ptrend<0.0001). The inverse association was more apparent among participants without diabetes history and was robust in men and women as well as in alcohol drinkers and non-drinkers. In summary, the association for pancreatic cancer risk was stronger for the aggregated than individual healthy lifestyle factors. These findings suggest that a more comprehensive lifestyle modification strategy would be more effective for prevention of pancreatic cancer than the change of a single lifestyle factor.
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Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma findings from a prospective cohort study
Cancer Epidemiology Biomarkers & Prevention, 2021Co-Authors: Hung N Luu, Renwei Wang, Jaideep Behari, Andrew O Odegaard, Aizhen Jin, George Boonbee Goh, Claire E Thomas, Jose C Clemente, Woonpuay KohAbstract:Background. While the associations between individual lifestyle factors and risk of hepatocellular carcinoma (HCC) have been previously described, their combined impact on HCC risk is unknown. Methods. The association of a Composite Score of healthy lifestyle factors, including body mass index, alcohol consumption, cigarette smoking, alternative Mediterranean diet, and sleep duration, and HCC risk was examined in the Singapore Chinese Health Study, an on-going prospective cohort study of 63,257 Chinese. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI). Conditional logistic regression method was used to evaluate this Composite lifestyle Score-HCC risk association among a subset of individuals who tested negative for hepatitis B surface antigen (HBsAg) and anti-hepatitis C antibody. Results. After a mean follow-up of 17.7 years, 561 participants developed HCC. Individuals with higher Composite Scores representing healthier lifestyles (range 0-8) were at significantly lower risk of HCC. Compared to the lowest Composite Score category (0-4), the HRs (95% CIs) for the Composite Scores of 5, 6, 7, and 8 were 0.67 (0.62-0.85), 0.61 (0.48-0.77), 0.49 (0.37-0.65), and 0.13 (0.06-0.30), respectively (Ptrend<0.0001). A similar inverse association was observed in participants with negative HBsAg and anti-HCV negative serology (HR=0.38, 95% CI: 0.19-0.79; for the highest versus the lowest category of the Composite Scores (Ptrend=0.001). Conclusion. Healthy lifestyles protects against HCC development, especially for individuals without hepatitis B virus and hepatitis C infections. Impact. Our current study highlight the importance of a comprehensive lifestyle modification strategy for HCC primary prevention.
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abstract 2344 Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma findings from a prospective cohort study
Epidemiology, 2020Co-Authors: Hung N Luu, Renwei Wang, Jaideep Behari, Jennifer M Adamshaduch, Andrew O Odegaard, George Goh Bee, Aizhen Jin, Woonpuay Koh, Jianmin YuanAbstract:Background. While the associations between individual lifestyle factors and risk of hepatocellular carcinoma (HCC) were examined substantially, their combined impact on HCC risk has not been evaluated. Methods. The association of a Composite Score of healthy lifestyle factors, including body mass index, alcohol consumption, cigarette smoking, alternative Mediterranean Diet (aMED), and sleep duration, with the risk of developing HCC was examined in the Singapore Chinese Health Study (SCHS), an on-going prospective cohort of 63,257 Chinese men and women aged 45-74 at enrollment in 1993-1998 with up to 25 years of follow-up. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI) of HCC with the Composite Score after adjustment for multiple potential confounders. The unconditional logistic regression method was used to confirm the association between the Composite lifestyle Score and HCC risk among hepatitis B surface antigen (HBsAg) negative individuals to eliminate its potential confounding effect. Results. After a mean follow-up of 17.7 years, 561 participants of the SCHS developed HCC. Individuals with higher Composite Scores, which represented for healthier lifestyles, were at significantly lower risk of HCC. Compared with the lowest Composite Score (i.e., 0-4), the HRs (95% CIs) for 5, 6, 7 and 8 were 0.48 (0.36-0.64), 0.44 (0.34-0.67), 0.37 (0.28-0.48), and 0.26 (0.17-0.39), respectively (Ptrend Conclusion. Healthy lifestyles are protective against the development of HCC, especially for individuals without viral infection. This finding highlights the importance of a comprehensive lifestyle modification strategy for primary prevention of HCC. Funding: The Singapore Chinese Health Study was supported by the National Institutes of Health (NIH) of the United States (grants # R01 CA144034 and UM1 CA182876). Citation Format: Hung N. Luu, Renwei Wang, Jaideep Behari, Jennifer Adams-Haduch, Andrew O. Odegaard, George Goh Bee, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan. Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma: Findings from a prospective cohort study [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2344.
Jianmin Yuan - One of the best experts on this subject based on the ideXlab platform.
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Composite Score of healthy lifestyle factors and the risk of pancreatic cancer in a prospective cohort study
Cancer Prevention Research, 2021Co-Authors: Hung N Luu, Renwei Wang, Aizhen Jin, Woonpuay Koh, Pedram Paragomi, Randall E Brand, Jianmin YuanAbstract:While the associations between individual lifestyle factors and risk of pancreatic cancer were studied extensively, their combined impact has not been examined. We evaluated the association of a Composite Score of healthy lifestyle factors, including body mass index, cigarette smoking, the Alternative Healthy Eating Index-2010 (AHEI-2010), sleep duration, and physical activity with pancreatic cancer risk in the Singapore Chinese Health Study, an on-going prospective cohort study of 63,257 Chinese aged 45-74 at enrollment in 1993-1998 with up to 25 years of follow-up. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI) with adjustment for multiple potential confounders. We identified 316 incident pancreatic cancer cases among the cohort participants after a mean 17 years of follow-up. Individuals with higher Composite Scores representing healthier lifestyle were at significantly lower risk of pancreatic cancer. The multivariate-adjusted HRs (95% CIs) of pancreatic cancer incidence for the Composite Scores 2, 3, 4, 5, 6-7 were 0.60 (0.50-0.91), 0.48 (0.32-0.71), 0.45 (0.31-0.67), 0.41 (0.27-0.62) and 0.38 (0.24-0.62), respectively, compared with the Scores 0-1 (Ptrend<0.0001). The inverse association was more apparent among participants without diabetes history and was robust in men and women as well as in alcohol drinkers and non-drinkers. In summary, the association for pancreatic cancer risk was stronger for the aggregated than individual healthy lifestyle factors. These findings suggest that a more comprehensive lifestyle modification strategy would be more effective for prevention of pancreatic cancer than the change of a single lifestyle factor.
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abstract 2344 Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma findings from a prospective cohort study
Epidemiology, 2020Co-Authors: Hung N Luu, Renwei Wang, Jaideep Behari, Jennifer M Adamshaduch, Andrew O Odegaard, George Goh Bee, Aizhen Jin, Woonpuay Koh, Jianmin YuanAbstract:Background. While the associations between individual lifestyle factors and risk of hepatocellular carcinoma (HCC) were examined substantially, their combined impact on HCC risk has not been evaluated. Methods. The association of a Composite Score of healthy lifestyle factors, including body mass index, alcohol consumption, cigarette smoking, alternative Mediterranean Diet (aMED), and sleep duration, with the risk of developing HCC was examined in the Singapore Chinese Health Study (SCHS), an on-going prospective cohort of 63,257 Chinese men and women aged 45-74 at enrollment in 1993-1998 with up to 25 years of follow-up. Cox proportional hazard regression method was used to estimate hazard ratio (HR) and its 95% confidence interval (CI) of HCC with the Composite Score after adjustment for multiple potential confounders. The unconditional logistic regression method was used to confirm the association between the Composite lifestyle Score and HCC risk among hepatitis B surface antigen (HBsAg) negative individuals to eliminate its potential confounding effect. Results. After a mean follow-up of 17.7 years, 561 participants of the SCHS developed HCC. Individuals with higher Composite Scores, which represented for healthier lifestyles, were at significantly lower risk of HCC. Compared with the lowest Composite Score (i.e., 0-4), the HRs (95% CIs) for 5, 6, 7 and 8 were 0.48 (0.36-0.64), 0.44 (0.34-0.67), 0.37 (0.28-0.48), and 0.26 (0.17-0.39), respectively (Ptrend Conclusion. Healthy lifestyles are protective against the development of HCC, especially for individuals without viral infection. This finding highlights the importance of a comprehensive lifestyle modification strategy for primary prevention of HCC. Funding: The Singapore Chinese Health Study was supported by the National Institutes of Health (NIH) of the United States (grants # R01 CA144034 and UM1 CA182876). Citation Format: Hung N. Luu, Renwei Wang, Jaideep Behari, Jennifer Adams-Haduch, Andrew O. Odegaard, George Goh Bee, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan. Composite Score of healthy lifestyle factors and risk of hepatocellular carcinoma: Findings from a prospective cohort study [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2344.
Stephen M Cornish - One of the best experts on this subject based on the ideXlab platform.
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a randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome Composite Score and bone mineral in older adults
Applied Physiology Nutrition and Metabolism, 2009Co-Authors: Stephen M Cornish, Philip D Chilibeck, Lisa Pausjennsenl Pausjennsen, Jay H Biem, Talaei Khozanit Khozani, Vijitha Senanayakev Senanayake, Hassanali Vatanparast, Jonathan P Little, Susan J Whiting, Punam PahwaAbstract:A randomized double-blind placebo controlled study design was used to assess the effects of flaxseed lignan complex supplementation during exercise training on a metabolic syndrome Composite Score ...
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a randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome Composite Score and bone mineral in older adults
Applied Physiology Nutrition and Metabolism, 2009Co-Authors: Stephen M Cornish, Philip D Chilibeck, Lisa Pausjennsenl Pausjennsen, Jay H Biem, Talaei Khozanit Khozani, Vijitha Senanayakev Senanayake, Hassanali Vatanparast, Jonathan P Little, Susan J Whiting, Punam PahwaAbstract:A randomized double-blind placebo controlled study design was used to assess the effects of flaxseed lignan complex supplementation during exercise training on a metabolic syndrome Composite Score and osteoporosis risk in older adults. A total of 100 subjects (≥50 years) were randomized to receive flaxseed lignan (543 mg·day–1 in a 4050 mg complex) or placebo while completing a 6 month walking program (30–60 min·day–1, 5–6 days·week–1). Fasting serum glucose, triacylglycerol (TAG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, total cholesterol, interleukin-6, and tumor necrosis factor-α were measured every 2 months, while body composition, bone mineral density, and resting blood pressure were assessed at baseline and at 6 months. A Composite Z Score of 6 risk factors for metabolic syndrome (fasting glucose, HDL cholesterol, TAG, abdominal adiposity, blood pressure, and inflammatory cytokines) was calculated at baseline and at 6 months. Men taking placebo increased metab...
